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A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

Neural Regeneration research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn J.W.So Konstantin Feinberg Marina Manoraj Jenny Cheung Jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorschel SickKids research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

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Nematode parasite,Auchenacantha spp of flying lemur,Cynocephalus variegatus(Audebert,1799) from Indonesia:Morphological study with SEM

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Asian Pacific Journal of Tropical Biomedicine 2011年第6期1卷 434-438页

作者： Endang Purwaningsih zoological division of research centre on biology-lipi Widyasatwaloka Building

Objective:To observe morphology of Auchenacantha galeopteri(***),Auchenacantha spinosa(***) and Auchenacantha parva(***) from Sukabumi and Ujung Kulon, Indonesia using scanning electron microscopy(SEM).Methods:Specimens for light microscopy examination were fixed with warm 70%alcohol,cleared and mounted in lactophenol for wet *** were made with the aid of a drawing tube attached to a Nikon compound *** for SEM examination were processed according to *** were given in micrometers(μ m) as the average of findings,followed by the range in parentheses, unless otherwise ***:The measurements of Auchenacantha spp are same with those of previously *** striatums of male and female *** are widen towards outside and *** mouth of female with 6 lips,each of them is wider at base than distal end in *** and rectangular in *** species have dentiform protrusion from inner surface of lips,such structure absent in ***,but the lips with transverse festoon like pattern at anterior end of each ***:Using SEM,the lip and the striation pattern of three species of Auchenacantha can be clearly *** and Ujung Kulon are new locality of *** and ***,and *** is the new record in Indonesia.

关键词： Oxyuridae Auchenacantha Parasite Flying lemur Cynocephalus variegatus Distribution Indonesia

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New host and locality records of snake intestinal nematode Kalicephalus spp in Indonesia

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Asian Pacific Journal of Tropical Biomedicine 2011年第2期1卷 121-123页

作者： Endang Purwaningsih Mumpuni zoological division Research Centre on Biology-LIPIWidyasatwaloka Building

Objective:To observe three species of Kalicephalus found in three species of snake(Ophkphagus hannah,Ptyas mucosus,and Naja Sputatrix) during research on Capture Snake for Trading in Java and Snake Biodiversity in Kalimantan ***:Specimens for light microscopy examination were fixed with warm 70%alcohol,cleared and mounted in lactophenol for wet *** were made with the aid of a drawing tube attached to a Nikon compound *** were given in micrometers(μ) as the average of findings,followed by the range in parentheses,unless otherwise ***:Kalkephalus(Costatus) indicus was found from 7 Ptyas mucosus,Kalicephalus bungari from 2 Naja sputatrix and 1 Kalicephalus(Costatus) indicus and Kalicephalus assimilis found from 1 Ophiophagus *** morphology and measurement of three species of Kalicephalus found in this study were close to those described ***:New finding of host of Kalicephalus(Costalus) indicus and Kalicephalus bungari was a snake species of Naja *** records of locality were Kalimantan island as the new locality of Kalicephalus assimilis,and Java island was new locality of Kalicephalus(Costatus) indicus.

关键词： Strongyloidea Kalicephalus Snakes New record Indonesia Intestinal nematode New host

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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru C.Guo division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British Columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science Core Collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P GC-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

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The first report of new species:Trichuris landak n. sp

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Asian Pacific Journal of Tropical Biomedicine 2013年第2期3卷 85-88页

作者： Endang Purwaningsih zoological division of research Center on biology-lipi Widyasatwaloka BuildingJl.Raya Bogor Km 46Cibinong 16911Indonesia

Objective:To study nematode parasites morphology of Hystrix javanica(***),both through the feces and internal ***:Feces were observed by direct smear method,internal organs were observed after dissecting the *** for light microscopy examination were fixed with 70%warm alcohol,cleared and mounted in lactophenol for wet *** for SEM examination were postfixed in cacodylate buffer and glutaraldehyde,dehydrated through a graded series of alcohol and freeze *** specimens were attached to stubs with double cello-tape,coated with gold and observed with a JSM5310LV electron *** were made with the aid of a drawiug tube attached to Olympus compound microscope,other figures were photographs of scanning electron microscope *** were given in micrometers as the mean followed by the range in parentheses,unless otherwise ***:The nematode species found in the intestine of *** are Gireterakis girardi and a new species,Trihuris *** new species differs with previously reported species from Hystrix because of having stylet and short cervical *** pattern of bacillary band is closed to Trichuris trichiurus,the species that infect human,but differs because the surface of its vulva is not covered with densely ***:The species of nematodes found on *** were Gireterakis girardi and a new species Trichuris landak *** two species are newly recorded in Indonesia.

关键词： Hystrix Javan porcupine Gireterakis girardi Trichuris landak n.sp. Java Indonesia

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Parasitic nematodes from turtles:New species and new record from Indonesia

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Journal of Coastal Life Medicine 2015年第8期 607-611页

作者： Endang Purwaningsih Mumpuni zoological division of research centre on biology-lipi Widyasatwaloka BuildingJl Raya Bogor Km 46Cibinong 16911Indonesia

Objective:To describe the morphological characteristics of some species of parasitic nematodes found in freshwater turtles from Sumatera(Amyda cartilaginea)and Kalimantan(Notochelys platynota).Methods:Specimens for light microscopy examination were fixed with warm 70%alcohol,cleared and mounted in lactophenol for stout specimens and glycerine for delicate specimens,prior to wet *** were made with the aid of a drawing tube attached to an Olympus compound *** for scanning electron microscope examination were fixed in cacodylate buffer and glutaraldehyde,dehydrated in alcohol concentration series,dried in vacuum dried and coated with gold in Eiko-IB2 Ion *** were given in micrometers as the mean followed by the range in parentheses,unless otherwise ***:Four species of parasitic nematodes were found,namely,Monhysterides jambiensis sp.n.(***),Spiroxys sumatraensis sp.n.(***),Cissophyllus laverani and Cissophyllus *** differed from Monhysterides lissemydis in ratio of right-to-left spicule(1:3 in *** vs.1:3.8-5.6 in ***)and had no *** also differed from Monhysterides testudinicola in longer spicule(11.2%-12.7%in *** vs.5.6%-6%of body length),ratio right-to-left spicule(1:3 in *** vs.1:2)and the numbers of caudal papillae and differed from Monhysterides testudinicola because of the lateral alae began from the half posterior of body,but that in *** began from anterior part of body,behind the anterior *** differed from Spiroxys annulatus in having tooth at median lobe and having no well mark cuticular collar behind the based of lips and constriction at the base of pseudolabium was not *** differed from Spiroxys transversalata in having no tooth at median lobes of each pseudolabium and differed from Spiroxys chelodinae in the unpaired position of median caudal papillae since it was

关键词： Nematode Turtle Monhysterides Spiroxys Cissophyllus New species Indonesia

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A framework for quantifying properties of 3-dimensional movement-based signals

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Current Zoology 2010年第3期56卷 327-336页

作者： Shaun TD NEW Richard A PETERS ARC centre of Excellence in Vision Science Division of EvolutionEcology & GeneticsResearch School of BiologyThe Australian National University

Understanding how signal properties are optimized for the reliable transmission of information requires accurate de- scription of the signal in time and space. For movement-based signals where movement is restricted to a single plane, measure- ments from a single viewpoint can be used to consider a range of viewing positions based on simple geometric calculations. However, considerations of signal properties from a range of viewing positions for movements extending into three-dimensions （3D） are more problematic. We present here a new framework that overcomes this limitation, and enables us to quantify the extent to which movement-based signals are view-specific. To illustrate its application, a Jacky lizard tail flick signal was filmed with synchronized cameras and the position of the tail tip digitized for both recordings. Camera aligmnent enabled tl^e construction of a 3D display action pattern profile. We analyzed the profile directly and used it to create a detailed 3D animation. In the virtual environment, we were able to film the same signal from multiple viewing positions and using a computational motion analysis algorithm （gradient detector model） to measure local image velocity in order to predict view dependent differences in signal properties. This approach will enable consideration of a range of questions concerning movement-based signal design and evolu- tion that were previously out of reach [Current Zoology 56 （3）： 327-336, 2010].

关键词： Signal evolution Sensory Ecology Movement-based signal 3D Display Action Pattern

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Are TrkB receptor agonists the right tool to fulfill the promises for a therapeutic value of the brain-derived neurotrophic factor?

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Neural Regeneration research 2024年第1期19卷 29-34页

作者： Marta Zagrebelsky Martin Korte division of Cellular Neurobiology Zoological InstituteTU BraunschweigBraunschweigGermany Helmholtz centre for Infection research AG NINDBraunschweigGermany

Brain-derived neurotrophic factor signaling via its receptor tro pomyosin receptor kinase B regulates several crucial physiological *** has been shown to act in the brain,promoting neuronal survival,growth,and plasticity as well as in the rest of the body where it is involved in regulating for instance aspects of the *** to its crucial and very pleiotro pic activity,reduction of brain-derived neurotrophic factor levels and alterations in the brain-derived neurotrophic factor/tropomyosin receptor kinase B signaling have been found to be associated with a wide spectrum of neurological *** r,because of its poor bioavailability and pharmacological properties,brain-derived neurotrophic factor itself has a very low therapeutic ***,the concomitant binding of exogenous brain-derived neurotrophic factor to the p75 neurotrophin receptor has the potential to elicit several unwanted and deleterious side *** re,developing tools and approaches to specifically promote tropomyosin receptor kinase B signaling has become an important goal of translational *** the newly developed tools are different categories of tropomyosin receptor kinase B receptor agonist *** this review,we give a comprehensive description of the diffe rent tro pomyosin receptor kinase B receptor agonist drugs developed so far and of the res ults of their application in animal models of several neurological ***,we discuss the main benefits of tropomyosin receptor kinase B receptor agonists,concentrating especially on the new tropomyosin receptor kinase B agonist *** benefits observed both in vitro and in vivo upon application of tropomyosin receptor kinase B receptor agonist drugs seem to predominantly depend on their general neuroprotective activity and their ability to promote neuronal ***,tro pomyosin receptor kinase B agonist antibodies have been shown to specifically bind the tropomyosin recepto

关键词： Alzheimer's disease brain-derived neurotrophic factor depression Parkinson's disease tropomyosin receptor kinase B receptor

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Electrochemical behavior of cerium(Ⅳ) in a RTIL and its mixture with ethanol

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Journal of Rare Earths 2014年第7期32卷 641-647页

作者： Arijit Sengupta M.S.Murali P.K.Mohapatra Radiochemistry division Bhabha Atomic Research Centre

A systematic study was carried out to explore the electrochemical behavior of Ce in room temperature ionic liquid（CnmimBr, where n=6, 8, 10） and mixture of C6 mimBr and ethanol by cyclic voltammetry. With increase in the number of carbon atoms on the alkyl substituent on methyl imidazolium cation, the electrochemical window of the ionic liquids was found to extend towards more negative potential value, as a result there was a possibility of reduction of Ce to lower oxidation states. The diffusion coefficient and activation energy for the diffusion were calculated in all the ionic liquids and one of their mixtures with ethanol. With increase in n value, the diffusion coefficient of Ce decreased due to increase in viscosity of the medium while the activation energy for the diffusion followed a reverse trend for C6 mimBr, C8 mimBr and C10 mimBr, respectively. The observations indicated that the nature of species of Ce might be different in room temperature ionic liquids（RTILs） from that present in their mixtures with ethanol.

关键词： cerium cyclic voltammetry diffusion coefficient activation energy ethanol Cn mimBr (n=6, 8, 10) rare earths

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Distribution and Environmental Suitability of the Smallscaled Rock Agama, Paralaudakia microlepis(Sauria: Agamidae) in the Iranian Plateau

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Asian Herpetological research 2014年第3期5卷 161-167页

作者： Natalia B.ANANJEVA Evgeny A.GOLYNSKY Seyyed Saeed HOSSEINIAN YOUSEFKHANI Rafaqat MASROOR Department of Herpetology Zoological Institute Russian Academy of Sciences Department of biology Faculty of Science Ferdowsi University of Mashhad zoological Sciences division Pakistan Museum of Natural History

Predictive potential distribution modeling is of increasing importance in modern herpetological studies and determination of environmental and conservation priorities. In this article we provided results of analysis and forecasts of the potential distribution of smallscaled rock agama Paralaudakia microlepis （Blanford, 1874） using the distribution models through Maxent （***/- schapire / maxent）. We made an attempt for comparison of input of bioclimatic factors and characteristics of biotope distribution for three species of genus Paralaudalda. Constructed model identified dissemination of Paralaudakia microlepis enough performance （AUC = 0.972 with dispersion 0.003）. According to the map constructed, the most suitable habitats of smallscaled rock agama Paralaudakia microlepis are located in southern and eastern Iran, the west of central Pakistan and southeastern Afghanistan.

关键词： Iranian Plateau Agamidae Potential species distribution modeling Paralaudakia microlepis Maxentmodeling

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