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Contact engineering for temperature stability improvement of Bi-contacted MoS2 field effect transistors

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Science China(Information Sciences) 2024年第6期67卷 172-179页

作者： Zizheng LIU Qing ZHANG Xiaohe HUANG Chunsen LIU Peng ZHOU State Key Laboratory of Integrated Chip and Systems School of MicroelectronicsZhangjiang Fudan International Innovation CenterFudan University Frontier institute of Chip and System Shanghai Key Lab for Future Computing Hardware and SystemFudan University Shaoxin Laboratory

Semimetallic bismuth（Bi） is one of the most effective strategies for reducing the contact resistance of two-dimensional transition metal dichalcogenide field effect transistors（FETs）. However, the low melting point of Bi contact（271.5℃） limits its reliable applications. In this study, we demonstrated that the temperature stability of Bi-contacted electrodes could be improved by inserting a high-melting point semimetallic antimony（Sb） between the Bi contacting layer and the gold（Au） capping layer. The proposed Bi/Sb/Au contact electrodes tended to form a metal mixture with a continuous surface during the heating process（Voids appeared on the surface of the Bi/Au contact electrodes after heating at 120℃）. Because of the improved contacting layer formed by the semimetal Bi/Sb alloy, the fabricated Bi/Sb/Au-contacted molybdenum sulfide（MoS2） FETs with different gate lengths demonstrated higher on-state current stability after heating treatment than the Bi/Au contact. Because of the Bi/Sb/Au contact and poly（methyl methacrylate） package, the MoS2FETs demonstrated time stability of at least two months from the almost unchanged transfer characteristics. The electrical stability indicates that the insertion of semimetallic Sb is a promising technology for reliable Bi-based contact.

关键词： temperature stability semimetallic bismuth contact semimetallic antimony contact MoS2 FETs time stability

Clinical applications of neurolinguistics in neurosurgery

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Frontiers of Medicine 2021年第4期15卷 562-574页

作者： Peng Wang Zehao Zhao Linghao Bu Nijiati Kudulaiti Qiao Shan Yuyao Zhou N.U.Farrukh Hameed Yangming Zhu Lei Jin Jie Zhang Junfeng Lu Jinsong Wu Glioma Surgery Division Neurologic Surgery DepartmentHuashan HospitalFudan UniversityShanghai 200040China Brain Function Laboratory Neurosurgical Institute ofFudan UniversityShanghai 201100China institute of Brain-Intelligence Technology Zhangjiang LabShanghai 200135China

The protection of language function is one of the major challenges of brain *** the past century,neurosurgeons have attempted to seek the optimal strategy for the preoperative and intraoperative identification of language-related brain *** have investigated the neural mechanism of language,developed neurolinguistics theory,and provided unique evidence to further understand the neural basis of language functions by using intraoperative cortical and subcortical electrical *** the emergence of modern neuroscience techniques and dramatic advances in language models over the last 25 years,novel language mapping methods have been applied in the neurosurgical practice to help neurosurgeons protect the brain and reduce *** rapid advancements in brain-computer interface have provided the perfect platform for the combination of neurosurgery and *** this review,the history of neurolinguistics models,advancements in modern technology,role of neurosurgery in language mapping,and modern language mapping methods(including noninvasive neuroimaging techniques and invasive cortical electroencephalogram)are presented.

关键词： neurolinguistics language mapping dual pathway model neurosurgery

Safety, pharmacokinetics, and biomarkers of F-652, a recombinant human interleukin-22 dimer, in healthy subjects

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Cellular & Molecular Immunology 2019年第5期16卷 473-482页

作者： Kai-Yang Tang Jason Lickliter Zhi-Hua Huang Zong-Shu Xian Han-Yang Chen Cheng Huang Chong Xiao Yu-Peng Wang Ying Tan Lin-Feng Xu Yu-Liang Huang Xiao-Qiang Yan Generon(Shanghai)Corporation Ltd. Zhangjiang Hi-Tech ParkShanghaiChina Nucleus Network MelbourneVICAustralia

F-652 is a recombinant fusion protein consisting of two human interleukin-22(IL-22)molecules linked to an immunoglobulin constant region(IgG 2-Fc).IL-22 plays critical roles in promoting tissue repair and suppressing bacterial *** safety,pharmacokinetics(PK),tolerability,and biomarkers of F-652 were evaluated following a single dose in healthy male volunteers in a randomized,double-blind,placebo-controlled *** single-dose subcutaneous(SC)injection of F-652 at 2.0µg/kg into healthy subjects,six out of six subjects experienced delayed injection site reactions,which presented as erythematous and/or discoid eczematous lesions 10 to 17 days post-dosing.F-652 was then administered to the healthy subjects via an intravenous(IV)infusion at 2.0,10,30,and 45µg/*** severe adverse event(SAE)was observed during the *** the IV-dosed cohorts,eye and skin treatment emergent adverse events(TEAEs)were observed in the 30 and 45µg/kg cohorts.F-652 IV dosing resulted in linear increases in C max and AUC(0–t),and the T 1/2 ranged from 39.4 to 206h in the *** IV injection of F-652 induced dose-dependent increases in serum marker serum amyloid A,C-reactive protein,and FIB,and decreased serum *** serum levels of 36 common pro-inflammatory cytokines/chemokines were not altered by the treatment of F-652 at 45μg/*** conclusion,IV administration of F-652 to healthy male volunteers is safe and well-tolerated and demonstrates favorable PK and pharmacodynamic *** results warrant further clinical development of F-652 to treat inflammatory diseases.

关键词： Interleukin-22 F-652 Pharmacokinetics Pharmacodynamics Safety

Nickel-Catalyzed Regio-and Stereoselective Defluorinative Arylation of gem-Difluorinated Cyclopropanes

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Chinese Journal of Chemistry 2024年第8期42卷 823-828页

作者： Shutao Qi Yunkai Hua Liangkai Pan Junfeng Yang Junliang Zhang Department of Chemistry Fudan University2005 Songhu RoadShanghai200438 China Fudan zhangjiang institute Shanghai201203 China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiangHenan 453007China

Comprehensive Summary,Herein,we report nickel-catalyzed cross-coupling of gem-difluorinated cyclopropanes with boronic acids,providing the corresponding arylated 2-fluoroallylic *** approach used commercially available phosphine ligand Xantphos to obtain monofluorinated alkenes with high regioselectivity and *** studies proposed a Ni(II)-fluoroallyl pathway and excluded the radical pathway.

关键词： Nickel Monofluoroolefin Cyclopropane Regioselectivity Stereoselectivity C-C coupling Cross-coupling Synthetic methods

Ultrahigh density inside a nanobubble

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Science China(Physics,Mechanics & Astronomy) 2020年第8期63卷 132-133页

作者： HaiPing Fang Department of Physics East China University of Science and TechnologyShanghai 200237China zhangjiang Laboratory Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China

Gas bubbles are very common in our daily life and are often seen in water and *** a large gas bubble in a liquid,the pressure differenceΔP within and outside the bubble is governed by the Laplace equationΔP=γ/R,whereγis the surface tension at the interface between the bubble and liquid,and R is the bubble ***,for tiny bubbles.

关键词： bubble governed interface

Understand the Temperature Sensing Behavior of Solid-state Polymerized PEDOT Hybrid Based on X-ray Scattering Studies

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Chinese Journal of Polymer Science 2024年第1期42卷 105-112,I0010页

作者： Zhen-Hang He Guang-Feng Liu Ze-Kun Zhou Zhen Liu Yi-Shu Zeng Peng Zhang School of Materials Science and Engineering Key Laboratory for Polymeric Composite and Functional Materials of Ministry of EducationSun Yat-sen UniversityGuangzhou 510275China Shanghai Advanced Research institute(zhangjiang Laboratory) Chinese Academy of SciencesShanghai 201204China

Poly(3,4-ethylenedioxythiophene)(PEDOT) is one of the most successful conductive polymers that recently has been used in wearable sensors for human health monitoring. In this work, we prepared a series of PEDOT hybrids consisting of PEDOT, sodium poly(styrene sulfonate)(PSSNa) and polyethylene oxide(PEO), and their preparation could be scaled-up via an adapted solid-state polymerization process. The resistance of the as-prepared PEDOT:PSS/PEO hybrid shows clear temperature response, i.e., it decreases almost linearly with the temperature increase. To understand this phenomenon, the in situ synchrotron radiation wide-and small-angle X-ray scattering(WAXS/SAXS) characterizations were undertaken to study the temperature-dependent microstructure change of the PEDOT:PSS/PEO hybrid. It demonstrated that PEDOT formed conductive paths in the hybrids, which were not destroyed by the PEO crystallization. As temperature increased, the PEO crystals' melting and the accompanying reorganization of PEDOT chains endowed the hybrid sample temperature responsiveness. Based on these fundamental knowledges, the hybrid materials were used to fabricate flexible wearable sensor that showing temperature sensing performance with an accuracy of 1 ℃. These findings shed lights on the scalable manufacturing of wearable sensors for body temperature monitoring.

关键词： Solid-state polymerization PEDOT hybrid Structure-property correlation X-ray scattering

VEGF, HIF-1α, and Metabolic Indicators in Esophageal Squamous Cell Carcinoma

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Proceedings of Anticancer Research 2024年第2期8卷 7-12页

作者： Yangyan Chen Shanghai zhangjiang institute of Medical Innovation Shanghai 201204China

Objective:To explore and analyze the expression and clinical significance of vascular endothelial growth factor(VEGF),hypoxia-inducible factor 1α(HIF-1α),and metabolic indicators in esophageal squamous cell carcinoma(ESCC).Methods:Sixty ESCC patients admitted to the hospital from October 2021 to October 2023 were selected as the ESCC *** normal healthy patients from the same period were chosen as the control *** serum samples and tissue samples were *** indicators of all study subjects were obtained based on the basic biochemical results upon ***-PCR was utilized to detect the expression of VEGF and HIF-1αin ESCC ***:The expression of VEGF and HIF-1αin the ESCC T3+T4 group was significantly higher than that of the carcinoma in situ(Tis)group,T1+T2 group,and control ***,the expression of HIF-1αwas found to be related to the expression of VEGF,showing a significant correlation between the *** differences in the levels of metabolic indicators were observed between the ESCC group and the control group(P<0.05).Conclusion:Metabolic indicators are associated with the onset of ESCC in *** lipid metabolism plays a crucial role in the occurrence and development of *** expression of VEGF and HIF-1αin ESCC tissues significantly correlates with the tumor stage,providing a new reference for the diagnosis and treatment of ESCC.

关键词： VEGF HIF-1α Metabolic index Esophageal squamous cell carcinoma(ESCC)

High Performance Microwave Absorption Material Based on Metal-Backboned Polymer

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Chinese Journal of Polymer Science 2024年第12期42卷 1881-1887,I0006页

作者： Jia-Ning Xu Kai-Wen Zeng Yi-Feng Zhang Yi-Bei Yang Zi-Wei Liu Yue Liu Jia-Jia Wang Kai-Lin Zhang Yan-Ru-Zhen Wu Hao Sun Hui-Sheng Peng State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceInstitute of Fiber Materials and Devicesand Laboratory of AdvancedMaterialsFudanUniversityShanghai200438China Frontiers Science Center for Transformative Molecules Schoolof Chemistry and Chemical Engineeringand Zhangjiang Institute for Advanced StudyShanghai JiaoTongUniversityShanghai200240China

Metal-backboned polymers with anisotropy microstructures are promising for conductive,optoelectronic,and magnetic functional ***,the structure-property relationships governing the interplay between the chemical structure and electromagnetic property of the metal-backboned polymer have been rarely *** we report a carbon/nickel hybrid from metal-backboned polymer to serve as electromagnetic wave-absorbing materials,which exhibit high microwave absorption capacity and tunable absorption *** presence of nickel backbones promote the generation of heterogeneous interfaces with carbon during calcination,thereby enhancing the wave-absorbing capacity of the carbon/nickel *** C/Ni hybrids show a minimal reflection loss of-49.1 dB at 13.04 GHz,and its frequency of the absorption band can be adjusted by controlling the thickness of the absorption layer.

关键词： Nickel Metal-backboned polymer Carbon Hybrid material

Selective Enrichment of Low-Abundance DNA Variants Based on Programmable Peptide Nucleic Acid Probes

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Chinese Journal of Chemistry 2024年第21期42卷 2572-2580页

作者： Yi Zhang Zhi Weng Zixuan Huang Qian Li Chunhai Fan Shihua Luo Ping Song School of Biomedical Engineering Zhangjiang Institute for Advanced Study and National Center for Translational MedicineShanghai Jiao Tong UniversityShanghai200240 China School of Chemistry and Chemical Engineering New Cornerstone Science LaboratoryFrontiers Science Center for Transformative MoleculesZhangjiang Institute for Advanced Study and National Center for Translational MedicineShanghai Jiao Tong UniversityShanghai200240 China Department of Traumatology Rui Jin HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200025 China

Single-nucleotide variants(SNVs)are crucial in disease development,but their accurate detection is challenging due to their low abundance and interference from wild-type *** nucleic acid analogs like peptide nucleic acids(PNAs)have been used for SNV detection,they often lack programmable sensitivity and specificity due to poorly calculated thermodynamics and ***,we present a computational method for calculating the stacking energy of PNA and DNA hybrids,leveraging nearest neighbor *** against experimental data from 16 sequences under varied hybridization conditions yielded good agreement using Bland-Altman analysis,with all data points falling within the confidence *** findings indicate that PNA-DNA hybridization is thermodynamically more stable and exhibits kinetics 140-fold faster than DNA-DNA hybridization for identical *** this computational framework,we designed PNA toehold probes,which were screened via simulations and *** combined approach facilitated the identification of highly sensitive and specific PNA toehold probes for single point mutation detection via strand displacement *** results demonstrate the successful application of PNA toehold probes for detecting point mutations with high sensitivity and specificity,achieving a selective amplification of approximately 200-fold for variants with a variant allele frequency(VAF)of 0.5%using quantitative polymerase chain reaction.

关键词： Peptide nucleic acids Thermodynamics Strand displacement reaction SNVs detection I Biosensors Nucleic Acids Kinetics