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Preliminary Assessment of the COVID-19 Outbreak Using 3-Staged Model e-ISHR

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Journal of Shanghai Jiaotong university(Science) 2020年第2期25卷 157-164页

作者： LI Sijia SONG Kun YANG Boran GAO Yucen GAO Xiaofeng School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China zhiyuan college Shanghai Jiao Tong UniversityShanghai 200240China

The outbreak of coronavirus disease 2019(COVID-19)in Wuhan has aroused widespread concern and attention from all over the *** articles have predicted the development of the *** of them only use very basic SEIR model without considering the real *** this paper,we build a model called e-ISHR model based on SEIR *** we add hospital system and time delay system into the original model to simulate the spread of COVID-19 ***,in order to take the government's control and people's awareness into consideration,we change our e-ISHR model into a 3-staged model which effectively shows the impact of these factors on the spread of the *** using this e-ISHR model,we fit and predict the number of confirmed cases in Wuhan and China except *** also change some of parameters in our *** results indicate the importance of isolation and increasing the number of beds in hospital.

关键词： coronavirus disease 2019(COVID-19) epidemic prediction 3-staged model hospital system government's control

RsaL is a self-regulatory switch that controls alternative biosynthesis of two AHL-type quorum sensing signals in Pseudomonas aeruginosa PA1201

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mLife 2024年第1期3卷 74-86页

作者： Ya-Wen He Zi-Jing Jin Ying Cui Kai Song Bo Chen Lian Zhou State Key Laboratory of Microbial Metabolism Joint International Research Laboratory of Metabolic and Developmental SciencesSJTU-NLBP Joint R&D Centre for Biopesticides and BiofertilizersSchool of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghaiChina zhiyuan Innovative Research Centre Student Innovation CentreZhiyuan CollegeShanghai Jiao Tong UniversityShanghaiChina

Pseudomonas aeruginosa is a ubiquitous and metabolically versatile microorganism naturally found in soil and *** is also an opportunistic pathogen in plants,insects,animals,and *** response to increasing cell density,*** uses two acylhomoserine lactone(AHL)quorum-sensing(QS)signals(i.e.,N-3-oxo-dodecanoyl homoserine lactone[3-oxo-C12-HSL]and Nbutanoyl-homoserine lactone[C4-HsL]),which regulate the expression of hundreds of ***,how the biosynthesis of these two QS signals is coordinated remains *** studied the regulation of these two QS signals in the rhizosphere strain ***1201 sequentially produced 3-oxo-C12-HSL and C4-HSL at the early and late growth stages,*** highest 3-oxo-C12-HSL-dependent elastase activity was observed at the early stage,while the highest C4-HSL-dependent rhamnolipid production was observed at the late *** atypical regulator RsaL played a pivotal role in coordinating 3-oxo-C12-HSL and C4-HSL biosynthesis and QS-associated *** repressed las/transcription by binding the-10 and-35 boxes of the lasl *** contrast,RsaL activated rhll transcription by binding the region encoding the 5'-untranslated region of the rhll ***,RsaL repressed its own expression by binding a nucleotide motif located in the-35 box of the rsaL ***,RsaL acts as a molecular switch that coordinates the sequential biosynthesis of AHL QS signals and differential virulence in ***,C4-HSL activation by RsaL was independent of the Las and Pseudomonas quinolone signal(PQS)QS signaling ***,we propose a new model of the QS regulatory network in PA1201,in which RsaL represents a superior player acting at the top of the hierarchy.

关键词： N-3-oxo-dodecanoyl homoserine lactone N-butanoyl-homoserine lactone Pseudomonas aeruginosa quorum sensing RsaL

Deflections of photoelectron classical trajectories in screened Coulomb potentials of H_2^+

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Chinese Physics B 2015年第11期24卷 59-62页

作者：秦博雅王培杰何峰 zhiyuan college Shanghai Jiao Tong University Beijing Key Laboratory for Nano-Photonics and Nano-Structure Department of Physics Capital Normal University Key Laboratory for Laser Plasmas (Ministry of Education) and Department of Physics and Astronomy IFSA Collaborative Innovation Center Shanghai Jiao Tong University

The photoelectron momentum distribution of H＋ in circularly polarized laser fields is studied based on classical trajectory calculations. We screen Coulomb potentials at different radii, and trace trajectories of an ensemble of electrons in such screened Coulomb potentials and circularly polarized laser fields. Simulations show that electron trajectories are bent by Coulomb fields, resulting in the laser-intensity-dependent drift of photoelectron momentum distributions in the laser polarization plane. This study intuitively explains how Coulomb potentials modify photoelectron momenta.

关键词： hydrogen molecular ion photoelectron momentum distribution strong laser field

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Seven-day triple therapy is a better choice for Helicobacter pylori eradication in regions with low antibiotic resistance

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World Journal of Gastroenterology 2015年第46期21卷 13073-13079页

作者： Yue-Feng Tong Jun Lv Li-Yuan Ying Fang Xu Bo Qin Ming-Tong Chen Fei Meng Miao-Ying Tu Ning-Min Yang You-Ming Li Jian-Zhong Zhang Department of Gastroenterology The First People’s Hospital of Yongkang Department of Research Service Zhiyuan Inspection Medical Institute Department of Clinical Laboratory Zhiyuan Medical Inspection Institute CO.LTD Department of Gastroenterology The First Affiliated HospitalCollege of MedicineZhejiang University State Key Laboratory of Infectious Disease Prevention and Control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and Prevention Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases

AIM: To investigate whether 7-d triple therapies are still valid in populations with low levels of ***: A total of 1106 Helicobacter pylori(H. pylori)-positive patients were divided into three groups,each of which received one type of 7-d triple therapy. Therapeutic outcomes of the patients were assessed by the 13C-urea breath test at 8 wk after treatment. The susceptibility of H. pylori to antibiotics was determined by an agar-dilution method. Data analysis was performed by χ2 ***: The eradication rates in groups A,B and C were 90.71%(332/366),90.46%(313/346) and 90.87%(189/208),respectively(P = 0.986). The resistance rates were 8.91% for clarithromycin,14.78% for levofloxacin and 0% for amoxicillin. The eradication rate was significantly different between clarithromycin-and levofloxacin-resistant patients(P < 0.05) in group A. Patients whose treatment failed in group A also had a higher clarithromycin resistance rate than did successive patients(P = 0.034). However,levofloxacin resistance had no obvious influence on the eradication rate. Furthermore,three main antibiotics(clarithromycin,levofloxacin and amoxicillin) had lower DID(defined daily dose per 1000 inhabitants per day) in this ***: Clarithromycin resistance is the main reason for the failure of 7-d triple therapy. In populations with low levels of resistance,a 7-d triple therapy is a viable choice. The choice of therapy should not be influenced by conditions in high antibiotic resistance regions.

关键词： Helicobacter pylori Seven-day triple therapy Eradi

Precise sensitivity recognizing,privacy preserving,knowledge graph-based method for trajectory data publication

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Frontiers of Computer Science 2022年第4期16卷 219-221页

作者： Xianxian Li Bing Cai Li-e Wang Lei Lei Guangxi Key Lab of Multi-source Information Mining and Security Guangxi Normal UniversityGuilin541004China college of Computer Science and Information Engineering Guangxi Normal UniversityGuilin541004China Nanning Tiancheng zhiyuan Intellectual Property Service Co.Ltd. Nanning530000China

1Introduction The existing privacy protection methods of trajectory data publication have two ***,existing methods[1-3]cannot resist attribute link attacks *** practical scenarios,it is necessary to integrate data from a variety of fields for data analysis,such as cross-domain *** usually need to obtain the user attributes outside of the trajectory data as background knowledge.

关键词： knowledge outside preserving

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The art of two-dimensional soft nanomaterials

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Science China Chemistry 2019年第9期62卷 1145-1193页

作者： Caini Zheng Jinhui Zhu Chongqing Yang Chenbao Lu Zhenying Chen Xiaodong Zhuang The Two-Dimensional Soft Materials Lab (The Soft2D Lab) School of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai 200240 China State Key Laboratory of Metal Matrix Composites Shanghai Key Laboratory of Electrical Insulation and Thermal Ageing Shanghai Jiao Tong University Shanghai 200240 China zhiyuan college Shanghai Jiao Tong University Shanghai 200240 China

The discovery of graphene has triggered the explosive development of two-dimensional(2D) nanomaterials, including both inorganic and organic species. Benefiting from the simple elemental composition, inorganic 2D nanomaterials were the center research in the past decade, which has long shadowed the research of 2D organic(or soft) nanomaterials. Although many kinds of2D soft nanomaterials have been successfully prepared, a unified definition for them is still impossible due to the complicate and quite different chemical structures between each other and even relying on totally different techniques to distinguish them. Since our first review on 2D soft nanomaterials in 2015, this field has moved forward with big success. In this review, we will focus on the development of 2D soft nanomaterials after 2015. In order to deliver better overview of this field, new and comprehensive classification is used in this review: 2D aromatic molecules, graphene and graphene nanoribbons, graphyne and graphdiyne,BxCyNznanosheets, 2D polymers, 2D supramolecules, crystalline 2D assemblies, 2D covalent organic frameworks, 2D metalorganic frameworks, sandwich-like 2D porous polymers, 2D polymer nanosheets, etc. The focus of this review lies on synthetic strategies and the challenges of characterization, definition and fundamental understanding.

关键词： two dimensional soft material nanosheet layered structure sandwich-like structure

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Poly(ethylene oxide)-graft-methotrexate Macromolecular Drugs Conjugating via Aminopteridine Ring Exhibit Potent Anticancer Activity

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Chinese Journal of Chemistry 2014年第1期32卷 57-65页

作者： Weiwei Guo Meng Zheng Yinan Zhong Fenghua Meng Chao Deng[*] zhiyuan Zhong[*] Biomedical Polymers Laboratory and Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application Department of Polymer Science and Engineering College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou Jiangsu 215123 China Email: Chao Deng (cdeng@***) Zhiyuan Zhong (zyzhong@***)[*]Biomedical Polymers Laboratory and Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application Department of Polymer Science and Engineering College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou Jiangsu 215123 China Tel./Fax: 0086-0512-65880098

Water soluble poly(ethylene oxide)-graft-methotrexate (PEO-g-MTX) conjugates with a robust amide linkage via the amine or carboxylic acid groups of MTX were designed,prepared and investigated for in vitro anti-tumor *** was conjugated to multi-functional PEO containing multiple pendant carboxylic acid (PEO-g-COOH)or amine groups (PEO-g-NH2) via the carbodiimide chemistry,which afforded PEO-g-MTX conjugates with an amide bond to the aminopteridine ring or carboxylic acid groups of MTX (denoted as PEO-g-MTX(COOH) and PEO-g-MTX(NH2),respectively).Dynamic light scattering (DLS) revealed that all PEO-g-MTX conjugates,with MTX contents varying from 4.8 to 19.6 wt％,existed as unimers in phosphate buffer (PB,pH 7.4,20 mmol·L-1).Interestingly,MTT assays showed that PEO-g-MTX(COOH) exhibited potent anti-tumor activity in HeLa,A549,KB and NIH3T3 cells with cytotoxicity profiles comparable to that of free *** contrast,PEO-g-MTX(NH2)revealed diminishing cytostatic effect with IC50 (half maximal inhibitory concentration) ten to hundred times higher than that of PEO-g-MTX(COOH).Moreover,PEO-g-MTX(COOH) conjugates allowed facile conjugation with targeting ***,folate-decorated PEO-g-MTX(COOH) macromolecular drugs showed apparent targetability to folate receptor-overexpressing KB cells with an IC50 over 12-fold lower than non-targeting PEO-g-MTX-(COOH) control and about 2-fold lower than free MTX under otherwise the same conditions.

关键词： functional poly(ethylene oxide) methotrexate macromolecular drug folate drug delivery

Vacuolar H^(+)-ATPase and BZR1 form a feedback loop to regulate the homeostasis of BR signaling inArabidopsis

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Molecular Plant 2023年第12期16卷 1976-1989页

作者： Yu-Tong Jiang Lu-Han Yang Ji-Xuan Zheng Xian-Chen Geng Yu-Xuan Bai Yu-Chen Wang Hong-Wei Xue Wen-Hui Lin School of Life Sciences and Biotechnology The Joint International Research Laboratory of Metabolic&Developmental SciencesShanghai Jiao Tong UniversityShanghai 200240China Shanghai Collaborative Innovation Center of Agri-Seeds Joint Center for Single Cell BiologyShanghai 200240China School of Agricuture and Biology Shanghai Jiao Tong UniversityShanghai 200240China zhiyuan college Shanghai Jiao Tong UniversityShanghai 200240China

Brassinosteroid(BR)is a vital plant hormone that regulates plant growth *** RESISTANT1(BZR1)is a key transcription factor in BR signaling,and its nucleocytoplasmic localization is crucial for BR ***,the mechanisms that regulate BzR1 nucleocytoplasmic distribution and thus the homeostasis of BR signaling remain largely *** vacuole is the largest organelle in mature plantcells and plays a key role in maintenance of cell ular pH,storage of intracellular substances,and transport *** this study,weuncovered anovel mechanismof BR signaling homeostasis regulatedbythe vacuolar H+-ATPase(V-ATPase)and BZR1 feedback *** results revealed that the vha-a2 vha-a3 mutant(vha2,lacking V-ATPase activity)exhibits enhanced BR signaling with increased total amount of BZR1,nuclearlocalized BZR1,and the ratio of BZR1/phosphorylated BZR1 in the *** biochemical assays revealed that VHA-a2 and VHA-a3 of V-ATPase interact with the BZR1 protein through a domain that is conserved across multiple ***-a2 and VHA-a3 negatively regulate BR signaling by interacting with BzR1 and promoting its retention in the ***,a series of molecular analyses demonstrated that nuclear-localized BZR1 could bind directlyto specific motifs in the promoters of VHA-a2 andVHAa3topromote their *** together,these results suggest that V-ATPase and BzR1 mayforma feedback regulatory loop to maintain thehomeostasis of BR signaling in Arabidopsis,providing new insights into vacuole-mediated regulation of hormone signaling.

关键词： BR BZR1 vacuole V-ATPase tonoplast

Adaptive Agent-Based Modeling Framework for Collective Decision-Making in Crowd Building Evacuation

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Journal of Shanghai Jiaotong university(Science) 2021年第4期26卷 522-533页

作者： CHEN Feier ZHA0 Qiyuan CA0 Mingming CHEN Jiagi FU Guiguan State Key Laboratory of Ocean Engineering Key Laboratory of Marine Intelligent Equipment and System of Ministry of EducationShanghai Jiao Tong UniversityShanghai200240China Marautec Co. Ltd.Shanghai201206China zhiyuan college Shanghai Jiao Tong UniversityShanghai200240China School of Mathematical Sciences Shanghai Jiao Tong UniversityShanghai200240China Institute of Fintech Shanghai University of Finance and EconomicsShanghai200433China

Crowd evacuation in different situations is an important topic in the research field of safety. This paper presents a hybrid model for heterogeneous pedestrian evacuation simulation. Our adaptive agent-based model (ABM) combines the strength of human crowd behavior description from classical social force models with discrete dynamics expression from cellular automaton models by extending the conception of floor field. Several important factors which may influence the results of decision-making of pedestrians are taken into consideration, such as the location of sign, the attraction of exit, and the interaction among pedestrians. To compare the effect of information on the pedestrians, we construct three decision-making mechanisms with different assumptions. To validate these three simulation models, we compare the numerical results from different perspectives with rational range in the case study where the Tampere Theater evacuation was carried out. The ABM framework is open for rules modification and could be applied to different building plans and has implication for architectural design of gates and signs in order to increase the evacuation efficiency.

关键词： adaptive agent-based model evacuation simulation emergency interaction heterogeneity