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Oncocytic adrenocortical tumor with uncertain malignant potential in pediatric population: A case report and review of literature

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World Journal of Clinical Cases 2021年第20期9卷 5675-5682页

作者： Xiao-Chun Chen Yun-Man Tang Yu Mao Dao-Rui Qin Department of pediatric Surgery Sichuan Academy of Medical Sciences Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Oncocytic adrenocortical tumor(OACT)is rare,with few cases reported in the *** more than 20 cases in children have been *** clinical characteristics,diagnosis,treatment and prognosis of children with OACT are summarized based on a literature review,in order to improve the understanding of OACT in *** SUMMARY We report a case of a 17-mo-old patient who was admitted to our hospital due to symptoms of odynuria and fever,which are clinical features consistent with a functional adrenocortical *** patient was diagnosed with OACT of uncertain malignant *** tomography indicated a soft tissue giant tumor in the right adrenal region,approximately 4.3 cm×5.5 cm in *** nodular and speckled calcifications were observed in the *** patient received robot-assisted laparoscopic right adrenal tumor *** pathological results were consistent with OACT,and immunohistochemical results showed cytokeratin+/-,chromogranin A+,synaptophysin-,neuronspecific enolase-,S100-,Ki67 about 10%,CD34-and D2-40-.After surgery,urinary tract ultrasonography was reviewed monthly,catecholamine hormone and sex hormone levels were examined every 2 mo and computed tomography was performed every 6 *** date,no tumor metastasis or recurrence has been identified in this *** levels of sex hormones and catecholamine hormones decreased to normal 1 mo after *** OACT is rare in the pediatric population,with few cases reported in the *** most pediatric OACTs are benign,malignant cases have been *** resection is the preferred option in most patients.

关键词： Oncocytic adrenocortical tumor Adrenocortical tumor Robotic surgery Children Case report

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Prediction of esophageal and gastric histology by macroscopic diagnosis during upper endoscopy in pediatric celiac disease

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World Journal of Gastroenterology 2017年第4期23卷 646-652页

作者： Erin D Boschee Jason YK Yap Justine M Turner Department of pediatrics University of Alberta Edmonton Clinic Health Academy University of Alberta Hospital Division of pediatric Gastroenterology Department of PediatricsUniversity of Alberta

AIMTo determine the sensitivity of macroscopic appearance for predicting histological diagnosis at sites other than duodenum in pediatric celiac disease (CD).METHODSEndoscopic and histologic findings in pediatric patients undergoing upper endoscopy for first-time diagnosis of CD at Stollery Children’s Hospital from 2010-2012 were retrospectively *** charts from 140 patients were reviewed. Esophageal and gastric biopsies were taken in 54.3% and 77.9% of patients, respectively. Endoscopic appearance was normal in the esophagus and stomach in 75% and 86.2%. Endoscopic esophageal diagnoses were eosinophilic esophagitis (EE) (11.8%), esophagitis (7.9%), glycogenic acanthosis (1.3%) and non-specific abnormalities (3.9%). Endoscopic gastric diagnoses were gastritis (8.3%), pancreatic rest (0.9%), and non-specific abnormalities (4.6%). Histology was normal in 76.3% of esophageal and 87.2% of gastric specimens. Abnormal esophageal histology was EE (10.5%), esophagitis (10.5%), glycogenic acanthosis (1.3%) and non-specific (1.3%). Gastritis was reported in 12.8% of specimens. Sensitivity and specificity of normal endoscopy for predicting normal esophageal histology was 86.2% and 61.1%, and for normal gastric histology was 87.4% and 21.4%.CONCLUSIONIn the absence of macroscopic abnormalities, routine esophageal and gastric biopsy during endoscopy for pediatric CD does not identify major pathologies. These findings have cost and time saving implications for clinical practice.

关键词： Endoscopy Histology Esophagus Gastric biopsy Celiac disease

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Zinc deficiency in the pediatric age group is common but underevaluated

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World Journal of pediatrics 2017年第4期13卷 360-366页

作者： Dogus Vuralli Leyla Tumer Alev Hasanoglu Department of pediatrics Gazi University Faculty of MedicineAnkaraTurkey Department of pediatric Metabolism and Nutrition Gazi University Faculty of MedicineAnkaraTurkey

Background:Subclinical micronutrient deficiencies have been gradually becoming more important as a public health problem and drawing attention of the health *** it has been known that detecting and treating people having deficiency symptoms alone is no longer *** is important to detect and prevent any deficiency before it displays clinical *** deficiency is one of the most widespread micronutrient *** this study,we aimed to evaluate the zinc status and the associated factors in healthy school-age ***:The study was carried out in schools in Altindag,the district of Ankara.A total of 1063 healthy children,585 girls and 478 boys,aged 5-16 years were included in the *** zinc,high-sensitivity C-reactive protein levels and white blood cell count were measured.A serum zinc level 10 years of age the cutoffs for serum zinc concentration were set at 66 μg/dL for females and 70 μg/dL for males.A questionnaire was developed to collect socioeconomic and demographic information of the ***:The prevalence of subclinical zinc deficiency in children attending the study was detected to be 27.8%.This high ratio showed zinc deficiency was an important health problem in the Altindag district of Ankara,***:Evaluating the indicators of zinc deficiency such as serum zinc concentration,dietary zinc intake and stunting prevalence,this study is the most comprehensive epidemiological study performed in children in *** study reveals the high prevalence of subclinical zinc deficiency and indicates that zinc deficiency is a public health concern for the study population.

关键词： nutritional deficiency subclinical zinc

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Intestinal ascariasis at pediatric emergency room in a developed country

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World Journal of Gastroenterology 2014年第38期20卷 14058-14062页

作者： Shuichiro Umetsu Tsuyoshi Sogo Kentaro Iwasawa Takeo Kondo Tomoyuki Tsunoda Manari Oikawa-Kawamoto Haruki Komatsu Ayano Inui Tomoo Fujisawa Department of pediatric Hepatology and Gastroenterology Saiseikai Yokohama City Tobu Hospital Department of pediatrics Toho University Medical CenterSakura Hospital

Ascaris lumbricoides infection is rare among children in developed *** large numbers of adult Ascaris in the small intestine can cause various abdominal symptoms,this infection remains asymptomatic until the number of worms in the intestine considerably increases in most *** causing bilious vomiting suggesting ileus is rare,especially in developed countries.A 6-year-old boy who lived in Japan,presented with abdominal colic,bilious vomiting at the pediatric emergency *** appeared pale,and had no abdominal distention,tenderness,palpable abdominal mass,or findings of *** experienced bilious vomiting again during a physical *** tests showed mild elevation of white blood cells and C-reactive protein *** of adenovirus,rotavirus,and norovirus were not detected from his stool,and stool culture showed normal *** showed multiple,round-shaped structures within the small intestine,and a tubular structure in a longitudinal scan of the small *** endoscopy showed a moving worm of Ascaris in the *** ascariasis should be considered as a cause of bilious vomiting in children,even at the emergency room in industrial *** examination and capsule endoscopy are useful for diagnosis of pediatric intestinal ascariasis.

关键词： Ascaris lumbricoides Paralytic ileus Capsule endoscopy Ultrasound Bilious vomiting

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Evolving strategies: Enhancements in managing eosinophilic esophagitis in pediatric patients

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World Journal of Clinical pediatrics 2024年第1期13卷 14-22页

作者： Ahmed Elghoudi Doaa Zourob Eman Al Atrash Fatima Alshamsi Manal Alkatheeri Hassib Narchi Rana Bitar Department of pediatric Sheikh Khalifa Medical CityAbu DhabiUnited Arab Emirates Division of pediatric Gastroenterology Sheikh Khalifa Medical CityAbu DhabiUnited Arab Emirates pediatric Residency Program Sheikh Khalifa Medical CityAbu DhabiUnited Arab Emirates College of Medicine and Health Sciences United Arab Emirates UniversityAlainAbu DhabiUnited Arab Emirates

Eosinophilic esophagitis is a newly recognized disease first described about 50 years *** definition,diagnosis,and management have evolved with new published consensus guidelines and newly approved treatment available to pediatricians,enabling a better understanding of this disease and more targeted treatment for *** describe the definition,presentation,and diagnosis of eosinophilic esophagitis including management,challenges,and future directions in *** definition,diagnosis,and management of eosinophilic esophagitis have evolved over the last 50 *** guidelines and newly approved biologic treatment have enabled pediatricians to better understand this disease and allow for more targeted treatment for *** describe the definition,presentation,diagnosis,management,and treatment in addition to the challenges and future directions of eosinophilic esophagitis management in children.

关键词： Eosinophilic esophagitis Esophagitis Gastroesophageal reflux disease Food allergy Dysphagia

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Effectiveness of psychosocial interventions for pediatric patients with scoliosis:a systematic review

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World Journal of pediatric Surgery 2023年第2期6卷 63-69页

作者： Maike van Niekerk Ann Richey John Vorhies Connie Wong Kali Tileston pediatric Orthopaedic Surgery Stanford UniversityStanfordCaliforniaUSA Lane Medical Library Stanford UniversityStanfordCaliforniaUSA

Background pediatric patients affected by scoliosis have complex psychological and social care needs,and may benefit from psychosocial *** therefore aimed to summarize evidence of the efficacy of psychosocial interventions for this patient *** Literature was identified by searching Medline,PsycINFO,Embase,EBSCO Cumulated Index to Nursing and Allied Health Literature(CINAHL),and Cochrane Central Register of Controlled Trials(CENTRAL)from database inception to 20 March *** that evaluated the effectiveness of psychosocial interventions for pediatric patients diagnosed with scoliosis and reported at least one quantitative outcome were *** eligibility,data extraction,and quality assessment(using the Cochrane Collaboration's Risk of Bias Tool and Methodological Index for Non-Randomized Studies)were performed by two independent *** are presented using narrative *** We identified ten studies,all of which focused on adolescent idiopathic *** included a total of 1007 participants,most of whom were *** studies focused on patients undergoing bracing,six on patients undergoing spinal surgery,and one on patients *** compliance monitoring and counseling were found to significantly improve brace compliance quality and *** mental healthcare delivery by nurses after spinal surgery was similarly found to improve *** studies examined the efficacy of brief educational interventions;most did not report clear evidence of their *** methodological quality of studies was often unclear due to limitations in articles'reporting *** Research on the efficacy of psychosocial interventions for pediatric patients with scoliosis is limited,with interventions involving frequent patient-provider interactions showing the most *** clinical and research efforts should focus on developing and testing psychosocial interventions for

关键词： patients scoliosis nurse

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The Evaluation of pediatric HIV Care in Congo

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Open Journal of pediatrics 2017年第3期7卷 197-204页

作者： J. Kambourou L. N. Motoula Latou Moyen Engoba A. R. Okoko H. L. Atanda G. Moyen pediatric Intensive Care Service University Center Hospital (UCH) of Brazzaville Brazzaville Congo Faculty of Health Sciences Université Marien-Ngouabi Brazzaville Congo Medico Social Centre Total EP Pointe-Noire Congo

pediatric AIDS is still a public health issue. In order to improve the care of children living with HIV, a study was carried out between January and December 2014, that is in 12 months at University Center Hospital (UCH) of Brazzaville, in the two Ambulant Treatment Centers (ATCs) of Brazzaville and Pointe-Noire, In three general hospitals and seven base hospitals. Heads of centers and follow-up files of children aged 0 to 15 constituted the target population. The study variables concern the provision of care, the organization of structures and personnel, and data management. Thirteen health facilities, 13 heads of centers and 520 medical files were selected. HIV care was effective in nine out of eleven departments, only the two CTAs offered the entire package of activities. The diagnosis was made in WHO stage 3 in 433 cases (83.3%), the pre-therapeutic assessment in 246 cases (47.2%);Psychological care in 84 cases (16.1%) whose 80 (95.2%) in the ACT, nutritional management in 4 cases (0.7%). Nine out of 13 centers did not have computer tools or materials for patient information and education;No center had sufficient staff. The dispensation of Anti-retroviral drugs (ARDs) is not based on any standard and the safety conditions of the laboratory providers are not guaranteed. The importance of the observed dysfunction makes it necessary to improve the general conditions of care.

关键词： Evaluation pediatric HIV/AIDS Care Congo

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pediatric non-cirrhotic portal hypertension:Endoscopic outcome and perspectives from developing nations

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World Journal of Hepatology 2021年第10期13卷 1269-1288页

作者： Moinak Sen Sarma Jayendra Seetharaman Department of pediatric Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical SciencesLucknow 226014Uttar PradeshIndia

Non-cirrhotic portal hypertension(NCPH)forms an important subset of portal hypertension in *** bleed and splenomegaly are their predominant *** features show cytopenias(hypersplenism)and preserved hepatic synthetic *** sessions of endoscopic variceal ligation or endoscopic sclerotherapy eradicate esophageal varices in almost all *** variceal eradication,there is an increased risk of other complications like secondary gastric varices,cholangiopathy,colopathy,growth failure,especially in extra-hepatic portal vein obstruction(EHPVO).Massive splenomegaly-related pain and early satiety cause poor quality of life(QoL).Meso-Rex bypass is the definitive therapy when the procedure is anatomically feasible in *** portosystemic shunt surgeries with splenectomy are indicated when patients present late and spleen-related issues *** surgeries prevent rebleed,improve growth and ***-cirrhotic portal fibrosis(NCPF)is a less common cause of portal hypertension in children in developing *** in the second decade,massive splenomegaly and patent portal vein are discriminating features of *** surgery is required in severe cases when endotherapy is insufficient for the *** hepatic fibrosis(CHF)presents with firm palpable liver and *** plate malformation forms the histological hallmark of *** is commonly associated with Caroli’s disease,renal cysts,and syndromes associated with neurological *** CHF has a favourable prognosis requiring *** transplanta-tion is required when there is decompensation or recurrent cholangitis,especially in Caroli’s *** liver-kidney transplantation is indicated when both liver and renal issues are present.

关键词： Extrahepatic portal vein obstruction Non-cirrhotic portal fibrosis Portosystemic shunt surgery Congenital hepatic fibrosis

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pediatric inflammatory bowel disease

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World Journal of Gastroenterology 2006年第20期12卷 3204-3212页

作者： Karen A Diefenbach Christopher K Breuer Department of Surgery Yale University School of Medicine Division of Pediatric Surgery330 Cedar StreetRm. 132 FMBNorth HavenCT 06520United States

Inflammatory bowel disease is an important cause of gastrointestinal pathology in children and adolescents. The incidence of pediatric inflammatory bowel disease is increasing; therefore, it is important for the clinician to be aware of the presentation of this disease in the pediatric population. Laboratory tests, radiology studies, and endoscopic procedures are helpful in diagnosing inflammatory bowel disease and differentiating between Crohn＇s disease and ulcerative colitis. Once diagnosed, the goal of medical management is to induce remission of disease while minimizing the side effects of the medication. Specific attention needs to be paid to achieving normal growth in this susceptible population. Surgical management is usually indicated for failure of medical management, complication, or malignancy. Algorithms for diagnostic evaluation and treatment of pediatric inflammatory bowel disease are presented. The specific psychosocial issues facing these patients are also discussed in this review as are the future goals of research in the complex problem of pediatric inflammatory bowel disease.

关键词： pediatric Inflammatory bowel Ulcerative colitis Crohn's disease

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A pediatric non-protein losing Menetrier's disease successfully treated with octreotide long acting release

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World Journal of Gastroenterology 2012年第21期18卷 2727-2729页

作者： Giovanni Di Nardo Salvatore Oliva Marina Aloi Federica Ferrari Simone Frediani Adriana Marcheggiano Salvatore Cucchiara Department of pediatrics Pediatric Gastroenterology and Liver Unit Sapienza University of Rome00161 Rome Italy Department of Medical Science Sapienza University of Rome00161 Rome Italy

pediatric Menetrier's disease (MD) is an uncommon, acute, self-limited hypertrophic gastropathy characterized by enlarged gastric folds associated with epithelial hyperplasia and usually accompanied by protein losing gastropathy. Gastric cytomegalovirus infection is found in one third of MD children and its treatment is often associated with remission. Diagnosis often requires fullthickness biopsy due to inability to detect typical histological findings with conventional endoscopic biopsy. We report an uncommon case of non self-limited pediatric MD needing endoscopic mucosal resection for diagnosis which was then successfully treated with octreotide long-acting release (LAR). To the best of our knowledge, this is the first pediatric MD case successfully treated with octreotide LAR. Our experience suggests octreotide LAR as treatment for refractory MD before gastrectomy.

关键词： Menetrier’s disease Octreotide Endoscopic mucosal resection Children

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