检索结果-南通市图书馆

An unprecedented synthesis of axially chiral biaryls by rearrangement and aromatization of carbocations with central-to-axial conversion of chirality

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第9期67卷 2998-3003页

作者： Qi Liu Xue-Dong Li Liang Cheng Li Liu Beijing National Laboratory for molecular Sciences(BNLMS) CAS Key Laboratory of Molecular Recognition and FunctionCAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

The central-to-axial chirality conversion represents a fascinating class of chemical processes consisting of the destruction of stereogenic centers and the simultaneous installation of axial chiral elements,which provides efficient methods for the preparation of axially chiral ***,developing catalytic asymmetric approaches for constructing these central chirality precursors and the efficient central-to-axial chirality conversion remains a challenge due to the requirement of aromatization or elimination *** this work,we have developed an unprecedented enantioselective intramolecular FriedelCrafts alkylation with unactivated-ketone carbonyls from which a chiral tertiary alcohol was generated with high efficiency and excellent *** addition,the central-to-axial chirality conversion strategy has been successfully applied to the synthesis of enantioenriched biaryls via a less-explored carbocation-initiated rearrangement and aromatization under the promotion of Lewis *** methodology provided a straightforward and sustainable access to a broad range of biaryl-2-carboxylic acid and in excellent yields(up to 92%)and excellent central-to-axial chirality conversion(up to 99%conversion percentage).This work could be a great model for developing new methods for synthesizing axially chiral biaryls and a general protocol for the rearrangement and aromatization of carbocations for further functionalization.

关键词： br?nsted acid catalysis desymmetrization phosphoric acid axially chiral biaryls central-to-axial conversion

mRNA vaccine technology for infectious diseases and beyond

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第10期67卷 2267-2270页

作者： Pei Hao Xiao Li Xuan Li Wu Zhong Key Laboratory of molecular Virology and Immunology Shanghai Institute of Immunity and InfectionChinese Academy of SciencesShanghai 200031China Changchun Veterinary Research institute Chinese Academy of Agricultural SciencesChangchun 130122China Key Laboratory of Synthetic Biology CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China National Engineering Research Center for the Emergency Drug Beijing Institute of Pharmacology and ToxicologyBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

The rise of mRNA vaccine technology Vaccines stand as one of the most significant medical advancements,playing a crucial role in the prevention of infectious diseases and the improvement of global *** triumph of smallpox vaccination stands as a towering achievement in the annals of healthcare,leading to the complete elimination of a oncedevastating disease and showcasing the efficacy of vaccination methods.

关键词： methods vaccination prevention

Solid-state lithium-ion batteries for grid energy storage:opportunities and challenges

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第1期67卷 43-66页

作者： Xin Chang Yu-Ming Zhao Boheng Yuan Min Fan Qinghai Meng Yu-Guo Guo Li-Jun Wan CAS Key Laboratory of molecular Nanostructure and Nanotechnology CAS Research/Education Center for Excellence in Molecular SciencesBeijing National Laboratory for Molecular Sciences(BNLMS)Institute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China

The energy crisis and environmental pollution drive more attention to the development and utilization of renewable *** the capricious nature of renewable energy resource,it has difficulty supplying electricity directly to consumers stably and efficiently,which calls for energy storage systems to collect energy and release electricity at peak *** to their flexible power and energy,quick response,and high energy conversion efficiency,lithium-ion batteries stand out among multiple energy storage technologies and are rapidly deployed in the *** superior performance and ensuring the safety of energy storage systems,intrinsically safe solid-state electrolytes are expected as an ideal alternative to liquid *** this review,we systematically evaluate the priorities and issues of traditional lithium-ion batteries in grid energy *** lithium-ion batteries containing liquid electrolytes,solid-state lithium-ion batteries have the potential to play a more significant role in grid energy *** challenges of developing solid-state lithium-ion batteries,such as low ionic conductivity of the electrolyte,unstable electrode/electrolyte interface,and complicated fabrication process,are discussed in ***,the safety of solid-state lithium-ion batteries is *** the obtained insights,inspiring prospects for solid-state lithium-ion batteries in grid energy storage are depicted.

关键词： lithium-ion batteries grid energy storage solid-state electrolytes interface stability

Rbfox1 controls alternative splicing of focal adhesion genes in cardiac muscle cells

在线全文

学校读者我要写书评

暂无评论

Journal of molecular Cell Biology 2024年第1期16卷 54-65页

作者： Peter Zorn Jaime Calvo Sánchez Tala Alakhras Barbara Schreier Michael Gekle Stefan Hüttelmaier Marcel Köhn Junior Group‘Non-coding RNAs and RBPs in Human Diseases’ Medical FacultyUniversity of Halle–Wittenberg06120 Halle(Saale)Germany Julius Bernstein institute of physiology Medical FacultyUniversity of Halle–Wittenberg06112 Halle(Saale)Germany institute of molecular Medicine Medical FacultyUniversity of Halle–Wittenberg06120 Halle(Saale)Germany

Alternative splicing is one of the major cellular processes that determine the tissue-specific expression of protein ***,it remains challenging to identify physiologically relevant and tissue-selective proteins that are generated by alternative ***,we investigated the target spectrum of the splicing factor Rbfox1 in the cardiac muscle context in more *** using a combination of in silico target prediction and in-cell validation,we identified several focal adhesion proteins as alternative splicing targets of *** focused on the alternative splicing patterns of vinculin(metavinculin isoform)and paxillin(extended paxillin isoform)and identified both as potential Rbfox1 *** analyses suggested that both isoforms are promoted by Rbfox1 due to binding in the *** adhesions play an important role in the cardiac muscle context,since they mainly influence cell shape,cytoskeletal organization,and cell–matrix *** data confirmed that depletion of Rbfox1 changed cardiomyoblast morphology,cytoskeletal organization,and multinuclearity after differentiation,which might be due to changes in alternative splicing of focal adhesion ***,our results indicate that Rbfox1 promotes alternative splicing of focal adhesion genes in cardiac muscle cells,which might contribute to heart disease progression,where downregulation of Rbfox1 is frequently observed.

关键词： Rbfox1 alternative splicing focal adhesion cardiac muscle cells

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

跷跷板运动:平衡植物免疫与生长

Science Bulletin 2024年第1期69卷 3-6页

作者：邓一文何祖华 National Key Laboratory of Plant molecular Genetics CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China

Plants face the constant challenge of allocating limited resources to both immunity and growth to ensure survival and reproduction,therefore,one major aim of crop breeding is to balance disease resistance with *** review highlights the intricate interplay between plant immunity and growth,shedding light on the underlying molecular mechanisms and potential strategies for optimizing these vital agronomic *** discuss the role of signaling pathways,epigenetic regulation,long non-coding RNAs,and post-translational modifications in mediating the balance between immunity and *** also highlight recent findings on the rewiring of signals of immunity and growth which provide valuable insights into manipulation of these pathways for crop *** understanding the fine-tuning mechanisms of plant immunity and growth,we can develop innovative approaches to enhance disease resistance in future crops without compromising yield potential.

关键词： immunity 植物免疫 crops

Structural insights into AtABCG25,an angiosperm-specific abscisic acid exporter

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plant Communications 2024年第1期5卷 284-295页

作者： Jian Xin Yeling Zhou Yichun Qiu He Geng Yuzhu Wang Yi Song Jiansheng Liang Kaige Yan Department of Chemical Biology School of Life SciencesSouthern University of Science and TechnologyShenzhen 518055China institute of Plant and Food Science Department of BiologySchool of Life SciencesSouthern University of Science and TechnologyShenzhen 518055China Max Planck institute of molecular Plant physiology Potsdam-GolmGermany institute for Biological Electron Microscopy Southern University of Science and TechnologyShenzhenGuangdongChina

Cellular hormone homeostasis is essential for precise spatial and temporal signaling responses and *** acid(ABA)plays pivotal roles in orchestrating various developmental and stress re-sponses and confersfitness benefits over ecological and evolutionary timescales in terrestrial *** ABA level is regulated by complex processes,including biosynthesis,catabolism,and ***25 is thefirst ABA exporter identified through genetic screening and affects diverse ABA *** the structural basis of ABA export by ABCG25 is critical for further manipulations of ABA homeostasis and *** used cryo-electron microscopy to elucidate the structural dynamics of AtABCG25 and successfully characterized different states,including apo AtABCG25,ABA-bound AtABCG25,and ATP-bound AtABCG25(E232Q).Notably,AtABCG25 forms a homodimer that fea-tures a deep,slit-like cavity in the transmembrane domain,and we precisely characterized the critical residues in the cavity where ABA *** binding triggers closure of the nucleotide-binding domains and conformational transitions in the transmembrane *** show that AtABCG25 belongs to a conserved ABCG subfamily that originated during the evolution of *** subfamily neofunctionalized to regulate seed germination via the endosperm,in concert with the evolution of this angio-sperm-specific,embryo-nourishing ***,thesefindings provide valuable insights into the intricate substrate recognition and transport mechanisms of the ABA exporter AtABCG25,paving the way for genetic manipulation of ABA homeostasis and plantfitness.

关键词： AtABCG25 abscisic acid ABC transporters cryo-EM structure

Heterocatalytic ethylene methoxycarbonylation via a pseudo-hydride pathway over Pt_(1)/MoS_(2)

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第8期67卷 2427-2428页

作者： Bo-Hang Zhao Bin Zhang institute of molecular Plus Department of ChemistrySchool of ScienceTianjin UniversityTianjin 300072China

Ethylene (C2H4) methoxycarbonylation (EMC) with CO and methanol (CH3OH) to methyl propanoate (MP) is industrially important due to its 100% atom efficiency [1].However, the heavy reliance on homogeneous Pd-based catalysts and strong acid media over commercial EMC processes still causes economic and environmental concerns [2]. At present, supported single-atom catalysts (SACs) can serve as bridges for accessing homogeneous catalysts in traditional heterogeneous catalytic processes.

关键词： processes. catalytic hydride

New pharmacological tools:the use of diterpenes to promote adult hippocampal neurogenesis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第8期19卷 1629-1630页

作者： Ricardo Gomez-Oliva Pedro Nunez-Abades Carmen Castro Department of Biomedicine Biotechnology and Public HealthDivision of PhysiologyUniversity of CadizCadizSpain Biomedical Research and Innovation institute of Cadiz(INiBICA) CadizSpain Department of physiology University of SevilleSevilleSpain

Tissue regeneration maintains homeostasis and preserves the functional features of each ***,not all tissues show a strong repairing *** is the case of the central nervous *** is now well established that the generation of new functional neurons from stem cells in the adult brain occurs in specific regions of the brain of different species such as rodents,birds,primates,and humans(Eriksson et al.,1998).

关键词： capacity maintain preserve

Recent progress on rapid diagnosis of COVID-19 by point-of-care testing platforms

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第3期35卷 66-75页

作者： Ya-Nan Tang Dingding Jiang Xuejun Wang Yunqi Liu Dacheng Wei State Key Laboratory of molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200433China institute of molecular Materials and Devices Fudan UniversityShanghai 200433China

The outbreak of COVID-19 has drawn great attention around the ***-CoV-2 is a highly infectious virus with occult transmission by many mutations and a long incubation *** particular,the emergence of asymptomatic infections has made the epidemic even more ***,early diagnosis and timely management of suspected cases are essential measures to control the spread of the *** simple,portable,and accurate diagnostic techniques for SARS-CoV-2 is the key to epidemic *** advantages of point-of-care testing technology make it play an increasingly important role in viral detection and *** review summarizes the point-of-care testing platforms developed by nucleic acid detection,immunological detection,and nanomaterial-based biosensors ***,this paper provides a prospect for designing future highly accurate,cheap,and convenient SARS-CoV-2 diagnostic technology.

关键词： COVID-19 Point-of-care testing platforms Nucleic acid detection Asymptomatic infection Biosensors