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Pericytes may facilitate SARS-CoV-2 entry into the nervous system

Journal of Bio-X Research 2023年第1期6卷 23-36页

作者： Zijian Kang Jing Wang Tong Meng Hao Zhang Da Xu Haiyi Gong Zhenyan Chang Zifu Li Xingang Cui Jianru Xiao Adnan I.qureshi Wang Zhou Jianmin Liu Huji Xua Department of Rheumatology and Immunology Changzheng Hospital Department of Neurosurgery Changhai HospitalSecond Military Medical University Division of Spine Department of OrthopedicsShanghai General HospitalSchool of MedicineShanghai Jiaotong University Tongji university Cancer Center School of MedicineTongji University Department of Orthopaedic Oncology Changzheng Hospital Department of Urology The Third Affiliated HospitalSecond Military Medical University Department of Pathology Shanghai Tenth People’s HospitalTongji University School of MedicineShanghaiChina zeenat qureshi stroke institutes and university of missouri ColumbiaMOUSA Peking-Tsinghua Center for Life Sciences School of Medicine Tsinghua UniversityBeijingChina

Objective:Although the neurological and olfactory symptoms of coronavirus disease 2019 have been identified,the neurotropic properties of the causative virus,severe acute respiratory syndrome-associated coronavirus 2(SARS-CoV-2),remain *** sought to identify the susceptible cell types and potential routes of SARS-CoV-2 entry into the central nervous system,olfactory system,and respiratory ***:We collected single-cell RNA data from normal brain and nasal epithelium specimens,along with bronchial,tracheal,and lung specimens in public *** susceptible cell types that express SARS-CoV-2 entry genes were identified using single-cell RNA sequencing and the expression of the key genes at protein levels was verified by *** compared the coexpression patterns of the entry receptor angiotensin-converting enzyme 2(ACE2)and the spike protein priming enzyme transmembrane serine protease(TMPRSS)/cathepsin L among the ***:The SARS-CoV-2 entry receptor ACE2 and the spike protein priming enzyme TMPRSS/cathepsin L were coexpressed by pericytes in brain tissue;this coexpression was confirmed by *** the nasal epithelium,ciliated cells and sustentacular cells exhibited strong coexpression of ACE2 and *** and glia in the brain and nasal epithelium did not exhibit coexpression of ACE2 and ***,coexpression was present in ciliated cells,vascular smooth muscle cells,and fibroblasts in tracheal tissue;ciliated cells and goblet cells in bronchial tissue;and alveolar epithelium type 1 cells,AT2 cells,and ciliated cells in lung ***:Neurological symptoms in patients with coronavirus disease 2019 could be associated with SARS-CoV-2 invasion across the blood-brain barrier via ***,SARS-CoV-2-induced olfactory disorders could be the result of localized cell damage in the nasal epithelium.

关键词： ACE2 coronavirus disease 2019 SARS-CoV-2 single-cell RNA sequencing TMPRSS2

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