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World Journal of Clinical Cases 2022年第23期10卷 8323-8329页

作者： Dawn Suwanie Tan Fiona Millicent Cheung Dekai Ng Tin Lung Alan Cheung department of orthopaedic surgery International Orthopaedic ClinicSingapore329563Singapore

BACKGROUND Femoral and tibial stress injuries are commonly found in long distance running *** fractures have rarely been reported in athletes performing high intensity interval training(HIIT)*** objective of this study was to report a case of a patient who presented with medial tibial stress syndrome and femoral neck stress fracture after performing HIIT *** SUMMARY A 26 year old female presented with bilateral medial tibial *** had been performing HIIT exercise for 45 min,five times weekly,for a seven month *** tibial pain was gradual in onset,and was now severe and worse on exercise,despite six weeks of *** resonance imaging(MRI)revealed bilateral medial tibial stress *** she was taking norethisterone for birth control,a dual energy X-ray absorbitometry scan was performed which demonstrated normal bone mineral density of her lumbar spine and femoral *** was managed conservatively with analgesia and physiotherapy,but continued to exercise against medical *** presented again six months later with severe right hip *** of her right hip demonstrated an incomplete stress fracture of her subtrochanteric *** symptoms resolved with strict rest and *** HIIT may cause stress injury of the tibia and femur in young individuals.

关键词： High intensity interval training Medial tibial stress syndrome Femoral neck stress fracture Exercise Fracture Case report

Wrist joint moments of walker-assisted gait:a study of biomechanics and instrumentation

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仪器仪表学报 2007年第9期28卷 1537-1542页

作者： Ming Dong Wang Weijie Wan Baikun Hu Yong department of Biomedical Engineering and Scientific Instrument Tianjin University Tianfin 300072 China department of orthopaedic and trauma surgery University of Dundee UK department of orthopaedics and traumatology Hong Kong University Hong Kong SAR China

While walkers are commonly prescribed to improve patient stability and ambulatory ability,quantitative study of the biomechanical and functional requirements for effective walker use is *** investigate the changes in wrist joint moments that occur with the use of a standard walker,a strain gauge-based walker instrumentation sys- tem was developed for the measurement of wrist joint *** walker dynamometer was integrated with an up- per extremity biomechanical *** system data were collected for twelve healthy,right-handed young a- dults following informed *** upper extremity kinematic data were acquired with a six-camera motion a- nalysis *** joint moments at the wrist were determined in the three clinical planes using the inverse dy- namics *** showed that during a walker-assisted gait there were several typical demands of wrist abduc- tor,adductor,flexor and external *** interesting'bare phase'of wrist joint moments was also found in phase angle[-30°,30°]of gait *** description of wrist joint moments during walker-assisted gait may pro- vide insight into walker use parameters and rehabilitative strategies.

关键词：生物力学仪表助行器辅助步法桡腕关节矩

Open wedge re-correction high tibial osteotomy in an elderly patient with a varus angulated non-united dome-shaped high tibial osteotomy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第11期14卷 1054-1058页

作者： Steffen SCHROTER Lukas KONSTANTINIDIS Tobias M. KRAUS Fabian STUBY Ulrich STOCKLE Thomas FREUDE department of traumatology and Reconstructive surgery BG Trauma Center department of orthopaedics and trauma surgery University Medical Centre Freiburg

The high tibial osteotomy(HTO)is a wellestablished and commonly used treatment for younger and active patients with a medial unicompartmental osteoarthritis of the knee and varus *** aim of this technique is to shift the load to a functional lateral compartment in order to delay total knee *** dome-shaped HTO was introduced by Blaimont et al.(1975)and later popularized by Maquet(1980).Out of 118 cases,96 cases of overcorrection,13 cases of undercorrection,and 9 cases

关键词： HTO MPTA high

Arterial complications, venous thromboembolism and deep venous thrombosis prophylaxis after anterior cruciate ligament reconstruction: A systematic review

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World Journal of Orthopedics 2016年第9期7卷 604-617页

作者： Rob Paulus Augustinus Janssen Max Reijman Daan Martijn Janssen Jan Bernardus Antonius van Mourik department of Sports Medicine and orthopaedic surgery Máxima Medical Center department of orthopaedics and trauma Máxima Medical Center department of orthopaedic surgery Erasmus MC University Medical Center Rotterdam

AIM To summarize the current knowledge on vascular complications and deep venous thrombosis(DVT) prophylaxis after anterior cruciate ligament(ACL) *** A systematic review was conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses statement. MEDLINE, EMBASE, Cochrane,Web of Science, CINAHL, PubMed publisher, and Google scholar medical literature databases were searched up to November 10, 2015. Any arthroscopic surgical method of primary or revision intra-articular ACL reconstruction of all graft types in humans was included. A risk of bias assessment was *** Fourty-seven studies were included in the *** were the most frequently reported arterial complication after ACL reconstruction, irrespective of graft type or method of graft fixation with an incidence of 0.3%. The time to diagnosis of arterial complications after ACL reconstruction varied from days to mostly weeks but even years. After ACL reconstruction without thromboprophylaxis, the incidence of DVT was 9.7%, of which 2.1% was symptomatic. The incidence of pulmonary embolism was 0.1%. Tourniquet time > 2 h was related to venous *** is indicated in patients with risk factors for venous *** After ACL reconstruction, the incidence of arterial complications,symptomatic DVT and pulmonary embolism was 0.3%, 2.1% and 0.1% respectively. Arterial complications may occur with all types of arthroscopic ACL reconstruction, methods of graft fixation as well as any type of graft. Patients considered to be at moderate or high risk of venous thromboembolism should routinely receive thromboprophylaxis after ACL reconstruction.

关键词： Anterior cruciate ligament reconstruction Arterial complication Pseudoaneurysm Venous thromboembolism Pulmonary embolism Thromboprophylaxis

Evidence-based approach to providing informed consent for hip fracture surgery during the COVID-19 era

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World Journal of Orthopedics 2021年第6期12卷 386-394页

作者： Rory Cuthbert David Ferguson Babar Kayani Saeef Haque Aoun Ali Asif Parkar Peter Bates Krishna Vemulapalli department of trauma&orthopaedic surgery Queen's Hospital-RomfordLondon RM70AGUnited Kingdom department of trauma&orthopaedic surgery Royal London HospitalLondon E11FRUnited Kingdom

BACKGROUND Hip fractures are the most common reason for inpatient orthopaedic trauma *** surgical intervention for hip fractures has remained a clinical priority throughout the coronavirus disease 2019(COVID-19)*** this,there is a paucity of clinical guidance addressing the informed consent process for hip fracture surgery in COVID-19 positive *** is of paramount medicolegal importance in a high-risk patient *** To quantify the additional perioperative risks for COVID-19 positive patients undergoing hip fracture surgery and provide clinicians with an evidence-based framework to establish an informed consent *** Two hundred and fifty nine consecutive patients undergoing surgical intervention for hip fractures in four hospitals in the United Kingdom were recruited.51 patients were confirmed positive for *** outcomes were analyzed over a 30-d postoperative ***-19 positive and COVID-19 negative patients were compared after adjustment for confounding *** COVID-19 positive patients had more intensive care admissions(27%vs 5%,Psurgery should be consented for the additional risk of postoperative complications(including lower respiratory tract infection,ARDS,deep vein thrombosis and pulmonary embolism),increased requirement for intensive care admission,lo

关键词： COVID-19 Hip fractures Mortality Morbidity Outcome assessment Informed consent

Paeoniflorin,the Main Monomer Component of Paeonia lactiflora,Exhibits Anti-inflammatory Properties in Osteoarthritis Synovial Inflammation

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Chinese Journal of Integrative Medicine 2024年第5期30卷 433-442页

作者： CHEN Pu ZHOU Jun RUAN An-min MA Yu-feng WANG Qing-fu department of orthopaedic surgery Beijing University of Chinese Medicine Third Affiliated HospitalBeijing 100029China department of orthopaedic surgery Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China department of orthopaedic surgery Beijing Longfu HospitalBeijing 100010China

Objective:To explore the mechanism of paeoniflorin(PF)on osteoarthritis(OA)synovial inflammation from network pharmacology to experimental ***:Targets of OA were constructed by detecting the database of network database platforms(Therapeutic Target database,Drug Bank and Gene Cards),and the targets of PF were constructed by Pub Chem and Herbal Ingredients'Targets *** Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)analysis of these co-targeted genes were conducted via Database for Annotation,Visualization,and Integrated Discovery(DAVID)database,and protein-protein interaction(PPI)networks were conducted via the search tool for the retrieval of interacting genes(STRING)*** counting kit-8(CCK-8)assay was performed to assess the potential toxicity of PF on human OA fibroblast-like synoviocytes(FLS),quantitative real-time polymerase chain reaction(q PCR),enzyme-linked immunosorbent assay(ELISA)and Western blot were used to verify the potential mechanism of PF in synovial ***:Twenty-six co-targeted genes were *** enrichment results showed that these co-targeted genes were most likely localized in the cytoplasm,and the biological processes mainly involved'cellular response to hypoxia''lipopolysaccharide(LPS)-mediated signaling pathway'and'positive regulation of gene expression'.KEGG pathway analysis indicated that these co-targeted genes may function through pathways associated with'hypoxia-inducible factor-1(HIF-1)signaling pathway'and'tumornecrosis factor(TNF)signaling pathway'.The PPI network showed that the top 3 hub genes were TP53,TNF,and *** docking results showed that PF was well docking with ***-8 showed no potential toxicity of 10,20 and 50μmol/L PF on human OA *** PF significantly decreased the expression levels of interleukin-1β,interleukin-6,TNF-αmatrix metalloproteinase 13(MMP13),and a disintegrin and metalloproteinase with thrombospondin motifs 5(ADAMTS5)and TNF

关键词： paeoniflorin osteoarthritis synovial inflammation tumor necrosis factor-α network pharmacology Paeonia lactiflora

Anterolateral rotatory instability in vivo correlates tunnel position after anterior cruciate ligament reconstruction using bone-patellar tendon-bone graft

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World Journal of Orthopedics 2017年第12期8卷 913-921页

作者： Yasutaka Tashiro Ken Okazaki Koji Murakami Hirokazu Matsubara Kanji Osaki Yukihide Iwamoto Yasuharu Nakashima department of orthopaedic surgery University of Pittsburgh department of orthopaedic surgery Kyushu University

AIM To quantitatively assess rotatory and anterior-posterior instability in vivo after anterior cruciate ligament(ACL) reconstruction using bone-patellar tendon-bone(BTB) autografts, and to clarify the influence of tunnel positions on the knee *** Single-bundle ACL reconstruction with BTB autograft was performed on 50 patients with a mean age of 28 years using the trans-tibial(TT)(n = 20) and trans-portal(TP)(n = 30) techniques. Femoral and tibial tunnel positions were identified from the high-resolution 3 D-CT bone models two weeks after surgery. Anterolateral rotatory translation was examined using a Slocum anterolateral rotatory instability test in open magnetic resonance imaging(MRI) 1.0-1.5 years after surgery, by measuring anterior tibial translation at the medial and lateral compartments on its sagittal images. Anterior-posterior stability was evaluated with a Kneelax3 *** A total of 40 patients(80%) were finally followed up. Femoral tunnel positions were shallower(P < 0.01) and higher(P < 0.001), and tibial tunnel positions were more posterior(P < 0.05) in the TT group compared with the TP group. Anterolateral rotatory translations in reconstructed knees were significantly correlated with the shallow femoral tunnel positions(R = 0.42, P < 0.01), and the rotatory translations were greater in the TT group(3.2 ± 1.6 mm) than in the TP group(2.0 ± 1.8 mm)(P < 0.05). Side-to-side differences of Kneelax3 arthrometer were 1.5 ± 1.3 mm in the TT, and 1.7 ± 1.6 mm in the TP group(N.S.). Lysholm scores, KOOS subscales and reinjury rate showed no difference between the two *** Anterolateral rotatory instability significantly correlated shallow femoral tunnel positions after ACL reconstruction using BTB autografts. Clinical outcomes, rotatory and anterior-posterior stability were overall satisfactory in both techniques, but the TT technique located femoral tunnels in shallower and higher positions, and tibial tunnels in more p

关键词： Anterior cruciate ligament Patellar tendon Bone-patellar tendon-bone Rotatory instability Magnetic resonance imaging Tunnel position Anatomic Singlebundle

Operative treatment of metastatic breast cancer in the spine with regard to molecular phenotypes

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Journal of Cancer Metastasis and Treatment 2019年第5期4卷 108-119页

作者： Daniel Adler Wojciech Pepke Michael Akbar Spine Center Department of Orthopaedic SurgeryTrauma Surgery and Division of Spinal Cord InjuryRuprecht-Karls-UniversityHeidelberg 69118Germany

With more than one million new diseases per year breast cancer is the most common malignancy in women. Metastatic breast cancer remains an incurable disease and the spinal column is most likely affected by metastases. A significantly prolonged patient survival is the consequence of modern oncologic treatment options in the last decade. Surgical treatment of vertebral metastases has become an increasing focus for spine surgeons. With the turn of the millennium it was possible to classify breast cancer into four intrinsic phenotypes with various survival rates. Well known scoring systems help surgeons to evaluate the patient's prognosis and to choose adequate treatment options. However, tumor entities are differentiated without regard to the molecular subtypes. In this article we describe surgical treatment options in metastatic lesions to the spine with regard to molecular phenotypes of breast cancer malignancy. It is crucial to correctly estimate the expected survival time to plan invasiveness of therapy regarding metastatic spine surgery.

关键词： Spine metastases breast cancer phenotypes subtypes molecular level prognosis

Football injuries of the ankle: A review of injury mechanisms, diagnosis and management

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World Journal of Orthopedics 2016年第1期7卷 8-19页

作者： Raymond J Walls Keir A Ross Ethan J Fraser Christopher W Hodgkins Niall A Smyth Christopher J Egan James Calder John G Kennedy department of Foot and Ankle surgery Hospital for Special Surgery New York University of Miami/Jackson Memorial Hospital department of trauma and orthopaedic surgery Chelsea and Westminster Hospital

Football is the most popular sport worldwide and is associated with a high injury rate, most of which are the result of trauma from player contact. Ankle injuries are among the most commonly diagnosed injuries in the game. The result is reduced physical activity and endurance levels, lost game time, and considerable medical cost. Sports medicine professionals must employ the correct diagnostic tools and effective treatments and rehabilitation protocols to minimize the impact of these injuries on the player. This review examines the diagnosis, treatment, and postoperative rehabilitation for common football injuries of the ankle based on the clinical evidence provided in the current literature.

关键词： Management Soccer Football Ankle Injury

Advancement in utilization of magnetic resonance imaging and biomarkers in the understanding of schizophrenia

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World Journal of Clinical Cases 2025年第1期13卷 11-15页

作者： Aidan K Tirpack Danyaal G Buttar Mandeep Kaur department of Psychiatry Campbell University School of Osteopathic MedicineBuies CreekNC 27506United States department of Psychiatry and Behavioral Health Mercyhealth Hospital and Trauma CenterJanesvilleWI 53548United States

Historically,psychiatric diagnoses have been made based on patient’s reported symptoms applying the criteria from diagnostic and statistical manual of mental *** utilization of neuroimaging or biomarkers to make the diagnosis and manage psychiatric disorders remains a distant *** have been several studies that examine brain imaging in psychiatric disorders,but more work is needed to elucidate the complexities of the human *** this editorial,we examine two articles by Xu et al and Stoyanov et al,that show developments in the direction of using neuroimaging to examine the brains of people with schizo-phrenia and *** et al used magnetic resonance imaging to examine the brain structure of patients with schizophrenia,in addition to examining neurotransmitter levels as *** et al used functional magnetic resonance imaging to look at modulation of different neural circuits by diagnostic-specific scales in patients with schizophrenia and *** two studies provide crucial evidence in advancing our understanding of the brain in prevalent psychiatric disorders.

关键词： Schizophrenia Magnetic resonance imaging Biomarkers Neurotransmitters Psychiatric disorders