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Perceived infection transmission routes, infection control practices, psychosocial changes, and management of COVID-19 infected healthcare workers in a tertiary acute care hospital in Wuhan: a cross-sectional survey

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Military Medical Research 2020年第4期7卷 418-429页

作者： Ying-Hui Jin Qiao Huang Yun-Yun Wang Xian-Tao Zeng Li-Sha Luo Zhen-Yu Pan Yu-Feng Yuan Zhi-Min Chen Zhen-Shun Cheng Xing Huang Na Wang Bing-Hui Li Hao Zi Ming-Juan Zhao Lin-Lu Ma Tong Deng Ying Wang Xing-Huan Wang Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan University169 Donghu RoadWuchang DistrictWuhan 430071HubeiChina Department of Evidence-Based Medicine and Clinical Epidemiology The Second Clinical CollegeWuhan UniversityWuhan 430071HubeiChina Division of Medical Affairs Zhongnan Hospital of Wuhan UniversityWuhan 430071HubeiChina Department of Hepatopancreatobiliary Surgery Zhongnan Hospital of Wuhan UniversityWuhan 430071HubeiChina Division of Social and Medical Development Zhongnan Hospital of Wuhan UniversityWuhan 430071HubeiChina Department of Respiratory Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071HubeiChina School of Nursing and Health Henan UniversityKaifeng 475000HenanChina Institute of Evidence-Based Medicine and Knowledge Translation Henan UniversityKaifeng 475000HenanChina Department of Infectious Diseases Zhongnan Hospital of Wuhan UniversityWuhan 430071HubeiChina Leishenshan hospital in Wuhan Wuhan 430200HubeiChina

Background:Many healthcare workers were infected by coronavirus disease 2019(COVID-19)early in the epidemic posing a big challenge for epidemic ***,this study aims to explore perceived infection routes,influencing factors,psychosocial changes,and management procedures for COVID-19 infected healthcare ***:This is a cross-sectional,single hospital-based *** recruited all 105 confirmed COVID-19 healthcare workers in the zhongnan hospital of Wuhan University from February 15 to 29,*** participants completed a validated *** consent was obtained from all *** causes of infection,infection prevention,control knowledge and behaviour,psychological changes,symptoms and treatment were ***:Finally,103 professional staff with COVID-19 finished the questionnaire and was included(response rate:98.1%).Of them,87 cases(84.5%)thought they were infected in working environment in hospital,one(1.0%)thought their infection was due to the laboratory environment,and 5(4.9%)thought they were infected in daily life or community *** of throat collection and physical examination were the procedures perceived as most likely causing their infection by nurses and doctors ***-three(41.8%)thought their infection was related to protective equipment,utilization of common equipment(masks and gloves).The top three first symptoms displayed before diagnosis were fever(41.8%),lethargy(33.0%)and muscle aches(30.1%).After diagnosis,88.3%staff experienced psychological stress or emotional changes during their isolation period,only 11.7%had almost no emotional ***(Umifenovir;an anti-influza drug;69.2%)was the drug most commonly used to target infection in mild and moderate ***:The main perceived mode of transmission was not maintaining protection when working at a close distance and having intimate contact with infected *** psychological intervention is necessa

关键词： COVID-19 SARS-CoV-2,2019-nCoV Healthcare worker Healthcare professional Infection transmission route Psychosocial status

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A retrospective study of patients complaining of nontraumatic acute abdominal pain,admitted in the emergency department of an urban hospital in China

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Emergency and Critical Care Medicine 2023年第4期3卷 149-155页

作者： Guanguan Luo Qinqin Liu Zhongxiang Zhang Xiaoqing Jin Emergency Center Zhongnan Hospital of Wuhan UniversityWuhanHubeiChina Second Clinical College of Wuhan University Zhongnan Hospital of Wuhan UniversityWuhanHubeiChina

Background:Nontraumatic acute abdominal pain(AAP)accounts for a large proportion of emergency department(ED)*** study aimed to explore the underlying correlations among basic information,imaging examinations,and ***:A total of 7453 patients complaining of AAP,admitted to the ED of zhongnan hospital of Wuhan University,were enrolled in this retrospective study from January 1 to December 30,*** collected the following information from the patients:sex,age,date of visit,pain location,nature of pain,level of severity,imaging(computed tomography,x-ray,and ultrasound),diagnosis,and outcomes(re-lease from the hospital,transfer to another hospital,transfer to another department,observation room,hospitalization,or death).Results:According to this study,AAP was more common in female than male.A total of 82.11%patients of AAP were in level 3 of se-verity,while 0.19%patients were in level 1.A total of 77.20%of the patients had undergone *** pain and colic are the 2 most common types of *** abdominal pain(NSAP)is the most common *** the diagnosis of NSAP and gastroenteritis,female patients were more prevalent than male patients,but for renal colic,male patients were 3 times as many as female ***-specific abdominal pain,biliary colic,and cholecystitis are the 3 leading causes in patients 65 years or *** abdominal pain,renal colic,and gastroenteritis are the 3 leading causes of AAP in patients younger than 65 ***:With the help of imaging,clinicians can specify a diagnosis and perform corresponding treatment in most ***,making a precise diagnosis of AAP within a short period is still *** research should be conducted to seek safer and more effective techniques to streamline clinicians’work.

关键词： Abdominal pain Diagnosis Emergency department Epidemiology Gastroenterology

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Neuroprotective Effect of Granulocyte Colony-stimulating Factor in a Focal Cerebral Ischemic Rat Model with Hyperlipidemia

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2012年第6期32卷 872-878页

作者：洪艳邓长生章军建朱江李芹 Department of Gastroenterology Zhongnan Hospital of Wuhan University Department of Neurology Zhongnan Hospital of Wuhan University Department of Pediatrics Zhongnan Hospital of Wuhan University

Granulocyte colony-stimulating factor (G-CSF) has been demonstrated to have neuroprotective effects in rat model with focal cerebral ischemia through anti-apoptotic pathways and by promoting proliferation of neural stem cells. In the present study, we examined the neuroprotective effect of G-CSF in an acute focal cerebral ischemia rat model with lipid metabolism disorder. Eighty male SD rats were randomly divided into normal diet control group (NC group) and high-fat diet group (HFD group) (n = 40 in each). In HFD group, rats were fed on high fat diet to induce atherosclerosis. After 29 days, 4 rats from each group were sacrificed to evaluate the effects of different diets, and the middle cerebral artery occlusion (MCAO) was performed in the rest of the rats. MCAO rats received either G-CSF (50 μg·kg–1·mL–1) or phosphate buffered saline (PBS) injection through the external jugular vein for 5 days, which was followed by 5-bromo-deoxy uridine (BrdU, i.p., 50 mg/kg) injection for another 7 days. To evaluate the effects of G-CSF treatment on neurological function, the modified neurological severity score (mNSS) was calculated. The vascular distribution, ischemic cells proliferation, cell apoptosis and the expression of vascular endothelial growth factor (VEGF) were measured to determine the effects of G-CSF treatment. Our results showed that G-CSF-treated rats had a lower mNSS than PBS-treated rats in both NC group and HFD group. G-CSF injection promoted endothelial cell proliferation and vascular regeneration, and inhibited cell apoptosis. The serum and tissue levels of VEGF were significantly increased after G-CSF treatment. It is concluded that G-CSF exerts its neuroprotective effect in focal cerebral ischemia rats with hyperlipidemia by enhancing angiogenesis, promoting cells proliferation, decreasing cell apoptosis, and increasing local VEGF expression.

关键词： granulocyte colony-stimulating factor hyperlipidemia stroke neuroprotection vascular endothelial growth factor

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Non-coding RNAs in acute ischemic stroke:from brain to periphery

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Neural Regeneration Research 2025年第1期20卷 116-129页

作者： Shuo Li Zhaohan Xu Shiyao Zhang Huiling Sun Xiaodan Qin Lin Zhu Teng Jiang Junshan Zhou Fuling Yan Qiwen Deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs microRNAs neuroinflammation non-coding RNAs oxidative stress

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Coagulation indices and fibrinogen degradation products as predictive biomarkers for tumor-node-metastasis staging and metastasis in gastric cancer

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 110-120页

作者： Yi-Qing Shen Qiu-Wan Wei Yi-Ren Tian Yun-Zhi Ling Min Zhang Clinical Laboratory Civil Aviation Shanghai HospitalGubei Branch of Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200000China Clinical Laboratory Tongji Hospital of Tongji UniversityShanghai 200000China

BACKGROUND Gastric cancer(GC)is a prevalent malignancy with a substantial health burden and high mortality rate,despite advances in prevention,early detection,and *** with the global average,Asia,notably China,reports disproportionately high GC *** disease often progresses asymptoma-tically in the early stages,leading to delayed diagnosis and compromised ***,it is crucial to identify early diagnostic biomarkers and enhance treatment strategies to improve patient outcomes and reduce *** Retrospectively analyzed the clinical data of 148 patients with GC treated at the Civil Aviation Shanghai hospital between December 2022 and December *** associations of coagulation indices-partial thromboplastin time(APTT),prothrombin time(PT),thrombin time(TT),fibrinogen,fibrinogen degradation products(FDP),fasting blood glucose,and D-dimer(D-D)with TNM stage and distant metastasis were *** Prolongation of APTT,PT,and TT was significantly correlated with the GC TNM ***,abnormal coagulation system activation was closely related to disease *** FDP and D-D were significantly associated with distant metastasis in GC(P<0.05),suggesting that increased fibrinolytic activity contributes to increased metastatic *** Our Results reveal coagulation indices,FDPs as GC biomarkers,reflecting abnormal coagulation/fibrinolysis,aiding disease progression,metastasis prediction,and helping clinicians assess thrombotic risk for early intervention and personalized treatment plans.

关键词： Coagulation indexes Fibrinogen degradation products Gastric cancer Tumor-node-metastasis staging Distant metastasis

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Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

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Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan Yin Jiahui Kang Xuan Cheng Hui Gao Shujia Huo Haiwei Xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

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Contraceptive Efficacy and Local Effects of Bioceramic IUD in Rat

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Journal of Wuhan University of Technology(Materials Science) 2006年第4期21卷 99-101页

作者：王燕张元珍 zhongnan hospital of Wuhan University Wuhan 430071China

The contraceptive efficacy and local effects of bioceramw IUD in rat were studied. The experiment was divided into four groups ： bioceramic IUD group ; stainless steel IUD group ; operation control group ; normal control group. All IUD samples were put into uterus of rats, The experimental results show that the alumina bioceramic has a strong contraceptive effect for those rats. In bioceramic IUD group the endometrial inflammation reaction was as mild as that in stainless IUD group during *** days （ 30 days ） and gradually abated with time during the late days （60 days ）. The experiments show that the alumina bioceramic has a good biocompatibility and contraceptive effects and hint at the alumina bioceramw IUD may become a more safety reproduction family planning IUD.

关键词： alumina bioceramic IUD contraception

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CBioProfiler:A Web and Standalone Pipeline for Cancer Biomarker and Subtype Characterization

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Genomics, Proteomics & Bioinformatics 2024年第3期22卷 153-165页

作者： Xiaoping Liu Zisong Wang Hongjie Shi Sheng Li Xinghuan Wang Department of Urology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Pathology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Cancer Precision Diagnosis and Treatment and Translational Medicine Hubei Engineering Research Center Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Biological Repositories Zhongnan Hospital of Wuhan UniversityWuhan 430071China

Cancer is a leading cause of death worldwide,and the identification of biomarkers and subtypes that can predict the long-term survival of cancer patients is essential for their risk stratification,treatment,and ***,there are currently no standardized tools for exploring cancer biomarkers or *** this study,we introduced Cancer Biomarker and subtype Profiler(CBioProfiler),a web server and standalone application that includes two pipelines for analyzing cancer biomarkers and *** cancer biomarker pipeline consists of five modules for identifying and annotating cancer survival-related biomarkers using multiple survival-related machine learning *** cancer subtype pipeline includes three modules for data preprocessing,subtype identification using multiple unsupervised machine learning methods,and subtype evaluation and *** also includes CuratedCancerPrognosisData,a novel R package that integrates reviewed and curated gene expression and clinical data from 268 *** studies cover 43 common blood and solid tumors and draw upon 47,686 clinical *** web server is available at https://***/and https://***/CBioProfiler/,and the standalone app and source code can be found at https://***/liuxiaoping2020/CBioProfiler.

关键词： CBioProfiler Cancer biomarker Cancer subtype Machine learning Web app

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Predicting colorectal adenomatous polyps in patients with chronic liver disease: A novel nomogram

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World Journal of Gastroenterology 2025年第2期31卷 71-84页

作者： Yu-Qin Li Wen-Tao Kuai Lin Chen Ming-Hui Zeng Xue-Mei Tao Jia-Xin Han Yue-Kui Wang Lian-Xin Xu Li-Ying Ge Yong-Gang Liu Shuang Li Liang Xu Yu-Qiang Mi Clinical School of the Second People’s hospital Tianjin Medical UniversityTianjin 300192China Department of Hepatology Tianjin Second People’s HospitalTianjin 300192China Department of Pathology Clinical School of the Second People’s HospitalTianjin 300110China Endoscopy Center Tianjin Second People’s HospitalTianjin 300192China

BACKGROUND Colorectal polyps are commonly observed in patients with chronic liver disease(CLD)and pose a significant clinical concern because of their potential for *** To explore the clinical characteristics of colorectal polyps in patients with CLD,a nomogram was established to predict the presence of adenomatous polyps(AP).METHODS Patients with CLD who underwent colonoscopy at Tianjin Second People’s hospital from January 2020 to May 2023 were *** data including laboratory results,colonoscopy findings,and pathology reports were *** variables for the nomogram were identified through least absolute shrinkage and selection operator regression,followed by multivariate logistic *** performance of the model was evaluated using the area under the receiver area under curve,as well as calibration curves and decision curve *** The study enrolled 870 participants who underwent colonoscopy,and the detection rate of AP in patients with CLD was 28.6%.Compared to individuals without polyps,six risk factors were identified as predictors for AP occurrence:Age,male sex,body mass index,alcohol consumption,overlapping metabolic dysfunction-associated steatotic liver disease,and serum ferritin *** novel nomogram(AP model)demonstrated an area under curve of 0.801(95%confidence interval:0.756-0.845)and 0.785(95%confidence interval:0.712-0.858)in the training and validation *** curves indicated good agreement among predicted and actual probabilities(training:χ^(2)=11.860,P=0.157;validation:χ^(2)=7.055,P=0.530).The decision curve analysis underscored the clinical utility of the nomogram for predicting the risk of *** The AP model showed reasonable accuracy and provided a clinical foundation for predicting the occurrence of AP in patients with CLD,which has a certain predictive value.

关键词： Metabolic dysfunction associated steatotic liver disease Fatty liver Chronic liver disease Colorectal adenomas Hepatitis Risk factors

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Controversies around the treatment of peritoneal metastases of colorectal cancer

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 260-264页

作者： Francisco J Morera-Ocon Clara Navarro-Campoy Ticiano Guastella Francisco Landete-Molina Department of General Surgery Hospital General de RequenaRequena 46340Spain Department of Gynecology and Obstetrics Hospital 9 OctubreValencia 46015Spain Department of Pathology Hospital General de RequenaRequena 46340Spain

In this editorial we examine the article by Wu et al published in the World Journal of Gastrointestinal *** resection for peritoneal metastases from colorectal cancer(CRC)has been gradually accepted in the medical oncology community.A randomized trial(PRODIGE 7)on cytoreductive surgery(CRS)with hyperthermic intraperitoneal chemotherapy(HIPEC)failed to prove any benefit of oxaliplatin in the overall survival of patients with peritoneal metastases from colorectal ***,isolated systemic chemotherapy for CRC stage IV has demonstrated a reduced response in peritoneal metastases than that obtained in other metastatic sites such as the *** tool is required in those patients to achieve more local control of the *** groups in peritoneal surgery continue to use HIPEC in their procedures,using other agents than oxaliplatin for peritoneal cavity infusion,such as mitomycin *** patients present with complex surgical issues to manage,and consequently a large burden of complications has to be ***,identifying patients who will benefit from CRS with or without HIPEC would be of great interest.

关键词： Colorectal cancer Peritoneal metastasis Hyperthermic intraoperative chemotherapy Treatment strategies Peritoneal Surface Oncology GroupInternational

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