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Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

Neural Regeneration research 2025年第7期20卷 2015-2028页

作者： Jian yang Jiang Wu Xueshun Xie Pengfei Xia Jinxin Lu Jiale Liu Lei Bai Xiang Li Zhengquan Yu Haiying Li Department of Neurosurgery&Brain and Nerve research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina institute of Stroke research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(PLIN2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased PLIN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting PLIN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing

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Anomalous quality factor evolution of induced transparency in a virtualized coupled-oscillator system

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Science China(Physics,Mechanics & Astronomy) 2025年第1期68卷 144-151页

作者： Yunhan yang Han Jia Tuo Liu Yuzhen yang Jun yang Key Laboratory of Noise and Vibration research Institute of AcousticsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Acoustics Institute of AcousticsChinese Academy of SciencesBeijing 100190China

The phenomenon of induced transparency,characterized by a high quality(Q)factor,holds significant importance in the fields of high-precision sensing,energy storage and wave *** transparency systems are often constrained by the limited experimentally accessible parameter space and the lack of independent control over intrinsic parameters,thereby hindering advanced research on high-Q *** we propose a virtualized coupled-oscillator system that enables reconfigurable induced transparency in the reflection *** virtually incorporating a pair of coupled oscillators into an individual acoustic meta-atom,we achieve the manipulation of induced transparency in a decoupled,wide-ranging,and elaborate *** the diverse evolutions across the intrinsic parameter space,we show experimentally a counter-intuitive increase in the Q-factor of the transparency window,which is attributed to the enhanced dissipation of the bright ***,a constant group delay at the center frequency is observed accompanying this *** work demonstrates an intriguing platform as well as a novel strategy to engineer high-Q induced transparency phenomenon,and paves the way towards applications in programmable acoustic sensors,filters and slow-wave devices.

关键词： induced transparency acoustic meta-atom high quality-factor scattering programmable intrinsic parameter

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Dietary carbohydrate intake and risk of type 2 diabetes:a 16-year prospective cohort study

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Science China Life Sciences 2025年

作者： Lu Gan Yi yang Bin Zhao Kai Yu Kehua Guo Fang Fang Zhiguang Zhou Demetrius Albanes Jiaqi Huang Key Laboratory of Diabetes Immunology Ministry of Education and Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University CSU-Sinocare Research Center for Nutrition and Metabolic Health Xiangya School of Public Health Central South UniversityFurong Laboratory Division of cancer Epidemiology and Genetics National Cancer Institute NIH Department of Health and Human Services School of Computer Science and Engineering Central South University institute of Environmental Medicine Karolinska Institute National Clinical research Center for Metabolic Diseases Key Laboratory of Diabetes Immunology Ministry of Education and Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University

Despite considerable research underscoring the importance of carbohydrate intake in relation to the risk of type 2 diabetes(T2D), a comprehensive assessment of this relationship is currently lacking. We aimed to examine the associations of various types and food sources of dietary carbohydrate intake with the risk of T2D, to evaluate potential effect modification by other factors, including genetic susceptibility,and to explore the potential mediators for such associations. The present study included 161,872 participants of the UK Biobank who were free of prevalent cancer, cardiovascular disease, or diabetes, and had at least one validated 24-h dietary recall assessment. Multivariableadjusted age-stratified Cox proportional hazard regression models were applied to estimate hazard ratios(HRs) and 95% confidence intervals(CI) for the associations of various types and food sources of dietary carbohydrate intake with risk of T2D. During a median follow-up of13.6 years, 4,176 incident cases of T2D were identified. In the multivariable-adjusted models, a greater intake of fiber, carbohydrates from whole grains, and carbohydrates from non-starchy vegetables was significantly associated with a lower risk of T2D(highest vs. lowest quantile, HR [95% CI]=0.70 [0.62–0.79], 0.74 [0.67–0.82], and 0.83 [0.75–0.92], respectively, all P for trend <0.005). In contrast, a higher intake of starch and carbohydrate from starchy vegetables was associated with an increased risk of T2D(highest vs. lowest quantile, HR [95%CI]=1.31 [1.16–1.48] and 1.19 [1.09–1.31], respectively, both P for trend <0.005). Replacing one serving of refined grains or starchy vegetables with an equal amount of whole grains or non-starchy vegetables was associated with 4% to 10% lower risk of T2D(all P values <0.001).The observed associations were generally similar across population subgroups, including individuals with different genetic susceptibility to T2D. Mediation analyses of the inverse association between T

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Preface to the Special Topic on Solar Energy Meteorology

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Advances in Atmospheric Sciences 2025年第2期42卷 249-251页

作者： Dazhi yang Xiang’ao XIA School of Electrical Engineering and Automation Harbin Institute of TechnologyHarbin 150001China Chongqing research institute of Harbin institute of Technology Chongqing 401151China institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China

Advances in Atmospheric Sciences has long been a natural home for atmospheric scientists,but as the scope of the atmospheric sciences rapidly expands,it is logical and attractive to also broaden the scope of the *** this point,we are pleased to present this special topic on solar energy meteorology,a collection of five invited articles,addressing several important aspects including satellite remote sensing,solar system modeling,photovoltaic power forecasting,thermal balance of solar panels,and decarbonization *** articles are contributed by established scientists,and readers can expect to enjoy the content of this special topic.

关键词： Solar meteorology attractive

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Late spring-early summer drought and soil properties jointly modulate two pine species? decline and climatic sensitivity in temperate Northern China

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Forest Ecosystems 2025年第01期 146-158页

作者： Yuheng Li Zhaofei Fan Lihong Xu Xiao Zhang zhongjie Shi Xiaohui yang Wei Xiong Ling Cong Semyun Kwon Leilei Pan Hanzhi Li Shuo Wen Xiaoyan Shang institute of Geographic Sciences and Natural Resources research Chinese Academy of Sciences research institute of Ecological Conservation and Restoration Chinese Academy of Forestry University of Chinese Academy of Sciences College of Forestry Wildlife and Environment Auburn University Ecology and Nature Conservation institute Chinese Academy of Forestry research institute of Desertification Studies Chinese Academy of Forestry institute of Ecological Restoration Kongju National University Chungcheongnam-do

Increasing temperatures and severe droughts threaten forest vitality globally. Prediction of forest response to climate change requires knowledge of the spatiotemporal patterns of monthly or seasonal climatic impacts on the growth of tree species, likely driven by local climatic aridity, climate trends, edaphic conditions, and the climatic adaption of tree species. The ability of tree species to cope with changing climate and the effects of environmental variables on growth trends and growth-climate relationships across diverse bioclimatic regions are still poorly understood for many species. This study investigated radial growth trends, interannual growth variability, and growth-climate sensitivity of two dominant tree species, Pinus tabulaeformis(PT) and Pinus sylvestris var. mongolica(PS), across a broad climatic gradient with a variety of soil properties in temperate Northern China. Using a network of 83 tree ring chronologies(54 for PT and 29 for PS) from 1971 to 2010, we documented that both species maintained constant growth trends at wet sites, while both displayed rapid declines at dry sites. We reported the species-specific drivers of spatial heterogeneity in growth trends, interannual growth variability, and growth-climate relationships. Calculated climatic variables and soil properties were identified as the most critical factors affecting the growth trends and growth-climate relationships. However, climatic variables play more essential roles than soil properties in determining the spatial heterogeneity of the growth-climate *** clay content and higher soil nutrient regimes can exacerbate the moisture-related susceptibility of tree growth. Our findings highlight that soil properties emerged as important modulating factors to predict the drought vulnerability of forests in addition to climatic variables. Considering the continued climate warmingdrying trend in the future, both pines will face a more severe growth decline and increase in dr

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Tetraphenylethylene-derived organic cages with persistent photogenic radicaloids and efficient photothermal conversion

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Science China Chemistry 2025年第2期68卷 661-669页

作者： Suqiong Yan Bo yang Fanda Feng Yuan Zhang Shirong Ban Hui Ma Wei Huang State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210093China Shenzhen research institute of Nanjing University Shenzhen 518057China

Transformation of the electronic spin states has received significant interest in recent years because of its applications in the magnetic information storage materials and optical response ***,it can be formidably challenging to use ultraviolet(UV)light as a contactless stimulus to alter the electronic spin states of the supramolecular *** by the approach on the radical cation mechanism of the Scholl reaction and the photocyclization reactivity of tetraphenylethylene(TPE)derivatives,we report two photochromic cages(cage-TPE-1 and cage-TPE-2)that can be photochemically transformed from electron paramagnetic resonance(EPR)-silent to EPR-active form via UV irradiation due to the photo-induced electron transfer process at the TPE *** provided a strong single-electron signal with a g value of 2.003 in cage-TPE-1 and cage-TPE-2 but no signal was detected for the pristine samples without the *** transformation can be monitored by ultraviolet–visible–near-infrared(UV–vis–NIR)and photoluminescence(PL)*** photogenic radical cage intermediate was unstable in solution resulting in the degradation and intramolecular cyclization of the reactive species,while the radicals were found to be stable and persistent in the solid state due to the spin delocalization,the steric protection of confined cavities,and the oxygen *** theoretical calculations and spectral measurements suggest that the photogenic radical cage-TPE-2(•+)experiences photocyclization on the TPE *** with the close-shell cage,the radical cage-TPE-1(•+)and cage-TPE-2(•+)exhibit better photothermal conversion performance due to the incubated infrared absorption from open-shell electron feature and reduced band gap.

关键词： supramolecular cage photogenic radical photocyclization photothermal conversion

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Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan Junling Lü Chunchi Zhang Dong Liang Lei yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th research institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

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Modular miniaturized synthesis and in situ biological evaluation facilitate rapid discovery of potent Mra Y inhibitors as antibacterial agents

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Chinese Chemical Letters 2025年第2期36卷 29-31页

作者： Mianling yang Meehyein Kim Peng Zhan Department of Medicinal Chemistry Key Laboratory of Chemical Biology Ministry of Education School of Pharmaceutical SciencesShandong University Infectious Diseases Therapeutic research Center Korea Research Institute of Chemical Technology (KRICT)

Despite the availability of effective antibacterial drugs, the increasing prevalence of antibiotic-resistant bacteria is primarily attributed to their excessive and inappropriate utilization. Antimicrobial resistance (AMR) represents one of the most concerning global health and development threats [1]. Thereby, the continuous escalation in AMR necessitates urgent advancements in novel antibacterial strategies. The MraY enzyme, which plays a pivotal role in synthesizing bacterial cell wall-composing polysaccharides, holds significant potential as a target for antibacterial agents [2]. However, its conformational dynamics have presented substantial challenges in developing MraY-targeting inhibitors.

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Hyperosmolality tolerance of freshwater largemouth bass Micropterus salmoides to brackish in early ontogenetic stages of eggs,embryos,and yolk-sac larvae

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Journal of Oceanology and Limnology 2025年第1期43卷 286-298页

作者： Du LUO Dingtian yang South China Sea institute of Oceanology Chinese Academy of SciencesGuangzhou 510301China Pearl River Fisheries research institute Chinese Academy of Fishery SciencesGuangzhou 510380China University of Chinese Academy of Sciences Beijing 100049China

Salinity is recognized as a pivotal factor limiting the migration of freshwater fish to brackish *** largemouth bass(LMB,Micropterus salmoides),a globally translocated freshwater fish,exhibits estuarine distribution,yet its hyperosmoregulatory capacity during early ontogenetic stages remains inadequately *** investigate the impact of freshwater salinization,a series of experiments were conducted in Guangzhou and Foshan,*** reveal that freshwater-activated mature eggs and naturally fertilized oocytes maintained nearly identical osmotic homeostasis,with diameters of 1.38±0.07 mm and 1.37±0.05 mm,***,both exhibited peak water excretion at a salinity of ***,a reduction in water permeability was observed in hyperosmotic *** hatching rates increased from 27.5%±14.4%in the 1.0 group to 75.1%±12.0%in the 6.0 group under fluctuating temperature ***-sac LMB larvae consistently reduced survival time from 12.5 d at 1.0 to 50.7±2.1 min at salinity of ***,more developed larvae also experienced a decrease in survival *** regression models fitting lethal time with salinity indicated a sharp decrease between 10.0 and *** findings offer practical insights for predicting distribution patterns and enhancing aquaculture technology for ***,they may contribute theoretically to the broader understanding of the osmoregulatory mechanisms of freshwater fish.

关键词： osmotic homeostasis acute toxicity median lethal time hatching rate dose-response model

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Resilient satellite-based PNT system design and key technologies

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Science China Earth Sciences 2025年第3期68卷 669-682页

作者： Yuanxi yang Zheng YAO Yue MAO Tianhe XU Dixing WANG Key Laboratory of Smart Earth Xi'an research institute of Surveying and Mapping Department of Electronic Engineering Tsinghua University School of Space Science and Technology Shandong University

Satellite-based positioning navigation and timing(PNT) system is the most fundamental and convenient application system in PNT fields now and in the future, thus the satellite-based PNT service system should be more and more robust, reliable and easy to be applied. Aiming at the weak service performance of the existing BeiDou constellation in the Antarctic and Arctic regions and the possible discontinuous problems in the autonomous orbit determination using BeiDou terminals on board of low earth orbit(LEO) satellites, we propose a scheme to optimize the BeiDou constellation configuration. A relatively optimized deep space PNT service constellation is designed in order to overcome the weak service capability of the BeiDou navigation constellation in deep space. We find that more satellites in the same orbital plane have better positioning geometry than increasing the number of constellation orbital planes. Furthermore, the idea of resilient satellite-based PNT service mode combining deep, high, medium, and low earth orbit navigation constellations is proposed, in order to improve the service capability of multi navigation constellations. To strengthen the satellite PNT service ability, the resilient strategies of on-board phased array antenna, on-board atomic clocks and satellite signal generator are proposed, in which the adaptively possible adjustment of signal power, signal frequency, signal modulation waveform and information format are discussed. Some examples to demonstrate the resilient satellite-based PNT application modes are given.

关键词： BeiDou navigation constellation Resilient navigation constellation Resilient PNT service Resilient signal modulation Adaptive signal power

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