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China CDC weekly 2024年第22期6卷 503-508页

作者： Wenzhao Liu xinying Zeng Qi Su Lin xiao Shiwei Liu Tobacco control Office Chinese Center for Disease Control and PreventionBeijingChina

What is already known about this topic?In 2013,31.61%of students perceived quitting smoking as difficult,61.73%considered smoking less attractive,and 73.89%believed that secondhand smoke is definitely harmful to *** is added by this report?The percentage of students who perceived quitting smoking as difficult increased from 31.61%in 2013 to 38.83%in 2021,while the percentage of students who found smoking less attractive rose from 61.73%to 69.40%.Conversely,there was a decrease in the percentage of students who perceived secondhand smoke as harmful,from 73.89%to 68.46%.An increased awareness of the hazards of secondhand smoke was associated with a reduction in smoking *** are the implications for public health practice?It is imperative to enhance health education efforts that aim to raise awareness of the hazards of secondhand smoke.

关键词： smoke attractive Junior

Prevalence of Vitamin A Deficiency in Children Aged 6 to 17 Years—Western and Central Rural Areas,China,2012–2021

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China CDC weekly 2024年第3期6卷 51-55页

作者： Peipei Xu Juan Xu Wei Cao Titi Yang Qian Gan Hongliang Wang Ruihe Luo Hui Pan Qian Zhang National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijingChina

What is already known about this topic?Vitamin A deficiency(VAD)is a leading global nutritional concern,ranking among the top four major nutritional deficiencies *** prevalence of VAD is unevenly distributed across various regions,both within China and *** is added by this report?The report adds valuable insights into the vitamin A nutritional status of rural students aged 6–17 years who participated in the Nutrition Improvement Programme for Rural Compulsory Education Students(NIPRCES).Over the decade from 2012 to 2021,there was a modest improvement in vitamin A *** prevalence of VAD and sub-clinical VAD(SVAD)declined as the students *** the majority of the survey years,the incidence of VAD was higher among males and western regions compared to females and central regions,*** are the implications for public health practice?A comprehensive approach,incorporating dietary diversification,nutrition education,and food fortification,should be implemented to prevent VAD and SVAD especially in males,younger children and children in western areas.

关键词： vitamin Rural younger

Evaluation of the Effectiveness of“5E”Comprehensive Injury prevention Strategy for Fall prevention Among the Rural Elderly—Six Pilot Villages,Yunnan Province and Chongqing Municipality,China,2018–2023

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China CDC weekly 2024年第14期6卷 277-281页

作者： Fujin Sun Rong Luo Hui Han National center for Women and Children’s Health Chinese Center for Disease Control and PreventionBeijingChina

What is already known about this topic?The mortality rate and disease burden associated with falls among the elderly in China are on the *** can play a crucial role in preventing and managing *** is added by this report?The application of the“5E”injury prevention strategy led to a decrease in both the occurrence of falls and the likelihood of subsequent *** physical activity and maintaining a positive outlook were identified as protective measures against falls,while sleep issues and hearing impairment were found to increase the risk of *** are the implications for public health practice?The group-based comprehensive intervention strategy is crucial as it offers an innovative intervention model and empirical evidence for decreasing fall rates among elderly individuals living in rural areas.

关键词： Chongqing Rural prevention

Establishment of the benchmarking tool for evaluating the operation of biorepositories for pathogenic resource using a modified Delphi method

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生物安全与健康(英文) 2024年第04期06卷 199-205页

作者： Hong Geng Liu Dongxin Zhao Yuanyuan Zhai Yalin Zhao Fengzekuan Wang Yanhai Jiang Mengnan Wei Qiang National Pathogen Resource center Chinese Center for Disease Control and Prevention Beijing China China center for Food and Drug International Exchange Beijing China Henan Puruixin Data Technology Co. Ltd Henan China Tonglu center for disease control and prevention Zhejiang China National Institute for Viral disease control and prevention Chinese Center for Disease Control and Prevention Beijing China

In recent years, as the infectious diseases caused by pathogens such as novel coronavirus and mpox (formerly called monkeypox) spread globally, the significance of identification, preservation, and sharing of pathogenic resources become prominent. Along with the rapid development of biorepositories, it is imperative to evaluate their operation in a scientific manner. By using the literature review and modified Delphi method, this study develops a benchmarking tool for the comprehensive evaluation of the operation of biorepositories for pathogenic resources. The effective response rates of both rounds of expert surveys were 100 %. The authority coefficients (Cr) were 0.82 and 0.85, respectively, manifesting the reliability of consultation results. In the second-round survey, the Kendall’s coefficient of concordance (Kendall’s W) of all indicators ranged from 0.09 to 0.31 (P < 0.001), the comprehensive score ranged from 4.02 to 4.94, the standard deviation ranged from 0.21 to 0.77, and the coefficient of variation (CV) ranged from 0.04 to 0.22, indicating that the expert opinions reached consensus. The final benchmarking tool was composed of 4 primary indicators, 12 secondary indicators, and 65 tertiary indicators. The weights of the four primary indicators allocated through the ranksum ratio method, namely organizational structure, management requirements, biobanking capacity, and sharing capacity, were 30.50 %, 30.08 %, 25.45 %, and 13.97 %, respectively. The benchmarking tool established in this study provides references for the comprehensive evaluation of the operation and puts forward advice for the sustainable development of biorepositories for pathogenic resources.

关键词： Biorepository Pathogenic resource Evaluation Benchmarking tool Modified Delphi method

Neglected Time Intervals Before “1-3-7” Approach About Imported Malaria Cases-China, 2014–2021

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China CDC weekly 2024年第17期6卷 363-367页

作者： Zhiquan He Yuanjing Kou Dan Wang Ying Liu xiaofeng Lyu Hui Yan Wen Lin Xuan Zhang Duoquan Wang Shizhu Li Hongwei Zhang Henan Provincial center for disease control and prevention Zhengzhou CityHenan ProvinceChina Anhui Provincial center for disease control and prevention Hefei CityAnhui ProvinceChina Guangxi Zhuang autonomous Region center for disease control and prevention Nanning CityGuangxi Zhuang Autonomous RegionChina Hubei Provincial center for disease control and prevention Wuhan CityHubei ProvinceChina Zhejiang Provincial center for disease control and prevention Hangzhou CityZhejiang ProvinceChina National Institute of Parasitic diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)National Health Commission Key Laboratory of Parasite and Vector BiologyShanghaiChina School of Global Health Chinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghaiChina

Summary What is already known about this topic?China’s“1-3-7”approach outlines specific targets to guide and monitor the processes of case reporting,investigation,and ***,few studies have examined the time intervals preceding the initial step,and the timeline from the arrival of imported malaria cases in China to their diagnosis has been largely *** is added by this report?The study demonstrated that the median duration from arrival in China to the onset of symptoms for *** was 78 days,with 71.59%of imported cases manifesting symptoms after more than one *** ***,the median interval was 42 days,with 55.91%exceeding one ***,the median time from symptom onset to malaria treatment in China between 2014 and 2021 was 2 days,with an interquartile range(IQR)of 1-4 *** are the implications for public health practice?This study represents the initial effort to delineate the chronology of imported malaria cases,from their arrival in China to their subsequent *** results underscore the importance of providing malaria health education to populations arriving from ***,enhancing physician training is crucial for improving the diagnosis of malaria.

关键词： diagnosis Malaria exceeding

Emergence of Erythromycin-Resistant and Pertactin-and Filamentous Hemagglutinin-Deficient Bordetella pertussis Strains—Beijing,China,2022-2023

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China CDC weekly 2024年第20期6卷 437-441页

作者： Guilan Zhou Ying Li Hairui Wang Yuanyuan Wang Yuan Gao Juan Xu Fengshuang Wang Tao Peng Maojun Zhang Zhujun Shao National Key Laboratory of Intelligent Tracking and Forecasting for Infectious diseases National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Shunyi District center for disease control and prevention BeijingChina

Summary What is already known about this topic?Pertussis has reemerged as a significant public health threat,primarily due to variations in Bordetella pertussis strains,antimicrobial resistance,and vaccine *** is added by this report?All isolated strains were identified as ptxA1/ptxC2/ptxP3/prn150/fim2-1/fim3-1/fhaB1/tcfA2 type and exhibited resistance to erythromycin.

关键词： vaccine pertussis primarily

Epidemiological Characteristics of Human Parainfluenza Viruses Infections-China,2019-2023

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China CDC weekly 2024年第12期6卷 235-241,I0003,I0004页

作者： Yixuan Gao Yingwei Ma Daxing Feng Feng Zhang Biao Wang xiaoqing Liu Bing Zhu Hui xie Linqing Zhao xiaoru Long Ying Chen Bing Wang Jie Jiang Zhen Zhu Yan Zhang Aili Cui Baicheng xia Naiying Mao National Key Laboratory of Intelligent Tracking and Forecasting for Infectious diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Precision Medicine Research center Children’s Hospital of ChangchunChangchun CityJilin ProvinceChina Henan Provincial center for disease control and prevention Zhengzhou CityHenan ProvinceChina Laboratory of Viral diseases Qingdao Municipal Centre for Disease Control and PreventionQingdao CityShandong ProvinceChina Virus Laboratory Gansu Provincial Center for Disease Control and PreventionLanzhou CityGansu ProvinceChina Jiangxi Provincial center for disease control and prevention Nanchang CityGansu ProvinceChina Virus Laboratory Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou CityGuangdong ProvinceChina Institute for Immunization and prevention Beijing Center for Disease Prevention and ControlAcademy for Preventive MedicineInstitute of Tuberculosis Control Research and PreventionBeijingChina Laboratory of Virology Beijing Key Laboratory of Etiology of Viral Diseases in ChildrenCapital Institute of PediatricsBeijingChina Department of Infection Children’s Hospital of Chongqing Medical UniversityChongqingChina Inner Mongolia Autonomous Region Comprehensive center for disease control and prevention Hohhot CityInner Mongolia Autonomous RegionChina Shenyang Prefecture center for disease control and prevention Shenyang CityLiaoning ProvinceChina

Introduction:A retrospective study based on sentinel surveillance was conducted in 10 provinciallevel administrative divisions(PLADs)in China to enhance the understanding of the epidemiological characteristics of human parainfluenza viruses(HPIVs).Methods:From January 2019 to June 2023,respiratory specimens were collected from individuals with acute respiratory infections(ARIs)and screened for four HPIVs serotypes and other common respiratory viruses using multiplex real-time polymerase chain reaction(PCR).This study analyzed the association of HPIVs infections with seasonal patterns,geographical distribution,demographic profiles,clinical features,and co-infection ***:During the study period,a total of 12,866 ARIs were *** overall detection rate of HPIVs was 6.15%,varying from 5.04%in 2022 to 9.70%in *** median age of HPIVs-infected patients was 3 ***2 was more prevalent among individuals aged 5–17 years(42.57%),while HPIV4 was more common in those over 65 years(12.24%).HPIV3(54.16%)and HPIV1(27.18%)were the predominant serotypes,and their prevalence exhibited significant seasonal fluctuations postcoronavirus disease 2019(COVID-19)*** peak of HPIV3 shifted three months later in 2020 compared to 2019 and returned to a summer peak *** peaks of HPIV1 were observed in 2021 following the peak of ***,coinfections were frequent in HPIVs cases(overall rate:22.12%),with human rhinovirus being the most common co-infecting ***:The prevalence of HPIVs in China was predominantly due to HPIV3 and HPIV1,and their seasonal patterns were altered by pandemic ***,continuous surveillance of HPIVs is essential.

关键词： prevalence seasonal Human

Effectiveness of C-Reactive Protein as a Tuberculosis Screening Test Among HIV-Infected Individuals—Shanghai,China,2021-2023

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China CDC weekly 2024年第35期6卷 891-895页

作者： Lixin Rao Zheyuan Wu Jing Chen Zhen Ning xin Shen Shanghai Municipal center for disease control and prevention ShanghaiChina

Summary What is already known about this topic?The World Health Organization(WHO)has recommended the inclusion of the C-reactive protein(CRP)test in active tuberculosis(ATB)screening algorithms among human immunodeficiency virus(HIV)-infected *** performance of the CRP test in African regions has been *** is added by this report?This study analyzed data from a big data platform of Shanghai medical records together with infectious disease surveillance systems.

关键词： Infect tuberculosis records

Downregulation of Serum PTEN Expression in Mercury-Exposed Population and PI3K/AKT Pathway-Induced Inflammation

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Biomedical and Environmental Sciences 2024年第4期37卷 354-366页

作者： MEI Peng DING En Min YIN Hao Yang DING Xue Xue WANG Huan WANG Jian Feng HAN Lei ZHANG Heng Dong ZHU Bao Li School of Public Health Nanjing Medical UniversityNanjing 210000JiangsuChina Institute of Occupational disease prevention Jiangsu Province Center for Disease Prevention and ControlNanjing 21000JiangsuChina Suzhou center for disease prevention and control Suzhou 215004JiangsuChina center for Global Health School of Public HealthNanjing Medical UniversityNanjing 210000JiangsuChina

Objective This study investigated the impact of occupational mercury(Hg) exposure on human gene transcription and expression, and its potential biological *** Differentially expressed genes related to Hg exposure were identified and validated using gene expression microarray analysis and extended validation. Hg-exposed cell models and PTEN lowexpression models were established in vitro using 293T cells. PTEN gene expression was assessed using qRT-PCR, and Western blotting was used to measure PTEN, AKT, and PI3K protein levels. IL-6 expression was determined by *** Combined findings from gene expression microarray analysis, bioinformatics, and population expansion validation indicated significant downregulation of the PTEN gene in the high-concentration Hg exposure group. In the Hg-exposed cell model(25 and 10 μmol/L), a significant decrease in PTEN expression was observed, accompanied by a significant increase in PI3K, AKT, and IL-6 ***, a low-expression cell model demonstrated that PTEN gene knockdown led to a significant decrease in PTEN protein expression and a substantial increase in PI3K, AKT, and IL-6 *** This is the first study to report that Hg exposure downregulates the PTEN gene, activates the PI3K/AKT regulatory pathway, and increases the expression of inflammatory factors, ultimately resulting in kidney inflammation.

关键词： PTEN Occupational mercury exposure Occupational health PI3K/AKT pathway 293T cell IL-6

The Combined Effects of High Temperatures and Ozone Pollution on Medical Emergency Calls—Jinan City,Shandong Province,China,2013–2019

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China CDC weekly 2024年第2期6卷 30-35,I0001-I0007页

作者： Huiyun Chang Chong Liu xingyi Geng xiumiao Peng Ke Huang Liheng Wang Liangliang Cui Department of Scientific Research and Education Jinan Municipal Center for Disease Control and PreventionJinan Municipal Center for Disease Control and Prevention Affiliated to Shandong UniversityJinan CityShandong ProvinceChina Jinan Health Well Development center Jinan CityShandong ProvinceChina Department of Environmental Health Jinan Municipal Center for Disease Control and PreventionJinan CityShandong ProvinceChina Department of Emergency Jinan Medical Emergency CenterJinan CityShandong ProvinceChina

What is already known about this topic?Studies have extensively documented the separate and independent effects of extreme temperature and ozone on morbidity and mortality associated with respiratory and circulatory *** is added by this report?The study revealed a significant association between elevated temperature,ozone pollution,and the combined effect of high temperature and ozone pollution with an increased risk of all-cause medical emergency calls(MECs)and MECs specifically related to neurological *** are the implications for public health practice?Interventional measures should be implemented to mitigate exposure to high temperatures and ozone ***,during the warm season,it is crucial for relevant authorities to focus on disseminating scientific information regarding the health impacts of elevated temperatures and ozone ***,timely public health advisories should be issued to alert the public effectively.

关键词： ozone elevated pollution