检索结果-南通市图书馆

Copper ion/gallic acid MOFs-laden adhesive pomelo peel sponge effectively treats biofilm-infected skin wounds and improves healing quality

引用

Bioactive Materials 2024年第2期32卷 260-276页

作者： Jianqiu Yang Zhenzhen Huang Jiang Tan Jingye Pan Shixuan Chen Wenbing Wan Department of Orthopaedic Surgery The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China zhejiang engineering research center for Tissue Repair Materials Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang 325000China Key Laboratory of Intelligent Treatment and Life Support for Critical Diseases of zhejiang Province The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325000China zhejiang engineering research center for hospital emergency and process digitization The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325000China

Bacterial infection and scar formation remain primary challenges in wound *** address these issues,we developed a decellularized pomelo peel(DPP)functionalized with an adhesive PVA-TSPBA hydrogel and antibacterial gallic acid/copper *** hybrid wound dressing demonstrates favorable *** does not impede the proliferation of fibroblasts or immune cells and can stimulate fibroblast migration,endothelial angiogenesis,and M2 macrophage ***,the dressing can scavenge reactive oxygen species(ROS)and provide antioxidant ***,DPP+MOF@Gel effectively inhibits the viability of *** and *** in vitro and in *** histological observations revealed enhanced granulation tissue formation,re-epithelialization,and angiogenesis in the DPP+MOF@Gel group compared to other *** local immune response also shifted from a pro-inflammatory to a pro-regenerative status with DPP+MOF@Gel *** skin incision stitching experiment further exhibits DPP+MOF@Gel could reduce scar formation during wound *** together,the hybrid DPP+MOF@Gel holds great promise for treating bacteria-infected skin wounds and inhibiting scar formation during wound healing.

关键词： Wound healing Decellularized pomelo peel Bacteria infection Granulation tissue formation Scar formation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ellipsoidal porous patch with anisotropic cell inducing ability for inhibiting skin scar formation

引用

Engineered Regeneration 2022年第3期3卷 262-269页

作者： Wanqing Weng Junjie Chi Xiaocheng Wang Keqing Shi Fangfu Ye Yuanjin Zhao Joint center of Translational Medicine The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325035China Department of Clinical Laboratory Nanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Oujiang Laboratory(zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325001China Key Laboratory of Intelligent Treatment and Life Support for Critical Diseases of zhejiang Provincial Zhejiang Engineering Research Center for Hospital Emergency and Process DigitizationWenzhouZhejiang 325000China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

Scar formation has always been a difficult point to overcome in the field of clinical wound ***,we present an ellipsoidal porous patch with cell inducing ability for inhibiting scar *** patch was prepared by stretching a poly(lactic-co-glycolic acid)(PLGA)inverse opal film at the glass transition temperature to form a neatly arranged three-dimensional ellipsoidal porous *** anisotropic structure showed dramatic capability in directing cell growth and arrangement by reconstructing cell ***,the prolifera-tion of cells growing on the stretched patch was significantly suppressed without cell *** addition,benefitting from the abundant and connected nanopores,the patch could be imparted with a potent ability to promote cell migration by encapsulating fibroblast growth factor 2(FGF2)via the second filling of functional gelatin methacryloyl(GelMA)hydrogel into its *** a typical scar model,we have demonstrated that the resultant patch performed well in inhibiting scar formation characterized by inhibiting the excessive proliferation of fibroblasts,decreasing the deposition of type I collagen,reducing the scar index and achieved complete tissue *** results indicate the anisotropic inverse opal patch has an excellent application prospect in inhibiting scar formation during wound repair.

关键词： Inverse opal Biomaterial Porous film Hypertrophic scar Anisotropy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：