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A Case of Investigation and Diagnosis of Immune Thrombocytopenic Purpura After Vaccination of COVID-19 Inactivated Vaccine

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Journal of Clinical and Nursing Research 2024年第6期8卷 328-334页

作者： Hao Leng Ju Yan Xiaoling Zhu Xiaoxia Jiang Jingzhi Li Yundan Cheng Communicable disease prevention and control and Immunization Program Chongqing Banan District Disease Prevention and Control CenterChongqing 401320China

Objective:Analyze the relationship between inoculating one case of the COVID-19 inactivated vaccine(Vero cell)and immune thrombocytopenic purpura to provide a reference for the standardized handling of adverse events following ***:According to the"National Monitoring Program for Suspected Adverse Reactions to Vaccinations,"an on-site investigation,data collection and analysis,expert group diagnosis,and medical association assessment were conducted on a case of immune thrombocytopenic purpura in district A of Chongqing after vaccination with the inactivated COVID-19 *** assessment report was delivered to the three relevant parties,the case was reviewed,and the experience was ***:The investigation and diagnosis by the district-level vaccination abnormal reaction expert group concluded that the disease that occurred after vaccination with the COVID-19 inactivated vaccine was secondary immune thrombocytopenic purpura,an abnormal reaction to the *** medical damage was classified as Level II Grade *** vaccine production enterprise raised objections to this *** re-assessment by the municipal-level medical association,the conclusion was consistent with that of the district-level medical *** vaccine production enterprise did not raise any further ***:Through active collaboration among district and municipal-level medical associations,disease control institutions,and vaccination units,the recipients have been promptly and effectively treated,providing financial support for their subsequent treatment and safeguarding their *** investigation and disposal procedures for adverse events following immunization in Chongqing are clear,and the mechanism is *** is necessary to continue strengthening the monitoring of adverse events following immunization according to the existing plan and to ensure timely and standardized ***,it is crucial to strengthen vacci

关键词： Adverse events following immunization Immunizations COVID-19 inactivated vaccine(Vero cell) Immune thrombocytopenic purpura Investigation and diagnosis

Surveillance Report of the Prevalence and Risk Factors of Chronic Non-Communicable diseases in Tinghu district,Yancheng City,2021

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Proceedings of Anticancer Research 2024年第4期8卷 135-141页

作者： Lili Yan Zhiqin Kai center for disease control and prevention Tinghu DistrictYancheng CityJiangsu Province 224000China

Objective:To comprehensively understand the changes and prevalence of major chronic diseases among residents of Tinghu district,Yancheng City,in 2021,and to analyze the trends of the major risk factors for the onset of chronic diseases in the ***:Chronic diseases and their risk factors in Tinghu district in 2021 were monitored among the resident population who had lived in the district for five years or more and were aged 18 years or *** survey was conducted using random cluster sampling,with 7,130 questionnaires *** data processing,7,012 valid questionnaires were obtained,resulting in a qualification rate of 98.35%.Results:Among the chronic diseases reported in the survey population,hypertension had the highest prevalence at 37.61%,followed by dyslipidemia at 37.19%.Other chronic diseases were ranked in order of prevalence from highest to *** of gender,the top three chronic diseases were hypertension,diabetes,and *** regression analysis identified both non-preventable risk factors(such as family history,gender,and age)and preventable risk factors(such as smoking,sedentary behavior,overweight,and obesity)as significant contributors to the major chronic diseases in Tinghu ***:Analyzing the trends in the main risk factors for chronic disease incidence in Tinghu district,Yancheng City,provides a basis for developing a new comprehensive chronic disease prevention and control plan to address chronic disease prevention and management.

关键词： Chronic diseases Non-communicable Social factors Monitoring report

DNA vaccine prime and replicating vaccinia vaccine boost induce robust humoral and cellular immune responses against MERS-CoV in mice

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Virologica Sinica 2024年第3期39卷 490-500页

作者： Xiuli Shen Shuhui Wang Yanling Hao Yuyu Fu Li Ren Dan Li Wenqi Tang Jing Li Ran Chen Meiling Zhu Shuo Wang Ying Liu Yiming Shao National Key Laboratory of Intelligent Tracking and Forecasting for Infectious diseases National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Changping Laboratory Yard 28Science Park RoadChangping DistrictBeijing 102206China State Key Laboratory for Diagnosis and Treatment of Infectious diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China

As of December 2022,2603 laboratory-identified Middle East respiratory syndrome coronavirus(MERS-CoV)infections and 935 associated deaths,with a mortality rate of 36%,had been reported to the World Health Organization(WHO).However,there are still no vaccines for MERS-CoV,which makes the prevention and control of MERS-CoV *** this study,we generated two DNA vaccine candidates by integrating MERS-CoV Spike(S)gene into a replicating Vaccinia Tian Tan(VTT)*** to homologous immunization with either vaccine,mice immunized with DNA vaccine prime and VTT vaccine boost exhibited much stronger and durable humoral and cellular immune *** immunized mice produced robust binding antibodies and broad neutralizing antibodies against the EMC2012,England1 and KNIH strains of ***-Boost immunization also induced strong MERS-S specific T cells responses,with high memory and poly-functional(CD107a-IFN-γ-TNF-α)effector CD8t T *** conclusion,the research demonstrated that DNA-Prime/VTT-Boost strategy could elicit robust and balanced humoral and cellular immune responses against *** study not only provides a promising set of MERS-CoV vaccine candidates,but also proposes a heterologous sequential immunization strategy worthy of further development.

关键词： MERS-CoV VTT vaccine DNA vaccine Humoral and cellular immune responses Prime/boost strategy

Prevalence of nicotine dependence among smokers aged 40 years and older in China

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2024年第2期2卷 119-131页

作者： Ying Ji Shu Cong Jing Fan Ning Wang Wenjing Wang Xuping Song Liwen Fang Chinese Field Epidemiology Training Program Chinese Center for Disease Control and Prevention27 Nanwei RoadXicheng DistrictBeijing 100050China National center for Chronic and Non-communicable disease control and prevention Chinese Center for Disease Control and Prevention27 Nanwei RoadXicheng DistrictBeijing 100050China Zunyi center for disease control and prevention ZunyiGuizhou 563000China

Background:Nicotine dependence,also known as tobacco dependence,is a common chronic disease and a major risk factor for chronic respiratory *** present study was designed to determine the prevalence of nicotine dependence and its changes among smokers aged 40 years and older in China,to analyze the characteristics of nicotine dependence among smokers,and to provide a reference for smoking cessation ***:The data were sourced from nationally representative large-sample surveys conducted during 2014-2015 and 2019-2020 in the Chinese population,covering 125 counties(districts)in 31 provinces,autonomous regions and *** related to smoking and nicotine dependence among residents≥40 years old were collected in face-to-face interviews.A total of 20,062 and 18,975 daily smokers were included in the 2014-2015 and 2019-2020 surveys,*** severity of nicotine dependence was evaluated according to the Fagerström Test for Nicotine Dependence and Heaviness of Smoking *** level and change in nicotine dependence among daily smokers aged≥40 years were estimated using a complex weighted sampling design,and their influencing factors were ***:Levels of nicotine dependence among daily smokers aged≥40 years in China could be divided into very low,low,medium,high,and very high,accounting for 31.1%,27.9%,13.4%,20.5%,and 7.1%of the total,*** average Fagerström Test for Nicotine Dependence score was 3.9(95%confidence interval[CI]:3.8-4.0),with the prevalence of medium-high nicotine dependence being 41.0%(95%CI:39.0-42.9%)and that of high and very high nicotine dependence being 27.6%(95%CI:26.0-29.3%),both of which were significantly higher in men than in women(both P<0.001).Among daily smokers,those with a low education level,age at smoking initiation<18 years,and with smoking duration of≥20 years had a higher degree of nicotine *** terms of geographic region,the level of medium-high nicotine d

关键词： Nicotine dependence Chronic obstructive pulmonary disease Surveillance Smoking cessation Tobacco control Distribution

Clinical application value of long non-coding RNAs signatures of genomic instability in predicting prognosis of hepatocellular carcinoma

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2386-2392页

作者： Xiao-Wen Xing Xiao Huang Wei-Peng Li Ming-Ke Wang Ji-Shun Yang Department of disease control and prevention Naval Medical CenterNaval Medical UniversityShanghai 200052China Medical Care center Naval Medical UniversityShanghai 200052China

Hepatocellular carcinoma(HCC)presents challenges due to its high recurrence and metastasis rates and poor *** current clinical diagnostic and prognostic indicators exist,their accuracy remains imperfect due to their biol-ogical ***,there is a quest to identify improved biomarkers for HCC diagnosis and *** combining long non-coding RNA(lncRNA)expression and somatic mutations,Duan et al identified five representative lncRNAs from 88 lncRNAs related to genomic instability(GI),forming a GI-derived lncRNA signature(LncSig).This signature outperforms previously re-ported LncSig and TP53 mutations in predicting HCC *** this editorial,we comprehensively evaluate the clinical application value of such prognostic evaluation model based on sequencing technology in terms of cost,time,and ***,we provide an overview of various prognostic models for HCC,aiding in a comprehensive understanding of research progress in pro-gnostic evaluation methods.

关键词： Hepatocellular carcinoma Prognosis Prognostic model Biomarkers Genomic instability long non-coding RNA Clinical application value

Epidemiological characteristics of tuberculosis incidence and its macro-influence factors in Chinese mainland during 2014-2021

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Infectious diseases of Poverty 2024年第3期13卷 43-57页

作者： Le-le Deng Fei Zhao Zhuo-wei Li Wei-wei Zhang Guang-xue He Xiang Ren National Institute for Viral disease control and prevention Chinese Center for Disease Control and PreventionBeijing 102206China Department of Pharmacy Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical ScienceBeijing Key Laboratory of Drug Clinical Risk and Personalized Medication EvaluationBeijing 100730China Miyun district center for disease control and prevention Beijing 101500China School Of Public Health Binzhon Medical UniversityYantai 264000China Division of Infectious disease Key Laboratory of Surveillance and Early-Warning On Infectious DiseaseChinese Center for Disease Control and PreventionBeijing 102206China

Background Tuberculosis(TB)remains a pressing public health issue,posing a significant threat to individuals'well-being and *** study delves into the TB incidence in Chinese mainland during 2014-2021,aiming to gain deeper insights into their epidemiological characteristics and explore macro-level factors to enhance control and *** TB incidence data in Chinese mainland from 2014 to 2021 were sourced from the National Notifiable disease Reporting System(NNDRS).A two-stage distributed lag nonlinear model(DLNM)was constructed to evaluate the lag and non-linearity of daily average temperature(℃,Atemp),average relative humidity(%,ARH),average wind speed(m/s,AWS),sunshine duration(h,SD)and precipitation(mm,PRE)on the TB incidence.A spatial panel data model was used to assess the impact of demographic,medical and health resource,and economic factors on TB *** A total of 6,587,439 TB cases were reported in Chinese mainland during 2014-2021,with an average annual incidence rate of 59.17/100,*** TB incidence decreased from 67.05/100,000 in 2014 to 46.40/100,000 in 2021,notably declining from 2018 to 2021(APC=-8.87%,95%CI:-11.97,-6.85%).TB incidence rates were higher among males,farmers,and individuals aged 65 years and *** analysis revealed a significant cluster in Xinjiang,Qinghai,and Xizang from March 2017 to June 2019(RR=3.94,P71.73%),low sunshine duration(<6.18 h)increased the risk of TB incidence,while extreme low wind speed(<2.79 m/s)decreased the *** spatial Durbin model showed positive associations between TB incidence rates and sex ratio(β=1.98),number of beds in medical and health institutions per 10

关键词： Tuberculosis Surveillance Epidemiological characteristics Incidence Influence factor Distributed lag nonlinear model(DLNM) Spatial panel model China

Analysis of Epidemiological Characteristics of Varicella Before and After the Implementation of the Two-dose Varicella Vaccine Immunization Program in Banan district of Chongqing City

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Journal of Clinical and Nursing Research 2024年第6期8卷 335-344页

作者： Yundan Cheng Ju Yan Xiaoling Zhu Xiaoxia Jiang Jingzhi Li Hao Leng Chongqing Banan district disease prevention and control center 79 Bay County AvenueYudong StreetBanan DistrictChongqing 401320China

Objective:To explore the changes in the epidemiological characteristics of varicella before and after implementing the two-dose varicella vaccine(VarV)immunization program in the Banan district of Chongqing and to provide a reference for future epidemic prevention and ***:The data of reported varicella cases in Banan district from 2014 to 2023 were collected and analyzed using the China disease prevention and control Information *** epidemiological methods were employed to assess the changes in the reported incidence of varicella before(2014-2018)and after(2019-2023)the implementation of the two-dose VarV immunization ***:The average annual reported incidence rate of varicella in Banan district from 2014 to 2023 was 81.53 per 100,*** 2014 to 2018,the reported incidence rate showed an upward trend year by year(trend x2=223.96,Pdistrict,the vaccination rate increased yearly,and the reported incidence of varicella showed a downward *** incidence rate of varicella in children aged 5-9 years reduced significantly,but the overall downward trend for the entire population was not as ***

关键词： Varicella Varicella vaccine Immunization program Epidemiological characteristics

Urgent call for attention to diabetes-associated hospital infections

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World Journal of Diabetes 2024年第8期15卷 1683-1691页

作者： Xue-Lu Yu Li-Yun Zhou Xiao Huang Xin-Yue Li Qing-Qing Pan Ming-Ke Wang Ji-Shun Yang Department of disease control and prevention Naval Medical Center of PLANaval Medical UniversityShanghai 200052China Medical Care center Naval Medical Center of PLANaval Medical UniversityShanghai 200052China

In this editorial,we discuss the recent article by Zhao et al published in the World Journal of Diabetes,which highlights the importance of recognizing the risk indicators associated with diabetes mellitus(DM).Given the severe implications of healthcare-associated infections(HAIs)in hospitalized individuals-such as heightened mortality rates,prolonged hospitalizations,and increased costs-we focus on elucidating the connection between DM and nosocomial *** patients are susceptible to pathogenic bacterial invasion and subsequent infection,with some already harboring co-infections upon ***,DM is an important risk factor for nosocomial urinary tract infections and surgical site infections,which may indirectly affect the occurrence of nosocomial bloodstream infections,especially in patients with DM with poor glycemic *** evidence regarding the impact of DM on healthcare-associated pneumonias remains inconclusive,attention to this potential association is *** patients with DM should prioritize meticulous blood glucose management,adherence to standard operating procedures,hand hygiene practices,environmental disinfection,and rational use of drugs during *** studies are imperative to explore the main risk factors of HAIs in patients with DM,enabling the development of preventative measures and mitigating the occurrence of HAIs in these patients.

关键词： Diabetes mellitus Healthcare-associated infections Nosocomial urinary tract infections Surgical site infections Nosocomial bloodstream infections

Epidemiological Characterization of Dengue Fever—Yunnan Province,China,2010-2021

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China CDC weekly 2024年第20期6卷 457-462,I0002-I0007页

作者： Xiaoxiang Zhu Songwang Wang Yanfei Li Yu Cao Xuemei Su Xiaotao Zhao National Key Laboratory of Intelligent Tracking and Forecasting for Infectious diseases Chinese Center for Disease Control and PreventionBeijingChina Yunnan Institute of Parasitic diseases Pu’er CityYunnan ProvinceChina

Objective:The goal of this study is to analyze the epidemiological patterns of dengue fever across different districts and counties in Yunnan Province from 2010 to ***:In this study,we employed joinpoint regression analysis,spatial autocorrelation analysis,and space-time scan analysis to illustrate the spatiotemporal propagation and demographic influence of dengue fever,using both graphical and tabular presentations to clearly demonstrate the ***:Yunnan Province reported 14,098 cases of dengue fever during the period from 2010 to *** these,11,513 cases were caused by local transmission,2,566 were imported internationally,and 19 were inter-provincial *** trends emerged,revealing a surge in incidences during the summer and autumn *** sex ratio of male to female cases was 1:0.88,with a significant majority of 82.00%of cases involving individuals belonging to the age group of *** service workers constituted the most impacted occupational group,forming 20.96%of total cases.A spatio-temporal scan identified significant clustering of dengue fever cases across space and time,with the most pronounced cluster observed in southern Yunnan,primarily between 2015 and ***:Dengue fever in Yunnan Province manifests as biennial outbreaks,underscoring the necessity for increased surveillance,particularly in counties bordering other regions.

关键词： counties district revealing