Background:As the most common iron metabolism and storage organ,the specific regulatory mechanism and prognostic relevance of hepatocellular carcinoma(HCc)need further ***:We aimed to perform a multi-omics integration...
详细信息
Background:As the most common iron metabolism and storage organ,the specific regulatory mechanism and prognostic relevance of hepatocellular carcinoma(HCc)need further ***:We aimed to perform a multi-omics integration and a ferroptosis-associated signature of ***:Gene Expression Omnibus was searched for available data with ferroptosis inducers,and three independent datasets(GSE104462,GSE112384,and GSE142591)were ***-omic data with available clinical information of TCGA-LIHC and CHCC were retrieved from the Cancer Genome Atlas(TCGA,http://***/)and iProX database(***,IPx0000937000).Integrated multi-omics analyses revealed the difference among biological functions,the activation status of key signaling pathways,tumor microenvironment,and sorafenib resistance in ***-sample gene set enrichment analysis(ssGSEA)identified a novel panel associated with clinical and molecular attributes,including survival,immune microenvironment,sorafenib resistance,genetic profile,liver-specific proteome,and ***:We performed a multi-omics integrationfor ferroptosis-associated characterization of HCC using paired tumor and adjacent liver tissues from 370 samples of *** proposed a novel panel including twelve genes that could reflect the prognosis and capacity of ferroptosis(ATAD2,DTL,DUT,E2F2,GINS2,FOXK1,MCM4,MCM5,MTHFD1,PHF19,POLA1,THOC6).Samples with high ferroptosis prognostic scores suggested significantly inferior survival(P=0.0028),a lower degree of ferroptosis(P<0.001),and greater ferroptosis induction capacity(P<0.001).Conclusion:The score in our study revealed the inherent state and further potential of ferroptosis in tumor cells,which also distinct features in tumor metabolism,microenvironment,clinical phenotype,and potential therapeutics.
Dear Editor,Short tandem repeats(STRs),polymorphic DNA regions with a variable number of repeated units(2–6 base pairs),are attractive to forensic applications such as human identification and parentage testing[1].No...
详细信息
Dear Editor,Short tandem repeats(STRs),polymorphic DNA regions with a variable number of repeated units(2–6 base pairs),are attractive to forensic applications such as human identification and parentage testing[1].Nowadays,most of the commercial STR kits are designed based on STRs from the combined DNA index system(CODIS),European Standard Set(ESS),expanded CODIS,and extended ESS[2].In this study,we evaluated 21 STRs from GoldeneyeTM DNA ID 22NC kit(PeopleSpot Inc.,Beijing,China),which including 20 polymorphic non-CODIS STR loci(i.e.D1S1656,D2S441,D3S1744,D3S3045,D4S2366,D5S2500,D6S477,D7S1517,D7S3048,D8S1132,D10S1248,D10S1435,D11S2368,D13S325,D14S608,D15S659,D17S1290,D18S535,D19S253,D22GATA198B05)and a CODIS STR locus(D3S1358),in five ethnic groups(*** Han,Ningxia Hui,xinjiang Uygur,Xizang Tibetan,and Inner Mongolia Mongolian)of *** forensic genetic investigation of above loci may provide more genetic information in complex kinship testing and population studies[3,4].
Agricultural input and output status in southern xinjiang,China is introduced,such as lack of agricultural input,low level of agricultural modernization,excessive fertilizer use,serious damage of environment,shortage ...
详细信息
Agricultural input and output status in southern xinjiang,China is introduced,such as lack of agricultural input,low level of agricultural modernization,excessive fertilizer use,serious damage of environment,shortage of water resources,tremendous pressure on ecological balance,insignificant economic and social benefits of agricultural production in southern xinjiang,agriculture remaining a weak industry,agricultural economy as the economic subject of southern xinjiang,and backward economic development of southern *** the Aksu area as an example,according to the input and output data in the years 2002-2007,input-output model about regional agriculture of the southern xinjiang is established by principal component *** software is used in the process of solving the ***,Eviews software is adopted to revise and test the model in order to analyze and evaluate the economic significance of the results obtained,and to make additional explanations of the relevant *** the agricultural economic output is seriously restricted in southern xinjiang at present,the following countermeasures are put forward,such as adjusting the structure of agricultural land,improving the utilization ratio of land,increasing agricultural input,realizing agricultural modernization,rationally utilizing water resources,maintaining eco-environmental balance,enhancing the awareness of agricultural insurance,minimizing the risk and loss,taking the road of industrialization of characteristic agricultural products,and realizing the transfer of surplus labor force.
暂无评论