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Chinese Chemical Letters 2024年第6期35卷 161-167页

作者： Ya Song Mingxia Zhou Zhu Chen Huali Nie Jiao-Jing Shao Guangmin Zhou School of Materials and Metallurgy Guizhou UniversityGuiyang 550025China medical College of Guizhou University Guiyang 550025China College of Biological Science and medical Engineering Donghua UniversityShanghai 201620China Shenzhen Geim Graphene center Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China

The practical application of high-energy-density lithium-sulfur(Li-S)batteries have been highly praised for energy storage devices,while are largely hindered by the“shuttling effect”.Herein,core-shell carbon spheres composed of interlinked porous core and lamellar shell were designed to restrain the polysulfide *** microporous structure with pore size of around 1 nm effectively trap lithium ***,the interconnected porous core shortens the ion transfer distance and the lamellar carbon shell endows the carbon spheres with fast electron conduction,finally facilitating polysulfide conversion ***,the Li-S batteries with the carbon spheres as the interlayer show high discharge specific capacity of 1002 m Ah/g at 2 C with 574 m Ah/g remaining after 600 cycles,and high areal capacity of 5.48 m Ah/cm^(2) with sulfur loading of 4.67 mg/cm^(2) at 0.1 *** corresponding pouch cells also exhibit stable cycling stability with an initial discharge specific capacity of 1082 m Ah/g at 0.1 C.

关键词： Interlayer Shuttle effect Strong adsorption Porous carbon spheres Lithium-sulfur batteries

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肌骨系统疾病临床研究方法专家共识

中华医学杂志 2024年第23期104卷 2123-2141页

作者：中华医学会骨科学分会中国医师协会骨科医师分会国家老年疾病临床医学研究中心(湘雅医院) Department of Orthopedics Xiangya Hospital Central South University National Clinical Research Center for Geriatric Disorders Xiangya Hospital Changsha 410008 China Department of Orthopedics Third Hospital of Hebei Medical University Shijiazhuang 050051 China

肌骨系统疾病的临床研究对明确该类疾病的危险因素、规范和创新诊疗方法十分重要, 为进一步促进肌骨系统疾病临床研究规范化, 满足当前临床研究实践需要, 中华医学会骨科学分会、中国医师协会骨科医师分会及国家老年疾病临床医学研究中... 详细信息

肌骨系统疾病的临床研究对明确该类疾病的危险因素、规范和创新诊疗方法十分重要, 为进一步促进肌骨系统疾病临床研究规范化, 满足当前临床研究实践需要, 中华医学会骨科学分会、中国医师协会骨科医师分会及国家老年疾病临床医学研究中心(湘雅医院)组织专家基于国际权威肌骨系统疾病临床研究方法学标准和指南, 结合我国医疗卫生实践, 制订出符合我国国情的肌骨系统疾病临床研究方法专家共识, 旨在促进肌骨系统疾病临床研究规范化、科学化。

关键词：肌骨系统疾病临床研究专家共识

Two-year longitudinal change in choroidal and retinal thickness in school-aged myopic children:exploratory analysis of clinical trials for myopia progression

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Eye and Vision 2024年第4期10卷 1-10页

作者： Meiping Xu Xinping Yu Minghui Wan Kemi Feng Junxiao Zhang Meixiao Shen BjÖrn Drobe Hao Chen Jia Qu Jinhua Bao Eye Hospital and School of Ophthalmology and Optometry Wenzhou Medical UniversityWenzhouZhejiangChina National Clinical Research center for Ocular Diseases WenzhouZhejiangChina. WEiRC WMU-Essilor International Research CenterWenzhouZhejiangChina R&D Vision Sciences AMERA EssilorInternationalSingaporeSingapore

Background:With increasing axial length(AL)and myopia progression,the micro-structure of the retina and choroid gradually *** study describes the longitudinal changes in retinal and choroidal thickness in school-aged children with myopia and explores the relationship between changes in choroidal thickness and myopia ***:An exploratory analysis of a randomized trial was ***(n=168,aged 7 to 12 years)with myopia from-0.75 diopter(D)to-4.00 D were enrolled in this prospective longitudinal *** refraction,AL,retinal and choroidal thicknesses were measured at baseline and at 1-and 2-year follow-ups."Rapid progression myopia"was defined as increasing in myopia>1.00 D and'"stable progression myopia"was≤1.00 D during the 2-year *** affecting the changes in choroidal thickness were analysed using linear mixed ***:AL significantly increased by 0.67±0.24 mm with a myopic shift of-1.50±0.64 D over the 2 *** overall retinal thickness increased from 251.12±15.91μm at baseline to 253.47±15.74μm at the 2-year followup(F=23.785,P<0.001).The subfoveal choroidal thickness decreased from 231.03±54.04μm at baseline to 206.53±59.71μm at the 2-year follow-up(F=73.358,P<0.001).Choroidal thinning was significantly associated with AL elongation(β=-43.579μm/mm,P=0.002)and sex(β=-17.258,P=0.001).Choroidal thickness continued to decrease in subjects with rapid progression(F=92.06,P<0.001)but not in those with steady progression(F=2.23,P=0.119).Conclusion:Significant choroidal thinning was observed and was associated with rapid progression and *** findings indicate a need to understand the role of the choroid in eye growth and myopia ***/Precis:The macular choroidal thickness of myopic children is relevant to different degrees of myopic progression in this 2-year longitudinal *** findings suggest that control of choroidal thickness might work to regulate human ocular growth.

关键词： Axial length Choroidal thickness Children Myopia Spectral-domain optical coherence tomography

Two-sample Mendelian randomization analysis of causal relationship between eczema and autoimmune diseases

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中南大学学报（医学版） 2024年第6期49卷 932-942页

作者： CHEN Chunli YAN Siyu WAN Bangbei YU Yangyiyi ZENG Jinrong TAN Lina LU Jianyun Department of Dermatology Third Xiangya HospitalCentral South UniversityChangsha 410013 Reproductive medical center Hainan Women and Children’s Medical CenterHaikou 570208China

Objective:The causal relationship between eczema and autoimmune diseases has not been previously *** study aims to evaluate the causal relationship between eczema and autoimmune ***:The two‐sample Mendelian randomization(MR)method was used to assess the causal effect of eczema on autoimmune *** data from the Genome-Wide Association Study Catalog(GWAS)were obtained from the Integrative Epidemiology Unit(IEU)*** eczema and autoimmune diseases,genetic instrument variants(GIVs)were identified according to the significant difference(P<5×10−8).Causal effect estimates were generated using the inverse‐variance weighted(IVW)*** Egger,maximum likelihood,MR-PRESSO,and MR-RAPS methods were used for alternative *** tests,including heterogeneity,horizontal pleiotropy,and leave-one-out analyses,were ***,reverse causality was ***:Genetic susceptibility to eczema was associated with an increased risk of Crohn’s disease(OR=1.444,95%CI 1.199 to 1.738,P<0.001)and ulcerative colitis(OR=1.002,95%CI 1.001 to 1.003,P=0.002).However,no causal relationship was found for the other 6 autoimmune diseases,including systemic lupus erythematosus(SLE)(OR=0.932,P=0.401),bullous pemphigoid(BP)(OR=1.191,P=0.642),vitiligo(OR=1.000,P=0.327),multiple sclerosis(MS)(OR=1.000,P=0.965),ankylosing spondylitis(AS)(OR=1.001,P=0.121),rheumatoid arthritis(RA)(OR=1.000,P=0.460).Additionally,no reverse causal relationship was found between autoimmune diseases and ***:Eczema is associated with an increased risk of Crohn’s disease and ulcerative *** causal relationship is found between eczema and SLE,MS,AS,RA,BP,or vitiligo.

关键词： eczema atopic eczema autoimmune diseases Crohn’s disease ulcerative colitis Mendelian randomization

A FRET-Based Ratiometric H_(2)S Sensor for Sensitive Optical Molecular Imaging in Second Near-Infrared Window

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Research 2024年第3期2023卷 671-684页

作者： Shan Lei Kejia Jiang Chenqing Zhang Wei Sun Yuantao Pan Dong Wang Peng Huang Jing Lin Marshall Laboratory of Biomedical Engineering International Cancer CenterShenzhen Key Laboratory of Tumor Visualization Molecular MedicineLaboratory of Evolutionary Theranostics(LET)School of Biomedical EngineeringShenzhen University Medical SchoolShenzhen UniversityShenzhen 518055China. center for AIE Research College of Materials Science and EngineeringShenzhen UniversityShenzhen 518060China.

Second near-infrared(NIR-II)window optical molecular imaging kicks off a new revolution in high-quality imaging in vivo,but always suffers from the hurdles of inevitable tissue autofluorescence background and NIR-II probe ***,we prepare a Förster resonance energy transfer-based ratiometric NIR-II window hydrogen sulfide(H_(2)S)sensor through the combination of an H_(2)S-responsive NIR-II cyanine dye(acceptor,LET-1055)and an H_(2)S-inert rhodamine hybrid polymethine dye(donor,Rh930).This sensor not only exhibits high sensitivity and selectivity,but also shows rapid reaction kinetics(~20 min)and relatively low limit of detection(~96 nM)toward H_(2)S,allowing in vivo ratiometric NIR-II fluorescence imaging of orthotopic liver and colon tumors and visualization of the drug-induced hepatic H_(2)S *** findings provide the potential for advancing the feasibility of NIR-II activity-based sensing for in vivo clinical diagnosis.

关键词： H_ Infrared kinetics

Identification and application of a strong bidirectional acmN2p promoter from actinomycin D-producing streptomycetes

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Engineering Microbiology 2024年第1期4卷 108-114页

作者： Sainan Li Danfeng Tang Xu Zhao Manxiang Zhu Xiangcheng Zhu Yanwen Duan Yong Huang xiangya international Academy of Translational Medicine Central South UniversityChangsha 410013China Institute of Health and Medicine Hefei Comprehensive National Science CenterHefei 230093China Hunan Engineering Research center of Combinatorial Biosynthesis and Natural Product Drug Discovery Changsha 410011China National Engineering Research center of Combinatorial Biosynthesis for Drug Discovery Changsha 410011China

Natural product biosynthesis is controlled at multiple *** of naturally occurring promoters has facilitated the study of the synthetic biology of natural ***,we report the discovery of two highyield actinomycin D(ActD)-producing streptomycetes and the identification of a strong bidirectional acmN2p promoter from the ActD gene clusters and its application in heterologous expression of three core genes involved in the bacterial alkaloid bohemamine biosynthesis,providing a good example for identification of new promoters for synthetic biological applications.

关键词： Actinomycin D Bidirectional promoter Bohemamine Streptomyces

Degradation of FAK-targeting by proteolytic targeting chimera technology to inhibit the metastasis of hepatocellular carcinoma

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Oncology Research 2024年第4期32卷 679-690页

作者： XINFENG ZHANG SHUANG LI MEIRU SONG YUE CHEN LIANGZHENG CHANG ZHERUI LIU HONGYUAN DAI YUTAO WANG GANGQI YANG YUN JIANG YINYING LU The PLA 307 Clinical College of Anhui medical University The Fifth Clinical Medical College of Anhui Medical UniversityHefei230032China Liver Tumor Diagnosis and Research center 5th Medical Center of the PLA General HospitalBeijing100039China Department of Infection Diseases Guizhou Medical UniversityGuiyang550025China 4302 Clinical medical School Peking UniversityBeijingChina Cell and Gene Therapy Innovation center Beijing Lotuslake BiomedicalScience and Technology ParkBeijing102206China State Key Laboratory of Chemical Oncogenomics and the Institute of Biopharmaceutical and Health Engineering(iBHE) Shenzhen International Graduate SchoolTsinghua UniversityShenzhen518055China

Liver cancer is a prevalent malignant cancer,ranking third in terms of mortality *** and recurrence primarily contribute to the high mortality rate of liver *** carcinoma(HCC)has low expression of focal adhesion kinase(FAK),which increases the risk of metastasis and ***,the efficacy of FAK phosphorylation inhibitors is currently ***,investigating the mechanisms by which FAK affects HCC metastasis to develop targeted therapies for FAK may present a novel strategy to inhibit HCC *** study examined the correlation between FAK expression and the prognosis of ***,we explored the impact of FAK degradation on HCC metastasis through wound healing experiments,transwell invasion experiments,and a xenograft tumor *** expression of proteins related to epithelial-mesenchymal transition(EMT)was measured to elucidate the underlying *** results showed that FAK PROTAC can degrade FAK,inhibit the migration and invasion of HCC cells in vitro,and notably decrease the lung metastasis of HCC in *** expression of E-cadherin and decreased expression of vimentin indicated that EMT was ***,degradation of FAK through FAK PROTAC effectively suppressed liver cancer metastasis,holding significant clinical implications for treating liver cancer and developing innovative anti-neoplastic drugs.

关键词： Hepatocellular carcinoma(HCC) Focal adhesion kinase(FAK) Proteolytic targeting chimera technology(PROTAC) Epithelial-mesenchymal transformation(EMT) Metastasis

Association of Mosaic Chromosomal Alterations and Genetic Factors with the Risk of Cirrhosis

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Journal of Clinical and Translational Hepatology 2024年第6期12卷 562-570页

作者： Xinyuan Ge Lu Zhang Maojie Liu Xiao Wang Xin Xu Yuqian Yan Chan Tian Juan Yang Yang Ding Chengxiao Yu Jing Lu Longfeng Jiang Qiang Wang Qun Zhang Ci Song Department of Epidemiology China International Cooperation Center on Environment and Human HealthCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsuChina The Dumont-UCLA Transplant center Division of Liver and Pancreas TransplantationDepartment of SurgeryDavid Geffen School of Medicine at UCLALos AngelesCAUSA Department of Health Promotion center Jiangsu Province Hospital and Nanjing Medical University First Affiliated HospitalNanjingJiangsuChina Department of Infectious Disease The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina Department of Clinical Science Intervention and Technology(CLINTEC)Karolinska InstitutetStockholmSweden Changzhou medical center Nanjing Medical UniversityNanjingJiangsuChina Research Units of Cohort Study on Cardiovascular Diseases and Cancers Chinese Academy of Medical SciencesBeijingChina Collaborative Innovation center for Cancer Personalized Medicine Nanjing Medical UniversityNanjingJiangsuChina

Background and Aims:Age-related mosaic chromosomal alterations(mCAs)detected from genotyping of blood-de-rived DNA are structural somatic variants that indicate clonal *** study aimed to investigate whether mCAs contribute to the risk of cirrhosis and modify the effect of a polygenic risk score(PRS)on cirrhosis risk ***:mCA call sets of individuals with European ancestry were obtained from the UK *** PRS was constructed based on 12 susceptible single-nucleotide poly-morphisms for *** proportional hazard models were applied to evaluate the associations between mCAs and cirrhosis ***:Among 448,645 individuals with a median follow-up of 12.5 years,we identified 2,681 cas-es of cirrhosis,1,775 cases of compensated cirrhosis,and 1,706 cases of decompensated *** to non-carriers,individuals with copy-neutral loss of heterozygosity mCAs had a significantly increased risk of cirrhosis(hazard ratio(HR)1.42,95%confidence interval(CI)1.12-1.81).This risk was higher in patients with expanded cell fractions of mCAs(cell fractions≥10%*** fractions<10%),especially for the risk of decompensated cirrhosis(HR 2.03[95%CI 1.09-3.78]vs.1.14[0.80-1.64]).In comparison to non-carriers of mCAs with low genetic risk,individuals with expanded copy-neutral loss of heterozygosity and high genetic risk showed the highest cirrhosis risk(HR5.39[95%CI 2.41-12.07]).Conclusions:The presence of mCAs is associated with increased susceptibility to cirrhosis risk and could be combined with PRS for personalized cirrhosis risk stratification.

关键词： UK Biobank Cirrhosis Mosaic chromosomal alterations Polygenic risk score Genetic susceptibility Interaction effect

The lactylation index predicts the immune microenvironment and prognosis of pan-cancer patients

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BIOCELL 2024年第8期48卷 1223-1239页

作者： XUEJIA ZHAI JIE LIU JINWEI XIAO TAO ZHANG JUN WANG JIANJUN LI SHICANG YU Department of Oncology Southwest HospitalThird Military Medical University(Army Medical University)Chongqing400038China Department of Stem Cell and Regenerative Medicine Institute of Pathology and Southwest Cancer CenterSouthwest HospitalThird Military Medical University(Army Medical University)Chongqing400038China Key Laboratory of Cancer Immunopathology Ministry of EducationChongqing400038China international Joint Research center for Precision Biotherapy Ministry of Science and TechnologyChongqing400038China Jin-feng Laboratory Chongqing401329China

Background:Protein lactylation is a new way for the“metabolic waste”lactic acid to perform novel ***,our understanding of the contribution of protein lactylation to both tumor progression and therapeutic interventions remains *** construction of a scoring system for lactylation to predict the prognosis of pancancer patients and to evaluate the tumor immune microenvironment(TIME)would improve our understanding of the clinical significance of ***:Consensus clustering analysis of lactylation-related genes was used to cluster 177 pancreatic adenocarcinoma(PAAD)***,a scoring system was developed using the least absolute shrinkage and selection operator(LASSO)*** validation and external validation were both conducted to assess and confirm the predictive accuracy of the scoring ***,leucine rich repeat containing 1(LRRC1),a newly discovered lactylation-related gene,was analyzed in PAAD in ***:Utilizing the profiles of 332 lactylation-related genes,a total of 177 patients with PAAD were segregated into two distinct ***^(high) patients had a poorer prognosis than LacCluster^(low) *** the differential analysis between the LacCluster^(high) and LacCluster^(low) groups,we identified additional genes associated with *** genes were then integrated to construct the LacCluster-enhanced system,which enabled more accurate prognosis prediction for patients with ***,a lactylation index containing three genes(LacI-3)was constructed using LASSO *** was done to enhance the usability of the LacCluster-enhanced system in the *** to those in the LacI-3^(high) subgroup,patients in the LacI-3^(low) subgroup exhibited increased expression of immune checkpoint-related genes,more immune cell infiltration,lower tumor mutation burdens,and better prognoses,indicating a“hot tumor”***,knocking down the expression of LRRC1,

关键词： Pancreatic adenocarcinoma Pan-cancer Lactylation Prognosis Tumor immune microenvironment LRRC1

Limb Lengthening and Reconstruction Society orthopedic surgeons in the United States:An analysis of geographical distribution,academic,leadership,and demographic characteristics

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World Journal of Orthopedics 2024年第2期15卷 147-155页

作者： Amir Human Hoveidaei Reza Niakan Seyed Hossein Hosseini-Asl Abijith Annasamudram Janet D Conway international center for Limb Lengthening Rubin Institute for Advanced OrthopedicsSinai Hospital of BaltimoreBaltimoreMD 21215United States Student Research Committee Shiraz University of Medical SciencesShiraz 73Iran Students’Scientific Research center Tehran University of Medical SciencesTehran ***Iran

BACKGROUND The Limb Lengthening and Reconstruction Society(LLRS)is a premier orthopedic specialty organization that promotes limb reconstruction for all *** membership characteristics,however,are poorly *** study delineates orthopedic surgeon LLRS members’demographic traits,academic achievement,leadership attainment,and geographical distribution across the United *** To inform aspiring orthopedic professionals,as well as to promote growth and diversity in both the LLRS organization and overarching *** This cross-sectional study examined United States LLRS members’academic,leadership,demographic,and geographical *** reviewing the 2023 LLRS member directory,Google search results were matched to the listings and appended to the compiled *** and ethnicity were evaluated visually utilizing retrieved *** Hirsch index(H-index)of academic activity,residency and fellowship training,other graduate degrees,leadership positions,practice type(academic or non-academic),and spoken languages were *** members per state and capita determined geographic *** Mann Whitney U test was applied to compare H-index between males and females,as well as to assess member differences pertaining to affiliation with academic vs non-academic practice *** The study included 101 orthopedic surgeons,78(77.23%)Caucasian and 23(22.77%)non-Caucasian,79(78.22%)male and 22(21.78%)*** with DO degrees comprised only 3.96%(4)of the cohort,while the vast majority held MDs[96.04%(97)].Mean H-index was 10.55,with male surgeons having a significantly higher score(P=0.002).Most orthopedic surgeons(88.12%,)practiced in academic *** those professionals who occupied leadership positions,14%were women,while 86%were ***,19(37.25%)United States regions and the District of Columbia lacked an LLRS-member orthopedic *** per capita rate across the United States was 0.30 LLRS orthopedic

关键词： Limb lengthening and reconstruction Orthopedic surgeon demographics Orthopedic surgeon societal membership Orthopedic fellowships