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International Journal of Minerals,Metallurgy and Materials 2024年第4期31卷 697-711页

作者： Baosheng Liu Jiali Wei Shaohua Zhang Yuezhong Zhang Pengpeng Wu Daqing Fang Guorui Ma School of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024China State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049China Intelligent Equipment Research and Development Center Zhuhai Institute of Advanced Technology Chinese Academy of SciencesZhuhai 519080China Advanced Materials Research institute Zhuhai Dingmei Medical Technology Co.Ltd.Zhuhai 519000China

Mg-6Zn-2X(Fe/Cu/Ni)alloys were prepared through semi-co.tinuous casting,with the aim of identifying a degradable magnesium(Mg)alloy suitable for use in fracturing balls.A co.parative analysis was co.ducted to assess the impacts of adding Cu and Ni,which result in finer grains and the formation of galvanic co.rosion *** electronic microsco.y examination revealed that precipitated phases co.centrated at grain boundaries,forming a semi-co.tinuous network structure that facilitated co.rosion penetration in Mg-6Zn-2Cu and Mg-6Zn-2Ni *** co.rosion was observed in Mg-6Zn-2Fe,while galvanic co.rosion was identified as the primary mechanism in Mg-6Zn-2Cu and Mg-6Zn-2Ni *** the tests,the Mg-6Zn-2Ni alloy exhibited the highest co.rosion rate(approximately 932.9 mm/a)due to its significant potential *** testing showed that Mg-6Zn-2Ni alloy possessed suitable ultimate co.pressive strength,making it a potential candidate material for degradable fracturing balls,effectively addressing the challenges of balancing strength and degradation rate in fracturing applications.

关键词： magnesium alloys microstructure micro-galvanic co.rosion mechanical properties

A study on the application of diffuse axonal multi-axis general evaluation for braininjury assessment in small overlap barrier crash test

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Chinese Journal of Traumatology 2024年第4期27卷 200-210页

作者： Zhi Fu Yi Chang Tao Xiong Wen-Kai Gao Kui Li Yu Liu China Automotive Engineering Research institute co. Ltd.Chongqing401122China Chongqing University of Technology Chongqing400054China Chongqing Key Laboratory of Vehicle Crash/Bio-Impact and Traffic Safety Chongqing400042China co.lege of medical Informatics Chongqing Medical UniversityChongqing400016China

Purpose:Head injury criterion(HIC)co.panied by a rotation-based metric was widely believed to behelpful for head injury prediction in road traffic ***,the Euro-New Car AssessmentProgram utilized a newly developed metric called diffuse axonal multi-axis general evaluation(DAMAGE)to explain test device for human occupant restraint(THOR)head injury,which demonstratedexcellent ability in capturing co.cussions and diffuse axonal ***,there is still a lack ofco.prehensive understanding regarding the effectiveness of using DAMAGE for Hybrid III 50thpercentile male dummy(H50th)head injury *** objective of this study is to determinewhether the DAMAGE co.ld capture the risk of H50th brain injury during small overlap barrier ***:To achieve this objective,a total of 24 vehicle crash loading curves were co.lected as input datafor the multi-body *** co.mercially available mathematical dynamic models,namelyH50th and THOR,were utilized to investigate the differences in head injury ***,adecision method known as simple additive weighting was employed to establish a co.prehensive braininjury metric by inco.porating the weighted HIC and either DAMAGE or brain injury ***,35 sets of vehicle crash test data were used to analyze these brain injury ***:The rotational displacement of the THOR head is significantly greater than that of the *** maximum linear and rotational head accelerations experienced by H50th and THOR modelswere(544.6±341.7)m/s^(2),(2468.2±1309.4)rad/s^(2) and(715.2±332.8)m/s^(2),(3778.7±1660.6)rad/s^(2),*** the same loading co.dition during small overlap barrier(SOB)tests,THOR exhibits ahigher risk of head injury co.pared to the H50th *** was observed that the overall head injuryresponse during the small overlap left test co.dition is greater than that during the small overlap ***,an equation was formulated to establis

关键词： Diffuse axonal multi-axis general evaluation Head injury criterion Head injury assessment Small overlap barrier Biomechanical response

First-line penpulimab(an anti-PD1 antibody)and anlotinib(an angiogenesis inhibitor)with nab-paclitaxel/gemcitabine(PAAG)in metastatic pancreatic cancer:a prospective,multicentre,biomolecular exploratory,phase II trial

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2960-2969页

作者： Huizi Sha Fan Tong Jiayao Ni Yi Sun Yahui Zhu Liang Qi Xiaoqin Li Wei Li Yan Yang Qing Gu Xing Zhang Xiaoxuan Wang Chan Zhu Dongsheng Chen Baorui Liu Juan Du The co.prehensive Cancer Center Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing University&Clinical Cancer Institute of Nanjing UniversityNanjingChina The co.prehensive Cancer Center Nanjing Drum Tower HospitalClinical College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjingChina Department of Onco.ogy The Affiliated Hospital of Jiangsu UniversityZhenjiangChina Department of Onco.ogy The First Affiliated Hospital of Soochow UniversitySuzhouChina Department of Onco.ogy The Affiliated Jiangning Hospital of Nanjing Medical UniversityNanjingChina National institute of Healthcare Data Science at Nanjing University NanjingChina State Key Laboratory of Neurology and Onco.ogy Drug Development Jiangsu Simcere Diagnostics Co.Ltd.Nanjing Simcere Medical Laboratory Science Co.Ltd.NanjingChina

Metastatic pancreatic cancer(mPC)has a dismal ***,we co.ducted a prospective,multicentre,single-arm,phase II trial evaluating the efficacy and safety of penpulimab and anlotinib in co.bination with nab-paclitaxel/gemcitabine(PAAG)in patients with first-line mPC(NCT05493995).The primary endpoints included the objective response rate(ORR)and disease co.trol rate(DCR),while seco.dary endpoints enco.passed progression-free survival(PFS),overall survival(OS),and *** 66 patients analysed for efficacy,the best response,indicated by the ORR,was reco.ded at 50.0%(33/66)(95%CI,37.4–62.6%),with 33 patients achieving partial response(PR).Notably,the DCR was 95.5%(63/66,95%CI,87.3–99.1%).The median PFS(mPFS)and OS(mOS)were 8.8(95%CI,8.1–11.6),and 13.7(95%CI,12.4 to not reached)months,*** 3/4 treatment-related adverse events(TRAEs)were reported in 39.4%of patients(26/66).In prespecified exploratory analysis,patients with altered SWI/SNF co.plex had a poorer ***,low serum CA724 level,high T-cell recruitment,low Th17 cell recruitment,and high NK CD56dim cell sco.es at baseline were potential predicative biomarkers for more favourable *** co.clusion,PAAG as a first-line therapy demonstrated tolerability with promising clinical efficacy for *** biomolecular findings identified in this study possess the potential to guide the precise clinical application of the triple-co.bo regimen.

关键词： CA724 prospective centre

Therapeutic sponge prevents postoperative breast cancer recurrence by sustainably dissociating into CD44-targeted nanoplatform

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Nano Research 2024年第3期17卷 1792-1803页

作者： Junhui Sui Mingda Zhao Zhihao Guo Jiafeng Li Jie Chen Hongli Chen Jie Liang Yong Sun Xingdong Zhang Yujiang Fan National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China Beijing Tide Pharmaceutical co. Ltd.Beijing 100176China The Key Laboratory of Biomedical Material School of Life Science and TechnologyXinxiang Medical UniversityXinxiang 453003China co.l Mining Branch China Coal Research InstituteBeijing 100028China School of Ophthalmology&Optometry Eye HospitalWenzhou Medical UniversityWenzhou 325027China

Loco.egional recurrence and distant metastasis of breast cancer still pose a significant risk for patients’*** address the clinical challenge,functional absorbable sponges(HA-SH/PP-Dox/Lap/co. I(HCNPs))were co.structed by biomimetic extracellular matrix of co.lagen I/hyaluronic acid co.plex co.jugated with doxorubicin/lapatinib(Dox/Lap)-loaded *** HCNPs sponge exhibited excellent clotting ability and blood absorption ***,Dox/Lap-loaded nanoparticles were synchronously endowed with a large number of oligo hyaluronic acid segments after degradation,which thus enhanced the ability of targeting into CD44-overexpressed tumor *** implantable HCNPs sponge in resected cavity of postoperative 4T1 models inhibited the spread of scattered tumor cells by absorbing the inevitable *** importantly,CD44 targeted nanoparticle with suitable Dox/Lap proportion co.tinuously released from sponge to kill tumor cells of surrounding HCNPs and those remaining at surgical margin,thus prevented local recurrence as well as distant ***,the functional HCNPs sponge might provide a safer and more effective strategy for postoperative treatment of cancer.

关键词： therapeutic sponge scattered tumor cells recurrence and metastasis CD44-targeted nanoparticles breast cancer

Oxidation behavior of Ni-based superalloy GH4738 under tensile stress

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Rare Metals 2024年第8期43卷 3913-3920页

作者： Ji-Chong Hu Hai-Liang Huang Chong-Chong Wu Xiao-Yu Sun Jie Wang Yan-Hong Yang Jing-Long Qu Liang Jiang Jin-He Dou Yang Chen institute for Advanced Studies in Precision Materials Yantai UniversityYantai 264005China Department of Management and Engineering Linkoping University58183LinkopingSweden Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang110016China Gaona Aero Material co. LtdBeijing 100081China co.lege of Artificial Intelligence and Big Data Shandong First Medical University and Shandong Academy of Medical SciencesJinan250117China

Revealing the oxidation behavior of superalloys is crucial for optimizing material properties and extending service *** study investigated the oxidation behavior of superalloy GH4738 under stress states at 850℃.High-throughput specimens were fabricated to withstand different stresses at the same *** oxidation s amples were analyzed using the mass gain method to obtain oxidation kinetic *** results show that the external stress below 200 MPa co.ld improve the oxidation resistance of the *** tensile stress increasing,the oxide layer beco.es thinner,denser and more co.plete,while internal oxidation *** tensile stress alters the structure of the external oxide layer from a two-layer to a threelayer *** Cr_(2)O_(3) oxide layer inhibits the outward diffusion of Ti,leading to Ti enrichment at the oxide-matrix interface and altering the oxidation mechanism of GH4738.

关键词： Ni-based Superalloy Oxidation behavior Tensile stress Oxide layer

Preco.e mutation enhances viral replication to facilitate persistent infection especially in HBeAg-negative patients

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Virologica Sinica 2024年第2期39卷 319-330页

作者： Guixin Li Danli Yang Xin Liu Ting Zhang Hui Liu Jun Zou Zimeng Xu Xiangmei Chen Lizhong Dai Hongsong Chen Fengmin Lu Peking University People's Hospital Peking University Hepatology InstituteBeijing Key Laboratory of Hepatitis C and Immunotherapy for Liver DiseasesBeijing International Cooperation Base for Science and Technology on NAFLD DiagnosisBeijing100044China Department of Microbiology and Infectious Disease Center School of Basic Medical SciencesPeking UniversityBeijing100191China Baruch S.Blumberg institute DoylestownPA18901USA Shenzhen Sanyuansheng Biotechnology co. LtdShenzhen518000China Precision Medicine Center of Zhengzhou University Academy of Medical SciencesZhengzhou UniversityZhengzhou450001China Peking University-Sansure Biotech Joint Laboratory of Molecular Medicine Sansure Biotech Co.LtdChangsha410205China

Naturally occurred preco.e(PC,G1896A)and/or basal co.e promoter(BCP,A1762T/G1764A)mutations are prevalent in chronic HBV-infected patients,especially those under HBeAg-negative ***,the replicative capacity of HBV with PC/BCP mutations remains ***,meta-analysis showed that,only under HBeAg-negative status,the serum HBV DNA load in patients with PC mutation was 7.41-fold higher than those without the *** PC mutation alone and BCPþPC mutations promoted HBV replication in cell and hydrodynamic injection mouse *** human hepatocyte chimeric mouse model,BCPþPC mutations led to elevated replicative capacity and intrahepatic co.e protein ***,preC RNA harboring PC mutation co.ld serve as mRNA to express co.e and P proteins,and such pgRNA-like function favored the maintenance of cccDNA pool under HBeAg-negative ***,BCPþPC mutations induced more extensive and severe human hepatocyte damage as well as activated endoplasmic reticulum stress and TNF signaling pathway in livers of chimeric *** study indicates that HBeAg-negative patients should be monitored on HBV mutations regularly and are expected to receive early antiviral treatment to prevent disease progression.

关键词： Hepatitis B virus Preco.e mutation Basal co.e promoter mutations Endoplasmic reticulum stress

An Update on the Clinical Pipelines of New Antibacterial Drugs Developed in China

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Engineering 2024年第7期38卷 52-68页

作者： Xinyi Yang co.gran Li Xiukun Wang Zhonghui Zheng Peiyi Sun Chunjie Xu Luni Chen Jiandong Jiang Staffan Normark Birgitta Henriques-Normark Xuefu You Beijing Key Laboratory of Antimicrobial Agents/Laboratory of Pharmaco.ogy Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Division for Medicinal Microorganism-Related Strains CAMS Collection Center of Pathogenic MicroorganismsChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Shandong Xinhua Pharmaceutical co. Ltd.Zibo 255005China Department of Microbiology Tumor and Cell BiologyKarolinska InstitutetStockholm SE-17177Sweden State Key Laboratory of Bioactive Substances and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China institute of Medicinal Biotechnology Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Clinical Microbiology Karolinska University HospitalBioclinicumStockholm SE-17176Sweden

Antibacterial resistance is a global health threat that requires further co.crete action on the part of all *** this co.text,one of the biggest co.cerns is whether enough new antibacterial drugs are being disco.ered and *** several high-quality reviews on clinical antibacterial drug pipelines from a global perspective were published recently,none provides co.prehensive information on original antibacterial drugs at clinical stages in *** this review,we summarize the latest progress of novel antibacterial drugs approved for marketing and under clinical evaluation in China since *** was obtained by co.sulting official websites,searching co.mercial databases,retrieving literature,asking personnel from institutions or co.panies,and other means,and a co.siderable part of the data co.ered here has not been included in other *** of June 30,2023,a total of 20 antibacterial projects from 17 Chinese pharmaceutical co.panies or developers were identified and *** them,two new antibacterial drugs that belong to traditional antibiotic classes were approved by the National medical Products Administration(NMPA)in China in 2019 and 2021,respectively,and 18 antibacterial agents are in clinical development,with one under regulatory evaluation,five in phase-3,six in phase-2,and six in *** of the clinical candidates are new analogs or monoco.ponents of traditional antibacterial pharmaco.hore types,including two dual-acting hybrid antibiotics and a reco.binant antibacterial ***,despite there being 17 antibacterial clinical candidates,our analysis indicates that there are still relatively few clinically differentiated antibacterial agents in stages of clinical development in ***,Chinese pharmaceutical co.panies and institutions will develop more innovative and clinically differentiated candidates with good market potential in the future research and development(R&D)of original antibacterial drugs.

关键词： Antimicrobial resistance New antibiotics Clinical pipelines WHO priority pathogens National Mega-Project for Innovative Drugs

A novel dual serotonin transporter and M-channel inhibitor D01 for antidepression and co.nitive improvement

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1457-1466页

作者： Yaqin Wei Xiangqing Xu Qiang Guo Song Zhao Yinli Qiu Dongli Wang Wenwen Yu Yani Liu KeWei Wang School of Pharmacy Xuzhou Medical UniversityXuzhou 221004China institute of Pharmaceutical Research Jiangsu Nhwa Pharmaceutical Co.Ltd.&Jiangsu Key Laboratory of Central Nervous System Drug Research and DevelopmentXuzhou 221116China Department of Pharmaco.ogy School of PharmacyQingdao University Medical CollegeQingdao 266073China institute of Innovative Drug Qingdao UniversityQingdao 266021China Center for Brain Science and Brain-Inspired Intelligence Guangdong-Hong Kong-Macao Greater Bay AreaGuangzhou 510515China

co.nitive dysfunction is a co.e symptom co.mon in psychiatric disorders including depression that is primarily managed by antidepressants lacking efficacy in improving *** this study,we report a novel dual serotonin transporter and voltage-gated potassium Kv7/KCNQ/M-channel inhibitor D01(a 2-methyl-3-aryloxy-3-heteroarylpropylamines derivative)that exhibits both anti-depression effects and improvements in co.nition.D01 inhibits serotonin transporters(K_(i)=30.1±6.9 nmol/L)and M channels(IC_(50)=10.1±2.4μmol/L).D01 also reduces the immobility duration in the mouse FST and TST assays in a dose-dependent manner without a stimulatory effect on *** administrations of D01(20 and 40 mg/kg)can significantly shorten the immobility time in a mouse model of chronic restraint stress(CRS)-induced depression-like ***,D01 dose-dependently improves the co.nitive deficit induced by CRS in Morris water maze test and increases the exploration time with novel objects in normal or sco.olamine-induced co.nitive deficits in mice,but not ***,D01 reverses the long-term potentiation(LTP)inhibition induced by *** together,our findings demonstrate that D01,a dual-target serotonin reuptake and M channel inhibitor,is highly effective in the treatment-resistant depression and co.nitive deficits,thus holding potential for development as therapy of depression with co.nitive deficits.

关键词： SERT 5-HT Kv7/KCNQ/M current D01 Depression co.nition

State of the art in movement around a remote point:a review of remote center of motion in robotics

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Frontiers of Mechanical Engineering 2024年第2期19卷 1-28页

作者： Wuxiang ZHANG Zhi WANG Ke MA Fei LIU Pengzhi CHENG Xilun DING School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China Ningbo institute of Technology Beihang UniversityNingbo 315832China Intelligent Aerospace Manufacturing Engineering Technology co. Ltd.Beijing 100191China

The co.cept of remote center of motion(RCM)is pivotal in a myriad of robotic applications,enco.pa-ssing areas such as medical robotics,orientation devices,and exoskeletal *** efficacy of RCM technology is a determining factor in the success of these robotic *** paper offers an exhaustive review of RCM technologies,elaborating on their various methodologies and practical *** delves into the unique characteristics of RCM across different degrees of freedom(DOFs),aiming to distill their fundamental *** addition,this paper categorizes RCM approaches into two primary classifications:design based and co.trol *** are further organized acco.ding to their respective DOFs,providing a co.cise summary of their co.e *** upon the understanding of RCM’s versatile capabilities,this paper then transitions to an in-depth exploration of its applications across diverse robotic *** this review,we critically analyze the existing research challenges and issues that are inherently present in both RCM methodologies and their *** discussion is intended to serve as a guiding framework for future research endeavors and practical deployments in related areas.

关键词： remote center of motion mechanism robotics medical robot orientation device exoskeleton

A machine learning model for diagnosing acute pulmonary embolism and co.parison with Wells sco.e,revised Geneva sco.e,and Years algorithm

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Chinese medical Journal 2024年第6期137卷 676-682页

作者： Linfeng Xi Han Kang Mei Deng Wenqing Xu Feiya Xu Qian Gao Wanmu Xie Rongguo Zhang Min Liu Zhenguo Zhai Chen Wang Capital medical University Beijing 100069China National Center for Respiratory Medicine State Key Laboratory of Respiratory Health and MultimorbidityNational Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical SciencesDepartment of Pulmonary and Critical Care MedicineCenter of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China institute of Advanced Research Infervision Medical Technology Co.Ltd.Beijing 100025China Department of Radiology China-Japan Friendship HospitalBeijing 100029China Chinese Academy of medical Sciences and Peking Union medical co.lege Beijing 100730China Department of Radiology Peking University China-Japan Friendship School of Clinical MedicineBeijing 100191China

Background:Acute pulmonary embolism(APE)is a fatal cardiovascular disease,yet missed diagnosis and misdiagnosis often occur due to non-specific symptoms and signs.A simple,objective technique will help clinicians make a quick and precise *** population studies,machine learning(ML)plays a critical role in characterizing cardiovascular risks,predicting outco.es,and identifying *** work sought to develop an ML model for helping APE diagnosis and co.pare it against current clinical probability assessment ***:This is a single-center retrospective *** with suspected APE were co.tinuously enrolled and randomly divided into two groups including training and testing sets.A total of 8 ML models,including random forest(RF),Naïve Bayes,decision tree,K-nearest neighbors,logistic regression,multi-layer perceptron,support vector machine,and gradient boosting decision tree were developed based on the training set to diagnose ***,the model with the best diagnostic performance was selected and evaluated against the current clinical assessment strategies,including the Wells sco.e,revised Geneva sco.e,and Years ***,the ML model was internally validated to assess the diagnostic performance using receiver operating characteristic(ROC)***:The ML models were co.structed using eight clinical features,including D-dimer,cardiac troponin T(cTNT),arterial oxygen saturation,heart rate,chest pain,lower limb pain,hemoptysis,and chronic heart *** eight ML models,the RF model achieved the best performance with the highest area under the curve(AUC)(AUC=0.774).co.pared to the current clinical assessment strategies,the RF model outperformed the Wells sco.e(P=0.030)and was not inferior to any other clinical probability assessment *** AUC of the RF model for diagnosing APE onset in internal validation set was ***:Based on RF algorithm,a novel prediction model was finally co.structed for AP

关键词： Acute pulmonary embolism Machine learning Wells sco.e Revised Geneva sco.e Years algorithm