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Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting Zhang Yanlin Fu Peiyan Long Xiao Gao Zhengwei Wang Zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of endemic and Ethnic diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou center for disease control and prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation center for prevention and control of endemic and Ethnic Regional diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

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Perturbations in Amino Acid Metabolism in Children with Kaschin-Beck disease: A Study of Urinary Target Metabolomics

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Biomedical and Environmental Sciences 2019年第1期32卷 34-37页

作者： HU Jian WANG Yu Meng WANG Wei Yi ZHAO Zhi Jun LI Qiang WANG Li Hua The center for endemic disease control Chinese Center for Disease Control and Prevention Harbin Medical University Qinghai Institute for endemic disease prevention and control

Kaschin-Beck disease (KBD) is an endemic and chronic osteoarthropathy characterized by pathological aspects including chondrocyte degeneration, necrosis, progressive loss of articular cartilage, and secondary degenerative osteoarthrosis of epiphyseal cartilage, epiphyseal plate cartilage, and articular cartilage, during puberty[1]. The main clinical symptoms are limb joint pain, thickening, deformation, limited movement, muscle atrophy, and in case of more severely affected patients, short fingers (toes), short limbs, and even short stature[1].

关键词： Kaschin-Beck disease (KBD) Chronic osteoarthropathy Chondrocytic degeneration

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Evaluation of Colloidal Gold Immunochromatography for the Diagnosis of Human Brucellosis Caused by Smooth Brucella

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Biomedical and Environmental Sciences 2022年第8期35卷 764-767页

作者： DONG Shuai Bing TA Na WANG Li Ping FAN Meng Guang LI Yue Xi ZHANG Cui Hong ZHANG Li Jie WANG Zi Jun JIANG Hai Bejing center for disease prevention and control Bejing 100013China Inner Mongolia Autonomous Region Comprehensive center for disease control and prevention Hohhot 010031Inner Mongolia AutonomousChina Chinese center for disease control and prevention Beijing 102206China wulanchabu city center for endemic disease prevention and control Wulanchabu 012000Inner Mongolia AutonomousChina State Key Laboratory for Infectious disease prevention and control Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesNational Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBejing 102206China

Brucellosis is an infectious allergic zoonotic disease caused by bacterial species in the genus Brucella. It is a Class B infectious disease according to the Law on the prevention and control of Infectious diseases in China. According to the World Health Organization, brucellosis is currently a highly neglected zoonotic disease. Despite this, more than 170 countries have reported cases of brucellosis, and approximately 500,000 new cases are reported each year.

关键词： allergic cases neglected

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Genetic Features of 84 Genomes of Monkeypox Virus in Recent Circulation-Beijing Municipality,China,2023

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China CDC weekly 2023年第41期5卷 918-921页

作者： Daitao Zhang Haoyuan Jin Yulan Sun Yang Yang Renqing Li Weihong Li Xin Zhang Shuang Li Yanwei Chen Quanyi Wang Yang Pan Institute for Infectious disease and endemic disease control Beijing Center for Disease Prevention and ControlBeijingChina

The first indigenous incidence of Mpox(previously known as monkeypox)within Chinese mainland was documented in May 2023,with subsequent local and imported cases identified.A comprehensive understanding of the Mpox virus’s(MPXV)characteristics within Beijing remains *** this study,84 MPXV genomes from 82 local incidents and two imported instances,detected between May and July 2023,were *** MPXV strains fell within lineage C.1 of the West African clade,displaying limited genetic heterogeneity,encompassing 76–87 nucleotide substitutions and holding nucleotide identities between 99.996%and 100%.Phylogenetic exploration indicated that all genomes exhibited high homology to those presently prevalent in neighboring East Asian and Southeast Asian ***-six distinct haplotypes were identified among the strains,with 36.90%of genomes corresponding to four common haplotypes,suggesting repeated cross-regional introductions and restrained distribution via recurrent local *** findings elucidate the genetic diversity and phylogenesis of MPXVs during their nascent transmission within Beijing and provide vital information to enhance future Mpox containment strategies.

关键词： mainland restrained incomplete

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Development and Validation of a Model for Predicting Diabetic Nephropathy in Chinese People

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Biomedical and Environmental Sciences 2017年第2期30卷 106-112页

作者： MIAO Dan Dan PAN En Chun ZHANG Qin SUN Zhong Ming QIN Yu WU Ming Department of Chronic disease prevention and control Huai’an City Center for Disease Control and Prevention Department of Chronic disease prevention and control Jiangsu Provincial Center for Disease Control and Prevention

Objective To develop a risk model for predicting later development of diabetic nephropathy （DN） in Chinese people with type 2 diabetes mellitus （T2DM） and evaluate its performance with independent validation. Methods We used data collected from the project ＇Comprehensive Research on the prevention and control of Diabetes＇, which was a community-based study conducted by the Jiangsu center for disease control and prevention in 2013. A total of 11,771 eligible participants were included in our study. The endpoint was a clear diagnosis of DN. Data was divided into two components： a training set for model development and a test set for validation. The Cox proportional hazard regression was used for survival analysis in men and women. The model＇s performance was evaluated by discrimination and calibration. Results The incidence （cases per 10,000 person-years） of DN was 9.95 （95% CI; 8.66-11.43） in women and 11.28 （95% CI; 9.77-13.03） in men. Factors including diagnosis age, location, body mass index, high-density-lipoprotein cholesterol, creatinine, hypertension, dyslipidemia, retinopathy, diet control, and physical activity were significant in the final model. The model showed high discrimination and good calibration. Conclusion The risk model for predicting DN in people with T2DM can be used in clinical practice for improving the quality of risk management and intervention.

关键词： Type 2 diabetes mellitus Diabetic nephropathy Risk factors Model development andvalidation

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Effect of Reduction in Iodine Content of Edible Salt on the Iodine Status of the Chinese Population

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Biomedical and Environmental Sciences 2018年第9期31卷 645-653页

作者： HE Qian SU Xiao Hui LIU Peng FAN Li Jun MENG Fan Gang LIU Li Xiang LI Ming LIU Shou Jun Institute for Iodine Deficiency Disorders control Center for Endemic Disease Control Chinese Center for Disease Control and Prevention Harbin Medical University

Objective The aim of this study was to evaluate the impact of the revised Chinese National Standard GB26878-2011 ＇Iodine Content in Edible Salt＇ on the iodine status among the Chinese population. Methods In 2011 and 2014, the probability proportionate to size sampling（PPS） was used in each Chinese province to obtain the representative data. In each sampling unit, school children aged 8-10 years and pregnant women were selected. Key indicators included urinary iodine concentration（UIC）, thyroid volume（TV）, and the iodine content in edible household salt. Results The median urinary iodine concentration（MUIC） decreased between 2011 and 2014 from 238.6 to 197.9 μg/L in school-age children. The number of provinces with iodine excess decreased to zero. The proportion of children whose UIC was 〉 300 μg/L was 18.8% and decreased to 11% compared with 29.8% in 2011. There was no significant difference in UIC 〈 50 μg/L between 2014（4.3%） and 2011（3.7%）（P 〉 0.05）. The MUIC among pregnant women in 2014 was more concentrated between 110 and 230 μg/L. The goiter rate among children aged 8-10 years was unchanged, both the goiter rate of 2011 and 2014 remaining below 5%, in view of the sustainable elimination of iodine deficiency disorders. Conclusion The National Standard GB26878-2011 ＇Iodine Content in Edible Salt＇ that was introduced in March 2012 resulted in an overall improvement in iodine status, reducing the risk of excessive iodine intake in the Chinese population.

关键词： Urinary iodine concentration Thyroid volume PPS method

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Coverage of 13-Valent Pneumococcal Conjugate Vaccine Among Children 0–15 Months of Age—9 Provinces,China,2019–2021

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China CDC weekly 2023年第17期5卷 379-384页

作者： Lijun Liu Zhaonan Zhang Xixi Zhang Changsha Xu Yifan Song Li Li Jiakai Ye Zhiguo Wang Hui Liang Weiyan Zhang Ling Lin Ning Li Shujun Zhang Qianli Ma Wen Du Yongzhuo Jiao Lingsheng Cao Qi Qi Lei Cao Wenzhou Yu Sichuan center for disease control and prevention Chengdu CitySichuan ProvinceChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina Suqian center for disease control and prevention Suqian CityJiangsu ProvinceChina Jiangsu center for disease control and prevention Nanjing CityJiangsu ProvinceChina Zhejiang center for disease control and prevention Hangzhou CityZhejiang ProvinceChina Shandong center for disease control and prevention Jinan CityShandong ProvinceChina Anhui center for disease control and prevention Hefei CityAnhui ProvinceChina Hubei center for disease control and prevention Wuhan CityHubei ProvinceChina Hunan center for disease control and prevention Changsha CityHunan ProvinceChina Guizhou center for disease control and prevention Guiyang CityGuizhou ProvinceChina Gansu center for disease control and prevention Lanzhou CityGansu ProvinceChina

Summary What is already known on this topic?Limited data exist regarding the coverage of the 13-valent pneumococcal conjugate vaccine(PCV13)in China.A lack of official statistics,coupled with an insufficient body of published literature,hinders the accurate depiction of the current *** is added by this report?This study investigated the utilization of PCV13 and estimated its coverage in nine provinces across eastern,central,and western China between 2019 and *** an annual increase in PCV13 usage during this period,the overall coverage remained suboptimal.

关键词： spite coverage hinder

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Evaluation of the Integrated Information System for Brucellosis Case Diagnosis and Management-Inner Mongolia Autonomous Region,China,2019

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China CDC weekly 2021年第6期3卷 110-113页

作者： Shuaibing Dong Hai Jiang Mengguang Fan Yuexi Li Cuihong Zhang Shenghong Lin Yuliang Zhu Na Ta Jianke Guo Zijun Wang Lijie Zhang Liping Wang Division of Infectious disease Key Laboratory of Surveillance and Early Warning on Infectious DiseaseChinese Center for Disease Control and PreventionBeijingChina Beijing center for disease prevention and control Beijing Research Center for Preventive MedicineBeijingChina State Key Laboratory for Infectious disease prevention and control Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesNational Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Inner Mongolia Autonomous Region Comprehensive center for disease control and prevention HohhotInner MongoliaChina wulanchabu city center for endemic disease prevention and control WulanchabuInner MongoliaChina Office of General Administration Chinese Center for Disease Control and PreventionBeijingChina Department of Field Epidemiology Chinese Center for Disease Control and PreventionBeijingChina

What is already known about this topic?wulanchabu city center for endemic disease prevention and control had established and used a Brucellosis Integrated Information System(BIIS)since ***,it had not been systematically evaluated and promoted so *** is added by this report?The BIIS had significantly improved the efficiency of brucellosis reporting and provided convenience for follow-up management of cases,which was valuable for finishing completely routine ***,the stability of the system needs to be *** are the implications for public health practice?The results of the BIIS assessment demonstrated its advantages and disadvantages,which could provide some evidence for its implementation in other areas of China.

关键词： promoted Brucellosis systematically

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Rapid and High-throughput Identification of Recombinant Bacteria with Mass Spectrometry Assay

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Biomedical and Environmental Sciences 2014年第4期27卷 250-258页

作者： XIAO Di TAO Xiao Xia WANG Peng LIU Guo Dong GONG Ya Nan ZHANG Hui Fang WANG Hai Bin ZHANG Jian Zhong State Key Laboratory for Infectious disease prevention and control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and Prevention Collaborative Innovation center for Diagnosis and Treatment of Infectious diseases Provincial Key Laboratory for Plague control and prevention Yunnan Provincial Institute for Endemic Diseases Control and Prevention Beijing Municipal center for disease control and prevention Chaoyang District center for disease control and prevention Beijing

Objective To construct a rapid and high-throughput assay for identifying recombinant bacteria based on mass spectrometry. Methods Matrix assisted laser desorption ionization time-of-flight mass spectrometry （MALDI-TOF MS） techniques were used to identify 12 recombinant proteins （10 of Yersinia pestis, 1 of Campylobacter jejuni and 1 of Helicobacter pylori）. A classification model for the various phase of recombinant bacteria was established, optimized and validated, using MALDI-TOF MS-CIinProTools system. The differences in the peptide mass spectra were analyzed by using Biotyper and FIexAnalysis softwares. Results Models of GA, SNN, and QC were established. After optimizing the parameters, the GA recognition model showed good classification capabilities： RC=100%, mean CVA=98.7% （the CVA was 96.4% in phase 1, 100% in phase 2, 98.4% in phase 3, and 100% in phase 4, respectively） and PPV=95}. This model can be used to classify the bacteria and their recombinant, which only requires 3.7x103 cells for analysis. The total time needed is only 10 min from protein extraction to reporting the result for one sample. Furthermore, this assay can automatically detect and test 96 samples concurrently. A total of 48 specific peaks （9, 16, 9, and 14 for the four stages, respectively） was found in the various phase of recombinant bacteria. Conclusion MALDI-TOF MS can be used as a fast, accurate, and high-throughput method to identify recombinant bacteria, which provide a new ideas not only for recombinant bacteria but also for the identification of mutant strains and bioterrorism pathogens.

关键词： Recombinant bacteria MALDI-TOF MS ClinProTools Rapid identification Specific peaks

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Obesity rather than Metabolic Syndrome is a Risk Factor for Subclinical Hypothyroidism and Thyroid Autoimmunity

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Biomedical and Environmental Sciences 2021年第10期34卷 819-823页

作者： YAO Jin Yin LIU Peng ZHANG Wei WANG Ke Wei LYU Chun Peng ZHANG Zhi Wei CHEN Xiang Lan CHEN Yi WANG Xue Song DING Yong Xia MA Li Jun WANG Jing SUN Dian Jun center for endemic disease control Chinese Center for Disease Control and PreventionHarbin Medical UniversityHarbin 150081HeilongjiangChina Institute of endemic disease control Shandong ProvinceJinan 250000ShandongChina Heze center for disease control and prevention Heze 274000ShandongChina Jining center for disease control and prevention Jining 272000ShandongChina

In recent years,the incidences of thyroid diseases have gradually increased,and they may be associated with the development of diagnostic technologies,elevated public health awareness,nuclear radiation,environmental pollution,changes in lifestyle,work stress,excessive iodine intake,and other *** obesity can cause changes to the hypothalamic-pituitary-thyroid axis and deiodinase[1],obesity may be closely related to the high rate of thyroid diseases.

关键词： immunity obesity elevated

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