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A Case Report of a Rare Sarco.atoid Poorly Differentiated Adenocarcinoma Harboring co.current Mutations in the ROS1, EGFR, ARID1A, and NFKBIA Genes in the Lung

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Journal of Cancer Therapy 2024年第5期15卷 231-237页

作者： Jinlin Du Lanlan Li Shiqi Song Siqin Chen Yaxian Yang Jian Huang Department of Pathological Diagnosis and Research Center The Affiliated Hospital of Guangdong Medical University Zhanjiang China guangzhou Huayin Health Medical Group co. Ltd. Guangzhou China

ROS1 and EGFR are primary onco.enic drivers in non-small cell lung cancer (NSCLC) pathogenesis. However, EGFR mutations and ROS1 fusions are generally mutually exclusive in NSCLC, leading to a negligible probability of their co.occurrence. co.sequently, clinical data and treatment strategies for their simultaneous presence are remarkably scarce. This report details the first reco.ded case of a sarco.atoid, poorly differentiated lung adenocarcinoma harboring both a ROS1 fusion and an EGFR mutation, alongside ARID1A and NFKBIA gene mutations. Moreover, this case study enco.passes a review of instances featuring co.current ROS1 and EGFR mutations. The identified genetic alterations in ROS1, EGFR, ARID1A, and NFKBIA are pivotal in the etiology of NSCLC. These mutations significantly influence disease progression and are essential for the development of personalized therapeutic approaches. Reco.nizing the unique genetic profiles in patients permits healthcare providers to devise customized treatment regimens that target these specific mutations, thereby enhancing patient outco.es in NSCLC.

关键词： Non-Small Cell Lung Cancer ROS1 EGFR Sarco.atoid

Particles attrition of binary mixtures in the co.l-fueled chemical looping system based on fluidized bed

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Particuology 2024年第3期86卷 281-290页

作者： Heyu Li Zhe Sun Yan Cao guangzhou Institute of Energy co.version Chinese Academy of SciencesGuangzhou 510640China University of Chinese Academy of Sciences Bejing 100049China CAS Key Laboratory of Renewable Energy Guangzhou 510640China Guangdong Provincial Key Laboratory of New and Renewable Energy Research and Development Guangzhou 510640China co.lege of Chemistry and Chemical Engineering Anhui UniversityHefei230601China

In this work,a reactive air jet attrition device with auto-reco.ding and co.lection of elutriated fines was *** established insights into the physiochemical interaction and further co.related attrition behaviors between char and oxygen carriers under various operation *** attrition rate increased by over 110% upon the introduced co.(2),which brought in the significant effect of thermo-chemical stress,similarly in effects of the increased char addition ratio and the decreased sizes of char or hematite in different *** the char-hematite co.attrition process,the elutriated carbon loss of char with poor mechanical strength was found to be over 10%,while the reactive iron loss of hematite was found to be 6.3%,and was enriched in elutriated *** reaction-derived thermochemical stress and the co.lision-derived mechanical stress jointly co.trols the particle attrition during the cyclic transformation of oxygen carrier particles in co.l-fueled chemical looping fluidization,especially sig-nificant in its reduction stage.

关键词： Attrition Binary species Chemical looping Oxygen carrier co.(2)capture

Advances in the Study of Anoectochilus Roxburghii Extracts and Prospects for co.metic Application Potentials

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China Detergent & co.metics 2024年第1期9卷 45-53页

作者： Liu Xiaochun Chen Laicheng Yang Zhanhong Zou Jie School of Chemistry and Chemical Engineering Guangdong Pharmaceutical UniversityChina guangzhou Hemgathion Biotechnology co. Ltd.China

co.metics made from natural ingredients are beco.ing more and more co.mon because they co.tain bioactive co.pounds that provide many health benefits,are more environmentally friendly and *** roxburghii(AR)is a precious Chinese herb in China,possessing bioactive co.ponents including flavonoids,polysaccharides,volatile oils,kinsenoside,*** to its unique bioactivity and high safety,the prospect of development and utilization is very *** this paper,the extraction,separation and purification techniques of AR’s flavonoid,polysaccharides,volatile oils and kinsenoside are briefly ***,we discusses their co.formational relationships in co.metics with antioxidant,whitening,antibacterial and soothing effect,and looks forward to the study of Anoectochilus roxburghii in the field of co.metics,with a view to providing references to the development and utilization of this resource in the field of co.metics.

关键词： Anoectochilus roxburghii extract Anoectochilus roxburghii polysaccharides Anoectochilus flavonoids co.metic efficacy

Weakly-supervised instance co.segmentation via tensor-based salient co.peak search

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Frontiers of co.puter Science 2024年第2期18卷 83-92页

作者： Wuxiu QUAN Yu HU Tingting DAN Junyu LI Yue ZHANG Hongmin CAI School of co.puter Science Guangdong Polytechnic Normal UniversityGuangzhou 510665China School of co.puter Science and Engineering South China University of TechnologyGuangzhou 510006China

Instance co.segmentation aims to segment the co.occurrent instances among two *** task heavily relies on instance-related cues provided by co.peaks,which are generally estimated by exhaustively exploiting all paired candidates in point-to-point ***,such patterns co.ld yield a high number of false-positive co.peaks,resulting in over-segmentation whenever there are mutual *** tackle with this issue,this paper proposes an instance co.segmentation method via tensor-based salient co.peak search(TSCPS-ICS).The proposed method explores high-order co.relations via triple-to-triple matching among feature maps to find reliable co.peaks with the help of co.saliency *** proposed method is shown to capture more accurate intra-peaks and inter-peaks among feature maps,reducing the false-positive rate of co.peak *** having accurate co.peaks,one can efficiently infer responses of the targeted *** on four benchmark datasets validate the superior performance of the proposed method.

关键词： weakly-supervised co.segmentation co.peak tensormatching deep network instance segmentation

A potential giant gallium deposit hosted in the tailing dam of the Fankou Zn-Pb deposit in northern Guangdong Province, South China

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China Geology 2024年第1期7卷 157-160页

作者： Peng-peng Yu Zhao-bin Hu Yi Zheng Lan-xuan Guo Shi-yuan Ouyang Gui-qiang Yuan Shang-zhou Chen Cheng-ming Wang Xi Chen School of Earth Sciences and Geological Engineering Sun Yat-sen UniversityGuangzhou 510275China Guangdong Provincial Key Lab of Geological Process and Mineral Resources Survey Sun Yat-sen UniversityGuangzhou 510275China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519000China Zhongjin Lingnan Nonfemet co. LtdShenzhen 518000China

*** The Fankou giant zinc(Zn)-lead(Pb)deposit in Guangdong Province is well-known for its huge reserves of over 10 Mt(million ton)Zn+Pb metals and high ore-grade with Zn+Pb exceeding 15%(Guangdong Fankou Deposit Investigation Group,1980;Zhu XY et al.,2017).After 60 years of exploration and exploitation,the deposit has accumulated millions of tons of *** interesting question is that what co.ponents are hosted in these tailings,and whether some key and critical metals such as gallium and germanium are extremely enriched and worth further co.prehensive *** motivated us to co.duct an integrated set of field investigation,sampling,major-trace element analyses and reserve assessments about the Fankou *** this co.tribution,we disco.er that the tailings co.tain a variety of metal elements such as zinc,lead and gallium with co.prehensive utilization *** data can act as a scientific guidance for further exploration and utilization of the Fankou tailings,and aid to enhance the utilization efficiency of the key mineral resource in *** study also provide demonstration for future green mine co.struction in China.

关键词： deposit co.prehensive Guangdong

Penumbra-targeted Circo.DH siRNA-loaded nanoparticles alleviate neuronal apoptosis in focal brain ischaemia

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Stroke & Vascular Neurology 2024年第2期9卷 134-144,I0396-I0413页

作者： Yanfang Liu Tianyuan Zhang Xing Zou Zhongwen Yuan Yufeng Li Jiankun Zang Niu He Lizhen He Anding Xu Dan Lu Department of Neurology and Stroke Center Jinan University First Affiliated HospitalGuangzhouGuangdongChina Department of Clinical Neuroscience Institute The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdongChina Key Lab of guangzhou Basic and Translational Research of Pan-vascular Diseases The First Affiliated Hospital of Jinan UniversityGuangzhouChina

Background Nanoparticles(NPs)are a class of substances that can be loaded with therapeutic agents delivered to specific *** our earlier research,we identified a neuron-derived circular RNA(circRNA),circular oxoglutarate dehydrogenase(Circo.DH),as a promising therapeutic target for acute ischaemic *** study dedicated to explore a prospective preliminary strategy of Circo.DH-based NP delivered to the ischaemic penumbra region in middle cerebral artery occlusion/reperfusion(MCAO/R)*** Immunofluorescence in primary co.tex neurons and in vivo fluorescence imaging revealed endocytosis of Poly(lactide-co.glyco.ide)(PLGA)poly amidoamine(PAMAM)@Circo.DH small interfering RNA(siRNA)*** blotting analysis and CCK8 assay were performed to evaluate the apoptotic level in ischaemic neurons treated with PLGA–PAMAM@Circo.DH siRNA *** reverse transcription PCR experiments,mice behaviour test,T2 MRI analysis,Nissl and TdT-mediated dUTP nick end labeling(TUNEL)co.staining were performed to evaluate the apoptosis level of ischaemic penumbra neurons in MCAO/R *** evaluation of NPs in MCAO/R mice was detected by blood routine examination,liver and kidney function examination and HE *** PLGA–PAMAM@Circo.DH siRNA NPs were successfully *** of PLGA–PAMAM@Circo.DH siRNA NPs in ischaemic neurons alleviated neuronal apoptotic level in vitro and in ***,mice behaviour test showed that the neurological defects of MCAO/R mice were significantly alleviated after the tail injection of PLGA–PAMAM@Circo.DH siRNA NPs,and no toxic effects were *** In co.clusion,our results suggest that PLGA–PAMAM@Circo.DH siRNA NPs can be delivered to the ischaemic penumbra region and alleviate neuron apoptosis in MCAO/R mice and in ischaemic neurons;therefore,our study provides a desirable approach for using circRNA-based NPs for the treatment of ischaemic stroke.

关键词： OGD routine loaded

Circulating tumor cells shielded with extracellular vesicle-derived CD45 evade T cell attack to enable metastasis

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2114-2131页

作者： Chuan Yang Xueping Wang Kenneth K.W.To Caimei Cui Min Luo Shaoco.g Wu Lamei Huang Kai Fu Can Pan Zeyu Liu Teng Fan Caibo Yang Fang Wang Liwu Fu State Key Laboratory of Onco.ogy in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060P.R.China School of Pharmacy Faculty of MedicineThe Chinese University of Hong KongHong KongChina LABVIV Technology(Shenzhen)co. LtdShenzhen 518057China

Circulating tumor cells(CTCs)are precursors of distant metastasis in a subset of cancer patients.A better understanding of CTCs heterogeneity and how these CTCs survive during hematogenous dissemination co.ld lay the foundation for therapeutic prevention of cancer *** remains elusive how CTCs evade immune surveillance and elimination by immune *** this study,we unequivocally identified a subpopulation of CTCs shielded with extracellular vesicle(EVs)-derived CD45(termed as CD45^(+)CTCs)that resisted T cell attack.A higher percentage of CD45^(+)CTCs was found to be closely co.related with higher incidence of metastasis and worse prognosis in cancer ***,CD45^(+)tumor cells orchestrated an immunosuppressive milieu and CD45^(+)CTCs exhibited remarkably stronger metastatic potential than CD45−CTCs in ***,CD45 expressing on tumor surfaces was shown to form intercellular CD45-CD45 homophilic interactions with CD45 on T cells,thereby preventing CD45 exclusion from TCR-pMHC synapse and leading to diminished TCR signaling transduction and suppressed immune ***,these results pointed to an underappreciated capability of EVs-derived CD45-dressed CTCs in immune evasion and metastasis,providing a rationale for targeting EVs-derived CD45 internalization by CTCs to prevent cancer metastasis.

关键词： CD45 metastasis prevention

Transient NOE driven signal enhancement of INADEQUATE solid-state NMR spectrosco.y for the structural analysis of rubbers

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Magnetic Resonance Letters 2024年第3期4卷 35-41页

作者： Zhiwei Yan Yue-Qi Ye Rongchun Zhang South China Advanced Institute for Soft Matter Science and Technology(AISMST) School of Emergent Soft Matter(SESM)South China University of TechnologyGuangzhou510640China JEOL(Beijing)co. Ltd.Haidian DistrictBeijing100190China JEOL Ltd. MusashinoAkishimaTokyo196-8558Japan Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices South China University of TechnologyGuangzhou510640China

INADEQUATE(Incredible Natural Abundance DoublE QUAntum Transfer Experiment)is one of the most important techniques in revealing the carbon skeleton of organic solids in solid-state NMR ***,its use for structural analysis is quite limited due to the low natural abundance of^(13)C-^(13)C co.nectivity(~0.01%)and thus low ***,in semi-solids like rubbers,the sensitivity will be further significantly reduced by the inefficient cross polarization from 1H to^(13)C due to molecular motions induced averaging of^(1)H-^(13)C dipolar ***,in this study,we demonstrate that transient nuclear Overhauser effect(NOE)can be used to efficiently enhance^(13)C signals,and thus enable rapid acquisition of two-dimensional(2D)^(13)C INADEQUATE spectra of *** chlorobutyl rubber as the model system,it is found that an overall signalto-noise ratio(SNR)enhancement about 22%can be achieved,leading to significant timesaving by about 33%as co.pared to the direct polarization-based INADEQUATE *** experimental results on natural rubber and ethylene propylene diene monomer(EPDM)rubber are also shown to demonstrate the robust performance of transient NOE enhanced INADEQUATE experiment.

关键词： Transient NOE INADEQUATE Carbon skeleton Rubbers

Feedback enhanced tumor targeting delivery of albumin-based nanomedicine to amplify photodynamic therapy by regulating AMPK signaling and inhibiting GSTs

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Chinese Chemical Letters 2024年第8期35卷 481-485页

作者： Jiaqi Huang Renjiang Kong Yanmei Li Ni Yan Yeyang Wu Ziwen Qiu Zhenming Lu Xiaona Rao Shiying Li Hong Cheng School of Biomedical Engineering&Guangdong Provincial Key Laboratory of co.struction and Detection in Tissue Engineering Southern Medical UniversityGuangzhou 510515China School of Pharmaceutical Sciences Guangzhou Medical UniversityGuangzhou 511436China

Oxidative therapies receive a limited antitumor efficiency due to the insufficient reactive oxygen species(ROS)levels at focal sites and the evolvement of antioxidant defense ***,we develop an albumin-based nanomedicine to co.deliver chlorin e6(Ce6)and co.-SR4(CS),which can simultaneously enhance the yield and lethality of intracellular ROS for amplified photodynamic therapy(PDT).In which,CS acts as both an activator of AMP-activated protein kinase(AMPK)and an inhibitor of glutathione S-transferases(GSTs).Benefiting from it,the prepared HSA-Ce6@co.-SR4(HCCS)enables positive feed-back uptake by promoting AMPK phosphorylation,leading to rapid and extensive tumor accumulation of *** a result,HCCS obviously increases the ROS production to elevate intracellular oxidative ***,HCCS can inhibit GSTs to disturb the antioxidant defense system of tumor cells,intensifying the oxidative damage of ***,the PDT of HCCS is significantly strengthened by improving the ROS yield and lethality,which greatly declines the proliferation of breast cancer in *** study may open a window in the development of drug co.delivery system for enhanced oxidative therapy of tumors.

关键词： Human serum albumin Drug delivery Reactive oxygen species Positive feedback uptake Oxidative damage