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Heat stress affects mammary metabolism by influencing the plasma flow to the glands

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Journal of Animal Science and Biotechnology 2024年第5期15卷 1908-1917页

作者： Jia Zeng Diming Wang Huizeng Sun Hongyun Liu Feng‑Qi Zhao Jianxin Liu Institute of dairy Science College of Animal SciencesZhejiang UniversityHangzhouChina zhejiang key laboratory of dairy cow genetic improvement and milk quality research Zhejiang UniversityHangzhouChina Department of Animal&Veterinary Sciences University of VermontBurlingtonVTUSA

Background Environmental heat stress(HS)can have detrimental effects on milk production by compromising the mammary *** plasma flow(MPF)plays a crucial role in nutrient supply and uptake in the mam-mary *** this experiment,we investigated the physiological and metabolic changes in high-yielding cows exposed to different degrees of HS:no HS with thermal-humidity index(THI)below 68(No-HS),mild HS(Mild-HS,68≤THI≤79),and moderate HS(Mod-HS,79dairy cows was greater(Pcows under *** supply and consumption exhibited similar changes to the MPF under different HS,with no difference in ratio of oxygen consumption to supply(P=0.46).The mammary arterio-vein differences in glucose concentration were lower(Pdairy *** output from this study may help us to develop strategies to mitigate the impact of different degrees of HS on milk production.

关键词： dairy cow Heat stress Mammary metabolism Mammary plasma flow

Factors affecting early embryonic development in cattle:relevance for bovine cloning

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Frontiers of Agricultural Science and Engineering 2019年第1期6卷 33-41页

作者： Yanna DANG Kun ZHANG laboratory of Mammalian Molecular Embryology Institute of Dairy ScienceCollege of Animal SciencesZhejiang University

Female infertility represents a major challenge for improving the production ef?ciency in the dairy industry. Historically, fertility has declined whereas milk yield has increased tremendously due to intensive genetic selection. In vivo evidence reveals about 60% pregnancy loss takes place during the ?rst month following fertilization. Meanwhile, early embryo development is signi?cant for somatic cell nuclear transfer in cattle as a large proportion of cloned embryos fail to develop beyond periimplantation stage. Oocyte quality is of utmost importance for the early embryo to develop to term for both fertilized and cloned embryos. Epigenetic reprogramming is a key process occurring after fertilization and critical roles of epigenetic modi?ers during preimplantation development are now clear. Incomplete epigenetic reprogramming is believed to be a major limitation to cloning ef?*** of cloned embryos with epigenetic modifying drugs(e.g., Trichostatin A) could greatly improve cloning ef?ciency in both mice and cattle. Recently, the rapid progress in high-throughput sequencing technologies has enabled detailed deciphering of the molecular mechanisms underlying these events. The robust ef?ciency of genomic editing tools also presents an alternative approach to the functional annotation of genes critical to early development.

关键词： bovine cloning embryo development somatic cell nuclear transfer X-inactive specific transcript

Harnessing male germline epigenomics for the genetic improvement in cattle

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Journal of Animal Science and Biotechnology 2023年第5期14卷 1834-1853页

作者： Xiao Wang Wenlong Li Xia Feng Jianbin Li George E.Liu Lingzhao Fang Ying Yu laboratory of Animal genetics and Breeding Ministry of Agriculture and Rural Affairs of ChinaNational Engineering Laboratory of Animal BreedingCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China Konge Larsen ApS Kongens Lyngby 2800Denmark Institute of Animal Science and Veterinary Medicine Shandong Academy of Agricultural SciencesJinan 250100China Animal Genomics and improvement laboratory Agricultural Research ServiceHenry A.Wallace Beltsville Agricultural Research CenterUSDABeltsvilleMD 20705USA Center for Quantitative genetics and Genomics Aarhus UniversityAarhus 8000Denmark

Sperm is essential for successful artificial insemination in dairy cattle,and its quality can be influenced by both epi-genetic modification and epigenetic *** bovine germline differentiation is characterized by epigenetic reprogramming,while intergenerational and transgenerational epigenetic inheritance can influence the offspring’s development through the transmission of epigenetic features to the offspring via the ***,the selec-tion of bulls with superior sperm quality for the production and fertility traits requires a better understanding of the epigenetic mechanism and more accurate identifications of epigenetic *** have comprehensively reviewed the current progress in the studies of bovine sperm epigenome in terms of both resources and biological discovery in order to provide perspectives on how to harness this valuable information for genetic improvement in the cattle breeding industry.

关键词： Artificial insemination Cattle Epigenetic inheritance genetic improvement Germline epigenomics

Effects of Meteorological Factors on Overwintering Ability,Yield and quality of Forage Rape

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Agricultural Biotechnology 2021年第3期10卷 15-21,25页

作者： Yao ZHANG Junzhu GE Guangsheng ZHOU Xidong WU Yong an YANG Haipeng HOU Qian LIANG Zhiqi MA College of Agronomy&Resources and Environment Tianjin Agricultural UniversityTianjin 300392China National key Lab of Crop genetic improvement Huazhong Agricultural UniversityWuhan 430070China Tianjin High quality Agricultural Products Development Demonstration Center Tianjin 300061China Tianjin Planting Industry Development Service Center Tianjin 300061China

In order to investigate the effects of meteorological factors on rape overwintering ability,forage yield and quality of rape in the North China plain,Brassia campestris *** Brassica napus *** used in this *** results showed that compared with the *** ***,the growth period of *** *** shortened by 10-15 d,the overwintering rate(WR)increased by 50.6%,and the density after winter(PD)increased by 41.5%.The fresh forage yield(FFY)and dry forage yield(DFY)of the *** *** significantly increased by 40.9%and 38.1%compared with the *** ***.,respectively,while the forage quality of the *** *** rape was significantly better than that of the *** *** with the *** ***,the crude protein(CP),fat,ash and total fatty acid(TFA)contents of the *** *** of rape increased by 27.6%,42.9%,23.9%and 52.3%,respectively,and the milk productivity(HM),relative forage value(RFV)and relative forage quality(RFQ)increased by 14.0%,16.2%and 42.1%,*** light and heat resources before wintering increased the WR and PD(P0.05),and lower temperature during the wintering period led to lower WR(P0.05).The contents of CP,fat and TFA of rape had an extremely significant negative correlation with the temperature and sunshine hours before wintering,but an extremely significant positive correlation with the temperature during the wintering period and after regreening,as well as the sunshine hours and rainfall during the wintering period;and HM had an extremely significant positive correlation with the temperature,sunshine hours and rainfall during the wintering period,while RFV and RFQ were only extremely significantly positively correlated with the maximum temperature and *** summary,in the North China Plain

关键词： Forage rape Meteorological factors Wintering ability Forage yield Forage quality

A post-GWAS confirming the genetic effects and functional polymorphisms of AGPAT3 gene on milk fatty acids in dairy cattle

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Journal of Animal Science and Biotechnology 2021年第1期12卷 122-140页

作者： Lijun Shi Xin Wu Yuze Yang Zhu Ma Xiaoqing Lv Lin Liu Yanhua Li Feng Zhao Bo Han Dongxiao Sun Department of Animal genetics Breeding and ReproductionCollege of Animal Science and TechnologyKey Laboratory of Animal GeneticsBreeding and Reproduction of Ministry of Agriculture and Rural AffairsNational Engineering Laboratory for Animal BreedingChina Agricultural UniversityNo.2 Yuanmingyuan West RoadHaidian DistrictBeijing 100193China Institute of Animal Science Chinese Academy of Agricultural SciencesBeijing 100193China Beijing General Station of Animal Husbandry Beijing 100101China Beijing dairy Cattle Center Beijing 100192China.

Background: People are paying more attention to the healthy and balanced diet with the improvement of their living standards. milk fatty acids(FAs) have been reported that they were related to some atherosclerosis and coronary heart diseases in human. In our previous genome-wide association study(GWAS) on milk FAs in dairy cattle, 83 genomewide significant single nucleotide polymorphisms(SNPs) were detected. Among them, two SNPs, ARS-BFGL-NGS-109493 and BTA-56389-no-rs associated with C18 index(P = 0.0459), were located in the upstream of 1-acylglycerol-3-phosphate O-acyltransferase 3(AGPAT3) gene. AGPAT3 is involved in glycerol-lipid, glycerol-phospholipid metabolism and phospholipase D signaling pathways. Hence, it was inferred as a candidate gene for milk FAs. The aim of this study was to further confirm the genetic effects of the AGPAT3 gene on milk FA traits in dairy ***: Through re-sequencing the complete coding region, and 3000 bp of 5′ and 3′ regulatory regions of the AGPA T3 gene, a total of 17 SNPs were identified, including four in 5′ regulatory region, one in 5′ untranslated region(UTR),three in introns, one in 3′ UTR, and eight in 3′ regulatory region. By the linkage disequilibrium(LD) analysis with Haploview4.1 software, two haplotype blocks were observed that were formed by four and 12 identified SNPs,respectively. Using SAS9.2, we performed single locus-based and haplotype-based association analysis on 24 milk FAs in 1065 Chinese Holstein cows, and discovered that all the SNPs and the haplotype blocks were significantly associated with C6:0, C8:0 and C10:0(P A, g.146704373 A > G, g.146704618 A > G and g.146704699 G > A) changed the transcription factor binding sites(TFBSs) for transcription factors SMARCA3, REX1, VMYB, BRACH, NKX26, ZBED4, SP1, USF1, ARNT and FOXA1. Out of them, two SNPs were validated to impact transcriptional ac

关键词： AGPAT3 Chinese Holstein genetic effects milk fatty acids Potential causal mutation

Genome-wide association studies of lactation yields of milk, fat, protein and somatic cell score in New Zealand dairy goats

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Journal of Animal Science and Biotechnology 2020年第4期11卷 937-949页

作者： Megan Scholtens Andrew Jiang Ashley Smith Mathew Littlejohn Klaus Lehnert Russell Snell Nicolas Lopez-Villalobos Dorian Garrick Hugh Blair AL Rae Centre for genetics and Breeding School of AgricultureMassey UniversityPalmerston NorthNew Zealand Applied Translational genetics Group School of Biological SciencesThe University of AucklandAucklandNew Zealand research and Development Livestock Improvement CorporationRuakura RoadHamiltonNew Zealand.

Background: Identifying associations between genetic markers and traits of economic importance will provide practical benefits for the dairy goat industry, enabling genomic prediction of the breeding value of individuals, and facilitating discovery of the underlying genes and mutations. Genome-wide association studies were implemented to detect genetic regions that are significantly associated with effects on lactation yields of milk(MY), fat(FY),protein(PY) and somatic cell score(SCS) in New Zealand dairy ***: A total of 4,840 goats were genotyped with the Caprine 50 K SNP chip(Illumina Inc., San Diego, CA).After quality filtering, 3,732 animals and 41,989 SNPs were analysed assuming an additive linear model. Four GWAS models were performed, a single-SNP additive linear model and three multi-SNP Bayes C models. For the single-SNP GWAS, SNPs were fitted individually as fixed covariates, while the Bayes C models fit all SNPs simultaneously as random effects. A cluster of significant SNPs were used to define a haplotype block whose alleles were fitted as covariates in a Bayesian model. The corresponding diplotypes of the haplotype block were then fit as class variables in another Bayesian ***: Across all four traits, a total of 43 genome-wide significant SNPs were detected from the SNP GWAS. At a genome-wide significance level, the single-SNP analysis identified a cluster of variants on chromosome 19 associated with MY, FY, PY, and another cluster on chromosome 29 associated with SCS. Significant SNPs mapped in introns of candidate genes(45%), in intergenic regions(36%), were 0–5 kb upstream or downstream of the closest gene(14%) or were synonymous substitutions(5%). The most significant genomic window was located on chromosome 19 explaining up to 9.6% of the phenotypic variation for MY, 8.1% for FY, 9.1% for PY and 1% for ***: The quantitative trait loci for yield traits on chromosome 19 confirms reported findings in other dairy goat p

关键词： dairy goat GWAS milk production New Zealand QTL

genetic advancements and future directions in ruminant livestock breeding: from reference genomes to multiomics innovations

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Science China Life Sciences 2024年

作者： Songsong Xu Zhanerke Akhatayeva Jiaxin Liu Xueyan Feng Yi Yu Bouabid Badaoui Ali Esmailizadeh Juha Kantanen Marcel Amills Johannes A. Lenstra Anna M. Johansson David W. Coltman George E. Liu Ino Curik Pablo Orozco-terWengel Samuel R. Paiva Natalia A. Zinovieva Linwei Zhang Ji Yang Zhihong Liu Yachun Wang Ying Yu Menghua Li Faculty of Veterinary Medicine Utrecht University Department of Animal Breeding and genetics Faculty of Veterinary Medicine and Animal Science Swedish University of Agricultural Sciences Department of Biological Sciences University of Alberta Edmonton Department of Biology Western University Animal Genomics and improvement laboratory BARC USDA-ARS Department of Animal Science Faculty of Agriculture University of Zagreb Institute of Animal Sciences Hungarian University of Agriculture and Life Sciences (MATE) School of Biosciences Cardiff University Embrapa genetic Resources and Biotechnology Laboratory of Animal Genetics L.K. Ernst Federal Science Center for Animal Husbandry Moscow Region Frontiers Science Center for Molecular Design Breeding (MOE) Department of Neurology China-Japan Friendship Hospital College of Animal Science Inner Mongolia Agricultural University Sanya Institute of China Agricultural University State key laboratory of Animal Biotech Breeding College of Animal Science and Technology China Agricultural University Institute of Grassland research Chinese Academy of Agricultural Sciences laboratory of Biodiversity Ecology and Genome Department of Biology Faculty of Sciences Rabat Mohammed V University Department of Animal Science Faculty of Agriculture Shahid Bahonar University of Kerman Production Systems Natural Resources Institute Finland (Luke) Department of Animal genetics Center for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB-UB Campus de la Universitat Autònoma de Barcelona Departament de Ciència Animal i dels Aliments Universitat Autònoma de Barcelona

Ruminant livestock provide a rich source of products, such as meat, milk, and wool, and play a critical role in global food security and nutrition. Over the past few decades, genomic studies of ruminant livestock have provided valuable insights into their domestication and the genetic basis of economically important traits, facilitating the breeding of elite varieties. In this review, we summarize the main advancements for domestic ruminants in reference genome assemblies, population genomics, and the identification of functional genes or variants for phenotypic traits. These traits include meat and carcass quality, reproduction, milk production, feed efficiency, wool and cashmere yield,horn development, tail type, coat color, environmental adaptation, and disease resistance. Functional genomic research is entering a new era with the advancements of graphical pangenomics and telomere-to-telomere(T2T) gap-free genome assembly. These advancements promise to improve our understanding of domestication and the molecular mechanisms underlying economically important traits in ruminant livestock. Finally, we provide new perspectives and future directions for genomic research on ruminant genomes. We suggest how ever-increasing multiomics datasets will facilitate future studies and molecular breeding in livestock, including the potential to uncover novel genetic mechanisms underlying phenotypic traits, to enable more accurate genomic prediction models, and to accelerate genetic improvement programs.

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Effects of dairy bioactive peptides and lotus seeds/lily bulb powder on flavor and quality characteristics of goat milk yogurt

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Food Bioscience 2022年第3期47卷 442-449页

作者： Xinqi Zhao Ming Cheng Cunfang Wang Hua Jiang Xiaoning Zhang College of Food Science and Engineering Qilu University of Technology (Shandong Academy of Sciences)Jinan250353China Qingdao research Institute of Husbandry and Veterinary Qingdao266100China

The objective of this study was to evaluate the changes on flavor and quality characteristics of goat yogurt during storage with the addition of dairy bioactive peptides and a mixture of lotus seed and lily bulb *** the addition of dairy bioactive peptides and lotus seeds/lily bulb powder resulted in a fermentation time reduction,water holding capacity(WHC)improvement,and inhibition of post-acidification of goat yogurt during storage.A total of 50 volatile flavor components were detected in the goat milk yogurt samples,and the addition of the above two supplements were shown to be effective in improving the flavor and the textural properties of the goat milk yogurt during *** group added with lotus seeds/lily bulb powder showed the best WHC and textural properties,followed by the group added with dairy bioactive peptides alone and the group with both *** addition of both supplements was found to be useful in making up for the two defects of goat yogurt,prolonged fermentation and soft ***,dairy bioactive peptides and lotus seeds/lily bulb powder are recommended to be added to goat yogurt as nutritional supplements.

关键词： Lotus seeds/lily bulb powder dairy bioactive peptides Goat yogurt GC-IMS Texture properties