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A review on the scale-up of high-shear wet granulation processes and the impact of process parameters

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Particuology 2024年第9期92卷 180-195页

作者： Ana Rita Alves Marta Filipe Simões Sérgio Simões João Gomes University of Coimbra CERESDepartment of Chemical EngineeringFaculty of Sciences and TechnologyRua Sílvio Lima3030-790CoimbraPortugal Bluepharma-Indústria Farmacêutica São Martinho do BispoCoimbra3045-016Portugal Faculty of Pharmacy University of CoimbraAzinhaga de Santa Comba3000-548CoimbraPortugal

Wet granulation is one of the most important agglomeration processes,and high-shear granulation(HSG)one of the most employed technologies in the pharmaceutical *** most critical process parameters of HSG are discussed in this *** main concern in scaling up the wet granulation process is the differences between scales,which prevent the particles from having the same experience across all *** scale-up of wet granulation processes is commonly divided into two categories:engineering and attribute-based *** engineering-based scale-up approach is a strategy based on dimensional analysis and an attribute-based supported on the principles of“equifinality”,where process variables are adjusted to obtain equivalent granule *** work presents the effect of different HSG process parameters on the scale-up,as well as the use of process analytical tools(PAT)and modelling *** aim is to review applied scale-up approaches in HSG and discuss benefits and *** is proven why the scale-up for oral solid pharmaceutical products is still considered a hot topic and a very challenging task for development and engineering teams.

关键词： High-shear wetgranulation Parametric-based Attribute-based Physics-based modelling Impeller design Scale-up

Sensors Applied to Plant Breeding: Leaf Reflectance Indices (LRIs) and Resistance to Anthracnose in Capsicum annuum L. var. annuum

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Advances in Remote Sensing 2024年第1期13卷 1-17页

作者： Rosimara Barboza Bispo Maria Do Socorro Bezerra Araújo Antônio André da Silva Alencar Cláudia Pombo Sudré Rosana Rodrigues Plant Breeding Laboratory Darcy Ribeiro North Fluminense State University Campos dos Goytacazes Brazil Plant Breeding Laboratory University of the State of Mato Grosso Cáceres Brazil

The present work investigated the efficiency of leaf reflectance indices in the identification of Capsicum annuum L. var. annuum resistant to anthracnose in the fruit. Twenty-five F5:6 families originating from contrasting parents were assessed;the parents were accession UENF 2285 (susceptible to anthracnose) and accession UENF 1381, a hot pepper resistant to anthracnose in the fruit. The experiment was carried out in an experimental field in Campos dos Goytacazes, Rio de Janeiro, Brazil, between May and October of 2021. The treatments were arranged in a randomized block design, with three replications and five plants per plot. Fifteen LRIs were estimated using a CI-710 portable mini leaf spectrometer. The assessments covered all plant growth after flowering, and a total of six assessments were performed at 15-days intervals, beginning at 35 and ending 120 days after flowering (DAFs). Analysis of variance in a split-plot scheme was performed, as were tests of mean groupings and principal components analysis (PCA). The best period for evaluating leaf reflectance indices in C. annuum var. annuum is 120 days after flowering. The leaf reflectance indices PRI, CNDVI and Ctr2 stood out as effective in distinguishing between resistant and susceptible genotypes.

关键词： Phenotyping Bell Pepper CI-710 Colletotrichum scovillei

Animal models used to study direct peripheral nerve repair: a systematic review

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Neural Regeneration Research 2020年第3期15卷 491-502页

作者： Francisco Javier Vela Guadalupe Martínez-Chacón Alberto Ballestín JoséLuis Campos Francisco Miguel Sánchez-Margallo Elena Abellán Department of Microsurgery Jesús Usón Minimally Invasive Surgery CentreCáceresSpain Scientific Director Jesús Usón Minimally Invasive Surgery CentreCáceresSpain

Objective:Peripheral nerve repair is required after traumatic *** common condition represents a major public health problem *** after nerve repair depends on several factors,including the severity of the injury,the nerve involved,and the surgeon’s technical *** the precise microsurgical repair of nerve lesions,adequate functional recovery is not always achieved and,therefore,the regeneration process and surgical techniques are still being ***-clinical animal models are essential for this research and,for this reason,the focus of the present systematic review(according to the PRISMA statement)was to analyze the different animal models used in pre-clinical peripheral nerve repair *** sources:Original articles,published in English from 2000 to 2018,were collected using the Web of Science,Scopus,and PubMed *** selection:Only preclinical trials on direct nerve repair were included in this *** articles were evaluated by the first two authors,in accordance with predefined data *** measures:The primary outcomes included functional motor abilities,daily activity and regeneration *** outcomes included coaptation technique and animal ***:This review yielded 267 articles,of which,after completion of the screening,49 studies were *** were 1425 animals in those 49 studies,being rats,mice,guinea pigs,rabbits,cats and dogs the different pre-clinical *** nerves used were classified into three groups:head and neck(11),forelimb(8)and hindlimb(30).The techniques used to perform the coaptation were:microsuture(46),glue(12),laser(8)and mechanical(2).The follow-up examinations were histology(43),electrophysiological analysis(24)and behavioral observation(22).Conclusion:The most widely used animal model in the study of peripheral nerve repair is the *** animal models are also used but the cost-benefit of the rat model provides several strengths over the ***

关键词： nerve microsurgery peripheral nerve regeneration repair reconstruction direct nerve repair animal model coaptation PRISMA systematic review

A Novel Ensemble Learning System for Cyberattack Classification

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Intelligent Automation & Soft Computing 2023年第8期37卷 1691-1709页

作者： óscar Mogollón-Gutiérrez JoséCarlos Sancho Nunez Marávila Vegas Andrés Caro Lindo Department of Computer and Telematic Systems Engineering Universidad de ExtremaduraSchool of TechnologyCáceres10005Spain

Nowadays,IT systems rely mainly on artificial intelligence(AI)algorithms to process *** is generally used to extract knowledge from stored information and,depending on the nature of data,it may be necessary to apply different AI *** this article,a novel perspective on the use of AI to ensure the cybersecurity through the study of network traffic is *** is done through the construction of a two-stage cyberattack classification ensemble model addressing class imbalance following a one-vs-rest(OvR)*** the growing trend of cyberattacks,it is essential to implement techniques that ensure legitimate access to *** address this issue,this work proposes a network traffic classification system for different categories based on several AI *** the first task,binary models are generated to clearly differentiate each type of traffic from the *** binary models generated,an ensemble model is developed in two phases,which allows the separation of legitimate and illegitimate traffic(phase 1)while also identifying the type of illegitimate traffic(phase 2).In this way,the proposed system allows a complete multiclass classification of network *** estimation of global performance is done using a modern dataset(UNSW-NB15),evaluated using two approaches and compared with other state-of-art *** proposal,based on the construction of a two-step model,reaches an F1 of 0.912 for the first level of binary classification and 0.7754 for the multiclass *** results show that the proposed system outperforms other state-of-the-art approaches(+0.75%and+3.54%for binary and multiclass classification,respectively)in terms of F1,as demon-strated through comparison together with other relevant classification metrics.

关键词： Intrusion detection ensemble learning two-phase model UNSW-NB15 cybersecurity

Towards long-multitemporal change detection using SVI differencing by integrated DWT ISOCLUS: a model for forest temporal dynamics mapping

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International Journal of Digital Earth 2011年第2期4卷 108-132页

作者： Yashon O.Oumaa Ryutaro Tateishi Tateishi Laboratory Centre for Environmental Remote Sensing(CEReS)Graduate School of Science and TechnologyChiba University1-33 Yayoi-choInage-kuChiba 263-8522Japan Tateishi Laboratory Centre for Environmental Remote Sensing(CEReS)Chiba University1-33 Yayoi-choInage-kuChiba 263-8522Japan

Characterisation and mapping of land cover/land use within forest areas over long-multitemporal intervals is a complex *** complexity is mainly due to the location and extent of such areas and,as a consequence,to the lack of full continuous cloud-free coverage of those large regions by one single remote sensing *** order to provide improved long-multitemporal forest change detection using Landsat MSS and ETMin part of *** rainforest,and to develop a model for forest change monitoring,wavelet transforms analysis was tested against the ISOCLUS algorithm for the derivation of changes in natural forest cover,as determined using four simple ratio-based Vegetation Indices:Simple Ratio(SR),Normalised Difference Vegetation Index(NDVI),Renormalised Difference Vegetation Index(RDVI)and modified simple ratio(MSR).Based on statistical and empirical accuracy assessments,RDVI presented the optimal index for the case *** overall accuracy statistic of the wavelet derived change/no-change was used to rank the performances of the indices as:RDVI(91.68%),MSR(82.55%),NDVI(79.73%)and SR(65.34%).The integrated discrete wavelet transformISOCLUS(DWTISOCLUS)result was 42.65%higher than the independent ISOCLUS approach in mapping the change/no-change *** methodology suggested in this study presents a cost-effective and practical method to detect land-cover changes in support of decision-making for updating forest databases,and for long-term monitoring of vegetation changes from multisensor *** current research contributes to Digital Earth with regards to geo-data acquisition,data mining and representation of one forest systems.

关键词： digital earth long-multitemporal forest change detection Spectral Vegetation Index Differencing(SVID) ISOCLUS discrete wavelet transform(DWT) integrated DWTISOCLUS

Management of the Prosthetic Valve Thrombosis: This Time Is Different

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Case Reports in Clinical Medicine 2021年第7期10卷 185-190页

作者： Zineb Kounka Benjamín Roque-Rodríguez Luis Enrique Lezcano-Gort David Antonio Chipayo-Gonzáles Elena Gallego-Curto Cecilio Raúl Rodríguez-Carreras Department of Cardiology Complejo Hospitalario Universitario de C&aacute ceres C&aacute ceres Spain Intensive Care Unit Complejo Hospitalario Universitario de C&aacute ceres C&aacute ceres Spain

Prosthetic valve thrombosis (PVT) is a rare but serious entity. Its diagnosis and treatment can be challenging and mortality remains high regardless of its management. A 50-year-old man admitted with cardiac arrest, whose physical examination and echocardioscopy suggested PVT confirmed with fluoroscopy. Intra-aortic fibrinolysis was the treatment chosen with successful results.

关键词： Prosthetic Valve Thrombosis Intra-Aortic Fibrinolysis Low-Dose Slow Infusion

Effects of Aerosol Vertical Inhomogeneity on the Upwelling Radiance and Satellite Remote Sensing of Surface Reflectance

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Advances in Atmospheric Sciences 2001年第4期18卷 539-553页

作者：邱金桓 Nobuo Takeuchi Institute of Atmospheric Physics Chinese Academy of Sciences ceres Chiba University

There are two widely used radiative models without consideration of aerosol inhomogeneity for satellite remote sensing application, the Homogeneous Model and the Two-layer Model with aerosol in the lower layer. In this paper, effects of the aerosol vertical inhomogeneity on upwelling radiance and satellite remote sensing of surface reflectance are analyzed through numerical simulations by using two models. As shown in the simulations by using 24 representative aerosol models, there is often a considerably large error in upwel-ling radiance calculated by two models (Homogeneous and Two-layer) for the short wavelength channel with strong molecular scattering, owing to the difference between molecular and aerosol scattering proper-ties. For the long wavelength channel, the error is small if aerosol optical parameters are less variable with height, but it could also be significant if there are aerosol layers with different scattering phase functions and single scattering albedo. The radiance errors by the Homogeneous Model and the Two-layer Model can be up to 31.4% and 31.5% for the clean atmosphere, and in case of turbid atmosphere 67.8% and 59.2%, respectively. The radiance error could result in a large uncertainty of surface reflectance retrievals, especially for the short wavelength channel and the strongly absorbing aerosol. For the turbid atmosphere with strong-ly absorbing aerosol, the Homogeneous Model and the Two-layer Model are not suitable for atmospheric correction application. Key words Satellite remote sensing - Aerosol inhomogeneity - Surface reflectance - Radiance

关键词： Satellite remote sensing Aerosol inhomogeneity Surface reflectance Radiance

Global mapping of urban built-up areas of year 2014 by combining MODIS multispectral data with VIIRS nighttime light data

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International Journal of Digital Earth 2016年第10期9卷 1004-1020页

作者： Ram C.Sharma Ryutaro Tateishi Keitarou Hara Saeid Gharechelou Kotaro Iizuka Center for Environmental Remote Sensing(ceres) Chiba UniversityChibaJapan Department of Informatics Tokyo University of Information SciencesChibaJapan Research Institute for Sustainable Humanosphere Kyoto UniversityKyotoJapan

An improved methodology for the extraction and mapping of urban built-up areas at a global scale is presented in this *** Moderate Resolution Imaging Spectroradiometer(MODIS)-based multispectral data were combined with the Visible Infrared Imager Radiometer Suite(VIIRS)-based nighttime light(NTL)data for robust extraction and mapping of urban built-up *** MODIS-based newly proposed Urban Built-up Index(UBI)was combined with NTL data,and the resulting Enhanced UBI(EUBI)was used as a single master image for global extraction of urban built-up *** to higher variation of the EUBI with respect to geographical regions,a region-specific threshold approach was used to extract urban built-up *** research provided 500-m-resolution global urban built-up map of year *** resulted map was compared with three existing moderate-resolution global maps and one high-resolution map in the United *** comparative analysis demonstrated finer details of the urban built-up cover estimated by the resultant map.

关键词： Urban built-up areas VIIRS MODIS nighttime light Urban Built-up Index global mapping

Potential of Zimbabwean commercial probiotic products and strains of Lactobacillus plantarum as prophylaxis and therapy against diarrhoea caused by Escherichia coli in children

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Asian Pacific Journal of Tropical Medicine 2017年第1期10卷 57-62页

作者： Walter Chingwaru Jerneja Vidmar Department of Biological Sciences Faculty of ScienceBindura University Science EducationP.Bag 1020BinduraZimbabwe Maribor Institute of Biomedical Sciences Žitna ulica 102000 MariborSlovenia Institute ceres/Zavod ceres Lahovna 163000 CeljeSlovenia Department of Plastic and Reconstructive Surgery University Medical Centre MariborLjubljanska 52000 MariborSlovenia

Objective: To evaluate the potential of commercial fermented products sold in the country,and strains of Lactobacillus plantarum(L,plantarum)as prophylaxis and therapy against diarrhoea in children,Methods: The antimicrobial potential of cultures of lactobacilli enriched from 4 Zimbabwean commercial food/beverage products: Dairibord Lacto sour milk(DLSM),Probrand sour milk(PSM),Kefalos Vuka cheese(KVC) and Chibuku opaque beer(COB); and four strains of L,plantarum obtained from Balkan traditional cheeses against clinical strains of Escherichia coli(E,coli) was assayed using the well diffusion method,Three commercial paediatric antidiarrhoeal drug products: Biogaia(BG),Prolife(PL) and Probio Junior(PJ) and a mutant strain of E,coli [strain 11105(ATCC)- a vitamin B-12 auxotroph and penicillin G acylase-producing strain] were used as controls,An agar diffusion assay and a competitive exclusion assay were carried out on Mueller Hinton agar,Results: Crude cultures of putative lactobacillus strains obtained from Zimbabwean dairy products(Probrand sour milk,Kefalos Vuka vuka cheese and Chibuku opaque beer) had significantly higher antimicrobial activities against clinical strains of E,coli than strains of L,plantarum isolated from Balkan cheeses(CLP1,CLP2 or CLP3) and crude microbial cultures from commercial paediatric probiotic products(BG,PJ and PL) of a culture of Lactobacillus rhamnosus LGG(P<0.05),Conclusions: The putative Lactobacilli from four commercial Zimbabwean dairy products(Probrand sour milk,Kefalos Vuka vuka cheese and Chibuku opaque beer),and three strains of L,plantarum from Balkan cheeses(CLP1,CLP2 or CLP3) exhibited high antibacterial activities that can be harnessed to control paediatric diarrhoea that is caused by pathogenic strains of E,coli,Studies to characterise the probiotic potential of the live cultures in the products and the new strains of L,plantarum are underway.

关键词： Probiotic Inhibition Escherichia coli Lactobacillus plantarum Diarrhoea Paediatric