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A nanoagent for concurrent therapy of breast cancer bone metastasis and cancer-induced bone pain through SLC7A11 interruption and photodynamic therapy

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Chinese Chemical Letters 2024年第2期35卷 295-299页

作者： Qi Fu Zhongming Lian Mengya Niu Yaru Huang Yanqiu Ai Long He Dandan Zhang Cuixia Zheng Jian-Jun Yang Lei Wang Dandan Tian Department of Anesthesiology Pain and Perioperative MedicineThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450001China School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China Translational Medical Center of Huaihe Hospital Henan UniversityKaifeng 475004China Key Laboratory of Advanced Drug Preparation Technologies Ministry of EducationSchool of Pharmaceutical SciencesZhengzhou UniversityZhengzhou 450001China

Bone metastasis,a life-threatening complication of advanced breast cancer,is often accompanied by debilitating pain(cancer-induced bone pain,CIBP)that severely impairs life quality and *** concurrent treatment of bone metastases and CIBP remains a clinical challenge because the therapeutic options are *** this study,we construct a near-infrared light-activated nano-therapeutic system to meet this *** detail,sorafenib(SRF)and photosensitizer(chlorin e6,Ce6)are encapsulated into mesoporous hydroxyapatite nanoparticles(HANPs),which are further functionalized with hyaluronic acid(HA)to obtain HA-SRF/Ce6@HANPs *** designed nanoplatform destroys tumor cells in vitro and in vivo via the synergism of SRF(interrupting the exchange of cystine/glutamate by inhibiting SLC7A11)and photodynamic therapy(PDT,inducing reactive oxygen species generation).The decrease in tumor burden and reduction of extracellular glutamate significantly attenuate CIBP in mice model with developing bone ***,the combination of HA-SRF/Ce6@HANPs and PDT inhibit osteoclasts activation,promote osteoblast differentiation and accelerate bone ***,the nanoagent with good biocompatibility may provide an effective therapy method for the concurrent treatment of breast cancer bone metastasis and CIBP.

关键词： Breast cancer bone metastasis Cancer-induced bone pain Cystine/glutamate antiporter Sorafenib Photodynamic therapy

Self-Sustaining of Critical Park Microgrids Integrating Mobile Emergency Generators Subjective to Major Outage

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1441-1453页

作者： Quan Sui Lei Zhang School of Electrical and Information Engineering Zhengzhou UniversityZhengzhou 450001China School of Electrical and New Energy Three Gorges UniversityYichang 443002China

In the event of a major power outage,critical park microgrids(PMGs)could be self-sustaining if mobile emergency generators(MEGs)are stationed to share ***,the need for privacy protection and the value of flexible power support on minute-time scales have not been given enough *** address the problem,this paper proposes a new self-sustaining strategy for critical PMGs integrating ***,to promote the cooperation between PMG and MEG,a bi-level benefit distribution mechanism is designed,where the participants'multiple roles and contributions are identified,and good behaviors are also ***,to increase the alliance benefits,three loss coordination modes are presented to guide the power exchange at the minute level between the MEG and PMG,considering the volatility of renewable generation and *** this basis,a multi-time scale power-energy scheduling strategy is formulated via the alternating direction method of multipliers(ADMM)to coordinate the PMG and ***,a dimensionality reduction technology is designed to equivalently simplify the optimization problem to facilitate the adaptive-step-based ADMM *** studies indicate that the proposed strategy achieves the self-sustaining of PMGs integrating MEGs while increasing the economy by no less than 3.1%.

关键词： Distributed optimization loss coordination mode mobile emergency generator park microgrid power-energy self-sustaining privacy protection

Interfacial assembly of 2D polydopamine/graphene heterostructures with well-defined mesopore and tunable thickness for high-energy planar micro-supercapacitors

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Chinese Chemical Letters 2024年第7期35卷 439-444页

作者： Jieqiong Qin Zhi Yang Jiaxin Ma Liangzhu Zhang Feifei Xing Hongtao Zhang Shuxia Tian Shuanghao Zheng Zhong-Shuai Wu College of Science Henan Agricultural UniversityZhengzhou 450002China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China University of Chinese Academy of Sciences Beijing 100049China Mechanical and Electrical Engineering Institute Zhengzhou University of Light IndustryZhengzhou 450002China

Two-dimensional(2D)mesoporous pseudocapacitive polymer/graphene heterostructures combine the advanced merits of 2D materials and mesoporous materials,possessing unique nanosheet structure,large specific surface area(SSA),abundant oxygen/nitrogen-containing groups,desirable electrical conductivity and admirable electrochemical redox activity,and hold great potential for constructing high-performance planar micro-supercapacitors(MSCs).Herein,we demonstrate the interfacial assembly of 2D mesoporous polydopamine/graphene(mPDG)heterostructures with well-defined mesopore structure(12 nm)and adjustable thickness(7.5–14.1 nm)for planar high-energy pseudocapacitive *** to medium thickness,exposed mesopore of 12 nm and large SSA of 108 m^(2)/g,the m PDG with 10.8 nm thickness reveals prominent mass capacitance of 419 F/g and impressive cycling stability with~96%capacitance retention after 5000 ***,the symmetric mPDG-based MSCs with“water-in-salt”gel electrolyte present wide voltage window of 1.6 V,superior volumetric energy density of 11.5 mWh/cm^(3),outstanding flexibility and self-integration ***,this work offers a new platform of controllably synthesizing 2D mesoporous heterostructures for high-performance MSCs.

关键词： 2D materials Mesopores Heterostructures Polydopamine High energy density Micro-supercapacitors

Venoarterial extracorporeal membrane oxygenation in acute myocardial infarction

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Emergency and Critical Care Medicine 2024年第1期4卷 1-3页

作者： Junhui Xing Department of Cardiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina.

IntroductionMortality and complications associated with acute myocardial infarction(AMI)have gradually decreased in the era of reperfusion ***,the outcomes are still poor for AMI patients with severe complications.[1]The quest for further improvement of the use of active mechanical circulatory support(MCS)devices is rapidly *** extracorporeal membrane oxygenation(VA-ECMO)is a form of heart-lung bypass that offers temporary mechanical support and simultaneous extracorporeal gas exchange,usually acting as a bridge to *** has been widely used since 1972,after its *** extracorporeal membrane oxygenation provides cardiopulmonary support and is used to rescue patients with cardiopulmonary *** use of VA-ECMO after AMI with severe complications is *** studies have demonstrated a significant increase in survival using VA-ECMO in patients with AMI,and early VA-ECMO initiation yields better *** review article is aimed at evaluating the use of VA-ECMO in patients with AMI.[2]

关键词： extracorporeal infarction arterial

2023年稀土及稀土磁性材料进出口情况分析

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China Rare Earth Information 2024年第2期30卷 14-21页

作者： Baotou Rare Earth Products exchange Baotou Rare Earth Products exchange

With the gradual recovery of the global economy,China's rare earth import and export trade has resumed *** 2023,China's total import and export of various rare earths and rare earth magnetic materials reached 290,000 ... 详细信息

关键词： commodity rare earth

Extracorporeal membrane oxygenation states basilar artery thrombectomy and left posterior cerebral artery stent thrombectomy:A case report

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World Journal of Clinical Cases 2024年第18期12卷 3589-3595页

作者： Li-Shan Ding Hao Liang Ming Zheng Meng Shen Zhao-Jun Li Rui-Peng Song Qing-Liang Chen Department of Radioactive Intervention Henan University of Traditional Chinese MedicineZhengzhou 450099Henan ProvinceChina Department of Radioactive Intervention Henan No.3 Provincial People’s HospitalZhengzhou 450006Henan ProvinceChina Department of Endocrinology Henan No.3 Provincial People’s HospitalZhengzhou 450000Henan ProvinceChina

BACKGROUND Extracorporeal membrane oxygenation(ECMO)is a new type of extracorporeal respiratory and circulatory assistance *** can drain venous blood out of the body and inject it into veins or arteries after being oxygenated by an oxygenator(membrane lung)to replace lung and heart functions in a short *** can provide tissue blood perfusion and gas exchange almost equivalent to cardiac output and extend the effective treatment time window for patients with acute circulatory failure to restore cardiopulmonary *** SUMMARY We report a case of an 81-year-old woman who underwent whole cerebral angiography,basilar artery thrombectomy and stent thrombectomy in the posterior artery of the left brain after implantation of *** patient was admitted to the hospital due to myocardial *** that the cause of the patient’s disturbance of consciousness was unknown and cerebrovascular accident could not be ruled out after the implantation of ECMO,the department of Radioactive Intervention performed cerebral *** the result of the angiography indicated vascular *** the basilar artery thrombectomy and stent thrombectomy in the posterior artery of the left brain,the patency of the occlusive vessel was *** Although the patient eventually died of circulatory failure,the result of this case verifies the feasibility of cerebral angiography and thrombectomy in patients with implanted ECMO in the intubated state.

关键词： Extracorporeal membrane oxygenation Blood circulation failure Nerve intervention Stent thrombectomy Case report

Co_(3)O_(4)中钴空位的精确构筑来促进羟基氧化物的形成加速水氧化反应

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Science China Materials 2024年第3期67卷 780-787页

作者：刘志娟汪广进郭锦瑜王燕勇 State Key Laboratory of Chem/Bio-sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China Henan Key Laboratory of Molecular Functional Materials Henan International Joint Laboratory of Tumor Theranostical Cluster MaterialsGreen Catalysis Centerand College of ChemistryZhengzhou UniversityZhengzhou 450001China School of Materials Science and Energy Engineering Foshan UniversityFoshan 528000China

缺陷位点的引入可以通过增加对反应中间体的亲和力来提高催化剂的催化能力.纳米材料中存在多种缺陷类型,如阳离子缺陷和阴离子缺陷.不同的缺陷位点对电催化性能的贡献不同.因此,构筑缺陷必须精准、明确,以便于确定最优的缺陷类型,促进... 详细信息

缺陷位点的引入可以通过增加对反应中间体的亲和力来提高催化剂的催化能力.纳米材料中存在多种缺陷类型,如阳离子缺陷和阴离子缺陷.不同的缺陷位点对电催化性能的贡献不同.因此,构筑缺陷必须精准、明确,以便于确定最优的缺陷类型,促进电化学反应.在这项工作中,我们以钴空位为例,分别成功合成了二价钴空位(Co3O 4-VCo(II))和三价钴空位(Co_(3)O_(4)-VCo(III))的Co_(3)O_(4).电化学结果表明,钴空位的引入可以显著提高Co_(3)O_(4)的电催化性能.Co_(3)O_(4)-VCo(II)表现出最突出的析氧反应(OER)性能,反应动力学速率最快.X射线光电子能谱分析表明,在OER过程中,VCo(II)的存在可以使CoOOH活性位点快速形成.密度泛函理论计算表明,钴空位的引入使Co_(3)O_(4)拥有类似金属的导电性.VCo(II)的存在使得O p带中心靠近费米能级,自由能势垒降低,电催化剂表面氧交换动力学速率加快,对反应中间体的吸附能最佳,从而表现出优异的电化学性能.本研究为设计高效的富缺陷电催化剂提供了重要指导.

关键词： cobalt vacancies spinel Co_(3)O_(4) electronic environment cobalt oxyhydroxides oxygen evolution reaction

Approach of hybrid soft computing for agricultural data classification

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International Journal of Agricultural and Biological Engineering 2015年第6期8卷 54-61页

作者： Shi Lei Duan Qiguo Si Haiping Qiao Hongbo Zhang Juanjuan Ma Xinming College of Information and Management Science Henan Agricultural UniversityZhengzhou 450002China Collaborative Innovation Center of Henan Grain Crops Zhengzhou 450002China zhengzhou commodity exchange Zhengzhou 450008China

Soft computing is an important computational paradigm,and it provides the capability of flexible information processing to solve real world *** data classification is one of the important applications of computing technologies in agriculture,and it has become a hot topic because of the enormous growth of agricultural data *** vector machine is a powerful soft computing technique and it realizes the idea of structural risk minimization principle to find a partition hyperplane that can satisfy the class *** set theory is another famous soft computing technique to deal with vague and uncertain *** learning is an effective method to learn multiple learners and combine their decisions for achieving much higher prediction *** this study,the support vector machine,rough set and ensemble learning were incorporated to construct a hybrid soft computing approach to classify the agricultural *** experimental evaluation of different methods was conducted on public agricultural *** experimental results indicated that the proposed algorithm improves the performance of classification effectively.

关键词： agricultural data soft computing rough set support vector machine ensemble learning classification

Probing the Efficiency of PPMG-Based Composite Electrolytes for Applications of Proton exchange Membrane Fuel Cell

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Transactions of Tianjin University 2024年第3期30卷 262-283页

作者： Shakeel Ahmed Faizah Altaf Safyan Akram Khan Sumaira Manzoor Aziz Ahmad Muhammad Mansha Shahid Ali Ata-ur-Rehman Karl Jacob School of Material Science and Engineering Henan International Joint Laboratory of Nano-Photoelectric Magnetic MaterialsHenan University of TechnologyZhengzhou 450001China Interdisciplinary Research Center for Hydrogen Technologies and Carbon Management King Fahd University of Petroleum and Minerals31261 DhahranSaudi Arabia School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

PPMG-based composite electrolytes were fabricated via the solution method using the polyvinyl alcohol and polyvinylpyrrolidone blend reinforced with various contents of sulfonated inorganic *** acid was employed as the sulfonating agent to functionalize the external surface of the inorganic filler,i.e.,graphene *** proton conductivities of the newly prepared proton exchange membranes(PEMs)were increased by increasing the temperature and content of sulfonated graphene oxide(SGO),i.e.,ranging from 0.025 S/cm to 0.060 S/*** induction of the optimum level of SGO is determined to be an excellent route to enhance ionic *** single-cell performance test was conducted by sandwiching the newly prepared PEMs between an anode(0.2 mg/cm^(2) Pt/Ru)and a cathode(0.2 mg/cm^(2) Pt)to prepare membrane electrode assemblies,followed by hot pressing under a pressure of approximately 100 kg/cm^(2) at 60℃for 5–10 *** highest power densities achieved with PPMG PEMs were 14.9 and 35.60 mW/cm^(2) at 25℃and 70℃,respectively,at ambient pressure with 100%relative *** showed that the newly prepared PEMs exhibit good electrochemical *** results indicated that the prepared composite membrane with 6 wt%filler can be used as an alternative membrane for applications of high-performance proton exchange membrane fuel cell.

关键词： Proton exchange membrane fuel cell Sulfonated graphene oxide Polyvinylpyrrolidone Solution casting Membrane electrode assembly Fuel cell performance