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Recombinant human epidermal growth factor combined with vacuum sealing drainage for wound healing in Bama pigs

Military Medical Research 2021年第4期8卷 510-522页

作者： Shuai Wei Wei Wang Li Li Hao-Ye Meng Chun-Zhen Feng Yu-Ying Dong Xi-Chi Fang Qi-Qiang Dong Wen Jiang Hai-Li Xin Zhan-Zhen Li Xin Wang Institute of Orthopaedics Beijing Key Lab of Regenerative Medicine in OrthopaedicsChinese PLA General HospitalBeijing 100583China. zhoushan dinghai guanghua hospital Zhoushan 316000ZhejiangChina. Tianjin hospital Tianjin UniversityTianjin 300211China. Geriatric Neurological Department of the Second Medical Center&National Clinical Research Center for Geriatric Diseases Chinese PLA General HospitalBeijing 100853China. Department of Orthopedics Traditional Chinese Medical Hospital of Xinjiang Uygur Autonomous RegionUrumqi 830000China. Department of Stomatology Chinese PLA General HospitalBeijing 100853China. Department of Plastic Surgery General Hospital of Taiyuan Iron and Steel Limited CompanyTaiyuan 030009China. Hand Microsurgery Department Shenzhen People’s HospitalShenzhen 518020GuangdongChina. Third Surgery Department Zhengzhou Renji HospitalZhengzhou 450000China. Department of Orthopedics the First Affiliated Hospital of Medical CollegeShihezi UniversityShiheziXinjiang 832000China. Pharmacy Department Chinese PLA General HospitalBeijing 100853China.

Background:Vacuum sealing drainage(VSD)and epidermal growth factor(EGF)both play an important role in the treatment of *** study aims to explore the effects of the combination of VSD and EGF on wound healing and the optimal concentration and time of ***:We tested the proliferation and migration capacity of HaCaT and L929 cells at different EGF concentrations(0,1,5,10,and 100ng/ml)and different EGF action times(2,10,and 30min).A full-thickness skin defect model was established using male,30-week-old Bama *** experiment included groups as follows:routine dressing change after covering with sterile auxiliary material(Control),continuous negative pressure drainage of the wound(VSD),continuous negative pressure drainage of the wound and injection of EGF 10min followed by removal by continuous lavage(V+E 10min),and continuous negative pressure drainage of the wound and injection of EGF 30min followed by removal by continuous lavage(V+E 30min).The wound healing rate,histological repair effect and collagen deposition were compared among the four ***:An EGF concentration of 10ng/ml and an action time of 10min had optimal effects on the proliferation and migration capacities of HaCaT and L929 *** drug dispersion effect was better than drug infusion after bolus injection effect,and the contact surface was *** with other groups,the V+E 10min group promoted wound healing to the greatest extent and obtained the best histological ***:A recombinant human epidermal growth factor(rhEGF)concentration of 10 ng/ml can promote the proliferation and migration of epithelial cells and fibroblasts to the greatest extent in *** combined with rhEGF kept in place for 10min and then washed,can promote wound healing better than the other treatments in vitro.

关键词： Vacuum sealing drainage Epidermal growth factor Skin wound healing Full-thickness skin defect

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