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Novel prognostic score based on the preoperative total bilirubinalbumin ratio and fibrinogen-albumin ratio in ampullary adenocarcinoma

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World Journal of Gastrointestinal Surgery 2023年第10期15卷 2247-2258页

作者： Xiao-Jie Zhang He Fei Chong-Yuan Sun Ze-Feng Li Zheng Li Chun-Guang Guo Dong-Bing Zhao Department of Pancreatic and gastric Surgical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGROUND The preoperative total bilirubin-albumin ratio(TBAR)and fibrinogen-albumin ratio(FAR)have been proven to be valuable prognostic factors in various *** To detect the prognostic value of TBAR and FAR in ampullary adenocarcinoma(AC)patients who underwent curative *** AC patients who underwent curative pancreaticoduodenectomy in the National cancer center of China between 1998 and 2020 were retrospectively *** prognostic cutoff values of TBAR and FAR were determined through the best survival separation ***,a novel prognostic score combining TBAR and FAR was calculated and validated through the logistic regression analysis and Cox regression *** A total of 188 AC patients were enrolled in the current *** best cutoff values of TBAR and FAR for predicting overall survival were 1.7943 and 0.1329,*** patients were divided into a TBAR-low group(score=0)vs a TBAR-high group(score=1)and a FAR-low group(score=0)vs a FAR-high group(score=1).The total score was calculated as a novel prognostic *** logistic regression analysis revealed that a high score was an independent protective factor for recurrence[score=1 vs score=0:Odds ratio(OR)=0.517,P=0.046;score=2 vs score=0 OR=0.236,P=0.038].In addition,multivariable survival analysis also demonstrated that a high score was an independent protective factor in AC patients(score=2 vs score=0:Hazard ratio=0.230,P=0.046).CONCLUSION A novel prognostic score based on preoperative TBAR and FAR has been demonstrated to have good predictive power in AC patients who underwent curative ***,more studies with larger samples are needed to validate this conclusion.

关键词： Ampullary adenocarcinoma Total bilirubin-albumin ratio Fibrinogen-albumin ratio Recurrence Overall survival

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Role of the gut microbiota in anticancer therapy:from molecular mechanisms to clinical applications

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Signal Transduction and Targeted Therapy 2023年第6期8卷 2687-2713页

作者： Lin-Yong Zhao Jia-Xin Mei Gang Yu Lei Lei Wei-Han Zhang Kai Liu Xiao-Long Chen Damian Kołat Kun Yang Jian-Kun Hu Department of General Surgery&Laboratory of gastric cancer State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengduChina gastric cancer center West China HospitalSichuan UniversityChengduChina State Key Laboratory of Oral Diseases West China Hospital of StomatologySichuan UniversityFrontier Innovation Center for Dental Medicine PlusSichuan UniversityChengduChina Department of Experimental Surgery Medical University of LodzLodzPoland

In the past period,due to the rapid development of next-generation sequencing technology,accumulating evidence has clarified the complex role of the human microbiota in the development of cancer and the therapeutic *** importantly,available evidence seems to indicate that modulating the composition of the gut microbiota to improve the efficacy of anti-cancer drugs may be ***,intricate complexities exist,and a deep and comprehensive understanding of how the human microbiota interacts with cancer is critical to realize its full potential in cancer *** purpose of this review is to summarize the initial clues on molecular mechanisms regarding the mutual effects between the gut microbiota and cancer development,and to highlight the relationship between gut microbes and the efficacy of immunotherapy,chemotherapy,radiation therapy and cancer surgery,which may provide insights into the formulation of individualized therapeutic strategies for cancer *** addition,the current and emerging microbial interventions for cancer therapy as well as their clinical applications are *** many challenges remain for now,the great importance and full potential of the gut microbiota cannot be overstated for the development of individualized anti-cancer strategies,and it is necessary to explore a holistic approach that incorporates microbial modulation therapy in cancer.

关键词： clinical mechanisms stated

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Leiomyosarcoma of the stomach: A case report

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World Journal of Clinical Cases 2019年第21期7卷 3575-3582页

作者： Wen-Zhe Kang Li-Yan Xue Yan-Tao Tian Department of Pancreatic and gastric Surgery National Cancer CenterNational Clinical Research Center for CancerCancer HospitalAcademy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Pathology National Cancer CenterNational Clinical Research Center for CancerCancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGROUND Leiomyosarcoma of the stomach is extremely rare,and only 13 cases have been reported in the *** the advent of KIT immunohistochemistry,gastrointestinal stromal tumors(GISTs)were misdiagnosed as leiomyomas and *** rarely occurs in organs besides the uterus and is rarely located in the *** SUMMARY A 57-year-old woman presented with the symptom of melena over a one-month *** had suffered weight loss,weakness,nausea and vomiting for fifteen *** a local hospital,computed tomography showed a very large mass in the stomach,and the results of endoscopic examination and histopathological diagnosis were *** received transfusion therapy and was transferred to our *** arrival at our hospital,the patient was *** denied any family history and had no specific past *** signs of pulmonary metastasis were found on chest *** resonance imaging and computed tomography confirmed a very large tumor in the stomach,and no visible signs of metastatic disease were *** October 30,2013,the patient underwent resection of the stomach tumor and did not undergo any adjuvant *** margins were negative and she had an uneventful recovery and was discharged after 12 *** year after surgery,the patient died at home,and the cause of death were gastrointestinal obstruction and *** that time,she was treated with Chinese medicine but the effect was not *** of gastrointestinal obstruction,the patient did not receive any *** Surgical resection is the standard treatment for gastric *** diagnosis of this tumor mainly depends on histopathological *** case may suggest the aggressive behavior and poor prognosis of this tumor.

关键词： Leiomyosarcoma Stomach Case report KIT Gastrointestinal stromal tumor Targeted next-generation sequencing

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Laparoscopic vs open total gastrectomy for advanced gastric cancer following neoadjuvant therapy:A propensity score matching analysis

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World Journal of Gastrointestinal Surgery 2022年第2期14卷 161-173页

作者： Hai-Tao Hu Fu-Hai Ma Jian-Ping Xiong Yang Li Peng Jin Hao Liu Shuai Ma Wen-Zhe Kang Yan-Tao Tian Department of Pancreatic and gastric Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021Beijing ProvinceChina

BACKGROUND Laparoscopic total gastrectomy(LTG)has drawn increasing attention over the *** LTG has shown surgical benefits compared to open TG(OTG)in early stage gastric cancer(GC),little is known about the surgical and oncological outcomes of LTG for advanced GC following neoadjuvant therapy(NAT).AIM To compare the long-and short-term outcomes of advanced GC patients who underwent LTG vs OTG following *** Advanced GC patients who underwent TG following NAT between April 2011 and May 2018 at the cancer Hospital of the Chinese Academy of Medical Sciences were enrolled and stratified into two groups:LTG and *** score matching analysis was performed at a 1:1 ratio to overcome possible *** In total,185 patients were enrolled(LTG:78;OTG:109).Of these,138 were paired after propensity score *** adjustment for propensity score matching,baseline parameters were similar between the two *** to OTG,LTG was associated with a significantly shorter length of hospital stay(P=0.012).The rates of R0 resection,lymph node harvest,and postoperative morbidity did not significantly differ between the two *** survival(OS)outcomes were comparable between the two *** T and N stages were found to be independent risk factors for *** LTG can be a feasible method for advanced GC patients following NAT,as it appears to be associated with better short-and comparable long-term outcomes compared to OTG.

关键词： gastric cancer Laparoscopic total gastrectomy Open total gastrectomy Neoadjuvant therapy Propensity score matching

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Liposarcoma of the stomach: Report of two cases and review of the literature

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World Journal of Gastroenterology 2018年第25期24卷 2776-2784页

作者： Wen-Zhe Kang Li-Yan Xue Gui-Qi Wang Fu-Hai Ma Xiao-Long Feng Lei Guo Yang Li Wei-Kun Li Yan-Tao Tian Department of Pancreatic and gastric Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Pathology National Cancer Center/ National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Endoscope National Cancer Center/ National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

Liposarcoma of the stomach is extremely rare, and only 37 cases have been reported worldwide. We herein report two cases of liposarcoma of the stomach. The first patient was referred to our hospital with upper abdominal discomfort. The endoscopic examination revealed a tumor mass about 3 cm in diameter. The patient underwent a partial gastrectomy and had an uneventful recovery. The histopathological examination revealed a welldifferentiated liposarcoma. The second patient had symptoms of upper abdominal discomfort combined with nausea and anorexia. Several palpable masses were found with endoscopy. Endoscopic submucosal dissection was the treatment used, and the postoperative course was uneventful. The histopathological diagnosis was a well-differentiated liposarcoma. The two patients did not undergo any adjuvant therapy. They are both currently in good condition without recurrence. Therefore, we believe that the outcome of liposarcoma of the stomach is positive, and surgical resection may be the first choice for treatment at present.

关键词： Pathology Signs and symptoms Diagnosis Liposarcoma Therapeutics

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Preoperative prognostic nutritional index predicts long-term outcomes of patients with ampullary adenocarcinoma after curative pancreatoduodenectomy

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1291-1300页

作者： Chong-Yuan Sun Xiao-Jie Zhang Zheng Li He Fei Ze-Feng Li Dong-Bing Zhao Department of Pancreatic and gastric Surgical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGROUND The prognostic nutritional index(PNI),a marker of immune-nutrition balance,has predictive value for the survival and prognosis of patients with various *** To explore the clinical significance of the preoperative PNI on the prognosis of ampullary adenocarcinoma(AC)patients who underwent curative *** The data concerning 233 patients diagnosed with ACs were extracted and analyzed at our institution from January 1998 to December *** patients were categorized into low and high PNI groups based on the cutoff value determined by receiver operating characteristic curve *** compared disease-free survival(DFS)and overall survival(OS)between these groups and assessed prognostic factors through univariate and multivariate *** The optimal cutoff value for the PNI was established at *** with a PNI≥45.3 were categorized into the PNI-high group,while those with a PNI<45.3 were assigned to the PNI-low *** within the PNI-low group tended to be of advanced age and exhibited higher levels of aspartate transaminase and total bilirubin and a lower creatinine level than were those in the PNI-high *** 5-year OS rates for patients with a PNI≥45.3 and a PNI<45.3 were 61.8%and 43.4%,respectively,while the 5-year DFS rates were 53.5%and 38.3%,*** in the PNI-low group had shorter OS(P=0.006)and DFS(P=0.012).In addition,multivariate analysis revealed that the PNI,pathological T stage and pathological N stage were found to be independent prognostic factors for both OS and *** The PNI is a straightforward and valuable marker for predicting long-term survival after *** PNI should be incorporated into the standard assessment of patients with AC.

关键词： Ampullary carcinoma Prognostic nutritional index Prognosis Pancreaticoduodenectomy

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Surgical resection of esophagogastric junction stromal tumor: How to protect the cardiac function

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World Journal of Gastroenterology 2021年第9期27卷 854-865页

作者： Guo-Liang Zheng Bao Zhang Yue Wang Yong Liu Hai-Tao Zhu Yan Zhao Zhi-Chao Zheng Department of gastric Surgery Cancer Hospital of China Medical University(Liaoning Cancer Hospital and Institute)Shenyang 110042Liaoning ProvinceChina

BACKGROUND Various surgical procedures have been described for gastrointestinal stromal tumors(GISTs)at the esophagogastric junction(EGJ)close to the ***,surgery for EGJ-GIST involving Z-line has been rarely *** To introduce a novel technique called conformal resection(CR)for open resection of EGJ-GIST involving *** In this retrospective study,43 patients having GISTs involving Z-line were *** perioperative outcomes of patients receiving CR(n=18)was compared with that of proximal gastrectomy(PG)(n=25).RESULTS CR was successfully performed in all the patients with negative microscopic *** mean operative time,time to first passage of flatus,and postoperative hospital stay was significantly shorter in the CR group(P<0.05),while the intraoperative blood loss was similar in the two *** postoperative gastroesophageal reflux as diagnosed by esophageal 24-h pH monitoring and quality of life at 3 mo were significantly in favor of CR compared to PG(both P<0.001).The 5-year disease-free survival between the two groups was similar(P=0.163).The cut-off value for the determination of CR or PG was 7.0 mm above the Z-line(83.33%sensitivity,84.00%specificity,83.72%accuracy).CONCLUSION CR is safe and feasible for EGJ-GIST located within 7.0 mm above the Z-line.

关键词： Esophagogastric junction stromal tumor Surgery Anti-reflux 36-Item shortform health survey Disease-free survival

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Survival outcomes and prognostic indicators for gastric cancer patients with positive peritoneal wash cytology but no peritoneal metastasis after radical gastrectomy

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World Journal of Gastrointestinal Oncology 2021年第1期13卷 24-36页

作者： Wen-Zhe Kang Yu-Xin Zhong Fu-Hai Ma Li-Yan Xue Jian-Ping Xiong Shuai Ma Yang Li Yi-Bin Xie Xu Quan Yan-Tao Tian Department of Pancreatic and gastric Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBejing 100021China

BACKGROUND Positive peritoneal wash cytology with no peritoneal metastasis(CY1P0)is a special type of distant gastric cancer metastasis,which describes a patient with positive peritoneal lavage cytology,but no definitive peritoneal metastasis,and there are no widely accepted treatment *** enrolled 48 primary CY1P0 gastric cancer patients treated by radical gastrectomy in this *** study illustrated the efficacy of radical gastrectomy for CY1P0 gastric cancer patients,and suggested that the pathological N factor and vascular invasion were significant independent risk factors for overall survival(OS).AIM To assess the survival of CY1P0 gastric cancer patient post-radical gastrectomy,and to identify factors associated with long-term *** Our study included 48 patients with primary CY1P0 gastric cancer who had radical gastrectomies at the cancer Hospital,Chinese Academy of Medical Sciences,Beijing,China between 2013 and 2018.R0 resection was achieved in all 48 *** patients received neoadjuvant *** patients received adjuvant chemotherapy and four received adjuvant *** statistics were available for 48 ***-up continued through March *** and multivariate analyses were performed using a Cox proportional hazards model to identify prognostic *** Median OS was 22.0 mo(95%confidence interval:13.366-30.634 mo)*** analyses demonstrated that tumor site(P=0.021),pathological N factor(P=0.001),pathological T factor(P=0.028),vascular invasion(P=0.046),and the level of CA199 prior to initiating therapy(P=0.002)were significant risk factors for *** analyses demonstrated that pathological N factor(P=0.001)and vascular invasion(P=0.031)were significant independent risk factors for *** This study suggested that radical gastrectomy may be efficient for CY1P0 gastric cancer patient post-radical gastrectomy and the pathological N factor and vas

关键词： gastric cancer Overall survival R0 resection Prognostic factors Lymph node metastasis

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Artificial intelligence in gastric cancer: Application and future perspectives

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World Journal of Gastroenterology 2020年第36期26卷 5408-5419页

作者： Peng-Hui Niu Lu-Lu Zhao Hong-Liang Wu Dong-Bing Zhao Ying-Tai Chen Department of Pancreatic and gastric Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Anesthesiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

gastric cancer is the fourth leading cause of cancer-related mortality across the globe,with a 5-year survival rate of less than 40%.In recent years,several applications of artificial intelligence(AI)have emerged in the gastric cancer field based on its efficient computational power and learning capacities,such as imagebased diagnosis and prognosis ***-assisted diagnosis includes pathology,endoscopy,and computerized tomography,while researchers in the prognosis circle focus on recurrence,metastasis,and survival *** this review,a comprehensive literature search was performed on articles published up to April 2020 from the databases of PubMed,Embase,Web of Science,and the Cochrane *** the current status of AI-applications was systematically summarized in gastric ***,future directions that target this field were also analyzed to overcome the risk of overfitting AI models and enhance their accuracy as well as the applicability in clinical practice.

关键词： gastric cancer Image-based diagnosis Prognosis prediction Artificial intelligence Machine learning Deep learning

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Construction of a predictive model for gastric cancer neuroaggression and clinical validation analysis: A single-center retrospective study

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2602-2611页

作者： Yu-Yin Lan Jing Han Yan-Yan Liu Lei Lan Department of Stomatology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghai 200071China Department of Biobank Zhejiang Cancer HospitalHangzhou 310005Zhejiang ProvinceChina Department of General Surgery Peking University First HospitalBeijing 100034China Department of Oncology Zhejiang HospitalHangzhou 310013Zhejiang ProvinceChina

BACKGROUND This study investigated the construction and clinical validation of a predictive model for neuroaggression in patients with gastric *** cancer is one of the most common malignant tumors in the world,and neuroinvasion is the key factor affecting the prognosis of ***,there is a lack of systematic analysis on the construction and clinical application of its prediction *** study adopted a single-center retrospective study method,collected a large amo-unt of clinical data,and applied statistics and machine learning technology to build and verify an effective prediction model for neuroaggression,with a view to providing scientific basis for clinical treatment decisions and improving the tr-eatment effect and survival rate of patients with gastric *** To investigate the value of a model based on clinical data,spectral computed to-mography(CT)parameters and image omics characteristics for the preoperative prediction of nerve invasion in patients with gastric *** A retrospective analysis was performed on 80 gastric cancer patients who under-went preoperative energy spectrum CT at our hospital between January 2022 and August 2023,these patients were divided into a positive group and a negative group according to their pathological *** data were collected,the energy spectrum parameters of primary gastric cancer lesions were measured,and single factor analysis was performed.A total of 214 image omics features were extracted from two-phase mixed energy images,and the features were screened by single factor analysis and a support vector *** variables with statist-ically significant differences were included in logistic regression analysis to construct a prediction model,and the performance of the model was evaluated using the subject working characteristic *** were statistically significant differences in sex,carbohydrate antigen 199 expression,tumor thickness,Lauren classification

关键词： gastric neoplasms Nerve invasion Tomography X-ray computer Imaging omics Diagnostic differentiation

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