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Obesogenic effects of six classes of emerging contaminants

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Journal of Environmental Sciences 2025年第5期151卷 252-272页

作者： Siying Wu Chaoyu Tong Jing Liu moe key laboratory of Environmental Remediation and Ecosystem Health College of Environmental and Resource SciencesZhejiang UniversityHangzhou 310058China

There is growing concern about the concept that exposure to environmental chemicals may be contributing to the obesity ***,there is no consensus on the obesogenic effects of emerging contaminants from a toxicological and environmental *** potential human exposure and experimental evidence for obesogenic effects of emerging contaminants need to be systematically *** main objective of this review is to provide recommendations for further subsequent policy development following a critical analysis of the literature for humans and experimental animals exposed to emerging *** article reviews human exposure to emerging contaminants(with a focus on antimicrobials,preservatives,water and oil repellents,flame retardants,antibiotics and bisphenols)and the impact of emerging contaminants on *** emerging contaminants have been widely detected in human biological *** studies provide evidence linking exposure to emerging contaminants to the risks of obesity in *** based on animalmodels and adipose cells show the obesogenic effects of emerging contaminants and identify modes of action by which contaminants may induce changes in body fat accumulation and lipid metabolic *** knowledge gaps in this area and future directions for further investigation are discussed.

关键词： Emerging contaminants Obesity Human exposure Preservatives Flame retardants Plasticizers Antibiotics

General expert consensus on the application of network pharmacology in the research and development of new traditional Chinese medicine drugs

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Chinese Journal of Natural Medicines 2025年第2期23卷 129-142页

作者： Shao Li Wei Xiao Institute of TCM-X/moe key laboratory of bioinformatics Bioinformatics Division BNRist/Department of Automation Tsinghua University State key laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture Jiangsu Kanion Pharmaceutical Co. Ltd.

The research and development of new traditional Chinese medicine(TCM) drugs have progressively established a novel system founded on the integration of TCM theory, human experience, and clinical trials(termed the “Three Combinations”). However, considering TCM's distinctive features of “syndrome differentiation and treatment” and “multicomponent formulations and complex mechanisms”, current TCM drug development faces challenges such as insufficient understanding of the material basis and the overall mechanism of action and an incomplete evidence chain system. Moreover, significant obstacles persist in gathering human experience data, evaluating clinical efficacy, and controlling the quality of active ingredients, which impede the innovation process in TCM drug development. Network pharmacology, centered on the “network targets” theory, transcends the limitations of the conventional“single target” reductionist research model. It emphasizes the comprehensive effects of disease or syndrome biological networks as targets to elucidate the overall regulatory mechanism of TCM prescriptions. This approach aligns with the holistic perspective of TCM, offering a novel method consistent with TCM's holistic view for investigating the complex mechanisms of TCM and developing new TCM drugs. It is internationally recognized as a “next-generation drug research model”. To advance the research of new tools, methods, and standards for TCM evaluation and to overcome fundamental, critical, and cutting-edge technical challenges in TCM regulation, this consensus aims to explore the characteristics, progress, challenges, applicable pathways, and specific applications of network pharmacology as a new theory, method, and tool in TCM drug development. The goal is to enhance the quality of TCM drug research and development and accelerate the efficiency of developing new TCM products.

关键词： Expert consensus Network pharmacology Research and development of new traditional Chinese medicine drugs

Stem-leaf saponins of Panax notoginseng attenuate experimental Parkinson's disease progression in mice by inhibiting microglia-mediated neuroinflammation via P2Y2R/PI3K/AKT/NFκB signaling pathway

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Chinese Journal of Natural Medicines 2025年第1期23卷 43-53页

作者： Hui Wu Chenyang Ni Yu Zhang Yingying Song Longchan Liu Fei Huang Hailian Shi Zhengtao Wang Xiaojun Wu Shanghai key laboratory of Compound Chinese Medicines The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines Institute of Chinese Materia Medica The MOE Innovation Centre for Basic Medicine Research on Qi-Blood TCM Theories Shanghai University of Traditional Chinese Medicine

Stem-leaf saponins from Panax notoginseng(SLSP) comprise numerous PPD-type saponins with diverse pharmacological properties; however, their role in Parkinson's disease(PD),characterized by microglia-mediated neuroinflammation, remains unclear. This study evaluated the effects of SLSP on suppressing microglia-driven neuroinflammation in experimental PD models, including the 1-methyl-4-phenylpyridinium(MPTP)-induced mouse model and lipopolysaccharide(LPS)-stimulated BV-2 microglia. Our findings revealed that SLSP mitigated behavioral impairments and excessive microglial activation in models of PD, including MPTP-treated mice. Additionally, SLSP inhibited the upregulation of inducible nitric oxide synthase(i NOS) and cyclooxygenase-2(COX2) and attenuated the phosphorylation of PI3K,protein kinase B(AKT), nuclear factor-κB(NFκB), and inhibitor of NFκB protein α(IκBα) both in vivo and in vitro. Moreover, SLSP suppressed the production of inflammatory markers such as interleukin(IL)-1β, IL-6, and tumor necrosis factor alpha(TNF-α) in LPS-stimulated BV-2cells. Notably, the P2Y2R agonist partially reversed the inhibitory effects of SLSP in LPStreated BV-2 cells. These results suggest that SLSP inhibit microglia-mediated neuroinflammation in experimental PD models, likely through the P2Y2R/PI3K/AKT/NFκB signaling pathway. These novel findings indicate that SLSP may offer therapeutic potential for PD by attenuating microglia-mediated neuroinflammation.

关键词： Microglia NFκB Neuroinflammation P2Y2 receptor Stem-leaf saponins of Panax Notoginseng

Experimental demonstration of 220-GHz terahertz signals wireless transmission over 4.6 km

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Science China(Information Sciences) 2025年第1期68卷 386-388页

作者： Yi WEI Jianjun YU Mingxu WANG Xiongwei YANG Qiutong ZHANG Jingwen TAN Bing ZHANG Ying WU Yang HAN Peng TIAN Wen ZHOU Kaihui WANG Feng ZHAO State key laboratory of ASIC and System Key Laboratory for Information Science of Electromagnetic Waves (MoE)School of Information Science and Technology Fudan University School of Electronic Engineering Xi'an University of Posts and Telecommunications

The advancement of terahertz (THz) communication technology drives the evolution of wireless communication systems,offering novel pathways and technical means for the development of future 6G communication *** wireless communication systems are often constrained by bandwidth limitations of electronic devices in high frequency ***,THz communication technology leverages the characteristics of electromagnetic waves to transcend these limitations,enabling communication athigher frequencies and wider bandwidths.

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Electro-functionalized 2D nitrogen-carbon nanosheets decorated with symbiotic cobalt single-atoms/clusters

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Journal of Energy Chemistry 2025年第2期101卷 385-391页

作者： Xinyan Zhou Sifan Qiao Zhenzhen Zhao Meiqi Liu Kexin Song Fuxi Liu Nailin Yue Xiujuan Li Meng Zou Wei Zhang key laboratory of Automobile Materials moe and School of Materials Science & Engineering and Electron Microscopy Center and International Center of Future Science and Jilin Provincial International Cooperation Key Laboratory of High-Efficiency Clean Energy Materials Jilin University key laboratory of Bionic Engineering Ministry of Education Jilin University

Two-dimensional（2D） materials loaded with single atoms and clusters are being set at the forefront of catalysis due to their distinctive geometric and electronic ***,the usually-complicated synthesis procedures impede in-depth clarification of their catalytic *** this end,herein we developed an efficient one-step dimension-reduction carbonization strategy,with which we successfully architected a highly-efficient catalyst for oxygen reduction reaction（ORR）,featured with symbiotic cobalt single atoms and clusters decorated in two-dimensional（2D） ultra-thin（3.5 nm thickness）nitrogen-carbon *** synergistic effects of the two components afford excellent oxygen reduction activity in alkaline media(E1/2=0.823 V ***) and thereof a high power density(146.61 mW cm-2) in an assembled Zn-air *** revealed by theoretical calculations,the cobalt clusters can regulate electrons surrounding those individual atoms and affect the adsorption of intermediate *** a consequence,the derived active sites of single cobalt atoms lead to a significant improvement of the ORR ***,our work may fuel interests to delicate architectu re of single atoms and clusters coexisting 2D support toward optimal electrocatalytic performance.

关键词： Carbon-Nitrogen Nanosheets Oxygen reduction reaction Single atoms and clusters Two-dimensional

Capsaicin(CAP) exerts a protective effect against ethanol-induced oxidative gastric mucosal injury by modulating the chemokine receptor 4 (CCR4)/Src/p47phox signaling pathway both in vitro and in vivo

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Chinese Journal of Natural Medicines 2025年第2期23卷 191-202页

作者： Zhiru Yang Haolin Guo Pengfei Zhang Kairui Liu Junli Ba Xue Bai Shiti Shama Bo Zhang Xiaoning Gao Jun Kang School of Life Sciences Tianjin University School of Traditional Chinese Medicine Beijing University of Chinese Medicine Tianjin Pharmaceutical and Cosmetic Evaluation and Inspection Center Institute for TCM-X MOE Key Laboratory of Bioinformatics Bioinformatics Division BNRist Department of Automation Tsinghua University Institute of Biomedical Research Henan Academy of Sciences

Ethanol(EtOH) is a common trigger for gastric mucosal diseases, and mitigating oxidative stress is essential for attenuating gastric mucosal damage. Capsaicin(CAP) has been identified as a potential agent to counteract oxidative damage in the gastric mucosa; however, its precise mechanism remains unclear. This study demonstrates that CAP alleviates EtOH-induced gastric mucosal injuries through two primary pathways: by suppressing the chemokine receptor 4(CCR4)/Src/p47phox axis, thereby reducing oxidative stress, and by inhibiting the phosphorylation and nuclear translocation of nuclear factor-κB p65(NF-κB) p65, resulting in diminished inflammatory responses. These findings elucidate the mechanistic pathways of CAP and provide a theoretical foundation for its potential therapeutic application in the treatment of gastric mucosal injuries.

关键词： Capsaicin Chemokine signaling Gastric mucosal damage NF-κB p65

High-throughput experimentation and machine learning-promoted synthesis of α-phosphoryloxy ketones via Ru-catalyzed P(O)O–H insertion reactions of sulfoxonium ylides

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Science China Chemistry 2025年第2期68卷 679-686页

作者： An Lin Jingyuan Liu Yougen Xu Haiting Wu Yating Chen Yan Zhang Lebin Su Xiaodan Zhao Kuangbiao Liao Institute of Organic Chemistry&moe key laboratory of Bioinorganic and Synthetic Chemistry School of ChemistrySun Yat-sen UniversityGuangzhou 510006China Guangzhou National laboratory Guangzhou 510005China Bioland laboratory Guangzhou 510005China

Herein,we report a novel and highly efficient method for the synthesis ofα-phosphoryloxy carbonyl compounds via Rucatalyzed P(O)O–H insertion reactions of sulfoxonium ylides and phosphinic acids,with the assistance of high-throughput experimentation(HTE)and machine learning(ML).A variety of P(O)O−H derivatives,including diarylphosphates,alkyl phosphates,and alkoxyphosphates,are competent candidates to react with sulfoxonium ylides in this transformation,and variousα-phosphoryloxy carbonyls and propylene phosphates are directly *** approach utilizes readily available sulfoxonium ylide as a carbene precursor,and features mild conditions,operational simplicity,and broad functional groups tolerance,and could be used for late-stage functionalization of structurally complex bioactive ***,a conducive exploration of the reaction space is also conducted(756 reactions)and a machine learning model for reaction yield prediction has been developed and applied,showcasing the practical application of this newly workflow(HTE-ML)in the field of synthetic chemistry.

关键词： α-phosphoryloxy ketones high-throughput experimentation machine learning P(O)O-H insertion sulfoxonium ylides

Sulfur atom occupying surface oxygen vacancy to boost the charge transfer and stability for aqueous Bi2O3 electrode

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Journal of Energy Chemistry 2025年第2期101卷 751-759页

作者： Guangmin Yang Jianyan Lin Guanwu Li Tian Li Dong Wang Weitao Zheng College of Physics Changchun Normal University School of Materials Science and Engineering Northwestern Polytechnical University key laboratory of Automobile Materials of moe School of Materials Science and Engineering and Jilin Provincial International Cooperation Key Laboratory of High-Efficiency Clean Energy Materials Jilin University

Oxygen vacancies（Ov） within metal oxide electrodes can enhance mass/charge transfer dynamics in energy storage ***,construction of surface Ovoften leads to instability in electrode structure and irreversible electrochemical reactions,posing a significant *** overcome these challenges,atomic heterostructures are employed to address the structural instability and enhance the mass/charge transfer dynamics associated with phase conversion mechanism in aqueous electrodes,Herein,we introduce an atomic S-Bi2O3heterostructure(sulfur（S） anchoring on the surface Ovof Bi2O3).The integration of S within Bi2O3lattice matrix triggers a charge imbala nce at the heterointerfaces,ultimately resulting in the creation of a built-in electric field（BEF）.Thus,the BEF attracts OH-ions to be adsorbed onto Bi within the regions of high electron cloud overlap in S-Bi2O3,facilitating highly efficient charge ***,the anchored S plays a pivotal role in preserving structural integrity,thus effectively stabilizing the phase conversion reaction of *** a result,the S-Bi2O3electrode achieves72.3 mA h g-1at 10 A g-1as well as high-capacity retention of 81.9% after 1600 *** innovative SBi2O3design presents a groundbreaking approach for fabricating electrodes that exhibit efficient and stable mass and charge transfer ***,it enhances our understanding of the underlying reaction mechanism within energy storage electrodes.

关键词： Anchoring effect Atomic heterostructure Charge/mass transfer Oxygen vavancy Structural integrity

Strategies for efficient enrichment of anaerobic ammonia oxidizing bacteria in activated sludge

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Journal of Environmental Sciences 2025年第5期151卷 703-713页

作者： Bin Tang Jin Wang Xingdong Gao Zhihua Li key laboratory of Northwest Water Resource Environmentand EcologyMOESchool of Environmental and Municipal EngineeringXi’an University of Architecture and TechnologyXi’an 710055China Xi’an key laboratory of Intelligent Equipment Technology for Environmental Engineering Xi’an University of Architecture and TechnologyXi’an 710055China

Anaerobic ammonia oxidation(Anammox)is an economical and sustainablewastewater nitrogen removal technology,and its application in the mainstream process is the inevitable trend of the development of ***,how to effectively enriching Anammox bacteria from the activated sludge remains challenging and restricts its extensive *** this study,the rapid and efficient enrichment of Anammox bacteriawas achieved by raising the reflux ratio and nitrogen loading rate(NLR)using conventional activated sludge as the *** the screening phase(days 1–90),the reflux ratio was increased to discharge partial floc sludge,resulting in the relative abundance of Candidatus Brocadiaceae increased from0.04%to 22.54%,which effectively reduced thematrix and spatial competition between other microorganisms and Anammox *** day 90,the stoichiometric ratio of the Anammox process closely approached the theoretical value of 1:1.32:0.26,indicating that the Anammox reaction was the primary nitrogen removal process in the *** the enrichment phase(days 91–238),the NLR increased from 0.43 to 1.20 kgN/(m^(3)·d)and removal efficiency was 71.89%,resulting in the relative abundance of Candidatus Brocadiaceae increased to 61.27%on day *** reactor operated steadily from days 444 to 498,maintaining the nitrogen removal rate(NRR)of 3.00 kgN/(m^(3)·d)and achieving successful sludge granulation with the particle size of 392.4μ*** short,this study provided a simple and efficient approach for enriching Anammox bacteria from the activated sludge,supporting to start an Anammox process efficiently.

关键词： Anammox Activated sludge Enrichment Nitrogen removal Strategy