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2004年生命系统建模仿真国际会议暨第一届全国生命系统建模仿真学术会议

作者： M.Umezu J.Kawai J.Suehiro M.Arita Y.Shiraishi K.Iwasaki T.Tanaka H.Niinami Integrative Bioscience and Biomedical Engineering Graduate School of Waseda University Tokyo Japan Integrative Bioscience and Biomedical Engineering Graduate School of Waseda University Tokyo Japan Yasuhisa Biomechanics Inc. Tokyo Japan Dept. of Cardiovascular Surgery Juntendo Medical University Tokyo Japan

There are two different methods for coronary artery bypass grafting: end-to-side and side-to-side anastomosis. In vitro mock test, flow visualization and animal experiments were performed in parallel to compare the hemodynamic effect between two methods. Thus, bioengineers can provide practical useful information to the clinical team.

关键词： coronary artery bypass grafting coronary simulator side-to-side anastomosis flow visualization

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Do ankle braces provide similar effects on ankle biomechanical variables in subjects with and without chronic ankle instability during landing?

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Journal of Sport and Health Science 2012年第2期1卷 114-120页

作者： Songning Zhang Michael Wortley Julia Freedman Silvernail Daniel Carson Maxime R.Paquette biomechanics/Sports Medicine Laboratory Department of KinesiologyRecreation and Sport StudiesThe University of TennesseeKnoxvilleTN 37934.USA Pellissippi State Community College KnoxvilleTN 37933USA Department of Kinesiology University of MassachusettsAmherstMA 01003USA biomechanics/Sports Medicine Laboratory Department of KinesiologyRecreation and Sport StudiesThe University of TennesseeKnoxvilleTN 37934USA

Purpose:The purpose of this study was to examine effects of a sport version of a semi-rigid ankle brace (ElementTM) and a soft ankle brace (ASO) on ankle biomechanics and ground reaction forces (GRFs) during a drop landing activity in subjects with chronic ankle instability (CAI)compared to healthy subjects with no history of ***:Ten healthy subjects and 10 subjects who had multiple ankle sprains participated in the study as the control and unstable subjects,*** CAI subjects were age,body mass index and gender matched with the control *** arch index and ankle functions of the subjects were measured in a subject screening *** the biomechanical test session,participants performed five trials of drop landing from 0.6 m,wearing no brace ( NB),ElementTM brace and ASO *** recording of three-dimensional kinematic (240 Hz)and GRF (1200 Hz) data were ***:The CAI subjects had lower ankle functional survey *** arch index and deformity results showed greater arch deformity of ElementTM against a static load than in NB and ASO due to greater initial arch position held by the *** participants had greater eversion velocity than healthy *** ASO brace reduced the first peak vertical GRF whereas ElementTM inc.eased 2nd peak vertical *** brace reduced eversion range of motion (ROM) and peak eversion velocity compared to NB and *** addition,ElementTM reduced dorsiflexion ROM and inc.eased peak plantarflexion moment compared to NB and ***:Results of static arch measurements and dynamic ankle motion suggest that the restrictions offered by both braces are in part due to more dorsiflexed ankle positions at contact,and higher initial arch position and stiffer ankle for ElementTM.

关键词： Drop landing Lateral ankle sprain Recurrent ankle sprain Semi-rigid ankle brace Soft ankle brace

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Alterations in neuromuscular activation patterns associated with walking in short-leg walking boots

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Journal of Sport and Health Science 2012年第1期1卷 43-48页

作者： Douglas Powell Kurt Clowers Maria Keefer Songning Zhang Neuromuscular biomechanics Laboratory Fairmont State UniversityFairmontWVUSA Anthropometry and biomechanics Facility NASA Johnson Space CenterHoustonTXUSA University of Texas Health Science Center HoustonTXUSA biomechanics/Sports Medicine Laboratory The University of TennesseeKnoxvilleTNUSA

Short-leg walking boots are a common intervention for acute and chronic lower extremity *** studies have examined the neuromuscular adaptations associated with short-leg walking boots and no previous study has investigated timing characteristics of muscle activation during *** purpose of the current study was to examine the timing and amplitudes of muscle activation of the extrinsic ankle musculature during walking in two types of short-leg walking ***:Eleven healthy young adults performed five level walking trials at a self-selected pace in each of three conditions:normal walking,Gait Walker and Equalizer short-leg walking *** reaction forces were collected from a force platform while surface electromyography (EMG)was collected from the tibialis anterior,peroneus longus and medial *** signals were rectified and smoothed using the root mean squared with a 20-ms smoothing window and were normalized to the largest mean of the normal walking trials.A repeated measures analysis of variance was used to assess the effect of short-leg walking boots on the onset,duration and amplitude of muscle ***:Short-leg walking boots were generally associated with earlier onsets of muscle activation and longer durations of muscle ***,there was no reduction in EMG ***:The findings of this study show that the induced alterations in muscle activation patterns may limit the short-leg walking ***(C)2012,Shanghai University of *** and hosting by Elsevier *** rights reserved.

关键词： Electromyography Gait Short-leg walker Walking Walking boot

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Sacroiliac joint stability: Finite element analysis of implant number, orientation, and superior implant length

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World Journal of Orthopedics 2018年第3期9卷 14-23页

作者： Derek P Lindsey Ali Kiapour Scott A Yerby Vijay K Goel Research and Development SI-BONE Inc. Engineering Center for Orthopaedic Research Excellence Departments of Bioengineering and Orthopaedic Surgery Colleges of Engineering and MedicineUniversity of Toledo

AIM To analyze how various implants placement variables affect sacroiliac(SI) joint range of motion. METHODS An experimentally validated finite element model of the lumbar spine and pelvis was used to simulate a fusion of the SI joint using various placement configurations of triangular implants(iF use Implant System~?). Placement configurations were varied by changing implant orientation, superior implant length, and number of implants. The range of motion of the SI joint was calculated using a constant moment of 10 N-m with a follower load of 400 N. The changes in motion were compared between the treatment groups to assess how the different variables affected the overall motion of the SI joint. RESULTS Transarticular placement of 3 implants with superior implants that end in the middle of the sacrum resulted in the greatest reduction in range of motion(flexion/extension = 73%, lateral bending = 42%, axial rotation = 72%). The range of motions of the SI joints were reduced with use of transarticular orientation(9%-18%) when compared with an inline orientation. The use of a superior implant that ended mid-sacrum resulted in median reductions of(8%-14%) when compared with a superior implant that ended in the middle of the ala. Reducing the number of implants, resulted in inc.eased SI joint range of motions for the 1 and 2 implant models of 29%-133% and 2%-39%, respectively,when compared with the 3 implant *** Using a validated finite element model we demonstrated that placement of 3 implants across the SI joint using a transarticular orientation with superior implant reaching the sacral midline resulted in the most stable construct. Additional clinical studies may be required to confirm these results.

关键词： Fusion biomechanics Minimally invasive surgery Sacroiliac joint dysfunction Finite element analysis

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The exploration of flow pattern in the superior vena cava of healthy adults:A 4D flow magnetic resonance imaging study

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Medicine in Novel Technology and Devices 2023年第2期18卷 159-168页

作者： Huaxia Pu Haoyao Cao Yubo Fan Jinge Zhang Simeng Wang Zhan Liu Xiaoyue Zhou Ning Jin Tinghui Zheng Liqing Peng Department of Radiology West China HospitalSichuan UniversityChengdu610041China Department of Applied Mechanics Sichuan UniversityChengdu610065China Sichuan University Yibin Park Yibin Institute of Industrial TechnologyYibin644000China Key Laboratory for biomechanics and Mechanobiology of the Ministry of Education School of Biological Science and Medical EngineeringBeihang UniversityBeijing100191China MR Collaboration Siemens Healthineers Ltd.Shanghai201318China Siemens Medical Solutions USA Inc.ChicagoIL60611USA Med-X Center for Informatics Sichuan UniversityChengdu610041China

Our study sought to investigate the blood flow pattern in the superior vena cava(SVC)of healthy adults and to describe the development and characteristics of the flow pattern using 4D flow magnetic resonance imaging(MRI).4D flow MRI data with full coverage of SVC and brachiocephalic veins(BVs)were acquired with a 3-Testa MRI in thirty healthy adults(age:28.70±9.09).Hemodynamic parameters in the SVC,inc.uding velocity,velocity vector,flow visualization(pathlines,streamlines),flow waveform and energy loss,were obtained with specialized commercial post-processing software based on 4D flow MRI *** study found that:(1)The SVC has a pulsating flow waveform with double peaks.(2)Based on BVs flow of the SVC pathline visualization,flow patterns could be divided into three development types:twining(n=14),untwining(n=)and no helical flow(n=7).(3)With the decreasing blood velocity,helical flow areas tended to gradually extend.(4)There were no significant differences in most hemodynamic parameters among the three *** exploration of the blood flow characteristics of normal SVC may be the first step for capturing pathogenic features before the patients develop symptoms with a certain positive *** potential physiological significance of these phenomena deserves more exploration in future studies.

关键词： Superior vena cava 4D flow magnetic resonance imaging Blood flow Circulation

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A CHALLENGE TO DEVELOPAN INEXPENSIVE“SPIRAL VORTEX PUMP”

A CHALLENGE TO DEVELOPAN INEXPENSIVE“SPIRAL VORTEX PUMP”

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亚州仿真会议暨第五届系统仿真和科学计算国际会议

作者： Tomohiro Tsujimoto Kiyotaka Iwasaki Wataru Saeki Kei Yoshida Makoto Arita Mitsuo Umezu Kou Imachi Kazuhiko Ishihara Takashi Tanaka Integrative Bioscience and Biomedical Engineering Graduate School of Science and Engineering Waseda UniversityTokyo Japan Integrative Bioscience and Biomedical Engineering Graduate School of Science and Engineering Waseda UniversityTokyo Japan Integrative Bioscience and Biomedical Engineering Graduate School of Science and Engineering Waseda UniversityTokyo Japan Integrative Bioscience and Biomedical Engineering Graduate School of Science and Engineering Waseda UniversityTokyo Japan Integrative Bioscience and Biomedical Engineering Graduate School of Science and Engineering Waseda UniversityTokyo Japan Integrative Bioscience and Biomedical Engineering Graduate School of Science and Engineering Waseda UniversityTokyo Japan The University of Tokyo Tokyo Japan The University of Tokyo Tokyo Japan yasuhisa biomechanics inc. Tokyo Japan.

It is well known that the cost of artificial heart is more expensive than other cardiovascular devices and its cost still tends to inc.ease. The cost is one of the important factors to be chosen by

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Review of in-vivo characterisation of corneal biomechanics

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Medicine in Novel Technology and Devices 2021年第3期11卷 34-39页

作者： Bernardo T.Lopes FangJun Bao JunJie Wang XiaoYu Liu LiZhen Wang Ahmed Abass Ashkan Eliasy Ahmed Elsheikh School of Engineering University of LiverpoolLiverpoolUK Department of Ophthalmology Federal Univerisity of Sao Paulo(UNIFESP)Sao PauloBrazil Eye Hospital Wenzhou Medical UniversityWenzhouChina The Institution of Ocular biomechanics Wenzhou Medical UniversityWenzhouChina Key Laboratory for biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Beijing Advanced Innovation Centre for Biomedical Engineering Beihang UniversityBeijingChina National Institute for Health Research(NIHR)Biomedical Research Centre for Ophthalmology Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of OphthalmologyLondonUK

The study of corneal biomechanics in vivo has been evolving fast in recent *** an organised corneal structure is necessary for its transparency,resistance to occasional external insults and bearing the intraocular pressure(IOP),which several clinically relevant events can *** review focuses on three techniques that are available for clinical use,namely the Ocular Response Analyzer(Reichert Ophthalmic Instruments,Buffalo,NY,USA),the Corvis ST(Oculus Optikgerate GmbH,Wetzlar,Germany)and the Brillouin Optical Scattering System(Intelon Optics inc.,Lexington,MA,USA).The princ.ples and the main parameters of each device are discussed along with their strategies to improve accuracy in the IOP measurement,corneal ectasia diagnosis,evaluation of corneal cross-linking procedures,and planning of corneal refractive surgeries.

关键词： Corneal biomechanics Corneal diagnosis Intraocular pressure Corneal ectasia Corneal cross linking

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A CFD Study of the Luminal Surface Concentration of Low Density Lipoproteins in Coronary Arteries:the Effects of Wall Motion

A CFD Study of the Luminal Surface Concentration of Low Dens...

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The Sixth World Congress on Computational Mechanics in Conjunction with the Second Asian-Pacific Congress on Computational Mechanics

作者： M.K.Kolandavel E.T.Fruend E.M.Pedersen S.Ringgaard P.G.Walker Centre for biomechanics and Medical Engineering School of Mechanical Engineering University of Leeds Leeds LS2 9JT United Kingdom MR-Centre Institute of Experimental Clinical Research Skejby Sygehus Denmark MR-Centre Institute of Experimental Clinical Research Skejby Sygehus Denmark MR-Centre Institute of Experimental Clinical Research Skejby Sygehus Denmark Centre for biomechanics and Medical Engineering School of Mechanical Engineering University of Leeds Leeds LS2 9JT United Kingdom

The transport of low density lipoproteins (LDLs) from the blood to the arterial wall and their accumulation within the arterial intima are key steps in atherogenesis. In coronary arteries these may be affected by the local haemodynamic factors inc.uding their physiological motion, whose effect on LDL transport has not been studied elsewhere. Therefore, this study was initiated to investigate the transport of LDL to the endothelium (a semi permeable membrane) in a moving 3-D model of the Left Anterior Descending (LAD) coronary artery segment by using the commercial finite volume CFD solver, FLUENT (v6.1.18, Fluent inc.. A time varying inlet parabolic velocity [1] and planar vessel wall motion waveforms [2-3] obtained from literature were imposed as boundary conditions. The results showed the occurrence of flow-dependent concentration polarization (the accumulation and elevation of luminal surface concentration of LDL due to water filtration through the semi permeable endothelium) of LDL [4] at the endothelial surface in varying degrees in pulsatile flow (static case) and pulsatile flow with wall motion (dynamic case). In both the cases, this effect was more pronounced at the inner wall of bend where wall shear stress (WSS) was lower. The motion induced elevation of WSS and stronger secondary flows seem to promote better cross mixing, resulting in a lower concentration of LDL, especially at the inner wall when compared to the pulsatile flow simulations. Taken together, these results suggest that the vessel wall motion may have a dominant influence on LDL transport. However the degree of influence would also depend on the individual motion patterns and the reaction mechanisms used. This warrants future studies on more physiologic models to gain a fundamental understanding on LDL transport and consequently on conditions such as atherosclerosis.

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