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Lumbar infection caused by Mycobacterium paragordonae:A case report

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World Journal of Clinical Cases 2021年第29期9卷 8879-8887页

作者： Ying-Zheng Tan Ting Yuan Liang Tan Yu-Qiu Tian Yun-Zhu Long Department of Infectious Diseases Zhuzhou Central HospitalZhuzhou 412000Hunan ProvinceChina Department of Spinal Surgery Zhuzhou Central HospitalZhuzhou 412000Hunan ProvinceChina

Mycobacterium paragordonae(***),a slow-growing,acid-resistant mycobacterial species,was first isolated from the sputum of a lung infection patient in South Korea in *** caused by *** are *** SUMMARY Herein,we report the case of a 53-year-old patient who presented with fever and low back *** nuclear magnetic resonance imaging revealed the destruction of the lumbar vertebra with peripheral abscess *** antiinfective and diagnostic anti-tuberculosis treatment,the patient had no further fever,but the back pain was not ***,the necrotic material was sent for pathological examination,and all tests related to tuberculosis were negative,but pus culture suggested nontuberculous *** necrotic tissue specimens were subjected to metagenomic next-generation sequencing,which indicated the presence of ***,the infecting pathogen was identified,and the treatment plan was *** patient was in good condition during the follow-up *** ***,a rare nontuberculous mycobacterium,can also cause spinal *** the clinic,it is necessary to identify nontuberculous mycobacteria for spinal infections similar to Mycobacterium tuberculosis.

关键词： Mycobacterium paragordonae Nontuberculous mycobacteria Spinal infection Lumbar spine infection Metagenomic next-generation sequencing Mycobacterium tuberculosis Case report

Drain-site hernia after laparoscopic rectal resection:A case report and review of literature

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World Journal of Clinical Cases 2022年第8期10卷 2637-2643页

作者： Jin Su Cheng Deng Hui-Ming Yin Department of General Surgery Zhuzhou Central HospitalThe Affiliated Zhuzhou Hospital of Xiangya Medical College of Central South UniversityZhuzhou 412000Hunan ProvinceChina Division of Science and Education Zhuzhou Central HospitalThe Affiliated Zhuzhou Hospital of Xiangya Medical College of Central South UniversityZhuzhou 412000Hunan ProvinceChina Department of General Surgery the Second Affiliated Hospital of Hunan University of Traditional Chinese MedicineChangsha 410000Hunan ProvinceChina

BACKGROUND Drain-site hernia(DSH)has an extremely low morbidity and has rarely been *** bowel obstruction is a frequent concurrent condition in most cases of DSH,which commonly occurs at the≥10 mm *** we report a rare case of DSH at the lateral 5 mm port site one month postoperatively without visceral ***,a brief review of the literature was conducted focusing on the risk factors,diagnosis,and prevention strategies for *** SUMMARY A 76-year-old male patient was admitted to our institution with intermittent abdominal pain and a local abdominal mass which occurred one month after laparoscopic radical resection of rectal cancer one year ago.A computed tomography scan showed an abdominal wall hernia at the 5 mm former drain-site in the left lower quadrant,and that the content consisted of the large *** elective herniorrhaphy was performed by closing the fascial defect and reinforcing the abdominal wall with a synthetic mesh *** postoperative period was *** patient was discharged seven days after the operation without surgery-related complications at the 1-mo follow-up *** Emphasis should be placed on DSH despite the decreased use of intra-abdominal *** is recommended that placement of a surgical drainage tube at the≥10 mm trocar site should be ***,it is advisable to have a comprehensive understanding of the risk factors for DSH and complete closure of the fascial defect at the drainage site for high-risk patients.

关键词： Drain-site hernia Abdominal hernia Laparoscopic surgery Surgical drainage Risk factor Case report

Two-step lifting method using the Wang Intestinal Strap for laparoscopic radical resection of mid-low rectal cancer(with video)

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Gastroenterology Report 2022年第1期10卷 656-658页

作者： Yu Zeng Feng Peng Xiaosong Gong Jianmei Yi Chuangkun Li Qing Wang Jin Wang Department of General Surgery Zhuzhou Central HospitalZhuzhouHunanP.R.China

Introduction Laparoscopic total mesorectal excision for mid-low rectal cancer is associated with several fundamental problems.A narrow pelvis,deep tumor location,obesity,and comparatively larger tumors lead to difficulties in performing clear dissection,accurately determining a safe distance from the lower margin of the tumor,and performing adequate lavage of the pelvic cavity distal to the tumor before sealing the rectum[1,2].

关键词： rectal cancer cavity

Intestinal intussusception caused by intestinal duplication and ectopic pancreas:A case report and review of literature

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World Journal of Clinical Cases 2022年第7期10卷 2261-2267页

作者： Tao-Li Wang Xiao-Song Gong Jin Wang Chen-Yan Long Department of Pathology Zhuzhou Hospital Affiliated to Xiangya School of MedicineCentral South UniversityZhuzhou 412007Hunan ProvinceChina The Second Department of General Surgery Zhuzhou Hospital Affiliated to Xiangya School of MedicineCentral South UniversityZhuzhou 412007Hunan ProvinceChina

BACKGROUND Intestinal intussusception caused by intestinal duplication and ectopic pancreas is extremely rare in the clinic and has not been reported *** SUMMARY A 29-year-old man was admitted to the hospital for chronic abdominal pain and *** preoperative diagnosis was intestinal obstruction and ***,laparotomy,partial small intestinal resection and extraintestinal decompression were *** pathology confirmed intestinal duplication and ectopic *** surgery,the patient recovered well with no *** recurrence was observed after more than 5 mo of *** We report a new case of a young male with intussusception caused by intestinal duplication and ectopic *** is the main treatment for these *** study aimed to raise awareness and provide information to improve the clinical management of this rare yet serious condition.

关键词： Intestinal intussusception Ectopic pancreas Intestinal duplication Intestinal obstruction Adult Case report

Perianal superficial CD34-positive fibroblastic tumor: A case report

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World Journal of Clinical Cases 2021年第20期9卷 5605-5610页

作者： Chen-Yan Long Tao-Li Wang The Second Department of General Surgery Zhuzhou Hospital Affiliated to Xiangya School of MedicineCentral South UniversityZhuzhou 412007Hunan ProvinceChina Department of Pathology Zhuzhou Hospital Affiliated to Xiangya School of MedicineCentral South UniversityZhuzhou 412007Hunan ProvinceChina

BACKGROUND Superficial CD34-positive fibroblast tumors(SCPFTs)are newly recognized fibroblast and myofibroblast tumors representing intermediate *** the best of our knowledge,fewer than 50 cases have been *** SCPFT has not been previously *** SUMMARY A 55-year-old man was hospitalized upon discovering a painless perianal lump 10 d *** examination showed a lump of approximately 3 cm×4 cm in the 7 to 8 o’clock direction in the perianal *** abscess was considered the primary *** removal surgery was performed under epidural *** pathology showed a well-circumscribed,soft tissuederived,spindle-cell tumor with strong CD34 positivity by *** final diagnosis was perianal *** were no complications,and the patient was followed for more than 8 mo without recurrence or *** We report a case of perianal superficial CD34-positive fibroblast *** rare mesenchymal neoplasm has distinctive histomorphology,which is important for *** consideration of clinical information,imaging,histology,and immunohistochemistry is important for diagnosis.

关键词： Superficiality CD34-positive Fibroblast tumor Perianal Diagnosis Case report

Fatal ventricular arrhythmias after osimertinib treatment for lung adenocarcinoma: a case report

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Journal of Geriatric Cardiology 2023年第3期20卷 242-246页

作者： Gui-Gao GUO Xin LUO Ke ZHU Ling-Ling LI Yang-Fan OU Cardiovascular Department Zhuzhou Hospital Affiliated to Xiangya School of MedicineCentral South UniversityZhuzhouHunanChina

Osimertinib,a third-generation epidermal growth factor receptor tyrosine kinase inhibitor(EGFR-TKIs),is approved globally as the first-line treatment for patients with EGFR mutations(EGFRm:Ex19del/L858R)and T790M resistance mutations in advanced non-small cell lung cancer(NSCLC).[1−3]With its widespread use,the cardiotoxicity of osimertinib has been of great *** to the *** and Drug Administration Adverse Events Reporting System(FAERS),the main cardiac-related adverse events with EGFR-TKIs are heart failure,QT prolongation,atrial fibrillation,acute myocardial infarction and pericardial effusion,and osimertinib has a higher incidence of QT prolongation,heart failure and atrial fibrillation than other EGFR-TKIs.

关键词： lung acute ventricular

Identification of the core promoter of STK11 gene and its transcriptional regulation by p53

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Progress in Natural Science:Materials International 2008年第3期18卷 273-280页

作者： Maojin Yao a,1, Yongjun Wang a,1, Hongwei Shen a, Wenfeng Ning a, Jianguang Tang a, Xiangping Wanga, Jie Li b, Shiquang Zhou a, Xin Yi a, Chenjie Li a, Yi Chu a, Fei Wanga, Xiaoliu Shi a, a The Second Xiang Ya hospital of central South University, Changsha 410011, China b Zhu Zhou No.1 hospital, zhuzhou 412000, China The Second Xiang Ya hospital of central South University Changsha 410011 China Zhu Zhou No.1 hospital ZhuZhou 412000 China

Peutz-Jeghers syndrome (PJS) is an autosomal dominant disease characterized by mucocutaneous pigmentation and hamartomatous polyps. Most cases of PJS involve the inactivation of germline mutations in the serine/threonine kinase gene STK11 which is also known as LKB1. The function of STK11 was previously linked to the tumor suppressor p53 and was shown to activate the p53 target p21/ WAF1. Recently, STK11 was reported to be interacting with p53 physically in the nucleus and it can directly or indirectly phosphorylate p53. Here we characterized the 50-flanking region of human STK11 gene and identified a 161-bp fragment with promoter activity. Sequence analysis, mutagenesis and gel shift studies revealed a binding site of Sp1 and p53, which affects the promoter activity. Mutation analyses showed that this fragment was required for p53-mediated transcriptional activation. This transcriptional activation was further confirmed by real-time quantitative RT-PCR and Western blot analysis. Transient transfection of p53 expression plasmid into fetal liver cell lines increased STK11 mRNA and protein levels. In conclusion, our results reveal a new role for p53 in elevating STK11 gene expres- sion via a positive feedback pattern.

关键词： Peutz-Jeghers syndrome STK11 p53 Promoter transcriptional regulation Tumor suppressor

Accessory navicular in children

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World Journal of Clinical Cases 2023年第35期11卷 8256-8262页

作者： Feng Xiang Zhi-Qing Liu Xi-Ping Zhang Yan-Jun Li Jie Wen Department of Traumatic Orthopedics Zhuzhou Central HospitalThe Affiliated Zhuzhou Hospital of Xiangya Medical CollegeCentral South UniversityZhuzhou 412007Hunan ProvinceChina Department of Pediatric Orthopedics Hunan Provincial People’s HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 410013Hunan ProvinceChina

Accessory navicular(AN)is a developmental variation of the secondary ossification center of the navicular *** percent of patients with AN will have pain symptoms that affect walking and *** the AN changes the position of the posterior tibial tendon insertion,children with AN often have posterior tibial tendon function insufficiency and flexible flat *** treatment is often required after failure of conservative *** article reviewed the etiology,clinical manifestations,complications,and treatment methods of AN.

关键词： Accessory navicular Posterior tibial tendon Flexible flatfoot Kidner procedure Treatment

Changes in sensorimotor regions of the cerebral cortex in congenital amusia:a case-control study

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Neural Regeneration Research 2021年第3期16卷 531-536页

作者： Jun-Jie Sun Xue-Qun Pan Ru Yang Zhi-Shuai Jin Yi-Hui Li Jun Liu Da-Xing Wu Department of Radiology the Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina Department of Radiology the Affiliated Zhuzhou Hospital of Xiangya College of MedicineCentral South UniversityZhuzhouHunan ProvinceChina Lister Hill National Center for Biomedical Communication National Library of MedicineBethesdaMDUSA Medical Psychological Center the Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina

Perceiving pitch is a central function of the human auditory system;congenital amusia is a disorder of pitch *** underlying neural mechanisms of congenital amusia have been actively ***,little attention has been paid to the changes in the motor rain within congenital *** this case-control study,17 participants with congenital amusia and 14 healthy controls underwent functional magnetic resonance imaging while resting with their eyes closed.A voxel-based degree centrality method was used to identify abnormal functional network centrality by comparing degree centrality values between the congenital amusia group and the healthy control *** found decreased degree centrality values in the right primary sensorimotor areas in participants with congenital amusia relative to controls,indicating potentially decreased centrality of the corresponding brain regions in the auditory-sensory motor feedback *** found a significant positive correlation between the degree centrality values and the Montreal Battery of Evaluation of Amusia *** conclusion,our study identified novel,hitherto undiscussed candidate brain regions that may partly contribute to or be modulated by congenital *** evidence supports the view that sensorimotor coupling plays an important role in memory and musical *** study was approved by the Ethics Committee of the Second Xiangya hospital,central South University,China(***20180101GZ01)on February 9,2019.

关键词： congenital amusia degree centrality lifelong impairment local functional connectivity music discrimination primary motor area primary sensorimotor area primary sensory area resting-state functional magnetic resonance imaging voxel-based analysis