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Disposition and Metabolism of 1 -Nitropropane in Rats and Chimpanzees

Biomedical and Environmental Sciences 1989年第3期2卷 249-264页

作者： MARGRET HAAS-JOBELIUS FRIEDHELM KORTE F.COULSTON Gesellschaft Gesellschaft Technische Universit t München Institut für chemie Lehrstuhl für kologische chemie Am L wentor D-8050 FreisingWeihenstephan Federal Republic of Germany and White Sands Research Center 2512 Christina Place Alamogordo New Mexico 88310 für Strahlen-und Umweltforschung mbH München Institut für kologische chemie Ingolst dter Landstrasse 1 D-8042 Neuherberg Federal Republic of Germany

The metabolic fate of 1 -nitropropane (1-NP) has not been previously reported. In this study male rats and chimpanzees were given single doses of 40 mg/kg ip and 5 mg/kg iv 1-[1-^(14)C]NP, respectively. The quantitative extent of urinary and fecal elimination was similar in both species. The rats excreted 16.5% ofthedosein urine and 1.7% in feces. For chimpanzees the respective values were 14.8 and 1.2%. Experiments with rats demonstrated that the major route of elimination was by exhalation. With a total elimination via the lungs of 72.6%, rats expired 10.3% of the dose as unchanged 1-NP. Five polar metabolites were isolated from the urine of chimpanzees. The two major metabolites were identified as 3-hydroxypropionic acid and 7V-methyl-N-2-(methylsulfinyl)ethylpropionic acid amide (NMPA). Both substances were also excreted in rat urine. The two identified metabolites indicate that 1-NP was degraded to propionic acid, part of which was modified to 3-hydroxypropionic acid or NMPA. A hypothetical pathway for the biochemical generation of NMPA is suggested.(c)1989 Academic Press, Inc.

关键词： ppm Nitropropane in Rats and Chimpanzees Disposition and Metabolism of 1

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Contamination of Environment with Polycyclic Aromatic Hydrocarbons in India

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Journal of Environmental Protection 2015年第11期6卷 1268-1278页

作者： Khageshwar Singh Patel Shobhana Ramteke Yogita Naik Bharat Lal Sahu Saroj Sharma Jutta Lintelmann Matuschek Georg School of Studies in Chemistry/Environmental Science Pt. Ravishankar Shukla University Raipur India Department of Chemistry Devi Rathi Mahila Mahavidhaya Rajnandagaon India GSF-Forschungszentrum für Umwelt und Gesundheit Institut für &#214 kologische chemie Neuherberg Germany

Environment in India is contaminated with polycyclic aromatic hydrocarbons (PAHs) due to occurring of large anthropogenic activities i.e. fuel combustion, mineral roasting and biomass burning. Hence, contamination of 13 toxic PAHs: phenanthrene, anthracene, fluoranthene, pyrene, benz (a) anthracene, ben-zo (b) fluoranthene, benzo (k) fluoranthene, benzo (a) pyrene, benzo (ghi) perylene, dibenz (ah) anthracene, indeno1,2,3-(cd) pyrene, coronene and coronene in the environment (i.e. ambient particulate matter, road dust, sludge and sewage) of the most industrialized area: Raipur city, India is described. The ΣPAH13 concentration in the 16 environment materials was ranged from 7980 - 1,051,300 μg/kg with mean value of 172,613 ± 154,726 μg/kg. The concentration variations, toxicities and sources of the PAHs in various environmental compartments are discussed.

关键词： Polycyclic Aromatic Hydrocarbons Dust Sewage Sludge

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吸烟改变人卵母细胞成熟期血管生成物质的分泌(德)

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世界核心医学期刊文摘（妇产科学分册） 2006年第6期2卷 40-40页

作者： Motejlek K. Palluch F. Neulen J. Grü mmer R. 马超 Frauenklinik fü r Gynkologische Endokrinologie und Reproduktionsmedizin Universit tsklinikum Pauwelsstraβe 30 52074 Aachen GermanyDr.

Objective: An adequate vascularization in the ovary is important for optimal oocyte maturation. By secreting vascular endothelial growth factor (VEGF) granulosa cells promote blood vessel growth. In addition, they paracrinely reduce the production of VEGF antagonist sVEGFR- 1 (soluble VEGF receptor 1) in endothelial cells. In the present study we examined the influence of smoking on the sVEGFR- 1 concentration in human follicular fluid and on the paracrine activity of granulosa cells. Material and Methods: Follicular fluid samples were obtained during oocyte retrieval from 50 smoking and 50 non- smoking women undergoing in- vitro fertilization treatment. Follicular fluids were used either directly for sVEGFR- 1 quantification or added to endothelial cell cultures to determine the soluble receptor concentration in culture supernatant after four days’ incubation. Results: In this study we were able to show that smokers have a distinctly higher concentration of soluble VEGF receptor 1 in follicular fluid than non- smokers (499.6± 77.7 pg/ml versus 159.2± 29.8 pg/ml). Also, follicular fluid of smoking women shows a significantly less inhibiting effect on endothelial sVEGFR- 1 production than of non- smoking women (1174.1 ± 93.8 pg/ml compared to 794.2 ± 70.1 pg/ml). Conclusion: A higher concentration of sVEGFR- 1 indicates decreased angiogenic activity in follicles of smokers which may result in reduced blood circulation during follicular growth and thus impaired oocyte maturation by malnutrition.

关键词：分泌血管内皮生长因子人卵母细胞非吸烟女性血管生成成熟期可溶性受体内皮细胞培养人卵泡液物质卵泡细胞

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