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A nanoagent for concurrent therapy of breast cancer bone metastasis and cancer-induced bone pain through SLC7A11 interruption and photodynamic therapy

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Chinese Chemical Letters 2024年第2期35卷 295-299页

作者： Qi Fu Zhongming Lian Mengya Niu Yaru Huang Yanqiu Ai Long He Dandan Zhang Cuixia Zheng Jian-Jun Yang Lei Wang Dandan Tian Department of Anesthesiology Pain and Perioperative MedicineThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450001China School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China Translational Medical Center of Huaihe Hospital Henan UniversityKaifeng 475004China Key Laboratory of Advanced Drug Preparation Technologies Ministry of EducationSchool of Pharmaceutical SciencesZhengzhou UniversityZhengzhou 450001China

Bone metastasis,a life-threatening complication of advanced breast cancer,is often accompanied by debilitating pain(cancer-induced bone pain,CIBP)that severely impairs life quality and *** concurrent treatment of bone metastases and CIBP remains a clinical challenge because the therapeutic options are *** this study,we construct a near-infrared light-activated nano-therapeutic system to meet this *** detail,sorafenib(SRF)and photosensitizer(chlorin e6,Ce6)are encapsulated into mesoporous hydroxyapatite nanoparticles(HANPs),which are further functionalized with hyaluronic acid(HA)to obtain HA-SRF/Ce6@HANPs *** designed nanoplatform destroys tumor cells in vitro and in vivo via the synergism of SRF(interrupting the exchange of cystine/glutamate by inhibiting SLC7A11)and photodynamic therapy(PDT,inducing reactive oxygen species generation).The decrease in tumor burden and reduction of extracellular glutamate significantly attenuate CIBP in mice model with developing bone ***,the combination of HA-SRF/Ce6@HANPs and PDT inhibit osteoclasts activation,promote osteoblast differentiation and accelerate bone ***,the nanoagent with good biocompatibility may provide an effective therapy method for the concurrent treatment of breast cancer bone metastasis and CIBP.

关键词： Breast cancer bone metastasis Cancer-induced bone pain Cystine/glutamate antiporter Sorafenib Photodynamic therapy

Self-Sustaining of Critical Park Microgrids Integrating Mobile Emergency Generators Subjective to Major Outage

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1441-1453页

作者： Quan Sui Lei Zhang School of Electrical and Information Engineering Zhengzhou UniversityZhengzhou 450001China School of Electrical and New Energy Three Gorges UniversityYichang 443002China

In the event of a major power outage,critical park microgrids(PMGs)could be self-sustaining if mobile emergency generators(MEGs)are stationed to share ***,the need for privacy protection and the value of flexible power support on minute-time scales have not been given enough *** address the problem,this paper proposes a new self-sustaining strategy for critical PMGs integrating ***,to promote the cooperation between PMG and MEG,a bi-level benefit distribution mechanism is designed,where the participants'multiple roles and contributions are identified,and good behaviors are also ***,to increase the alliance benefits,three loss coordination modes are presented to guide the power exchange at the minute level between the MEG and PMG,considering the volatility of renewable generation and *** this basis,a multi-time scale power-energy scheduling strategy is formulated via the alternating direction method of multipliers(ADMM)to coordinate the PMG and ***,a dimensionality reduction technology is designed to equivalently simplify the optimization problem to facilitate the adaptive-step-based ADMM *** studies indicate that the proposed strategy achieves the self-sustaining of PMGs integrating MEGs while increasing the economy by no less than 3.1%.

关键词： Distributed optimization loss coordination mode mobile emergency generator park microgrid power-energy self-sustaining privacy protection

Interfacial assembly of 2D polydopamine/graphene heterostructures with well-defined mesopore and tunable thickness for high-energy planar micro-supercapacitors

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Chinese Chemical Letters 2024年第7期35卷 439-444页

作者： Jieqiong Qin Zhi Yang Jiaxin Ma Liangzhu Zhang Feifei Xing Hongtao Zhang Shuxia Tian Shuanghao Zheng Zhong-Shuai Wu College of Science Henan Agricultural UniversityZhengzhou 450002China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China University of Chinese Academy of Sciences Beijing 100049China Mechanical and Electrical Engineering Institute Zhengzhou University of Light IndustryZhengzhou 450002China

Two-dimensional(2D)mesoporous pseudocapacitive polymer/graphene heterostructures combine the advanced merits of 2D materials and mesoporous materials,possessing unique nanosheet structure,large specific surface area(SSA),abundant oxygen/nitrogen-containing groups,desirable electrical conductivity and admirable electrochemical redox activity,and hold great potential for constructing high-performance planar micro-supercapacitors(MSCs).Herein,we demonstrate the interfacial assembly of 2D mesoporous polydopamine/graphene(mPDG)heterostructures with well-defined mesopore structure(12 nm)and adjustable thickness(7.5–14.1 nm)for planar high-energy pseudocapacitive *** to medium thickness,exposed mesopore of 12 nm and large SSA of 108 m^(2)/g,the m PDG with 10.8 nm thickness reveals prominent mass capacitance of 419 F/g and impressive cycling stability with~96%capacitance retention after 5000 ***,the symmetric mPDG-based MSCs with“water-in-salt”gel electrolyte present wide voltage window of 1.6 V,superior volumetric energy density of 11.5 mWh/cm^(3),outstanding flexibility and self-integration ***,this work offers a new platform of controllably synthesizing 2D mesoporous heterostructures for high-performance MSCs.

关键词： 2D materials Mesopores Heterostructures Polydopamine High energy density Micro-supercapacitors

Identification and characterization of FpRco1 in regulating vegetative growth and pathogenicity based on T-DNA insertion in Fusarium pseudograminearum

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Journal of Integrative Agriculture 2024年第9期23卷 3055-3065页

作者： Haiyang Li Yuan Zhang Cancan Qin Zhifang Wang Lingjun Hao Panpan Zhang Yongqiang Yuan Chaopu Ding Mengxuan Wang Feifei Zan Jiaxing Meng Xunyu Zhuang Zheran Liu Limin Wang Haifeng Zhou Linlin Chen Min Wang Xiaoping Xing Hongxia Yuan Honglian Li Shengli Ding College of Plant Protection Henan Agricultural UniversityZhengzhou 450046China National Key Laboratory of Wheat and Maize Crop Science Zhengzhou 450046China Henan Plant Health Protection Technology Engineering Research Center Zhenzhou 450046China

Fusarium pseudograminearum is a devastating pathogen that causes Fusarium crown rot(FCR)in wheat and poses a significant threat to wheat production in terms of grain yield and ***,the mechanism by which *** infects wheat remains *** this study,we aimed to elucidate these mechanisms by constructing a T-DNA insertion mutant library for the highly virulent strain WZ-8A of *** screening this mutant library,we identified nine independent mutants that displayed impaired pathogenesis in barley *** these mutants,one possessed a disruption in the gene FpRCO1 that is an ortholog of Saccharomyces cerevisiae RCO1,encoding essential component of the Rpd3S histone deacetylase complex in *** further investigate the role of FpRCO1 in ***,we employed a split-marker approach to knock out FpRCO1 in *** ***1 deletion mutants exhibit reduced vegetative growth,conidium production,and virulence in wheat coleoptiles and barley leaves,whereas the complementary strain restores these ***,under stress conditions,the FpRCO1 deletion mutants exhibited increased sensitivity to NaCl,sorbitol,and SDS,but possessed reduced sensitivity to H_(2)O_(2)compared to these characteristics in the wild-type ***-seq analysis revealed that deletion of FpRCO1 affected gene expression(particularly the downregulation of TRI gene expression),thus resulting in significantly reduced deoxynivalenol(DON)*** summary,our findings highlight the pivotal role of FpRCO1 in regulating vegetative growth and development,asexual reproduction,DON production,and pathogenicity of *** study provides valuable insights into the molecular mechanisms underlying *** infection in wheat and may pave the way for the development of novel strategies to combat this devastating disease.

关键词： Fusarium pseudograminearum T-DNA insertion Rpd3S complex FpRCO1 pathogenicity DON production

Approach of hybrid soft computing for agricultural data classification

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International Journal of Agricultural and Biological Engineering 2015年第6期8卷 54-61页

作者： Shi Lei Duan Qiguo Si Haiping Qiao Hongbo Zhang Juanjuan Ma Xinming College of Information and Management Science Henan Agricultural UniversityZhengzhou 450002China Collaborative Innovation Center of Henan Grain Crops Zhengzhou 450002China zhengzhou commodity exchange Zhengzhou 450008China

Soft computing is an important computational paradigm,and it provides the capability of flexible information processing to solve real world *** data classification is one of the important applications of computing technologies in agriculture,and it has become a hot topic because of the enormous growth of agricultural data *** vector machine is a powerful soft computing technique and it realizes the idea of structural risk minimization principle to find a partition hyperplane that can satisfy the class *** set theory is another famous soft computing technique to deal with vague and uncertain *** learning is an effective method to learn multiple learners and combine their decisions for achieving much higher prediction *** this study,the support vector machine,rough set and ensemble learning were incorporated to construct a hybrid soft computing approach to classify the agricultural *** experimental evaluation of different methods was conducted on public agricultural *** experimental results indicated that the proposed algorithm improves the performance of classification effectively.

关键词： agricultural data soft computing rough set support vector machine ensemble learning classification

Doping-driven dual heterogeneous interfacial structures boosting the durability of industry-compatible water splitting at high current density

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Science China Chemistry 2024年第10期67卷 3468-3481页

作者： Chunming Yang Lihai Zhou Zhijie Kong Xiang Li Wangchuan Zhu Guangqing Wang Yanzhong Zhen Feng Fu Yucang Liang Research Institute of Comprehensive Energy Industry Technology College of Chemistry&Chemical EngineeringYan’an UniversityYan’an 716000China Henan Key Laboratory of Crystalline Molecular Functional Materials Green Catalysis CenterCollege of ChemistryZhengzhou UniversityZhengzhou 450001China Institut für Anorganische Chemie Eberhard Karls UniversitätTübingen 72076Germany

Developing highly stable electrocatalysts under industry-compatible current densities(>500 mA cm^(-2))in an anion-exchange membrane water electrolyzer(AEMWE)is an enormous challenge for water ***,based on the results of density function theory calculations,a dual heterogeneous interfacial structured NiSe/Fe-Ni(OH)_(2)catalyst was subtly designed and successfully prepared by electrodepositing Fe-doped Ni(OH)_(2)on NiSe-loaded nickel foam(NF).Fe doping-driven heterogeneous structures in NiSe/Fe-Ni(OH)_(2)markedly boost catalytic activity and durability at industrially compatible current densities in single hydrogen and oxygen evolution reactions under alkaline *** particular,NiSe/Fe-Ni(OH)_(2)shows a negligible performance loss at 600 mA cm^(-2)at least 1,000 h for overall water splitting,a distinguished long-term durability acting as AEMWE electrodes at 600 mA cm^(-2)and 1 A cm^(-2)at 85℃for at least 95 *** to Fe doping-induced strong synergetic effect between Ni and Fe,dual heterostructure-promoted charge transfer and redistribution,abundant catalytic active sites,and improvement of stability and durability,a mechanism of Fe doping-driven heterogeneous interfacial structurepromoted catalytic performance was *** study provides a successful example of theory-directed catalyst preparation and pioneers a creative strategy for industry-compatible water splitting at high current density.

关键词： doping-induced heterojunction structure NiSe/Fe-Ni(OH)_(2) large current density anion-exchange membrane industrycompatible water electrolysis

Zeolites for the separation of ethylene,ethane,and ethyne

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Frontiers of Chemical Science and Engineering 2024年第9期18卷 137-146页

作者： Binyu Wang Qiang Li Haoyang Zhang Jia-Nan Zhang Qinhe Pan Wenfu Yan State Key Laboratory of Inorganic Synthesis&Preparative Chemistry College of ChemistryJilin UniversityChangchun 130012China Key Laboratory of Advanced Energy Catalytic and Functional Materials Preparation College of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450012China Key Laboratory of Advanced Materials of Tropical Island Resources(Ministry of Education) School of Chemistry and Chemical EngineeringHainan UniversityHaikou 570228China

The cost-effective separation of ethylene(C_(2)H_(4)),ethyne(C_(2)H_(2)),and ethane(C_(2)H_(6))poses a significant challenge in the contemporary chemical *** contrast to the energy-intensive high-pressure cryogenic distillation process,zeolite-based adsorptive separation offers a low-energy *** review provides a concise overview of recent advancements in the adsorptive separation of C_(2)H_(4),C_(2)H_(2),and C_(2)H_(6)using zeolites or zeolite-based *** commences with an examination of the industrial significance of these compounds and the associated separation ***,it systematically examines the utilization of various types of zeolites with diverse cationic species in such separation *** then it explores how different zeolitic structures impact adsorption and separation capabilities,considering principles such as cation-πinteraction,π-complexation,and steric separation concerning C_(2)H_(4),C_(2)H_(2),and C_(2)H_(6)***,it discusses methods to enhance the separation performance of zeolites and zeolite-based adsorbents,encompassing structural design,modifications,and ion exchange ***,it summarizes current research trends and future directions,highlighting the potential application value of zeolitic materials in the field of C_(2)H_(4),C_(2)H_(2),and C_(2)H_(6)separation and offering recommendations for further investigation.

关键词： zeolite ethylene ethane cation-πinteraction π-complexation

Covalent organic framework-based solid-state electrolytes for advanced batteries

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Science China Chemistry 2024年

作者： Desheng Feng Zhen Qin Yumei Ren Yuxi Xu School of Materials Science and Engineering Zhengzhou University of Aeronautics School of Engineering Westlake University

The emergence of solid-state batteries (SSBs) has generated significant interest in the field of energy storage, primarily due to their advantages such as high safety, high energy density and long lifetime. Solid state electrolytes (SSEs) play a crucial role in SSBs, which not only affects the ion transport efficiency, but also relates to the overall performance and stability of the *** recent years, SSEs based on covalent organic frameworks (COFs) have become a research focus in the battery field because of their unique structural characteristics and excellent performance. This review aims to provide an overview of the application and latest progress of COF-based SSEs in the field of advanced batteries. Firstly, the structural features of COFs and their advantages as SSEs are briefly introduced, followed by a summary of the types of COF-based SSEs (including neutral COF-based SSEs and ionic COF-based SSEs). The latest research progress in lithium ion batteries (LIBs), lithium metal batteries (LMBs), proton exchange membrane fuel cells (PEMFCs) and other advanced batteries recently is also discussed. Finally, we summarize and outlook the current research status, the challenges faced in practical application, the future research directions and application prospects of COF-based SSEs.

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Venoarterial extracorporeal membrane oxygenation in acute myocardial infarction

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Emergency and Critical Care Medicine 2024年第1期4卷 1-3页

作者： Junhui Xing Department of Cardiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina.

IntroductionMortality and complications associated with acute myocardial infarction(AMI)have gradually decreased in the era of reperfusion ***,the outcomes are still poor for AMI patients with severe complications.[1]The quest for further improvement of the use of active mechanical circulatory support(MCS)devices is rapidly *** extracorporeal membrane oxygenation(VA-ECMO)is a form of heart-lung bypass that offers temporary mechanical support and simultaneous extracorporeal gas exchange,usually acting as a bridge to *** has been widely used since 1972,after its *** extracorporeal membrane oxygenation provides cardiopulmonary support and is used to rescue patients with cardiopulmonary *** use of VA-ECMO after AMI with severe complications is *** studies have demonstrated a significant increase in survival using VA-ECMO in patients with AMI,and early VA-ECMO initiation yields better *** review article is aimed at evaluating the use of VA-ECMO in patients with AMI.[2]

关键词： extracorporeal infarction arterial