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Significant genomic introgression from grey junglefowl(Gallus sonneratii)to domestic chickens(Gallus gallus domesticus)

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1482-1493页

作者： Xiurong Zhao Junhui Wen Xinye Zhang Jinxin Zhang Tao Zhu Huie Wang Weifang Yang Guomin Cao Wenjie Xiong Yong Liu Changqing Qu Zhonghua Ning Lujiang Qu National Engineering Laboratory for Animal Breeding College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin Xinjiang Production and Construction CorpsTarim UniversityAlar 843300China Beijing municipal General Station of Animal Science Beijing 100107China Animal husbandry station of Fangchenggang FangchenggangGuangxi Province 538001China Animal disease prevention and control center of Fangchenggang FangchenggangGuangxi Province 538001China Beijing Agricultural Effect Poultry Industry Co. Ltd.Beijing 101100China Engineering Technology Research center of Anti‑aging Chinese Herbal Medicine of Anhui Province Fuyang Normal UniversityFuyangAnhui 236037China

Background Chicken is one of the most numerous and widely distributed species around the world,and many studies support the multiple ancestral origins of domestic *** research regarding the yellow skin phenotype in domestic chickens(regulated by BCO2)likely originating from the grey junglefowl serves as crucial evidence for demonstrating the multiple origins of ***,beyond the BCO2 gene region,much remains unknown about the introgression from the grey junglefowl into domestic ***,in this study,based on wholegenome data of 149 samples including 4 species of wild junglefowls and 13 local domestic chicken breeds,we explored the introgression events from the grey junglefowl to domestic *** We successfully detected introgression regions besides BCO2,including two associated with growth trait(IGFBP2 and TKT),one associated with angiogenesis(TIMP3)and two members of the heat shock protein family(HSPB2 and CRYAB).Our findings suggest that the introgression from the grey junglefowl may impact the growth performance of ***,we revealed introgression events from grey junglefowl at the BCO2 region in multiple domestic chicken breeds,indicating a phenomenon where the yellow skin phenotype likely underwent strong selection and was ***,our haplotype analysis shed light on BCO2 introgression event from different sources of grey junglefowl into domestic chickens,possibly suggesting multiple genetic flows between the grey junglefowl and domestic *** In summary,our findings provide evidences of the grey junglefowl contributing to the genetic diversity of domestic chickens,laying the foundation for a deeper understanding of the genetic composition within domestic chickens,and offering new perspectives on the impact of introgression on domestic chickens.

关键词： BCO2 Domestic chickens Grey junglefowl Introgression

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Combination of p-Coumaric acid and lactoferrin ameliorates cognitive deficits through suppressing C/EBPβ/AEP pathway and modulating intestinal flora in APP/PS1 mice

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Food Science and Human Wellness 2024年

作者： Yan Zhou Yi-Tian Sun Hui Guo Yan-Zi Liang Si-Yuan Zhu Yu Sha Zhong-Xiao Wan Jia-Ying Xu Jian-Rong Jiang Li-Qiang Qin Yun-Hong Li Department of Nutrition and Food Hygiene， School of Public Health， Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric diseases， MOE Key Laboratory of Geriatric diseases and Immunology， Suzhou Medical college of Soochow University Department of Medical Technology， Suzhou Vocational Health College State Key Laboratory of Radiation Medicine and Protection， School of Radiation Medicine and Protection， Suzhou Medical college of Soochow University Suzhou municipal center for disease control and prevention

Alzheimer's disease （AD） has become an important public health issue worldwide. P-Coumaric acid （CA） and lactoferrin （Lf） possessed antioxidant， anti-inflammatory， and anti-AD activities. Herein， we hypothesized that a combination treatment of CA and Lf would synergistically improve AD symptoms and studied its mechanisms. Twelve-week-old APP/PS1 mice were treated with CA， Lf， or both CA and Lf for 8 weeks. Results showed that individual and combined treatments could ameliorate cognitive deficits to varying degrees， with stronger effects for combined intervention than for CA or Lf alone. Specifically， combined treatment was most effective in improving nesting ability and reducing Aβ1-42deposition in mice. Moreover， combined treatment was more effective in suppressing APP， BACE1， and inflammation; it inhibited the CCAAT-enhancer-binding protein （C/EBPβ）/asparagine endopeptidase （AEP） signaling pathway in the hippocampus and colon and upregulated the expression of tight junction protein ZO-1 in the colon; it also decreased the F/B ratio at the phylum level and increased the relative abundance of Prevotellaceae， Lachnospira， and Eubacterium at the genus level. Overall， the combination of CA and Lf may ameliorate cognitive deficits in APP/PS1 mice by improving inflammation and inhibiting the C/EBPβ/AEP signaling pathway via modulating gut microbiome.

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Impact of COVID-19 pandemic on routine childhood vaccinations

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World Journal of Virology 2024年第2期13卷 1-4页

作者： Shi-Rong Lv Ming-Ke Wang Xue-Lu Yu Xin-Yue Li Ji-Shun Yang Department of disease control and prevention Naval Medical Center of PLANaval Medical UniversityShanghai 200052China Medical Care center Naval Medical Center of PLANaval Medical UniversityShanghai 200052China

Routine pediatric vaccination is one of the most effective public health inter-ventions for the control of a number of fatal ***,during the coronavirus disease 2019 pandemic,routine pediatric vaccination rates were severely affected by disruptions of health services and vaccine confidence *** and the United Nations have taken measures to re-establish routine pediatric vaccination,while additional efforts are needed to catch up and develop plans to ensure routine vaccination services for the future pandemics.

关键词： Vaccines Childhood immunizations COVID-19 SARS-CoV-2 Pandemic

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Pollution of HCHs,DDTs and PCBs in tidal flat of Hangzhou Bay 2009–2013

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Chinese Journal of Oceanology and Limnology 2016年第3期34卷 539-548页

作者：赵鹏龚文杰毛国华李继革徐奋奋施家威 Jiangbei center for disease control and prevention Ningbo Cixi center for disease control and prevention Ningbo Ningbo municipal center for disease control and prevention Ningbo

The concentration and distribution of three persistent organic pollutants （hexachlorocyclohexanes （HCHs）, dichlorodiphenyltrichloroethanes （DDTs） and polyehlorinated biphenyls （PCBs）） was assessed in tidal fiat sediments collected from the south bank of Hangzhou Bay, China from 2009 to 2013. Gas chromatography coupled to triple quadrupole mass spectrometry （GC-MS/MS） was used for analysis, based on United States Environmental Protection Agency methods EPAS080A, EPA8081B, and EPA3550B. The results showed that the levels of HCHs, DDTs and PCBs decreased in the order of DDTs 〉 HCHs 〉 PCBs, and their mass fractions ranged from 0.29-32.91, 0.09-13.19 and 0.16-4.10 ktg/kg （dry mass）, respectively. The levels of HCHs, DDTs and PCBs decreased slowly from 2009 to 2013, with considerably greater concentrations in winter than in spring and summer. In this study area, the concentrations of DDTs and HCHs decreased gradually towards the mouth of Hangzhou Bay, while the concentrations of PCBs were related to changes in the local economy. In addition, the sources of HCHs and DDTs were identified as atmospheric precipitation and historical residues, Finally, we predicted that PCBs pollution primarily originated from Aroclor 1254（Lot A4）, which might root in the illegal demolition and stacking of abandoned paint, transformer or electronic equipment in the south bank of Hangzhou Bay.

关键词： South Bank of Hangzhou Bay sediment hexachlorocyclohexanes (HCHs) dichlorodiphenyltrichloroethanes (DDTs) polychlorinated biphenyls (PCBs)

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Molecular Characteristics of Neisseria meningitidis Isolated during an Outbreak in a Jail: Association with the Spread and Distribution of ST-4821 Complex Serogroup C Clone in China

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Biomedical and Environmental Sciences 2013年第5期26卷 331-337页

作者： ZHANG Ji ZHOU Hai Jian XU Li HU Guang Chun ZHANG Xue Hua XU Sheng Ping LIU Zun Yu SHAO Zhu Jun Jinan municipal center for disease control and prevention State Key Laboratory for Infectious disease prevention and control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and Prevention

Objective To characterize the meningococcal strains isolated from cases and close contacts with meningococcal disease associated with an outbreak in a jail in May 2010 by investigating the national distribution of hyperinvasive ST-4821 serogroup C clone associated with this outbreak. Methods The cases were described based on the clinical symptoms and laboratory results. Pharyngeal swabs were cultured for N. meningitidis from men in the jail. Meningococcal isolates were identified by serogrouping, pulsed-field gel electrophoresis （PFGE） and multilocus sequence typing （MLST）, respectively. Four hundred and sixteen serogroup C N. meningitidis strains were collected from 27 provinces between 2003 and 2010 for a nationwide survey and analyzed by PFGE and MLST. Results Three persons in a jail system were infected with invasive N. meningitidis serogroup C. All isolates tested had matching PFGE patterns and belonged to the multilocus sequence type （ST） 4821 clonal complex. All 47 N. meningitidis strains were identified from the pharyngeal swabs of 166 peoples in the jail, and 26 of them belonged to ST-4821 serogroup C clone, and 90.14% （375/416） serogroup C strains identified in the nationwide survey belonged to the ST-4821 complex. The ST-4821 serogroup C clone was spread nationwide, distributed in 24 provinces, especially in eastern provinces between 2003 and 2010. Conclusion Endemic transmission and carriage rate of ST-4821 serogroup C clone are high in this jail system. The ST-4821 serogroup C clone is spreading in China and nationwide distributed despite the existence of some effective vaccines.

关键词： Pulsed-field gel electrophoresis Multilocus sequence typing Neisseria meningitidis ST-4821 Serogroup C

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Genome Analysis of Plasmodium falciparum:A Preliminary Observation-Sierra Leone,2022-2023

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China CDC weekly 2024年第17期6卷 368-373页

作者： Tianyu Wang Haimo Shen Bin Xu Wanxuan Yang Shenbo Chen Junhu Chen National Institute of Parasitic diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesNational Centre for International Research on Tropical DiseasesShanghaiChina School of Basic Medical Sciences and Forensic Medicine Hangzhou Medical CollegeHangzhou CityZhejiang ProvinceChina School of Global Health Chinese Centre for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghaiChina Hainan Tropical diseases Research center(Hainan Sub-center Chinese Center for Tropical Diseases Research)Haikou CityHainan ProvinceChina.

What is already known about this topic?Sierra Leone,with a gross domestic product(GDP)per capita below$300 and significant poverty,ranks among the world’s least developed countries(LDCs).Despite its modest population of 8.6 million,the nation reports approximately 2.6 million malaria cases ***,there has been no reporting on the malaria genome data from this *** is added by this report?In this study,we present the first reported wholegenome sequence analysis of 19 high parasite-density Plasmodium falciparum isolates from Sierra Leone,providing insights into the genomic epidemiology of this high-prevalence *** found a high degree of relatedness among infections and substantial genetic diversity,consistent with the gradual reduction in overall case ***,our whole-genome analysis revealed that,beyond drug-resistance genes,gene families related to blood cell invasion,immune evasion,and others are undergoing directional *** suggests that the population in Sierra Leone has developed a relatively strong acquired *** are the implications for public health practice?The genomic data not only facilitate the creation of single nucleotide polymorphism barcodes for case tracking but also enable the analysis of evolving transmission dynamics and selection ***,the samples from Sierra Leone exhibited higher selective pressures on resistance genes compared to those from Asia,a trend not commonly observed in other African *** suggests that less stringent healthcare systems and inconsistent treatment strategies can subject parasites to increased drug pressure,thereby accelerating the development of resistant strains.

关键词： epidemiology invasion Observation

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Soil amendment strategies determining microbial community composition and their assembly processes in a continuously cropped soil

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Soil Ecology Letters 2024年第3期6卷 85-95页

作者： Hongkai Liao Chunli Zheng Juan Li Jian Long Yaying Li Guizhou Provincial Key Laboratory of Mountain Environment Guizhou Normal UniversityGuiyang 550001China The Key Laboratory of Environmental Pollution Monitoring and disease control Ministry of EducationDepartment of ToxicologySchool of Public HealthGuizhou Medical UniversityGuiyang 550025China Key Laboratory of Urban Environment and Health Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Key Laboratory of Urban Environmental Processes and Pollution control Ningbo(Beilun)Zhongke Haixi Industry Technology Innovation CenterNingbo 315800China

Reductive soil disinfestation(RSD)is an important tool for sustainable agricultural ***,the differences in soil bacterial communities and their community assembly processes among RSD and other treatment strategies(e.g.,biochar and chemical fumigation)are still subject to open *** this study,soils subjected to various treatments–un-treated control(CK),chemical soil fumigation with CaCN2(CF),1%biochar(1%B),3%biochar(3%B),and reductive soil disinfestation(RSD)are *** samples were collected,incubated,and then used for growth of tomato *** Sloan neutral community model indicates that stochastic processes dominate in bacterial community assembly for both biochar and CF *** contrast,this work shows that RSD treatment can have a strong impact on soil bacterial community *** relative abundance of Firmicutes increased during unplanted soil incubation,whereas Proteobacteria and Bacteroidetes dominated in the rhizosphere after planting of *** stochasticity ratio reveals that deterministic selection played an important role in the bacterial assembly under RSD *** found that RSD amendment yielded lower biomass than that for other treatments after 28 days of tomato *** results suggest that although RSD treatment has great potential to rebuild soil bacterial ecology by shaping bacterial communities and their assembly processes,it is important to monitor and manage soil conditions(e.g.,soil nutrients or physical properties)before planting to ensure plant productivity.

关键词： amendment strategy reductive soil disinfestation bacterial community assembly processes

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Molecular Epidemiological Characteristics of Streptococcus pyogenes Strains Involved in an Outbreak of Scarlet Fever in China,2011

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Biomedical and Environmental Sciences 2013年第11期26卷 877-885页

作者： YOU Yuan Hai SONG Yan Yan YAN Xiao Mei WANG Hai Bin ZHANG Meng Han TAO Xiao Xia Li Lei Lei ZHANG Yu Xin JIANG Xi Hong ZHANG Bing Hua ZHOU Hao XIAO Di JIN Lian Mei FENG Zi Jian LUO Feng Ji ZHANG Jian Zhong Collabroative Innovation center for Diagnosis Treatment of Infectious disease State Key Laboratory for Infectious Disease Prevention and ControlNational Institute for Communicable Disease Control and Prevention Chaoyang District center for disease control and prevention Beijing Suzhou City center for disease control and prevention Office of disease control and Emergency Response Chinese Center for Disease Control and Prevention Harbin municipal center for disease control and prevention

Objective To investigate molecular characterization of streptococcus pyogenes isolates involved in an outbreak of scarlet fever in China in 2011. Methods Seventy-four 5treptococcol pyogenes involved in an outbreak of scarlet fever were isolated from pediatric patients in the areas with high incidence in China from May to August of 2011. Emm genotyping, pulsed-field gel electrophoresis （PFGE）, superantigen （SAg） genes and antimicrobial susceptibility profiling were analyzed for these isolates. Results A total of 4 different emm types were identified. Emm12 was the most prevalent type which contained four predominating PFGE patterns corresponding to four different virulence and superantigen profiles. Emm12（79.7%） and emml （14.9%） accounted for approximately 94% of all the isolates. The speA gene was all negative in emm12 isolates and positive in emml isolates. All strains were resistant to erythromycin, and 89.4% of them were resistant to erythromycin, tracycline, and clindamycin simultaneously. Conclusion Several highly diversified clones with a high macrolide resistance rate comprise a predominant proportion of circulating strains, though no new emm type was found in this outbreak. The data provide a baseline for further surveillance of scarlet fever, which may contribute to the explanation of the outbreak and development of a GAS vaccine in China.

关键词： Scarlet fever Streptococcus pyogenes Molecular epidemiology

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Pedestrian Injuries and the Relevant Burden in Shanghai, China: Implications for control

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Biomedical and Environmental Sciences 2015年第2期28卷 127-135页

作者： LI Yan Hong WANG Chun Fang SONG Gui Xiang PENG Juan Juan ZHOU De Ding SU Hui Jia GAO Ning YU Yan ZHONG Wei Jian ZHANG Hong Wei Department of Injury prevention and control Shanghai Municipal Center for Disease Control & Prevention Department of Vital Statistics Shanghai Municipal Center for Disease Control &Prevention Department of Epidemiology Second Military Medical University

Objective To study the associations of pedestrian injuries with age, income and educational level in Shanghai and to analyze the relative disease burden. Methods Information on pedestrian-related cases and deaths were collected from 494 hospitals and mortality registry systems from 1992 to 2010, and a multistage cluster sampling survey conducted in 2006. Logistic regression model was used in the analyses. Results The age group of 5-9 had the highest mortality and morbidity among children. Mortality increased obviously among those aged 60 or above. Individuals with an educational level under the primary school and with the lower family average income were more likely to suffer pedestrian-related injuries. Multivariate Logistic analysis demonstrated that lower income and lower educational level increased the risk of pedestrian injuries with the odds ratio of 1.40 （95% Cl： 1.15-1.71） and 1.70 （95% Cl： 1.20-2-40）, respectively. About 13.54% of the share of GDP for the healthcare, social security and welfare industries in Shanghai was occupied by the burden of pedestrian-related injuries in 2006. Conclusion Pedestrian-related injury has inverse association with victims＇ income and educational level. Children of 5-9 years old and adults over 60 with lower educational level and lower monthly income are the target persons to be intervened.

关键词： Pedestrian Injury Mortality Education Costs

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Study on Age and Education Level and Their Relationship with Fall-Related Injuries in Shanghai, China

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Biomedical and Environmental Sciences 2013年第2期26卷 79-86页

作者： LI Yan Hong SONG Gui Xiang YU Yan ZHOU De Ding ZHANG Hong Wei Department of Injury prevention and control Shanghai Municipal Center for Disease Control&Prevention Department of Vital Statistics Shanghai Municipal Center for Disease Control&Prevention Department of Epidemiology Second Military Medical University

Objective To study age and educational level and their relationship with fall-related injuries in Shanghai and to analyze the relevant costs. Methods Multistage cluster sampling was used for the selection of participants and standardized questionnaires were used for the information collection in 2006. Information on cases and deaths caused by fall-related injuries were obtained from 494 hospitals as well as from the mortality registry systems from 2001 till 2010. Results Of 45 857 participates, 674 suffered from fall-related injuries with the largest proportion among all injuries. The fall-related mortality increased from 10.63 per 100 000 in 2001 to 14.11 per 100 000 in 2010. The under-five mortality rate was the highest among children aged 0-14 years. Mortality increased dramatically among those aged 55 or above for the female and aged 60 or older for the male. Individuals with an educational level under the primary school were more likely to suffer fall-related injuries, accounting for 72.66% of all deaths and 49.24% of nonfatal cases respectively. The annual burden of fall-related injuries equated to 25.90% of the share of GDP for the healthcare, social security and welfare industries in 2006. Conclusion Fall-related injuries were inversely related to victims＇ educational level. Children under the age of 5, women over 55 years old and men over 60 years old with an educational level lower than the primary school are the most risky groups of populations for intervention measures.

关键词： Fall Injury Education Costs Mortality

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