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Qianjin Wenwu decoction suppresses renal interstitial fibrosis by enhancing the degradation of extracellular matrix in mice with unilateral ureteral obstruction

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Chinese Journal of Natural Medicines 2023年第4期21卷 253-262页

作者： JIN Chengshan WU Xiaotian YOU Yue WANG Yuing WU Jing ZUO Along ZHENG Yan GUO Jianpeng Key Laboratory of Natural Medicines of the Changbai Mountain Ministry of EducationCollege of PharmacyYanbian UniversityYanji 133002China yanbian University Hospital Yanji 133002China yanbian medical and health industry pilot base College of PharmacyYanbian UniversityYanji 133002China yanbian Chaoyao Biotechnology Co. Ltd.Yanji 133002China

Diabetic kidney disease(DKD)is the most common complication of diabetes mellitus(DM).Qianjin Wenwu decoction(QWD),a well-known traditional Korean medicine,has been used for the treatment of DKD,with satisfactory therapeutic effects.This study was designed to investigate the active components and mechanisms of action of QWD in the treatment of DKD.The results demonstrated that a total of 13 active components in five types were found in QwD,including flavonoids,flavonoid glycosides,phenylpropionic acids,saponins,coumarins,and lignins.Two key proteins,TGF-β1 and TIMP-1,were identified as the target proteins through molecular docking.Furthermore,QWD significantly suppressed Scr and BUN levels which increased after unilateral ureteral obstruction(UUO).Hematoxylin&eosin(H&E)and Masson staining results demonstrated that QWD significantly alleviated renal interstitial fibrosis in UUO mice.We also found that QWD promoted ECM degradation by regulating MMP-9/TIMP-1 homeostasis to improve renal tubulointerstitial fibrosis and interfere with the expression and activity of TGF-βl in DKD treatment.These findings explain the underlying mechanism of QWD for the treatment of DKD,and also provide methodological reference for investigating the mechanism of traditional medicine in the treatment of DKD.

关键词： QianJin Wenwu Decoction(QWD) Diabetic kidney disease(DKD) Pharmacodyamic material basis Molecular docking TGF-β1 Extracellular matrix(ECM)

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Extraction of Eugenol from Essential Oils by In Situ Formation of Deep Eutectic Solvents:A Green Recyclable Process

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Journal of Analysis and Testing 2024年第1期8卷 63-73页

作者： Lingqi Shen Xiangzi Jin Zhihui Zhang Yuexing Yi Jingyu Zhang Zuguang Li College of Chemical Engineering Zhejiang University of TechnologyHangzhou 310014China Department of Chemistry Yanbian UniversityYanji 133002China Transfar Zhilian Co. Ltd.Hangzhou 311215China

Eugenol is extensively utilized in chemical industry.In actual production,it is mainly separated from clove essential oils(EOs)through acid-base solutions.In this work,a simple,rapid and effective extraction process was developed for the extraction of eugenol from EOs samples by directly forming deep eutectic solvents(DESs)without using acid-base solutions.The proposed process is designed to dissolve EOs in n-hexane and eugenol was highly selective extracted into DESs with tetrabutylammonium chloride(TBAC).Hydrogen bonds in DESs can be broken by addition of water,resulting in a separation of the two phases,thus obtaining a hydrophobic yellowish eugenol in the upper layer.The quaternary ammonium salt in the lower aqueous solution can be reused after recovery.The most determining influence factors such as the structure of quaternary ammonium salt,the mole ratio of quaternary ammonium salt to eugenol and the amount of n-hexane were investigated.The forming conditions of DESs were studied by Box-Behnken design(BBD).Experiment was carried out under the optimal conditions and good experimental result was demonstrated by the developed process,a high extraction recovery of 92.51% and the purity was about 98.50%,which verifies the excellent performance for the proposed process.

关键词： Eugenol Deep eutectic solvent Essential oils Tetrabutylammonium chloride

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The role of corneal endothelium in macular corneal dystrophy development and recurrence

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Science China(Life Sciences) 2024年第2期67卷 332-344页

作者： Bi-Ning Zhang Benxiang Qi Chunxiao Dong Bin Zhang Jun Cheng Xin Wang Suxia Li Xiaoyun Zhuang Shijiu Chen Haoyun Duan Dewei Li Sujie Zhu Guoyun Li Yihai Cao Qingjun Zhou Lixin Xie Eye Institute of Shandong First medical University Qingdao Eye Hospital of Shandong First Medical UniversityQingdao 266071China State Key Laboratory Cultivation base Shandong Provincial Key Laboratory of OphthalmologyQingdao 266071China School of Ophthalmology Shandong First Medical UniversityQingdao 250021China Department of Medicine Qingdao UniversityQingdao 266071China Eye Institute of Shandong First medical University Eye Hospital of Shandong First Medical University(Shandong Eye Hospital)Jinan 250021China Department of Ophthalmology School of Clinical MedicineWeifang Medical UniversityWeifang 261072China Institute of Translational Medicine College of MedicineQingdao UniversityQingdao 266071China Key Laboratory of Marine Drugs of Ministry of Education Shandong Provincial Key Laboratory of Glycoscience and GlycotechnologySchool of Medicine and PharmacyOcean University of ChinaQingdao 266071China Laboratory for Marine Drugs and Bioproducts Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266071China Department of Microbiology Tumor and Cell BiologyBiomedicumKarolinska InstitutetStockholm 17177Sweden

Macular corneal dystrophy(MCD)is a progressive,bilateral stromal dystrophic disease that arises from mutations in carbohydrate sulfotransferase 6(CHST6).Corneal transplantation is the ultimate therapeutic solution for MCD patients.Unfortunately,postoperative recurrence remains a significant challenge.We conducted a retrospective review of a clinical cohort comprising 102 MCD patients with 124 eyes that underwent either penetrating keratoplasty(PKP)or deep anterior lamellar keratoplasty(DALK).Our results revealed that the recurrence rate was nearly three times higher in the DALK group(39.13%,9/23 eyes)compared with the PKP group(10.89%,11/101 eyes),suggesting that surgical replacement of the corneal endothelium for treating MCD is advisable to prevent postoperative recurrence.Our experimental data confirmed the robust m RNA and protein expression of CHST6 in human corneal endothelium and the rodent homolog CHST5 in mouse endothelium.Selective knockdown of wild-type Chst5 in mouse corneal endothelium(AC^(siChst5)),but not in the corneal stroma,induced experimental MCD with similar extracellular matrix synthesis impairments and corneal thinning as observed in MCD patients.Mice carrying Chst5 point mutation also recapitulated clinical phenotypes of MCD,along with corneal endothelial abnormalities.Intracameral injection of wild-type Chst5 rescued the corneal impairments in AC^(siChst5)mice and retarded the disease progression in Chst5 mutant mice.Overall,our study provides new mechanistic insights and therapeutic approaches for MCD treatment by highlighting the role of corneal endothelium in MCD development.

关键词： macular corneal dystrophy recurrence corneal endothelium keratan sulfate penetrating keratoplasty

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Characterization of Flame Retardancy and Oil-Water Separation Capacity of Superhydrophobic Silylated Melamine Sponges

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Fluid Dynamics & Materials Processing 2024年第2期20卷 383-400页

作者： Yongchun Liu Ni Qiao Yanli Yang Yanchun Li Chunxiao He Siyang Wang Chengcheng Liu Ruixia Lei Wang Li Wenwen Gao College of Chemistry and Chemical Engineering FLUOBON Pilot Base of Chemical EngineeringLongdong UniversityQingyang745000China Qingyang Solid and Hazardous Waste Pollution Prevention and Control Management Center Qingyang745000China Gansu Qingluyuan Environmental Monitoring Co. Ltd.Qingyang745000China School of Chemistry and Chemical Engineering Shanxi Key Laboratory of Low Metamorphic Coal Clean UtilizationYulin UniversityYulin719000China

A silylated melamine sponge(SMS)was prepared by two simple steps,namely,immersion and dehydration of a melamine sponge coated with methyltrichlorosilane.The silylated structure of SMS was characterized by FT-IR(Fourier-transform infrared)spectroscopy,SEM(Scanning electron microscopy)and in terms of water contact angles.Its oil-water absorption and separation capacities were measured by FT-IR and UV-visible spectrophoto-metry.The experimental results have shown that oligomeric silanol covalently bonds by Si-N onto the surface of melamine sponge skeletons.SMS has shown superhydrophobicity with a water contact angle exceeding 150°±1°,a better separation efﬁciency with regard to diesel oil(by 99.31%(wt/wt%)in oil-water mixture and even up to 99.99%(wt/wt%)for diesel oil in its saturated aqueous solution.Moreover,SMS inherited the intrinsicﬂame retardancy of the melamine sponge.In general,SMS has shown superhydrophobicity,high porosity,excellent selectivity,remarkable recyclability,and better absorption capacity for various oils and organic solvents,and a high separation efﬁciency for oil in saturated aqueous solutions.

关键词： Methyltrichlorosilane silylated melamine sponge(SMS) superhydrophobicity absorption capacity oil-water separable efﬁciency ﬂame retardancy

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Development of diabetic complications and influencing factors among 32653 type 2 diabetes patients:retrospective cohort study using a multi-state Markov

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medical Data Mining 2024年第2期7卷 1-8页

作者： Shu-Yuan Shi Hou-Yu Zhao Zhi-Ke Liu Ruo-Gu Meng Peng Shen Si-Yan Zhan Hong-Bo Lin Feng Sun Department of Epidemiology and health Statistics School of Public HealthPeking UniversityBeijing 100191China China Rehabilitation Science Institute Center for Prevention and Control of Disability of China Disabled Persons FederationBeijing 100068China National Institute of health Data Science Peking UniversityBeijing 100191China Yinzhou District Center for Disease Control and Prevention Ningbo 315100China

Background:Patients with type 2 diabetes are at high risk for developing multiple chronic complications.However,there is a lack of studies of the cumulative number of diabetic complications in China.Methods:A retrospective cohort study was performed from 2009 to 2021.Type 2 diabetes patients who were first diagnosed after the age of 35 years between January 1,2009,and December 31,2017,were included.Five states were defined according to the number of chronic complications:no(S0),one(S1),two(S2),three(S3),and four or more complications(S4).A multi-state Markov model was constructed to estimate transition probability,transition intensity,mean sojourn time,and the possible factors for each state.Results:The study included 32653 type 2 diabetes patients(mean age,59.59 years;15929(48.8%)male),and mean follow-up time of 7.75 years.In all,4375 transitions were observed.The 12-year transition probability of from state S0 to S1 was the lowest at 16.4%,while that from S2 to S3 was the highest,at 45.6%.Higher fasting blood glucose,lower high-density lipoprotein cholesterol,higher total cholesterol,and an unhealthy diet were associated with higher risk of progression from S0 to S1.Being female,less than 60 years old,weekly physical activity,and vegetarian diet decreased this risk.Being female and less than 60 years old reduced the likelihood of transition from S1 to S2,whereas lower high-density lipoprotein cholesterol increased this likelihood.Conclusions:Following the occurrence of two complications in type 2 diabetes patients,the risk for accumulating a third complication within a short time is significantly increased.It is important to take advantage of the stable window period when patients have fewer than two complications,strengthen the monitoring of blood glucose and blood lipids,and encourage patients to maintain good living habits to prevent further deterioration.

关键词： multi-state Markov model transition probability type 2 diabetes diabetic chronic complications

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Total synthesis and stereochemistry establishmentof tumescenamide A

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Organic Chemistry Frontiers 2022年第6期9卷 1675-1679页

作者： Hong Xue Shiming Fan Jingzhe Xu Shouxin Liu College of Science Yanbian UniversityYanji133002China College of Chemical&Pharmaceutical Engineering Hebei University of Science&TechnologyShijiazhuang050018China

Tumescenamide A (1), isolated from Streptomyces tumescens YM23-20, consists of a cyclic depsipeptideand a side-chain 2,4-dimethylheptanoate (Dmh). Herein, we report the first total synthesis of tumescenamide A (1) and establish its stereochemistry. The configuration of Dmh is 2S,4S and, notably, the configuration of Val is revised as D. In addition, a mild and practical method for the β-elimination of derivatives ofserine and threonine by using nano-K_(2)CO_(3) as a base was established. A highly stereoselective synthesis ofthe Dmh substructure was also developed.

关键词： synthesis stereochemistry elimination

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Dielectric polarization in MgFe_(2)O_(4) coating and bulk doping to enhance high-voltage cycling stability of Na_(2/3)Ni_(1/3)Mn_(2/3)O_(2) cathode material

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Journal of Energy Chemistry 2023年第6期81卷 200-211,I0007页

作者： Xiaoqian Xu Yizhen Huang Dan Li Qichang Pan Sijiang Hu Yahao Li Hongqiang Wang Youguo Huang Fenghua Zheng Qingyu Li Guangxi Key Laboratory of Low Carbon Energy Materials School of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541004GuangxiChina Hubei Provincial Collaborative Innovation Center for New Energy Microgrid College of Electrical Engineering&New EnergyChina Three Gorges UniversityYichang 443002HubeiChina Guangxi Scientific and Technological Achievements Transformation pilot Research base of Electrochemical Energy Materials and Devices Guangxi Normal UniversityGuilin 541004GuangxiChina

Charging P2-Na_(2/3)Ni_(1/3)Mn_(2/3)O_(2)to 4.5 V for higher capacity is enticing.However,it leads to severe capacity fading,ascribing to the lattice oxygen evolution and the P2-O2 phase transformation.Here,the Mg Fe_(2)O_(4) coating and Mg,Fe co-doping were constructed simultaneously by Mg,Fe surface treatment to suppress lattice oxygen evolution and P2-O2 phase transformation of P2-Na_(2/3)Ni_(1/3)Mn_(2/3)O_(2)at deep charging.Through ex-situ X-ray diffraction(XRD)tests,we found that the Mg,Fe bulk co-doping could reduce the repulsion between transition metals and Na+/vacancies ordering,thus inhibiting the P2-O2 phase transition and significantly reducing the irreversible volume change of the material.Meanwhile,the internal electric field formed by the dielectric polarization of Mg Fe_(2)O_(4) effectively inhibits the outward migration of oxidized O^(a-)(a<2),thereby suppressing the lattice oxygen evolution at deep charging,confirmed by in situ Raman and ex situ XPS techniques.P2-Na NM@MF-3 shows enhanced high-voltage cycling performance with capacity retentions of 84.8% and 81.3%at 0.1 and 1 C after cycles.This work sheds light on regulating the surface chemistry for Na-layered oxide materials to enhance the high-voltage performance of Na-ion batteries.

关键词： P2-Na_(2/3)Ni_(1/3)Mn_(2/3)O_(2) MgFe_(2)O_(4) Bulk doping Lattice oxygen evolution P2-O2 phase transformation

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On UAV Serving Node Deployment for Temporary Coverage in Forest Environment:A Hierarchical Deep Reinforcement Learning Approach

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Chinese Journal of Electronics 2023年第4期32卷 760-772页

作者： WANG Li WU Xuewei WANG Yanhui XIAO Zhe LI Liang FEI Aiguo School of Computer Science (National pilot Software Engineering School) Beijing University of Posts and Telecommunications School of Electronic Engineering Beijing University of Posts and Telecommunications

Unmanned aerial vehicles(UAVs) can be effectively used as serving stations in emergency communications because of their free movements, strong flexibility, and dynamic coverage. In this paper, we propose a coordinated multiple points based UAV deployment framework to improve system average ergodic rate, by using the fuzzy C-means algorithm to cluster the ground users and considering exclusive forest channel models for the two cases, i.e., associated with a broken base station or an available base station. In addition, we derive the upper bound of the average ergodic rate to reduce computational complexity. Since deep reinforcement learning(DRL) can deal with the complex forest environment while the large action and state space of UAVs leads to slow convergence, we use a ratio cut method to divide UAVs into groups and propose a hierarchical clustering DRL(HC-DRL) approach with quick convergence to optimize the UAV deployment. Simulation results show that the proposed framework can effectively reduce the complexity, and outperforms the counterparts in accelerating the convergence speed.

关键词： UAV deployment Forest channel model Deep reinforcement learning

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The Electrochemical Behavior and the Determination of Bavistin on Glassy Carbon Electrode

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Chinese Chemical Letters 1998年第8期9卷 747-748页

作者： Yuan Zhe PIAO Gui Fen WANG(Department of Chemistry, yanbian University, Yani 133002) Department of Chemistry Yanbian University Yanji 133002 China

In this paper, the electrochendcal behavior of bavistin (MBC) on glassy carbon electrode is reported. In a base solution of pH=9.0 NH3-NH4Cl, a sensitive anodic peak was found by cyclic voltammetry. Differential pulse stripping voltanunetry was applied for determing MBC in grains. The detection limit is 4×10-8mo/L.The recovery is from 91.3% to 95.7%. The method has advantages of simplicity and high sensitivity.

关键词： bavistin glassy carbon electrode, cyclic voltammetry differential pulse stripping voltammetry pesticide

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Shock-Resistant and Energy-Absorbing Properties of Bionic NiTi Lattice Structure Manufactured by SLM

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Journal of Bionic Engineering 2022年第6期19卷 1684-1698页

作者： Zhenglei Yu Renlong Xin Zezhou Xu Luming Sha Lixin Chen Yining Zhu Ping Liang Zhihui Zhang Zhenze Liu Qing Cao College of Communication Engineering Jilin UniversityChangchun130022China Key Laboratory of Engineering Bionics Ministry of EducationJilin UniversityChangchun130022China State Key Laboratory of Automotive Simulation and Control Jilin UniversityChangchun130022China School of Agriculture Yanbian UniversityYanji133002China

Each specific structure of organisms is the best choice under specific circumstances.The excellent characteristic structures of these organisms have great application potential in the design and multi-functional optimization of energy-absorbing structures such as vehicle collisions,satellite landings,and military equipment.In this paper,using the principle of structural bionics,using the advantages of the honeycomb structure and the light weight and high strength of beetle elytra,four bionic lattice structures are studied:CH,ZPRH,SCH and IBE.Using NiTi shape memory alloy,a unique material as the base material,samples are prepared using selective laser melting(SLM)technology.By comparing the test results of the quasi-static compression test with the results of the numerical simulation,it is found that compared with the other three bionic lattice structures,the SCH structure has the best energy absorption effect in the effective stroke in the test,and the specific energy absorption can reach 6.32 J/g.ZPRH,SCH,and IBE structures not only have good and stable deformation behavior,but also have excellent impact resistance and shape memory properties.The design of these structures provides a reference for the design of anti-shock cushioning structures with self-recovery functions in the future.

关键词： Engineering bionics Bionic structural design Additive manufacturing Quasi-static compression Numerical simulation Shape memory effect

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