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Effect of temporal variation rate of cross polar cap potential on the equatorial ionospheric vertical drift: A statistical study

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Science China(Technological Sciences) 2012年第5期55卷 1217-1223页

作者： XIONG Wen XU JiSheng WANG Hui XU Liang School of Electronic Information Wuhan UniversityWuhan 430079China

Based on the equatorial vertical ion drift measured by DMSP and cross polar cap potential （Фcpc） from AMIE output during 2001 to 2003, this paper investigates the relationship of Фcpc and its temporal variation rate （△Фcpc） with the disturbed ion velocity （△Vx） which is the difference between the disturbed days （Kp〉4） and quiet days （Kp〈2）. The statistical analysis shows：（1） The △Vx correlates better with AФcpc than with Фcpc, indicating that the electric field penetration is more easily to occur when solar wind input rapidly varies with time. （2） The optimal delay time of electric field penetration from the high-latitude magnetosphere to equatorial ionosphere has local time dependence which is longer on the nightside than on the dayside. It may be due to more complicated electrodynamic process on the nightside. （3） With the linear relationship between △Фcpc and △Vx, it is obtained that the penetration efficiency is about 4.5%-13.9% at day and 31%-42% at night, coinciding well with former studies.

关键词： equatorial ionosphere temporal variation rate of cross polar cap potential electric field penetration ion vertical drift time delay

Reusable electrochemical non-enzymatic glucose sensors based on Au-inlaid nanocages

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Nano Research 2022年第7期15卷 6490-6499页

作者： Lu Shen Zhen Liang Zhiyu Chen Can Wu Xuefeng Hu Jieyu Zhang Qing Jiang Yunbing Wang national Engineering Research center for Biomaterials Sichuan UniversityChengdu 610065China

Mass detection of glucose,which is required in many applications,remains *** commercial enzyme-based glucose test strips cannot be reused,and current non-enzymatic glucose sensors exhibit a narrow range of detection and slow glucose oxidation ***,controlled etching of Prussian blue analogue(PBA)nanocubes at the vertices is conducted and Au nanoparticles(Au NPs)are subsequently inlaid in the etched cavities by in-situ reduction of *** unique AuNP-PBA nanocomplexes exhibit low electrochemical potential for glucose oxidation,high electrocatalytic activity,and rapid redox electron transfer *** immobilization of the Au-inlaid nanomaterials on a fine Au wire leads to a non-enzymatic glucose sensor with a particularly wide linear detection range(10μM to 16 mM),excellent anti-interference,and fast *** importantly,the sensor is reusable,and its sensitivity is well maintained even after 150 times of *** new-concept material promises to enable high-throughput glucose detection at a low cost,which is essential in diabetic management and other healthcare applications.

关键词： non-enzymatic glucose sensors Prussian blue analogues gold nanoparticles electrochemistry reusable sensors

NAD+associated genes as potential biomarkers for predicting the prognosis of gastric cancer

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Oncology Research 2024年第2期32卷 283-296页

作者： XIANGDONG SUN HUIJUAN WEN FAZHAN LI IHTISHAM BUKHARI FEIFEI REN XIA XUE PENGYUAN ZHENG YANG MI Henan Key Laboratory for Helicobacter Pylori&Microbiota and GI Cancer Marshall Medical Research CenterThe Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Department of Gastroenterology The Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhouChina

Nicotinamide adenine dinucleotide(NAD+)plays an essential role in cellular metabolism,mitochondrial homeostasis,inflammation,and ***,the role of NAD+-regulated genes,including coding and long non-coding genes in cancer development is poorly *** constructed a prediction model based on the expression level of NAD+metabolism-related genes(NMRGs).Furthermore,we validated the expression of NMRGs in gastric cancer(GC)tissues and cell lines;additionally,β-nicotinamide mononucleotide(NMN),a precursor of NAD+,was used to treat the GC cell lines to analyze its effects on the expression level of NMRGs lncRNAs and cellular proliferation,cell cycle,apoptosis,and senescence-associated secretory phenotype(SASP).A total of 13 NMRGs-related lncRNAs were selected to construct prognostic risk signatures,and patients with high-risk scores had a poor *** immune checkpoint genes were upregulated in the high-risk *** addition,cell cycle,epigenetics,and senescence were significantly downregulated in the high-risk ***,we found that the levels of immune cell infiltration,including CD8 T cells,CD4 naïve T cells,CD4 memory-activated T cells,B memory cells,and naïve B cells,were significantly associated with risk ***,the treatment of NMN showed increased proliferation of AGS and MKN45 *** addition,the expression of SASP factors(IL6,IL8,IL10,TGF-β,and TNF-α)was significantly decreased after NMN *** conclude that the lncRNAs associated with NAD+metabolism can potentially be used as biomarkers for predicting clinical outcomes of GC patients.

关键词： NAD+ LncRNAs Cancer Cell infiltration Prognosis Tumor microenvironment

Ethereum smart contract security research:survey and future research opportunities

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Frontiers of Computer Science 2021年第2期15卷 143-160页

作者： Zeli WANG Hai JIN Weiqi DAI Kim-Kwang Raymond CHOO Deqing ZOU national Engineering Research center for Big Data Technology and System Services Computing Technology and System LabClusters and Grid Computing LabHubei Engineering Research Center on Big Data SecurityWuhan430074China School of Computer Science and Technology Huazhong University of Science and TechnologyWuhan430074China School of Cyber Science and Engineering Huazhong University of Science and TechnologyWuhan430074China Shenzhen Huazhong University of Science and Technology Research Institute Shenzhen518057China Department of Information Systems and Cyber Security University of Texas at San AntonioSan AntonioTX78249-0631USA

Blockchain has recently emerged as a research trend,with potential applications in a broad range of industries and *** particular successful Blockchain technology is smart contract,which is widely used in commercial settings(e.g.,high value financial transactions).This,however,has security implications due to the potential to financially benefit from a security incident(e.g.,identification and exploitation of a vulnerability in the smart contract or its implementation).Among,Ethereum is the most active and ***,in this paper,we systematically review existing research efforts on Ethereum smart contract security,published between 2015 and ***,we focus on how smart contracts can be maliciously exploited and targeted,such as security issues of contract program model,vulnerabilities in the program and safety consideration introduced by program execution *** also identify potential research opportunities and future research agenda.

关键词： smart contract security blockchain vulnerability unreliable data

An Approach for Network Function Combination Based on Least Busy Placement Algorithm

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China Communications 2016年第S1期13卷 167-176页

作者： XIE Lijun JIANG Yiming WANG Binqiang XIONG Gang CHENG Guozhen national Digital Switching System Engineering & Technological Research center

Recently, integrating Softwaredefined networking(SDN) and network functions virtualization(NFV) are proposed to address the issue that difficulty and cost of hardwarebased and proprietary middleboxes management. However, it lacks of a framework that orchestrates network functions to service chain in the network cooperatively. In this paper, we propose a function combination framework that can dynamically adapt the network based on the integration NFV and SDN. There are two main contributions in this paper. First, the function combination framework based on the integration of SDN and NFV is proposed to address the function combination issue, including the architecture of Service Deliver Network, the port types representing traffic directions and the explanation of terms. Second, we formulate the issue of load balance of function combination as the model minimizing the standard deviations of all servers' loads and satisfying the demand of performance and limit of resource. The least busy placement algorithm is introduced to approach optimal solution of the problem. Finally, experimental results demonstrate that the proposed method can combine functions in an efficient and scalable way and ensure the load balance of the network.

关键词： software-defined networking network functions virtualization load balance least busy placement algorithm contribution degree

Diagnosis,treatment,and prevention of monkeypox in children:an experts'consensus statement

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World Journal of Pediatrics 2023年第3期19卷 231-242页

作者： Rong-Meng Jiang Yue-Jie Zheng Lei Zhou Lu-Zhao Feng Lin Ma Bao-Ping Xu Hong-Mei Xu Wei Liu Zheng-De Xie Ji-Kui Deng Li-Juan Xiong Wan-Jun Luo Zhi-Sheng Liu Sai-Nan Shu Jian-She Wang Yi Jiang Yun-Xiao Shang Miao Liu Li-Wei Gao Zhuang Wei Guang-Hua Liu Gang Liu Wei Xiang Yu-Xia Cui Gen Lu Min Lu Xiao-Xia Lu Run-Ming Jin Yan Bai Le-Ping Ye Dong-Chi Zhao A-Dong Shen Xiang Ma Qing-Hua Lu Feng-Xia Xue Jian-Bo Shao Tian-You Wang Zheng-Yan Zhao Xing-Wang Li Yong-Hong Yang Kun-Ling Shen Diagnosis and Treatment center of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Respiratory Shenzhen Children’s HospitalShenzhen 518038China Branch for Emerging Infectious Disease Public Health Emergency CenterChinese Center for Disease Control and PreventionBeijing 102206China School of Population Medicine&Public Health Chinese Academy of Medical Science/Peking Union Medical CollegeBeijing 100730China Department of Dermatology Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s Health(Beijing)Beijing 100045China Department of Respiratory Beijing Children’s HospitalCapital Medical UniversityNational Clinical Research Center for Respiratory DiseasesNational Center for Children’s Health(Beijing)Beijing 100045China Department of Infectious Diseases Children’s Hospital of Chongqing Medical UniversityChongqing 400014China Tianjin Children’s Hospital Children’s Hospital of Tianjin UniversityTianjin 300134China Beijing Key Laboratory of Pediatric Respiratory Infection Diseases Key Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesResearch Unit of Critical Infection in ChildrenChinese Academy of Medical Sciences2019RU016Laboratory of Infection and VirologyBeijing Pediatric Research InstituteBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s Health(Beijing)Beijing 100045China Department of Infectious Diseases Shenzhen Children’s HospitalShenzhen 518038China Department of Infectious Diseases Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Ofce of Infection Management Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Department of Neurology Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Department of Pediatrics Tongji

Monkeypox is a zoonotic *** the first human monkeypox case was detected in 1970,it has been prevalent in some countries in central and western *** May 2022,monkeypox cases have been reported in more than 96 non-endemic countries and regions *** of September 14,2022,there have been more than 58,200 human monkeypox cases,and there is community *** cessation of smallpox vaccination in 1980,which had some cross-protection with monkeypox,resulted in a general lack of immunity to monkeypox,which caused global concern and *** of Sep-tember 14,2022,there are four monkeypox cases in China,including three in Taiwan province and one in Hong Kong *** foreign studies have shown that children are vulnerable to monkeypox and are also at high risk for severe disease or *** order to improve pediatricians'understanding of monkeypox and achieve early detection,early diagno-sis,early treatment,and early disposal,we have organized national authoritative experts in pediatric infection,respiratory,dermatology,critical care medicine,infectious diseases,and public health and others to formulate this expert consensus,on the basis of the latest"Clinical management and infection prevention and control for monkeypox"released by The World Health Organization,the"guidelines for diagnosis and treatment of monkeypox(version 2022)"issued by national Health Commission of the People's Republic of China and other relevant *** the development of this consensus,multidisciplinary experts have repeatedly demonstrated the etiology,epidemiology,transmission,clinical manifestations,laboratory examinations,diagnosis,differential diagnosis,treatment,discharge criteria,prevention,disposal process,and key points of prevention and control of suspected and confirmed cases.

关键词： Children Consensus Diagnosis Monkeypox Prevention Treatment

Fast local reconstruction by selective backprojection for low dose in dental computed tomography

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Chinese Physics C 2014年第10期38卷 117-125页

作者：闫镔邓林韩玉张峰汪先超李磊 national Digital Switching System Engineering and Technological Research center

The high radiation dose in computed tomography （CT） scans increases the lifetime risk of cancer, which becomes a major clinical concern. The backprojection-filtration （BPF） algorithm could reduce the radiation dose by reconstructing the images from truncated data in a short scan. In a dental CT, it could reduce the radiation dose for the teeth by using the projection acquired in a short scan, and could avoid irradiation to the other part by using truncated projection. However, the limit of integration for backprojection varies per PI-line, resulting in low calculation efficiency and poor parallel performance. Recently, a tent BPF has been proposed to improve the calculation efficiency by rearranging the projection. However, the memory-consuming data rebinning process is included. Accordingly, the selective BPF （S-BPF） algorithm is proposed in this paper. In this algorithm, the derivative of the projection is backprojected to the points whose x coordinate is less than that of the source focal spot to obtain the differentiated backprojection. The finite Hilbert inverse is then applied to each PI-line segment. S-BPF avoids the influence of the variable limit of integration by selective backprojection without additional time cost or memory cost. The simulation experiment and the real experiment demonstrated the higher reconstruction efficiency of S-BPF.

关键词： local reconstruction dental CT selective backprojection short scan

Current trends in nanomaterials-mediated biosensing platforms and signal amplification strategies for antibiotics detection in dairy products

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Food and Health 2024年第1期6卷 28-42页

作者： Cui-Yun Zhou Feng Jiang Chen-Xi Huang Hubei Provincial Institute for Food Supervision and Test Wuhan 430070China College of Food Science and Technology Huazhong Agricultural UniversityWuhan 430070China Key Laboratory of Detection Technology of Focus Chemical Hazards in Animal-derived Food for State Market Regulation wuhan 430070 China Hubei Provincial Engineering and Technology Research center for Food Quality and Safety Test Wuhan 430070China State Key Laboratory of Biocatalysis and Enzyme Engineering Hubei Key Laboratory of Industrial BiotechnologySchool of Life SciencesHubei UniversityWuhan 430062China

Dairy products have become one of the most prevalent daily foods worldwide,but safety concerns are *** dairy farming,unscrupulous traders misuse antibiotics to treat some diseases such as mastitis in cows,leading to antibiotic residues in dairy ***,sensitive,and simple detection methods for antibiotic residues are particularly important for food safety in dairy *** detection technology can effectively detect antibiotics,but there are defects such as complicated pre-treatment and high *** are widely used in food safety due to fast detection speed,low detection cost,strong anti-interference ability,and suitability for the field ***,these sensors often fail to trigger the signal conversion output due to low target *** cope with this issue,some high-efficiency signal amplification systems can be introduced to improve the detection sensitivity and linear range of *** this review,we focused on:(i)Sources and toxicity of major antibiotics in animal-derived foods.(ii)Nanomaterial-mediated biosensors for real-time detection of target antibiotics in animal-derived foods.(iii)Signal amplification techniques to increase the sensitivity of ***,future prospects and challenges in this research field are discussed.

关键词： Nanosensors Signal amplification Antibiotics detection Animal-derived foods.

Odd-Even Sequence Effect of Surface-Mediated Peptide Assemblies Observed by Scanning Tunneling Microscopy

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Chinese Journal of Chemistry 2012年第9期30卷 1987-1991页

作者：郭元元王晨轩侯静菲杨爱华张雪梅王宜冰张敏杨延莲王琛 national center for Nanoseience and Technology Beoing 100190China

The peptide assembly structures of polyglutamine （PolyQ） have been studied by using scanning tunneling microscopy （STM） with high spatial resolution in ambient conditions. 4,4＇-Bipyridyl （4Bpy） was introduced into the PolyQ7 and PolyQ8 peptide assemblies for labeling the C-termini of the peptides. The fine structures of the 4Bpy-PolyQ7 and 4Bpy-PolyQ8 co-assemblies are observed, and the statistics of the apparent peptide strand length reveal different length distributions for PolyQ7 and PolyQs. One predominant apparent peptide strand length is ob- served for PolyQ7 reflecting one predominant peptide conformation in assembly structures, while three major ap- parent strand lengths can be identified with PolyQ8 reflecting three co-existing peptide conformations in peptide as- semblies. Such drastic difference in assembling characteristics can be considered as a reflection of asymmetric ad- sorption effect ofpeptides relating to odd-even residue numbers of PolyQ7 and PolyQ8,

关键词： peptide adsorption conformation odd-even effect scanning tunneling microscopy