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Can the improvement of competitive adequacy and fairness reduce discriminatory M&A behavior?Evidence from the market access negative list pilot in China

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China Journal of Accounting Research 2024年第1期17卷 96-131页

作者： Xiongyuan Wang Jing Xu Shuai Wang School of Accounting Zhongnan University of Economics and LawWuhanChina institute of Ecological Civilization School of EconomicsZhongnan University of Economics and LawWuhanChina Huawei Technology co.ltd ShenzhenChina

corporate mergers and acquisitions(M&As)are subject to skewed logic due to excessive government regulation.China is progressively adopting the Market Access Negative List(MANL)pilot to transfer the power of resource allocation from the government to the market.Using the DID method,we examine the impact of relaxing market access regulation on firms’M&A behavior against China’s institutional background and the M&A events of listed companies from 2012 to 2019.The MANL significantly increases firms’M&A tendency and amount and strengthens the competitive adequacy and fairness of market-oriented M&A decisions.Post-M&A financial performance does not increase,but human capital productivity,innovation effectiveness and total factor productivity do,demonstrating the dynamic balance of profit and efficiency in M&As.

关键词： Transition economies Market access deregulation Market access negative list Mergers and acquisitions

Deployment optimization for target perpetual coverage in energy harvesting wireless sensor network

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Digital communications and Networks 2024年第2期10卷 498-508页

作者： Zhenkun Jin Yixuan Geng Chenlu Zhu Yunzhi Xia Xianjun Deng Lingzhi Yi Xianlan Wang wuhan Business University 430056China wuhan Research institute of Post and Telecommunication Wuhan430074China Hubei Key Laboratory of Distributed System Security Hubei Engineering Research Center on Big Data SecuritySchool of Cyber Science and EngineeringHuazhong University of Science and TechnologyWuhan430074China Hubei Chutian Expressway Digital Technology co.ltd Wuhan430074China School of Information and Safety Engineering Zhongnan University of Economics and LawWuhan430073China

Energy limitation of traditional Wireless Sensor Networks(WSNs)greatly confines the network lifetime due to generating and processing massive sensing data with a limited battery.The energy harvesting WSN is a novel network architecture to address the limitation of traditional WSN.However,existing coverage and deployment schemes neglect the environmental correlation of sensor nodes and external energy with respect to physical space.comprehensively considering the spatial correlation of the environment and the uneven distribution of energy in energy harvesting WSN,we investigate how to deploy a collection of sensor nodes to save the deployment cost while ensuring the target perpetual coverage.The confident Information coverage(CIC)model is adopted to formulate the CIC Minimum Deployment cost Target Perpetual coverage(CICMTP)problem to minimize the deployed sensor nodes.As the CICMTP is NP-hard,we devise two approximation algorithms named Local Greedy Threshold Algorithm based on CIC(LGTA-CIC)and Overall Greedy Search Algorithm based on CIC(OGSA-CIC).The LGTA-CIC has a low time complexity and the OGSA-CIC has a better approximation rate.Extensive simulation results demonstrate that the OGSA-CIC is able to achieve lower deployment cost and the performance of the proposed algorithms outperforms GRNP,TPNP and EENP algorithms.

关键词： Energy harvesting WSN Deployment optimization confident information coverage(CIC) Target perpetual coverage

Enhanced mechanical property by introducing bimodal grains structures in Cu-Ta alloys fabricated by mechanical alloying

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Journal of Materials Science & Technology 2024年第5期172卷 104-112页

作者： Ningyu Li Yongqin Chang Mingyang Li Yuxiang Chen Xinrui Luo Shichao Pei Fan Yang School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Xi’an Rare Metal Materials institute co.ltd Xi’an 710016China

Dispersion-strengthened copper alloys can achieve ultra-high strength,but usually at the expense of duc-tility.In this study,a strategy for overcoming strength-ductility tradeoffof Cu alloys is realized through the introduction of bimodal grains structures.Cu-Ta alloys with only 0.5 at.%Ta content were successfully prepared by mechanical alloying combined with spark plasm sintering.The samples prepared by one-step and two-step ball milling methods are named as Cu-Ta(Ⅰ)and Cu-Ta(Ⅱ),respectively.The microstructural characterizations revealed that ultra-fine equiaxed grains with uniformly dispersed Ta precipitates were obtained in the Cu-Ta alloys.High strength of 377 MPa for yield strength together with elongation of∼8%was obtained in Cu-Ta(Ⅰ).Bimodal grains structures composed of fine-grain zones and coarse-grain zones were successfully introduced into Cu-Ta(Ⅱ)by a two-step ball milling approach,and both yield strength(463 MPa)and elongation(∼15%)were significantly synergistic enhanced.The hardness values of both Cu-Ta(Ⅰ)and Cu-Ta(Ⅱ)were almost kept nearly constant with the increase of annealing time,and the softening temperatures of Cu-Ta(Ⅰ)and Cu-Ta(Ⅱ)are 1018 and 1013℃,reaching 93.9%and 93.5%T m of pure Cu(1083℃),respectively.It reveals that the Cu-0.5 at.%Ta alloys exhibit excellent thermal stability and exceptional softening resistance.Ta nanoclusters with semi-coherent structures play an essential role in enhancing the strength and microstructural stability of alloys.Bimodal structures are beneficial to the activation of back stress strengthening and the initiation and propagation of microcracks,thus obtaining the extraordinary combination of strength and elongation.This study provides a new way to fabricate dispersion-strengthened Cu alloys with high strength,high elongation,excellent thermal stability and softening resistance,which have potential application value in the field of the future fusion reactor.

关键词： Cu-Ta alloy Mechanical alloying Ta precipitates Bimodal structures Mechanical property

Nasal vaccination of triple-RBD scaffold protein with flagellin elicits long-term protection against SARS-coV-2 variants including JN.1

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2312-2323页

作者： Xian Li Mengxin Xu Jingyi Yang Li Zhou Lin Liu Min Li Shasha Wang Mei-Qin Liu Zhixiang Huang Zhen Zhang Shuning Liu Yunqi Hu Haofeng Lin Bowen Liu Ying Sun Qingguo Wu Zheng-Li Shi Ke Lan Yu Chen Huimin Yan Yao-Qing Chen wuhan institute of Virology Chinese Academy of SciencesWuhanChina Vaccine and Immunology Research Center Translational Medical Research InstituteShanghai Public Health Clinical CenterFudan UniversityShanghaiChina University of Chinese Academy of Sciences BeijingChina School of Public Health(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhenGuangdongChina State Key Laboratory of Virology Modern Virology Research CenterCollege of Life SciencesWuhan UniversityWuhanChina Aerosol Bio-Tech(Suzhou)co. LTDSuzhouJiangsuChina National Medical products Administration Key Laboratory for Quality Monitoring and Evaluation of Vaccines and biological products Sun Yat-sen UniversityGuanzhouChina

Developing a mucosal vaccine against SARS-coV-2 is critical for combatting the epidemic.Here,we investigated long-term immune responses and protection against SARS-coV-2 for the intranasal vaccination of a triple receptor-binding domain(RBD)scaffold protein(3R-NC)adjuvanted with a flagellin protein(KFD)(3R-NC+KFDi.n).In mice,the vaccination elicited RBD-specific broad-neutralizing antibody responses in both serum and mucosal sites sustained at high level over a year.This long-lasting humoral immunity was correlated with the presence of long-lived RBD-specific IgG-and IgA-producing plasma cells,alongside the Th17 and Tfh17-biased T-cell responses driven by the KFD adjuvant.Based upon these preclinical findings,an open labeled clinical trial was conducted in individuals who had been primed with the inactivated SARS-coV-2(IAV)vaccine.With a favorable safety profile,the 3R-NC+KFDi.n boost elicited enduring broad-neutralizing IgG in plasma and IgA in salivary secretions.To meet the challenge of frequently emerged variants,we further designed an updated triple-RBD scaffold protein with mutated RBD combinations,which can induce adaptable antibody responses to neutralize the newly emerging variants,including JN.1.Our findings highlight the potential of the KFD-adjuvanted triple-RBD scaffold protein is a promising prototype for the development of a mucosal vaccine against SARS-coV-2 infection.

关键词： vaccination vaccine sustained

A Non-canonical Excitatory PV RGC–PV SC Visual Pathway for Mediating the Looming-evoked Innate Defensive Response

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Neuroscience Bulletin 2024年第3期40卷 310-324页

作者： Man Yuan Sen Jin Gao Tan Siyuan Song Yizong Liu Huadong Wang Yin Shen Eye Center Renmin Hospital of Wuhan UniversityWuhan UniversityWuhan430060China The Brain cognition and Brain Disease institute Shenzhen Key Laboratory of Viral Vectors for BiomedicineShenzhen Institute of Advanced TechnologyChinese Academy of Sciences(CAS)Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsNational Medical Products Administration Key Laboratory for Research and Evaluation of Viral Vector Technology in Cell and Gene Therapy Medicinal ProductsShenzhen Key Laboratory of Quality Control Technology for Virus-Based TherapeuticsGuangdong Provincial Medical Products AdministrationShenzhen518055China Jan and Dan Duncan Neurological Research institute Baylor College of MedicineHouston77030USA State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Key Laboratory of Magnetic Resonance in Biological SystemsWuhan Center for Magnetic ResonanceInnovation Academy for Precision Measurement Science and TechnologyCASWuhan430071China Frontier Science Center of Immunology and Metabolism Medical Research InstituteWuhan UniversityWuhan430071China

Parvalbumin-positive retinal ganglion cells(PV+RGCs)are an essential subset of RGCs found in various species.However,their role in transmitting visual information remains unclear.Here,we characterized PV+RGCs in the retina and explored the functions of the PV+RGC-mediated visual pathway.By applying multiple viral tracing strategies,we investigated the downstream of PV+RGCs across the whole brain.Interestingly,we found that the PV+RGCs provided direct monosynaptic input to PV+excitatory neurons in the superficial layers of the superior colliculus(SC).Ablation or suppression of SC-projecting PV+RGCs abolished or severely impaired the flight response to looming visual stimuli in mice without affecting visual acuity.Furthermore,using transcriptome expression profiling of individual cells and immunofluorescence colocalization for RGCs,we found that PV+RGCs are predominant glutamatergic neurons.Thus,our findings indicate the critical role of PV+RGCs in an innate defensive response and suggest a non-canonical subcortical visual pathway from excitatory PV+RGCs to PV+SC neurons that regulates looming visual stimuli.These results provide a potential target for intervening and treating diseases related to this circuit,such as schizophrenia and autism.

关键词： Parvalbumin-positive retinal ganglion cell Innate fear Superior colliculus Excitatory-excitatory neuronal connection Looming-evoked defensive response Subcortical pathway

Aspartoacylase suppresses prostate cancer progression by blocking LYN activation

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Military Medical Research 2024年第2期11卷 180-205页

作者： Hong Weng Kang-Ping Xiong Wang Wang Kai-Yu Qian Shuai Yuan Gang Wang Fang Yu Jun Luo Meng‑Xin Lu Zhong‑Hua Yang Tao Liu Xing Huang Hang Zheng Xing-Huan Wang Department of Urology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Center for Evidence‑Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of biological Repositories Zhongnan Hospital of Wuhan UniversityWuhan 430071China Hubei Key Laboratory of Tumor biological Behaviors Wuhan 430071China Department of Pathology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Center for Pathology and Molecular Diagnostics Wuhan UniversityWuhan 430071China wuhan Research Center for Infectious Diseases and Cancer Chinese Academy of Medical SciencesWuhan 430071China

Background:Globally,despite prostate cancer(PCa)representing second most prevalent malignancy in male,the precise molecular mechanisms implicated in its pathogenesis remain unclear.consequently,elucidating the key molecular regulators that govern disease progression could substantially contribute to the establishment of novel therapeutic strategies,ultimately advancing the management of PCa.Methods:A total of 49 PCa tissues and 43 adjacent normal tissues were collected from January 2017 to December 2021 at Zhongnan Hospital of wuhan University.The advanced transcriptomic methodologies were employed to identify differentially expressed mRNAs in PCa.The expression of aspartoacylase(ASPA)in PCa was thoroughly evaluated using quantitative real-time PCR and Western blotting techniques.To elucidate the inhibitory role of ASPA in PCa cell proliferation and metastasis,a comprehensive set of in vitro and in vivo assays were conducted,including orthotopic and tumor-bearing mouse models(n=8 for each group).A combination of experimental approaches,such as Western blotting,luciferase assays,immunoprecipitation assays,mass spectrometry,glutathione S-transferase pulldown experiments,and rescue studies,were employed to investigate the underlying molecular mechanisms of ASPA's action in PCa.The Student‘s t-test was employed to assess the statistical significance between two distinct groups,while one-way analysis of variance was utilized for comparisons involving more than two groups.A two-sided P<0.05 was deemed to indicate statistical significance.Results:ASPA was identified as a novel inhibitor of PCa progression.The expression of ASPA was found to be significantly down-regulated in PCa tissue samples,and its decreased expression was independently associated with patients’prognosis(HR=0.60,95%CI 0.40–0.92,P=0.018).Our experiments demonstrated that modulation of ASPA activity,either through gain-or loss-of-function,led to the suppression or enhancement of PCa cell proliferation,migration,and invasion,respectively.The inhibitory

关键词： Prostate cancer Aspartoacylase LYN JNK AP-1 C-Jun Phosphorylation

Properties and microstructure of copper–titanium alloys with magnesium additions

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Rare Metals 2024年第5期43卷 2290-2299页

作者： Lue Huang Li-Jun Peng Jiang Li Xu-Jun Mi Gang Zhao Guo-Jie Huang Hao-Feng Xie Yi-Cheng Cao Wen-Jing Zhang Zhen Yang State Key Laboratory of Nonferrous Metals and Processes GRINM Group Co. Ltd. GRIMAT Engineering institute co. Ltd. School of Materials Science and Engineering Northeastern University General Research institute for Nonferrous Metals China Academy of Space Technology China Nonferrous Metals Mining Group (Tianjin) co.ltd

The volume fractions and morphology of precipitates in precipitation-strengthened Cu-Ti alloys,which precipitate mainly as continuous and discontinuous precipitates,are important for the application of the alloy.This study employed hardness and electrical conductivity tests transmission electron microscopy （TEM）,atom probe tomography （APT）,and first-principles calculations to demonstrate that the addition of Mg is effective for accelerating nanosized continuous β'-Cu4Ti precipitation as well as for suppressing the precipitation of coarse lamellar discontinuous β-Cu4Ti precipitates along the grain boundaries,resulting in Cu-Ti alloys with high yield strength and good electrical conductivity.The results showed that the continuous precipitation of β'-Cu4Ti was accelerated by the Mg additions,which reduced the supersaturation of the matrix,thereby reducing the chemical driving force for the discontinuous precipitates.On the other hand,Mg additions increased the mismatch between the discontinuous β-Cu4Ti precipitates and matrix decreased the nucleation rate of the discontinuous precipitates,and increased the spacing of the discontinuous precipitation layer,resulting in a lower growth rate of the discontinuous precipitates.Therefore,the addition of Mg to Cu-Ti alloys enhances the strength and improves the resistance to over-ageing.

关键词： Cu-Ti-Mg alloy Precipitation hardening Discontinuous precipitation continuous precipitation Microstructure formation mechanism

Characterization of blueberry exosome-like nanoparticles and miRNAs with potential cross-kingdom human gene targets

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Food Science and Human Wellness 2024年第2期13卷 869-878页

作者： Yangfan Leng Liubin Yang Siyi Pan Leilei Zhan Fang Yuan college of Food Science and Technology Huazhong Agricultural UniversityWuhan 430070China Hubei Key Laboratory of Fruit&Vegetable Processing&Quality control Huazhong Agricultural UniversityWuhan 430070China wuhan GeneCreate biological Engineering co. Ltd.Wuhan 430070China

Edible plant derived exosome-like nanoparticles(ELNs)have been shown to have multiple nutraceutical functions.However,the diversity of plant materials makes the plant derived ELN study challenging.More efforts are still needed to explore the feasible isolation methods of edible plant derived ELNs and the possible roles of food-derived ELNs in improving human health.In this study,a size exclusion chromatography based method was compared with the traditional ultracentrifugation method to isolate blueberry derived ELNs(B-ELNs),and the miRNA profile of B-ELNs was analyzed by high-throughput sequencing.A total of 36 miRNAs were found to be enriched in B-ELNs compared with berry tissue,and their potential cross-kingdom human gene targets were further predicted.Results showed that size exclusion chromatography was effective for B-ELN isolation.The most abundant miRNAs in B-ELNs mainly belonged to the miR166 family and miR396 family.Target gene prediction indicated that B-ELNs could potentially regulate pathways related to the human digestive system,immune system and infectious diseases.

关键词： Edible plant derived exosomes-like nanoparticles Size exclusion chromatography miRNA Target gene prediction Blueberry

Evaluation of the injection and plugging ability of a novel epoxy resin in cement cracks

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Petroleum Science 2024年第2期21卷 1211-1220页

作者： Guang-Yao Leng Wei Yan Hai-Mu Ye Er-Dong Yao Ji-Bin Duan Zheng-Xian Xu Ke-Pei Li Jing-Ru Zhang Zhong Li State Key Laboratory of Petroleum Resource&Prospecting China University of Petroleum(Beijing)Beijing102249China CNPC Liaohe Oilfield Gas Storage co.ltd Panjin124000LiaoningChina CNOOC Research institute co. Ltd.Beijing100028China

Sustained casing pressure(SCP)is a crucial issue in the oil and gas production lifecycle.Epoxy resins,exhibiting exceptional compressive strength,ductility,and shear bonding strength,have the potential to form reliable barriers.The injectivity and sealing capacity of the epoxy resin is crucial parameters for the success of shallow remediation operations.This study aimed to develop and assess a novel solid-free resin sealant as an alternative to Portland cement for mitigating fluid leakage.The investigation evaluated the viscosity,compressive strength,and brittleness index of the epoxy resin sealant,as well as its tangential and normal shear strengths in conjunction with casing steel.The flow characteristics and sealing abilities of conventional cement and epoxy resin were comparatively analyzed in cracks.The results showed that the application of a viscosity reducer facilitated control over the curing time of the epoxy resin,ranging from 1.5 to 6 h,and reduced the initial viscosity from 865.53 to 118.71 m Pa,s.The mechanical properties of the epoxy resin initially increased with a rise in curing agent content before experiencing a minor decrease.The epoxy resin containing 30%curing agent exhibited optimal mechanical properties.After a 14-day curing period,the epoxy resin's compressive strength reached81.37 MPa,2.12 times higher than that of cement,whereas the elastic modulus of cement was 2.99 times greater than that of the epoxy resin.The brittleness index of epoxy resin is only 3.42,demonstrating high flexibility and toughness.The tangential and normal shear strengths of the epoxy resin exceeded those of cement by 3.17 and 2.82 times,respectively.In a 0.5 mm-wide crack,the injection pressure of the epoxy resin remained below 0.075 MPa,indicating superior injection and flow capabilities.conversely,the injection pressure of cement surged dramatically to 2.61 MPa within 5 min.The breakthrough pressure of0.5 PV epoxy resin reached 7.53 MPa,decreasing the crack's permeability to 0.02 D,a mere 9.49%of the permeabilit

关键词： Sustained casing pressure Epoxy resin sealant Curing agent Viscosity reducer Mechanical properties Crack sealing