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Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

Neural Regeneration Research 2025年第9期20卷 2598-2610页

作者： Yi Wang Yuning li Yakun Gu Wei Ma Yuying Guan Mengyuan Guo Qianqian Shao Xunming Ji Jia liu Department of Clinical Laboratory Beijing Bo’ai HospitalChina Rehabilitation Research CenterCapital Medical UniversityBeijingChina beijing institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this *** aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive *** found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic *** addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic *** phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic ***,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein *** ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein *** together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.

关键词： biomarker high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment

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Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

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Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： Yan li Peng Hao Hongmei Duan Fei Hao Wen Zhao Yudan Gao Zhaoyang Yang Kwok-Fai So Xiaoguang li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-HongKong-Macao institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation

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lithiophilic li-Si alloy-solid electrolyte interface enabled by high-concentration dual salt-reinforced quasi-solid-state electrolyte

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Journal of Energy Chemistry 2024年第8期95卷 216-230,I0005页

作者： Yuanxing Zhang ling Zhang Zhiguang Zhao Yuxiang Zhang Jingwen Cui Chengcai liu Daobin Mu Yuefeng Su Borong Wu Feng Wu School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Chongqing innovation Center Beijing Institute of TechnologyChongqing 401120China collaborative innovation Center of Electric Vehicles in beijing Beijing 100081China

Solid polymer electrolytes(SPEs)are urgently required to achieve practical solid-state lithium metal batteries(LMBs)and lithium-ion batteries(liBs),Herein,we proposed a mechanism for modulating interfacial conduction and anode interfaces in high-concentration SPEs by *** electrolyte exhibits superior ionic conductivity and remarkable interface compatibility with salt-rich clusters:(1)polymer-plastic crystal electrolyte(P-PCE,TPU-SN matrix)dissociates ion pairs to facilitate li+transport in the electrolyte and regulates li^(+)diffusion in the *** crosslinking structure of the matrix compensates for the loss of mechanical strength at high-salt concentrations;(2)dual-anion TFSI^(-)_(n)-DFBOP^(-)_(m)in the li^(+)solvation sheath facilitates facile li^(+)desolvation and formation of salt-rich clusters and is conducive to the formation of li conductive segments of TPU-SN matrix;(3)theoretical calculations indicate that the decomposition products of liDFBOP form SEI with lower binding energy with liF in the SN system,thereby enhancing the interfacial electrochemical redox kinetics of SPE and creating a solid interface SEI layer rich in *** a result,the optimized electrolyte exhibits an excellent ionic conductivity of9.31×10^(-4)S cm^(-1)at 30℃and a broadened electrochemical stability up to 4.73 *** designed electrolyte effectively prevents the formation of li dendrites in li symmetric cells for over 6500 h at0.1 mA cm^(-2).The specific li-Si alloy-solid state half-cell capacity shows 711.6 mAh g^(-1)after 60 cycles at 0.3 A g^(-1).Excellent rate performance and cycling stability are achieved for these solid-state batteries with li-Si alloy anodes and NCM 811 *** 811‖Prelithiated silicon-based anode solid-state cell delivers a discharge capacity of 195.55 mAh g^(-1)and a capacity retention of 97.8%after 120 *** 811‖li solid-state cell also delivers capacity retention of 84.2%after 450 cycles.

关键词： Prelithiation li-Si alloy anode Solid-state electrolyte SEI layer

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Reorganizing electronic structure of li3V2(PO4)3 using polyanion(BO3)^3-:towards better electrochemical performances

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Rare Metals 2017年第5期36卷 397-402页

作者： Yu li Ying Bai Zhi Yang Zhao-Hua Wang Shi Chen Feng Wu Chuan Wu School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China collaborative innovation Center of Electric Vehicles in beijing Beijing 100081China

Doping modification of electrode materials is a sought-after strategy to improve their electrochemical performance in the secondary batteries field. Herein,polyanion（BO3）^3-doped li3V2（PO4）3 cathode materials were successfully synthesized via a wet coordination method. The effects of（BO3）^3- doping content on crystal structure, morphology and electrochemical performance were explored by X-ray diffraction（XRD）, scanning electron microscopy（SEM）, cyclic voltammetry（CV） and electrochemical impedance spectroscopy（EIS）. All the asprepared samples have the same monoclinic structure;among them, li3V2（PO4）（2.75）（BO3）（0.15） sample has relatively uniform and optimized particle size. In addition, this sample has the highest discharge capacity and the best cycling stability, with an initial discharge capacity of 120.4mAh·g^-1, and after 30 cycles at a rate of 0.1C, the discharge capacity still remains 119.3 mAh·g^-1. It is confirmed that moderate polyanion（BO3）^3- doping can rearrange the electronic structure of the bulk li3V2（PO4）3,lower the charge transfer resistance and further improve the electrochemical behaviors.

关键词： lithium-ion batteries Cathode materials li3V2(PO4)3 Polyanion doping (BO3)^3-

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Mass‑Spring‑Damping Theory Based Equivalent Mechanical Model for Cylindrical lithium‑ion Batteries under Mechanical Abuse

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Chinese Journal of Mechanical Engineering 2020年第2期33卷 161-174页

作者： Wenwei Wang Yiding li Cheng lin Sheng Yang National Engineering Laboratory for Electric Vehicles Beijing Institute of TechnologyBeijing 100081China collaborative innovation Center of Electric Vehicles in beijing Beijing Institute of TechnologyBeijing 100081China

An equivalent mechanical model with the equivalent physical meaning of mass-spring-damping is proposed for cylindrical lithium-ion batteries through experiments and *** equivalent mechanical model of a cylindrical lithium-ion battery consists of a spring-damping parallel ***,a spring-damping parallel unit connecting a damping unit in series is selected to construct the constitutive characteristics of the battery under mechanical *** results show that the equivalent mechanical model can more effectively describe the mechanical properties of the batteries than most cubic fitting models,of which the average relative error of the equivalent mechanical model under different states-of-charge is less than 6.75%.Combined with the proposed equivalent mechanical model,the failure process of the batteries was simulated and analyzed using LS-Dyna and *** rigid rod tests,failure occurred at the core and bottom of the batteries;under hemispherical punch tests,failure occurred at the core and top,consistent with the experimental *** average prediction error for the failure displacement under different abuse conditions is less than 4%in the *** equivalent mechanical model requires only a few parameters and can be recognized *** the future,the model can be used in safety warning devices based on mechanical penetration.

关键词： Cylindrical lithium-ion battery Mass-spring-damping theory Equivalent mechanical model Mechanical abuse condition Failure analysis

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Research Progress of Refractory High Entropy Alloys:A Review

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Chinese Journal of Mechanical Engineering 2022年第6期35卷 1-22页

作者： Xiaochang Xie Neng li Wei liu Shuai Huang Xiaoyong He Qiuying Yu Huaping Xiong Enhui Wang Xinmei Hou collaborative innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China beijing institute of Aeronautical Materials Beijing 100095China

Owing to superior comprehensive performance than conventional superalloys at high temperature,refractory high entropy alloy(RHEA)is becoming a promising candidate for the next generation high-temperature ***,contemporary aspects of corresponding development of RHEAs are reviewed to discuss various factors affecting the organization structure and service *** mainly covers alloying system and strengthening mechanism,the preparation method,plastic deformation and the related mechanism,as well as microstructure control by heat ***,the alloy systems and strengthening mechanism are *** is followed by different preparation methods and the comparison of strengths and shortcomings based on different ***,hot deformation behavior and plastic deformation under different loadings are *** on this,the influence of heat treatment on microstructures prior to and after the deformation is further ***,some important research areas to be carried out in future are pointed *** review will give a deep understanding of the effects of different factors on the service performance and provide scientific guide in designing RHEAs with improved performance.

关键词： Refractory high entropy alloy Preparation method Strengthening Plastic deformation Heat treatment

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Effect of Cr/Mn segregation on pearlite–martensite banded structure of high carbon bearing steel

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International Journal of Minerals,Metallurgy and Materials 2021年第4期28卷 665-675页

作者： Yun-long Wang Yin-li Chen Wei Yu institute of Engineering Technology University of Science and Technology BeijingBeijing 100083China collaborative innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China

The effect of Cr/Mn segregation on the abnormal banded structure of high carbon bearing steel was studied by reheating and hot *** the use of an optical microscope, scanning electron microscope, transmission electron microscope, and electron probe microanalyzer, the segregation characteristics of alloying elements in cast billet and their relationship with hot-rolled plate banded structure were *** formation causes of an abnormal banded structure and the elimination methods were *** indicate the serious positive segregation of C, Cr, and Mn alloy elements in the *** distribution of Cr/Mn elements could not be achieved after 10 h of heat preservation at 1200℃, and the spacing of the element aggregation area increased, but the segregation index of alloy elements *** alloying element segregation characteristics are present in the banded structure of the hot-rolled *** distinct white band is composed of martensitic *** formation of this abnormal pearlite–martensite banded structure is due to the interaction between the undercooled austenite transformation behavior of hot-rolled metal and the segregation of its alloying *** the air cooling after rolling, controlling the segregation index of alloy elements can reduce or eliminate the abnormal banded structure.

关键词： high carbon bearing steel elements segregation homogenization banded structure

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Effects of Cr content on corrosion behaviour and corrosion products of spring steels

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Journal of Iron and Steel Research International 2019年第9期26卷 1000-1010页

作者： Mao-fang Zuo Yin-li Chen Zhen-li Mi Yi-de Wang Hai-tao Jiang institute of Engineering Technology University of Science and Technology BeijingBeijing 100083China collaborative innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China

Neutral salt spray corrosion experiments of spring steels with different Cr contents were carried out for different corrosion periods. The optical microscope was used to observe the macroscopic corrosion morphology of the steel surface. The corrosion pit morphology of steel surface was observed by laser scanning confocal microscopy and scanning electron microscopy, and three-dimensional simulation was carried out. At the same time, the corrosion products (rust layer) were qualitatively and quantitatively analysed by X-ray diffraction. As the results show, Cr is beneficial to improving corrosion resistance of the experimental steel matrix, and the higher the content of Cr, the stronger the corrosion resistance will be. With increase in Cr content in steel, the development of corrosion process will be more effectively suppressed. With the increase in Cr content, the denser the corrosion products, the stronger the bond with the metal matrix is. The corrosion products have obvious stratification;the outer layer is mainly composed of c-FeOOH, which is relatively loose and not firmly integrated with the matrix, while the inner layer contains a-FeOOH and Fe3O4, which are relatively dense and closely integrated with the matrix. The types of corrosion are constantly changing during different phases of corrosion.

关键词： Spring steel Cr content Corrosion behaviour Corrosion product Rust layer

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Comparative calculation on li^+ solvation in common organic electrolyte solvents for lithium ion batteries

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Chinese Physics B 2020年第4期29卷 49-57页

作者： Qi liu Feng Wu Daobin Mu Borong Wu beijing Key Laboratory of Environment Science and Engineering School of Material Science and EngineeringCollaborative Innovation Center of Electric Vehicles in BeijingBeijing Institute of TechnologyBeijing 100081China

It is important for the electrolytes to maintain and enhance the lithium ion battery electrochemical performance,and solvation of li^+is a key parameter for the property of the *** comparative study on li^+ solvation structures,energy,enthalpy,Gibbs free energy,infrared and Raman spectra in common organic electrolyte solvents is completed by density functional theory(DFT)*** solvation reaction energy results suggest that the li^+solvation priority order is propylene carbonate(PC)>ethylene carbonate(EC)>ethyl methyl carbonate(EMC)>diethyl carbonate(DEC)>tetrahydrofuran(THF)>dimethyl carbonate(DMC)>1,3-dioxolane(DOL)>dimethoxyethane(DME)to form 5sol li^+.It is also indicated that the most innermost solvation shell compounds formations by stepwise spontaneous solvation reaction are four cyclic solvent molecules and three linear solvent molecules combining one li^+ forming 4sol-li^+ and 3sol-li^+,respectively,at room ***,the vibration peaks for C=O and C-O bonds in carbonate ester solvents-li^+ compounds shift to lower frequency and higher frequency,respectively,when the li^+ concentration increases in the solvation *** li-O stretching vibration peaks shift to higher frequency until forming 2solvent-li^+ complexes,and C-H stretching also shifts to higher frequency except for nDME-li^+ solvation *** Raman spectrum is more agile to characterize C-H vibrations and IR is agile to C=O,C-O,and li-O vibrations for li^+solvation compounds.

关键词： li^+solvation frequency shift infrared spectra Raman spectra

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High‑Mass‑Loading Electrodes for Advanced Secondary Batteries and Supercapacitors

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Electrochemical Energy Reviews 2021年第2期4卷 382-446页

作者： Feng Wu Mingquan liu Ying li Xin Feng Kun Zhang Ying Bai Xinran Wang Chuan Wu School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China collaborative innovation Center of Electric Vehicles in beijing Beijing 100081China

The growing demand for advanced electrochemical energy storage systems(EESSs)with high energy densities for electric vehicles and portable electronics is driving the electrode revolution,in which the development of high-mass-loading electrodes(HMLEs)is a promising route to improve the energy density of batteries packed in limited spaces through the optimal enlargement of active material loading ratios and reduction of inactive component ratios in overall cell ***,HMLEs face significant challenges including inferior charge kinetics,poor electrode structural stability,and complex and expensive production *** on this,this review will provide a comprehensive summary of HMLEs,beginning with a basic presentation of factors influencing HMLE electrochemical properties,the understanding of which can guide optimal HMLE *** strategies to improve the electrochemical performance of HMLEs accompanied by corresponding advantages and bottlenecks are subsequently discussed in terms of various factors ranging from inactive component modification to active material design to structural engineering at the electrode *** review will also present the recent progress and approaches of HMLEs applied in various EESSs,including advanced secondary batteries(lithium-/sodium-/potassium-/aluminum-/calcium-ion batteries,lithium metal anodes,lithium-sulfur batteries,lithium-air batteries,zinc batteries,magnesium batteries)and ***,this review will examine the challenges and prospects of HMLE commercialization with a focus on thermal safety,performance evaluation,advanced characterization,and production cost assessment to guide future development.

关键词： High mass loading Thick electrode High energy density Advanced secondary battery Supercapacitor

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