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Taming of trinitromethyl-oxadiazole to access high density and high oxygen balance via a dual modulation strategy

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Defence Technology(防务技术) 2025年第1期43卷 142-149页

作者： Jinya Zhang Teng Fei Jingwei Meng Jinxiong Cai Lei Zhang siping Pang Chunlin He school of Materials science&Engineering Beijing Institute of TechnologyBeijing 100081China Experimental Center of Advanced Materials School of Materials Science&EngineeringBeijing Institute of TechnologyBeijing 100081China hongqing innovation Center Beijing Institute of TechnologyChongqing 401120China

Energetic compounds bearing the trinitromethyl group are garnering broad attraction as potential candidates for a new generation of high energy dense *** this work,an effective dual modulation strategy involving both molecular isomerization and crystal morphology control was employed to design and optimize trinitromethyl-oxadiazole with improved comprehensive *** this dual strategy,3,5-bis(trinitromethyl)-1,2,4-oxadiazole(3)was synthesized,resulting in the formation of two distinct crystal morphologies(needle and sheet)corresponding to two crystal forms(3-a and3-b).Encouragingly,while maintaining ultra-high oxygen balance(21.73%),3 achieves impressive densities(1.97-1.98 g/cm^(3)).To our knowledge,the density of 1.98 g/cm^(3)for 3-a sets a new record among that of nitrogen-rich monocyclic ***,practical crystal morphology prediction was creatively introduced to guide the experimental crystallization conditions of 3,increasing the impact sensitivity and friction sensitivity from 1 J to 80 N(3-a)to 10 J and 240 N(3-b),***,the crystal structural analyses and theoretical calculations were conducted to elucidate the reasons of differences between 3-a and 3-b in density and *** work provides an efficient strategy to enhance performance of trinitromethyl derivatives,broadening the path and expanding the toolbox for energetic materials.

关键词： Energetic materials High oxygen balance High density Dual modulation Trinitromethyl group

The gut microbial metabolite indole‑3‑aldehyde alleviates impaired intestinal development by promoting intestinal stem cell expansion in weaned piglets

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Journal of Animal science and Biotechnology 2025年第1期16卷 455-470页

作者： Jiaqi Zhang Yahui Chen Xin Guo Xuan Li Ruofan Zhang Mengting Wang Weiyun Zhu Kaifan Yu Laboratory of Gastrointestinal Microbiology Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal HealthCollege of Animal Science and TechnologyNanjing Agricultural UniversityNanjing 210095China National Center for international research on Animal Gut Nutrition Nanjing Agricultural UniversityNanjing 210095China Wujiang Animal health inspection institute Suzhou 215200China

Background Weaning stress-induced diarrhea is widely recognized as being associated with gut microbiota ***,it has been challenging to clarify which specific intestinal microbiota and their metabolites play a crucial role in the antidiarrhea process of weaned *** in this study,we first observed that piglets with diarrhea exhibited a lower average daily gain and higher diarrhea score,and elevated levels of lipopolysaccharide(LPs)and D-lactate(D-LA)compared to healthy ***,we analyzed the differences in intestinal microbial composition and metabolite levels between healthy and diarrheal weaned *** piglets demonstrated intestinal microbiota dysbiosis,characterized pri-marily by a higher Firmicutes to Bacteroidota ratio,a deficiency of Lactobacillus amylovorus and Lactobacillus reuteri,and an increased abundance of Bacteroides ***-5287 and Bacteroides *** pro-filing of the gut microbiota based on Kyoto Encyclopedia of Genes and Genomes(KEGG)data was performed,and the results showed that tryptophan metabolism was the most significantly inhibited pathway in piglets with *** tryptophan metabolites were detected at lower concentrations in diarrheal piglets than in healthy ***,we explored the effects of dietary indole-3-aldehyde(iAld),a key tryptophan metabolite,on intestinal development and gut barrier function in weaned *** with 100 mg/kg iAld in the diet increased the small intestine index and improved intestinal barrier function by promoting intestinal stem cell(isC)expansion in *** promotion of isC expansion by iAld was also confirmed in porcine intestinal *** These findings revealed that intestinal microbial tryptophan metabolite iAld alleviates impaired intesti-nal development by promoting isC expansion in weaned piglets.

关键词： indole-3-aldehyde intestinal development intestinal microbiota intestinal stem cell Weaned piglets

influence mechanism of the flow of high-skilled talents on technological evolution in emerging countries

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Journal of Geographical sciences 2025年第02期35卷 409-431页

作者： JiN Wenwan ZHU shengjun LiN Xiongbin Department of Geography and spatial information Technology Zhejiang Collaborative Innovation Center for Land and Marine Spatial Utilization and Governance Research Ningbo University College of Urban and Environmental sciences Peking University

Globalization has resulted in a notable rise in the flow of high-skilled talent from emerging countries to developed nations. Current research on transnational talent flow mainly focuses on the destination countries, with less attention given to the perspective of the sending countries, particularly lacking a dynamic discussion on its impact on technological evolution in the origin countries. Based on the OECD REGPAT database, this paper aims to explore how talent groups migrating to developed countries facilitate the return of knowledge and technology to emerging countries and achieve breakthroughs in their technological evolution paths, while further discussing the potential mechanisms involved. The findings of this paper are as follows:(1) The technological development of emerging countries is a path-dependent process, where countries often branch into new technologies related to their preexisting knowledge base. Consequently, knowledge feedback from high-skilled talents increases the likelihood of sending countries developing unrelated technologies.(2) The mobility of talents across borders fosters more international collaborations and citations for patents that are unrelated to the local knowledge base, thus enriching the technological paths of sending countries.(3) The mobility of high-skilled talents primarily affects complex technologies, which have significant economic effects that encourage imitation by other ***, the effect on novel technologies is less significant due to their strong geographical stickiness. in general, this paper addresses the gaps in existing research on talent outflow and the technological evolution of origin countries, providing empirical evidence for the positive role of transnational talent mobility in the technological catch-up of emerging ***, it offers recommendations for talent export, import, and innovation policy formulation in these countries.

关键词： emerging countries mechanism research path-breaking talent flow technological evolution

Managing virus diseases in citrus:Leveraging high-throughput sequencing for versatile applications

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Horticultural Plant Journal 2025年第1期11卷 57-68页

作者： Hongming Chen Zhiyou Xuan Lu Yang song Zhang Mengji Cao integrative science Center of Germplasm Creation in Western China(Chongqing)science City Citrus Research InstituteSouthwest UniversityChongqing 400712China National Citrus Engineering research Center Citrus Research InstituteSouthwest UniversityChongqing 400712China

in this review,the advantages and advances in applying high-throughput sequencing(HTs)in the management of viral diseases in citrus,along with some challenges,are discussed to provide perspectives on future *** the initial implementation of HTs in citrus virology,a substantial number of citrus viruses have been identified,with a notable increase in the last 7 *** acquisition of viral genomes and various HTs-based omics analyses serve as crucial pillars for advancing research in the etiology,epidemiology,pathology,evolution,ecology,and biotechnology of citrus *** has notably contributed to disease diagnosis,such as the diagnoses of concave gum and impietratura,as well as to the surveillance of new virus risks and the preparation of virus-free ***,certain inherent defects in HTs and coupled bioinformatics analysis,such as challenges with sequence assembly and the detection of viral dark matter,require improvement to enhance practical *** addition,the utilization of HTs for the systematic management of citrus viral diseases remains limited,and drawing insights from other virus-plant pathosystems while integrating emerging compatible techniques and ideas may broaden its specific applications.

关键词： Deep sequencing Virus epidemics Functional genomics CRisPR/Cas Virus-host interactions

impact of residual antibiotics on microbial decomposition of livestock manures in Eutric Regosol:implications for sustainable nutrient recycling and soil carbon sequestration

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Journal of Environmental sciences 2025年第1期147卷 498-511页

作者： Linfa Fang Prakash Lakshmanan Xiaoxuan su Yujia shi Zheng Chen Yu Zhang Wei sun Junxi Wu Ran Xiao Xinping Chen interdisciplinary research Center for Agriculture Green Development in Yangtze River Basin College of Resources and EnvironmentSouthwest UniversityChongqing 400715China Key Laboratory of sugarcane Biotechnology and Genetic improvement(Guangxi) Ministry of Agriculture and Rural AffairsGuangxi Key Laboratory of Sugarcane Genetic ImprovementSugarcane Research InstituteGuangxi Academy of Agricultural SciencesNanning 530007China Queensland Alliance for Agriculture and Food innovation University of QueenslandSt Lucia 4067QLDAustralia Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and National Resources ResearchChinese Academy of SciencesBeijing 100101China

The land application of livestock manure has been widely acknowledged as a beneficial approach for nutrient recycling and environmental ***,the impact of residual antibiotics,a common contaminant of manure,on the degradation of organic compounds and nutrient release in Eutric Regosol is not well ***,we studied,how oxytetracycline(OTC)and ciprofloxacin(CiP)affect the decomposition,microbial community structure,extracellular enzyme activities and nutrient release from cattle and pig manure using litterbag incubation *** showed that OTC and CiP greatly inhibited livestock manure decomposition,causing a decreased rate of carbon(28%-87%),nitrogen(15%-44%)and phosphorus(26%-43%)*** relative abundance of gramnegative(G-)bacteria was reduced by 4.0%-13%while fungi increased by 7.0%-71%during a 28-day incubation ***-occurrence network analysis showed that antibiotic exposure disrupted microbial interactions,particularly among G-bacteria,G+bacteria,and *** changes in microbial community structure and function resulted in decreased activity of urease,β-1,4-N-acetyl-glucosaminidase,alkaline protease,chitinase,and catalase,causing reduced decomposition and nutrient release in cattle and pig *** findings advance our understanding of decomposition and nutrient recycling from manure-contaminated antibiotics,which will help facilitate sustainable agricultural production and soil carbon sequestration.

关键词： Residual antibiotics Livestock manure decomposition Microbial community Co-occurrence network Enzyme activities

Data-driven drug repositioning using olfactory omics profiles:challenges and perspectives in neurodegeneration

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Neural Regeneration research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejudo Adriana Cortés Mercedes Lachén-Montes Elena Anaya-Cubero Joaquín Fernández-irigoyen Enrique santamaría Clinical Neuroproteomics Unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven drug repositioning using olfactory omics profiles-challenges and perspectives in neurodegeneration:Neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in the central nervous *** diseases are often characterized as proteinopathies,which are disorders primarily driven by the aggregation or misfolding of specific amyloid proteins within cells,leading to their dysfunction and eventual *** the gain-of-function hypothesis related to the aggregation of these proteins,recently,an alternative hypothesis regarding the loss-of-function of the soluble monomeric proteins during the process of aggregation into amyloids is gaining *** last event is called proteinopenia and refers to conditions characterized by a deficiency or decrease in the levels of specific soluble proteins in the body(Ezzat et al.,2023).it has been demonstrated that levels of soluble proteins involved in neurodegenerative diseases are decreased.

关键词： diseases drug amyloid

Proteostasis failure:at the intersection between aging and Alzheimer's disease

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Neural Regeneration research 2025年第11期20卷 3221-3222页

作者： Natalia Poblete Claudio Hetz Center for Geroscience Brain Health and MetabolismSantiagoChile Biomedical Neuroscience institute Faculty of MedicineUniversity of ChileSantiagoChile Program of Cellular and Molecular Biology Institute of Biomedical SciencesFaculty of MedicineUniversity of ChileSantiagoChile Buck institute for research on Aging NovatoCAUSA

Lifestyle and demographics of the world's population are causing serious health problems impacting the brain,increasing the incidence of Alzheimer's disease(AD)and other types of *** we have gained important insights into the pathogenic mechanisms of AD,only palliative care is available to *** is characterized by the abnormal deposition of protein aggregates in the brain formed by amyloid β and hyper-phosphorylated,Tau in addition to neuroinflammation.

关键词： Alzheimer amyloid stasis

isoproterenol mechanisms in inducing myocardial fibrosis and its application as an experimental model for the evaluation of therapeutic potential of phytochemicals and pharmaceuticals

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Animal Models and Experimental Medicine 2025年第1期8卷 67-91页

作者： Lujain Bader Eddin Mohamed Fizur Nagoor Meeran Niraj Kumar Jha samer NGoyal shreesh Ojha Department of Pharmacology and Therapeutics College of Medicine and Health SciencesUAE UniversityAl AinUnited Arab Emirates school of Bioengineering&Biosciences Lovely Professional UniversityPhagwaraIndia Centre for Global health research Saveetha Medical CollegeSaveetha Institute of Medical and Technical SciencesSaveetha UniversityChennaiIndia shri Vile Parle Kelvani Mandal's institute of Pharmacy DhuleMaharashtraIndia Zayed Bin sultan Center for health sciences United Arab Emirates UniversityAl AinUnited Arab Emirates

Cardiac injury initiates repair mechanisms and results in cardiac remodeling and fi-brosis,which appears to be a leading cause of cardiovascular *** fi-brosis is characterized by the accumulation of extracellular matrix proteins,mainly collagen in the cardiac *** experimental studies have demonstrated that fibrotic injury in the heart is reversible;therefore,it is vital to understand differ-ent molecular mechanisms that are involved in the initiation,progression,and resolu-tion of cardiac fibrosis to enable the development of antifibrotic *** the many experimental models,one of the recent models that has gained renewed interest is isoproterenol(isP)-induced cardiac *** is a synthetic catecholamine,sympa-thomimetic,and nonselectiveβ-adrenergic receptor *** overstimulated and sustained activation ofβ-adrenergic receptors has been reported to induce biochemi-cal and physiological alterations and ultimately result in cardiac *** has been used for decades to induce acute myocardial ***,the use of low doses and chronic administration of isP have been shown to induce cardiac fibrosis;this practice has increased in recent *** or subcutaneous isP has been widely used in preclinical studies to induce cardiac remodeling manifested by fibrosis and *** induced oxidative stress with subsequent perturbations in cellular signaling cascades through triggering the release of free radicals is consid-ered the initiating mechanism of myocardial *** is consistently used to induce fibrosis in laboratory animals and in cardiomyocytes isolated from *** recent years,numerous phytochemicals and synthetic molecules have been evaluated in isP-induced cardiac *** present review exclusively provides a comprehensive summary of the pathological biochemical,histological,and molecular mechanisms of isP in inducing cardiac fibrosis and *** also summarizes the ap

关键词： cardiac fibrosis catecholamines experimental models isoproterenol myocardial fibrosis phytochemicals β-adrenergic receptors

synthesis and characteristics of Na-A zeolite from coal fly ash and application for adsorption of cerium(Ⅲ)

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Journal of Rare Earths 2025年第1期43卷 171-179,I0007页

作者： Amru Daulay Widi Astuti slamet sumardi Fika Rofiek Mufakhir Yayat iman supriyatna Tri Haryono Lukmanul Hakim samada research Center for Mining Technology National Research and Innovation Agency(BRIN)J.Ir.SutamiKm.5Tanjung BintangSouth LampungLampung ProvinceIndonesia school of Chemistry University of BirminghamB152TTUK

Recycling rare earth elements(REEs)from waste is necessary for an environmentally sustainable reuse and wastewater management ***-A zeolite was synthesized from coal fly ash(CFA)and applied for Ce^(3+)*** transform infrared(FTiR)spectra show peaks at 790,500 and 467 cm^(-1),which are bond vibrations of si-O-si,si with Al-O and si-O-.The surface area is 15.88 m^(2)/g,with a pore size of 2.14 *** images show a cubic shape,which indicates the formation of *** emission and energy disperse spectroscopy(EDs)shows the formation of si,Al,Na,and ***-A zeolite was applied for Ce^(3+)*** optimum conditions for Ce^(3+)adsorption are 50 ppm concentration,360 min,and pH *** maximum adsorption capacity is 176.49 mg/*** on the results,it is found that the adsorption of Ce^(3+)by Na-A zeolite is *** desorption test using HNO_(3) is more effective than using HCl and H_(2)sO_(4).A desorption efficiency of 97.22%is obtained at 4 *** test using real sample wastewater demonstrates an adsorption efficiency of 83.35%.

关键词： Coal fly ash Zeolite Na-A zeolite Adsorption Cerium(Ⅱ) Rare earths