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RICTOR/mTORC2 affects tumorigenesis and therapeutic efficacy of mTOR inhibitors in esophageal squamous cell carcinoma

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Acta Pharmaceutica Sinica B 2020年第6期10卷 1004-1019页

作者： Zhaoming Lu Xiaojing Shi Fanghua Gong Shenglei Li Yang Wang Yandan Ren Mengyin Zhang Bin Yu Yan Li Wen Zhao Jianying Zhang Guiqin Hou School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China Collaborative Innovation center of Cancer Chemoprevention Zhengzhou 450001China School of Pharmacy Wenzhou Medical UniversityWenzhou 325035China The First Affiliated Hospital Zhengzhou UniversityZhengzhou 450052China center of Advanced Analysis&Gene Sequencing Zhengzhou UniversityZhengzhou 450001China Henan Academy of Medical and Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450052China

Dysregulation of mTORCl/mTORC2 pathway is observed in many cancers and mTORC1 inhibitors have been used clinically in many tumor types;however,the mechanism of mTORC2 in tumorigenesis is still ***,we mainly explored the potential role of mTORC2 in esophageal squamous cell carcinoma(ESCC)and its effects on the sensitivity of cells to mTOR *** demonstrated that RICTOR,the key factor of mTORC2,and p-AKT(Ser473)were excessively activated in ESCC and their overexpression is related to lymph node metastasis and the tumor-node-metastasis(TNM)phase of ESCC ***,we found that mTORCl/mTORC2 inhibitor PP242 exhibited more efficacious anti-proliferative effect on ESCC cells than mTORC1 inhibitor RAD001 due to RAD001-triggered feedback activation of AKT ***,we demonstrated that down-regulating expression of RICTOR in ECa109 and EC9706 cells inhibited proliferation and migration as well as induced cell cycle arrest and ***,knocking-down stably RICTOR significantly suppresses RAD001-induced feedback activation of AKT/PRAS40 signaling,and enhances inhibition efficacy of PP242 on the phosphorylation of AKT and PRAS40,thus potentiates the antitumor effect of RAD001 and PP242 both in vitro and in *** findings highlight that selective targeting mTORC2 could be a promising therapeutic strategy for future treatment of ESCC.

关键词： RICTOR AKT RAD001 pp242 Esophageal squamous cell carcinoma

Molecular design for enhanced spin transport in molecular semiconductors

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Nano Research 2023年第12期16卷 13457-13473页

作者： Tingting Yang Yang Qin Xianrong Gu Xiangnan Sun Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China School of Material Science and Engineering Zhengzhou UniversityZhengzhou 450001China

Molecular semiconductors(MSCs),characterized by a longer spin lifetime than most of other materials due to their weak spin relaxation mechanisms,especially at room temperature,together with their abundant chemical tailorability and flexibility,are regarded as promising candidates for spintronic *** spintronics,as an emerging subject that utilizes the unique properties of MSCs to study spin-dependent phenomena and properties,has attracted wide *** molecular spintronic devices,MSCs play the role as medium for information transport,process,and storage,in which the efficient spin inject–transport process is the ***,we focus mainly on summarizing and discussing the recent advances in theoretical principles towards spin transport of MSCs in terms of the injection of spin-polarized carriers through the ferromagnetic metal/MSC interface and the subsequent transport within the MSC *** on the theoretical progress,we cautiously present targeted design strategies of MSCs that contribute to the optimization of spin-transport efficiency and give favorable approaches to exploring accessional possibilities of spintronic ***,challenges and prospects regarding current spin transport are also presented,aiming to promote the development and application of the rosy and energetic field of molecular spintronics.

关键词： molecular spintronics molecular semiconductors spin transport spin injection molecular design

Can NogoA Be a Suitable Target to Treat Ischemic Stroke?

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Neuroscience Bulletin 2024年第4期40卷 557-560页

作者： Suliman Khan Abdul Nasir Medical Research center The Second Affiliated Hospital of Zhengzhou UniversityZhengzhou540014China

Treating stroke or restoring brain function after stroke remains challenging for clinicians[1,2].Researchers have largely focused on developing neuroprotective strategies and translating these discoveries from rodent experiments to the clinical setting;however,these have been typified by several failures[2].It is known that astrocytes play a crucial role in the pathogenesis of ischemic stroke[3,4].They are activated in response to stimuli arising from injury,characterized by drastic changes to their morphology and function-associated gene *** astrocytes exacerbate secondary neurodegeneration(repair of nervous tissue by the generation of new neurons,glial cells,axons,myelin,or synapses)[5]as well as provide neuroprotection during CNS pathologies[6].It is worth noting that myelin-related neurite growth inhibitors induce the suppression of axon regeneration after stroke[7].

关键词： protective NogoA clinical

Red-emitting,self-oxidizing carbon dots for the preparation of white LEDs with super-high color rendering index

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Science China Chemistry 2021年第9期64卷 1547-1553页

作者： Xin Yang Laizhi Sui Boyang Wang Yongqiang Zhang Zhiyong Tang Bai Yang Siyu Lu Green Catalysis center College of ChemistryZhengzhou UniversityZhengzhou450001China State Key Lab of Molecular Reaction Dynamics Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian116023China Henan Institute of Advanced technology Zhengzhou UniversityZhengzhou450001China CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing100190China State Key Lab of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun130012China

Carbon dots(CDs),as a kind of carbon nanomaterials,have attracted widespread attention due to their unique structure and excellent optical properties,and they are low-cost,environmentally friendly and ***,the development of near-infrared(NIR)emission CDs remains a *** this study,we successfully prepared CDs with a maximum emission of714 nm using citric acid as the carbon source,thiourea and ammonium fluoride as the dopant source,and N,N-dimethylformamide as the *** quantum yield(QY)is as high as 22.64%.Interestingly,the prepared CDs self-oxidize in the presence of oxygen,resulting in a blue shift of their ***,they can be used to prepare white light-emitting diodes(WLEDs)without adding other fluorescent ***,the work presented herein constitutes the first report of WLEDs preparation from single CDs.

关键词： carbon dots near-infrared high quantum yields self-oxidation white LEDs

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Poly(vinyl alcohol)/Graphene Nanocomposite Hydrogel Scaffolds for Control of Cell Adhesion

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Journal of Renewable Materials 2020年第1期8卷 89-99页

作者： Xiaodong Wang Meng Su Chuntai Liu Changyu Shen Xianhu Liu Department of Materials Science and Engineering Tongji Zhejiang CollegeJiaxing314051China National Engineering Research center for Advanced Polymer Processing technology Zhengzhou UniversityZhengzhou450002China

Poly(vinyl alcohol)(PVA)/reduced graphene oxide(rGO)nanocomposites is prepared by the immersion of PVA/graphene oxide(GO)nanocomposites in the reducing agent aqueous *** PVA/graphene nanocomposites can be used as scaffold after treatment by chemical crosslinking *** surface hydrophilicity of the nanocomposite scaffolds decreased with the addition of GO or rGO by measuring the contact angles of *** electrical conductivity of PVA/rGO nanocomposite scaffold increased with rGO content *** highest conductivity of PVA/rGO nanocomposite scaffolds with 10 wt%rGO could reach to 12.16×10^(−3)S/*** NIH-3T3 fibroblasts attach and grow well on the surface of PVA/rGO nanocomposite scaffolds with increasing the content of *** number of cells obviously increases on the PVA/rGO nanocomposite scaffolds,especially,at 5 wt%and 10 wt%***,a good level of conductivity and a variation in the surface property of the PVA/rGO nanocomposite scaffolds have affected NIH-3T3 fibroblasts grow.

关键词： Graphene nanocomposites hydrogels scaffolds

Preparation of graphitic carbon nitride by electrodeposition

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Chinese Science Bulletin 2003年第16期48卷 1737-1740页

作者： LI Chao1,2, CAO Chuanbao1 & ZHU Hesun1 1. Research center of Materials Science, Beijing Institute of technology, Beijing 100081, China 2. Department of Chemical Engineering, zhengzhou Institute of Light Industry, zhengzhou 450002 China Correspondence should be addressed to Cao Chuanbao Research center of Materials Science Beijing Institute of Technology Beijing China Department of Chemical Engineering Zhengzhou Institute of Light Industry Zhengzhou China

The CNx thin film was deposited on Si(100) substrate from a saturated acetone solution of cyanuric tri-chloride and melamine (cyanuric trichloride/melamine=1︰1.5) at room temperature. X-ray diffraction (XRD) results showed that the diffraction peaks in the pattern coincided well with those of graphite-like carbon nitride calculated in the literature. The lattice constants (a=4.79 ? c=6.90 ) for g-C3N4 matched with those of ab initio calculations (a=4.74 ? c=6.72 ? quite well. X-ray photoelectron spectroscopy (XPS) measurements indicated that the elements in the de-posited films were mostly of C and N (N/C=0.75), and N (400.00 eV) bonded with C (287.72 eV) in the form of six-member C3N3 ring. The peaks at 800 cm-1, 1310 cm-1 and 1610 cm-1 in the Fourier transform infrared (FTIR) spec-trum indicated that triazine ring existed in the product. These results demonstrated that crystalline g-C3N4 was ob-tained in the CNx film.

关键词：沉淀薄膜饱和丙酮溶液三聚氰胺 X射线衍射石墨碳氮化合物晶格恒量光电子光谱测量法傅立叶变换红外光谱三嗪

Research on co-propagation of QKD and classical communication by reducing the classical optical power

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Chinese Physics B 2019年第4期28卷 70-75页

作者： Ru-Shi He Mu-Sheng Jiang Yang Wang Ya-Hui Gan Chun Zhou Wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography zhengzhou Information Science and technology Institute Synergetic Innovation center of Quantum Information and Quantum Physics University of Science and technology of China

We investigate the crosstalk noise, especially the spontaneous Raman scattering, in the optical fiber of a copropagation system between quantum key distribution(QKD) and classical communications. Although many methods have been proposed, such as increasing the wavelength spacing and narrowband filtering technique, to suppress Raman scattering noise, these methods greatly affect the performance of QKD. One way to solve the obstacle restricting the coexistence is to decrease the classical signal power. Based on the high gain of the gated avalanche photodiode and pulse position modulation, we demonstrate that the co-propagation system works effectively with only a small effect on long-haul fibers, which has great significance for the practical widespread commercialization of QKD.

关键词： QKD co-propagation spontaneous Raman scattering gated APD modulation formats

Recent advances in annulations enabled by nucleophilic Lewis base/metal dual catalysis

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Chinese Chemical Letters 2023年第10期34卷 12-26页

作者： Qian Wang Yinggao Meng Lulu Wu Er-Qing Li College of Chemistry Green Catalysis CenterZhengzhou UniversityZhengzhou 450001China School of Science Henan Agricultural UniversityZhengzhou 450002China

Metal/nucleophilic Lewis base dual catalysis has been recognized as a reliable and promising strategy for finishing ideal organic synthesis over the past *** new strategy can usually achieve some chemical reactions that cannot be realized by the traditionally mono-catalytic system,dramatically expanding the synthetic utility of chemical transformations by leveraging additional activation *** considerable progress has been made in the synthesis of a wide range of heterocyclic and biologically active compounds by using the combination of diversely metal/nucleophilic Lewis base dual catalysts,including metal/phosphine,metal/N-heterocyclic carbene(NHC)and metal/tertiary amine dual catalysis *** this review,we describe a comprehensive and updated advance of metal/nucleophilic Lewis base dual catalytic annualtion reactions,meanwhile,the related mechanism and the application of these annulation strategies in natural product total synthesis will be highlighted in detail.

关键词： Lewis base Metal catalysis Annualtion Dual catalysis Synthetic methods

PDNet:A Convolutional Neural Network Has Potential to be Deployed on Small Intelligent Devices for Arrhythmia Diagnosis

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Computer Modeling in Engineering & Sciences 2020年第10期125卷 365-382页

作者： Fei Yang Xiaoqing Zhang Yong Zhu Department of Computer Science and Engineering Southern University of Science and TechnologyShenzhenChina Cooperative Innovtion center of Internet Healthcare Zhengzhou UniversityZhengzhou450052China College of Computer Science and technology Huaqiao UniversityXiamen361021China

Heart arrhythmia is a group of irregular heartbeat conditions and is usually detected by electrocardiograms(ECG)*** the past years,deep learning methods have been developed to classify different types of heart arrhythmias through ECG based on computer-aided diagnosis systems(CADs),but these deep learning methods usually cannot trade-off between classification performance and parameters of deep learning *** tackle this problem,this work proposes a convolutional neural network(CNN)model named PDNet to recognize different types of heart arrhythmias *** the PDNet,a convolutional block named PDblock is devised,which is comprised of a pointwise convolutional layer and a depthwise convolutional ***,an improved loss function is utilized to improve the results of heart arrhythmias *** verify the proposed CNN model,extensive experiments are conducted on publicMIT-BIH ECG *** experimental results demonstrate that the proposed PDNet achieves an accuracy of 98.2%accuracy and outperforms state-of-the-art methods about 2%.

关键词： Electrocardiograms heart arrhythmia convolutional neural network PDblock loss