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Evaluation of Epstein-Barr Virus Salivary Shedding in HIV/AIDS Patients and HAART Use: A Retrospective Cohort Study

Virologica Sinica 2018年第3期33卷 227-233页

作者： Yan Yan Yong Ren Renfang Chen Jing Hu Yongjia Ji Junyang Yang Jiayin Shen Lvyin Hu Hao Pei Jun Wang Yuanwang Qiu Hongzhou Lu Lihua Huang center of Clinical Laboratory The Fifth People’s Hospital of Wuxi Affiliated to Jiangnan University wuxi Institute of Hepatology The Fifth People’s Hospital of Wuxi Affiliated to Jiangnan University The International Joint Research Laboratory for Infection and Immunity (china-Germany) The Fifth People’s Hospital of Wuxi Affiliated to Jiangnan University wuxi red ribbon care center of china red cross The Fifth People’s Hospital of Wuxi Affiliated to Jiangnan University The International Joint Research Laboratory for Infection and Immunity (china-Germany) Wuxi School of MedicineJiangnan University Department of Infectious Diseases Shanghai Public Health Clinical Center Fudan University

Little data is available on the evaluation of the occurrence rates of Epstein-Barr virus(EBV) in saliva and relationship with highly active antiretroviral therapy(HAART) use in HIV/AIDS patients in china. We conducted a retrospective cohort study of EBV serological tests for HIV/AIDS patients who were treated in the hospitals for infectious diseases in wuxi and Shanghai, china from May 2016 to April 2017. The EBV-seropositive samples were identified by ELISA. EBV-specific primers and probes were used for the quantitative detection of viral DNA from saliva via quantitative real-time polymerase chain reaction. CD4 cell counts of the HIV/AIDS patients were detected by a flow cytometry. A total of 372 HIV/AIDS patients were ultimately selected and categorized for this retrospective cohort study. For EBV IgG and IgM, the HIV/AIDS HAART use(H) and non-HAART use(NH) groups had significantly higher seropositive rates than the HIV-negative control group. The HIV/AIDS(NH) group had the highest seropositive rate(IgG, 94.27%; IgM, 68.98%) and the highest incidence of EBV reactivation or infection. For salivary EBV DNA-positive rates and quantities, the HIV/AIDS(H)(73.69%) and the HIV/AIDS(NH)(100%) groups showed significantly higher values than the HIV-negative control group(35.79%,[ twofold). Further, the salivary EBV DNA-negative population had significantly higher CD4 cell counts than the EBV DNA-positive population in the HIV/AIDS(H) group and the HIV/AIDS(NH) groups. Thus, HAART use is beneficial in decreasing the EBV salivary shedding in HIV/AIDS patients and indirectly decreases EBV transmission risk.

关键词：唾液病毒评估聚合酶链反应 EBV ELISA DNA 传染疾病

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