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Cyanobacteria-based near-infrared light-excited self-supplying oxygen system for enhanced photodynamic therapy of hypoxic tumors

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Nano Research 2021年第3期14卷 667-673页

作者： Yinghua Zhang Huifang Liu Xinyue Dai Hang Li Xiaohan Zhou Shizhu Chen Jinchao Zhang Xing-Jie Liang Zhenhua Li College of Chemistry&Environmental Science Analytical Chemistry Key Laboratory of Hebei ProvinceChemical Biology Key Laboratory of Hebei ProvinceHebei UniversityBaoding071002China Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education Institute of Life Science and Green DevelopmentHebei UniversityBaoding071002China College of Pharmaceutical Science Key Laboratory of Pharmaceutical Quality Control of Hebei ProvinceHebei UniversityBaoding071002China Beijing Pharmaceutical Group Company Limited Beijing100101China The National Institutes of Pharmaceutical R&D Co. Ltd.China Resources Pharmaceutical Group LimitedBeijing102206China CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and TechnologyBeijing100190China

Tumor hypoxia has been considered to induce tumor cell resistance to radiotherapy and anticancer chemotherapy,as well as predisposing for increased tumor ***,strategies for the eradication of the hypoxic tumor are highly *** therapy(PDT)is a new technique that can be used to treat tumors using laser irradiation to photochemically activate a *** to traditional radiotherapy and chemotherapy,photodynamic therapy has many advantages,such as good selectivity,low toxicity,and less trauma and ***,PDT is oxygen-dependent,and the lack of oxygen in hypoxic tumors renders photodynamic therapy ***,the earliest photosynthetic oxygen-generating organisms,can utilize water as an electron donor to reduce CO_(2) into organic carbon compounds along with continuously releasing oxygen under *** by this,herein,cyanobacteria were used as a living carrier of photosensitizer conjugated upconversion nanoparticles(UCNP)to construct a self-supplying oxygen PDT *** in the PDT efficiency for hypoxic tumors can be achieved as a result of in situ oxygen production by cyanobacteria under near-infrared(NIR)light using UCNP as a light harvesting antenna.A successful demonstration of this concept would be of great significance and could open the door to a new generation of carrier systems in the field of hypoxia-targeted drug transport platforms.

关键词： self-supplying oxygen cyanobacteria hypoxic tumor photodynamic therapy upconversion nanoparticles

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THE STUDY ON EFFECTS OF ELECTROACUPUNCTURE AT OUCH POINT ON THE MUSCLE REGENERATION IN RABBITS WITH CONTUSION BASED ON THE INHIBITION OF ERK SIGNAL PATHWAY BY U0126

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Journal of Integrative Medicine 2014年第3期 243-243页

作者： Huan Chen Bo Peng Fu-yun Li Xue Yu Hu-ying Lu Xiaoyan Wei Yuan-yuan Peng Yi-fan Fan Li Zhang Beijing University of Chinese Medicine Chinese Rehabilitation Research center

Objective: To observe the effects of electroacupuncture at ouch point on basic fibroblast growth factor(bFGF), proliferating cell nuclear antigen(PCNA) and extracellular signal-regulated kinase(ERK1/2) expression of U0126 inhibitor-injected rabbits with acute lumbar muscle ***: Forty male New Zealand rabbits were randomly divided into blank group(BG), model group(MG), model with inhibitor group(MI), electroacupuncture group(EA) and electroacupuncture with inhibitor group(EI), eight rabbits in each *** trauma methods were used to forming lumbar muscle *** level in serum was detected one day after *** staining, and PCNA and bFGF immunohistochemical staining were used for lumbar muscles of each rat 14 d after ***-blot was used to detect the expression of ERK1/2 ***: In myofiber average cross-sectional area, PCNA and ERK1/2 protein expressions of EA group were higher than MG group(P<0.05, or P<0.01) and EI group(P<0.05, or P<0.01); bFGF expression of EA group was significantly higher than MG group(P<0.01).Conclusion: ERK inhibitor U0126 can partly inhibit the proliferating effect of electroacupuncture at ouch point on muscle satellite ***/ERK signal pathway may be one of the main pathways through which electroacupuncture at ouch point promotes muscle regeneration.

关键词： ERK MG bFGF THE STUDY ON EFFECTS OF ELECTROACUPUNCTURE AT OUCH POINT ON THE MUSCLE REGENERATION IN RABBITS WITH CONTUSION BASED ON THE INHIBITION OF ERK SIGNAL PATHWAY BY U0126

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Management of facial burns

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Burns & trauma 2020年第1期8卷 269-276页

作者： David G.Greenhalgh Burn Department Shriners Hospitals for Children Northern California2425 Stockton Blvd.SacramentoCalifornia95817USA Firefighters Regional Burn center at University of California DavisDepartment of SurgeryUniversity of CaliforniaDavis2315 Stockton Blvd.SacramentoCalifornia95817USA

Burns to the face affect a part of the body that cannot be hidden and thus exposes potentially major changes in appearance to ***,it is incumbent upon the caregiver to optimize healing and minimize *** goal for partial-thickness burns is to have them heal within 2–3 weeks to minimize healing *** full-thickness burns there needs to be strategies to optimize the outcomes for skin grafting and minimize *** goal of this review is to discuss the best way to improve the outcomes of these devastating injuries.

关键词： Burns Scar Face Skin grafts Contracture Esthetics

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同侧偏盲:904例患者的临床-解剖关系

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世界核心医学期刊文摘（神经病学分册） 2006年第9期2卷 12-13页

作者： Kedar S. Lynn M.J. V. Biousse 谢琰臣 Neuroophthalmology Unit Emory Eye Center 1365-B Clifton Road NE Atlanta GA 30322 United States Dr.

Objective: To describe the clinical characteristics and clinical-anatomic correlations of homonymous hemianopia (HH). Background: Homonymous hemianopia impairs visual function and frequently precludes driving. Most knowledge of HH is based on relatively few cases with clinical-anatomic correlations. Methods: The authors reviewed medical records of all patients with HH seen in their service between 1989 and 2004. Demographic characteristics, characteristics of visual field defects, causes of visual field defects, neuroradiologic definition of lesion location, and associated neurologic deficits were recorded. Results: A total of 904 HH were found in 852 patients. A total of 340 HH (37.6%) were complete and 564 HH (62.4%) were incomplete. Homonymous quadrantanopia (264 HH, 29%) was the most common type of incomplete HH, followed by homonymous scotomatous defects (116 HH, 13.5%), partial HH (114 HH, 13%), and HH with macular sparing (66 HH, 7%). A total of 407 HH (45.0%) were isolated. Causes of HH included stroke (629 HH, 69.6%), trauma (123, 13.6%), tumor (102, 11.3%), brain surgery (22, 2.4%), demyelination (13, 1.4%), other rare causes (13, 1.4%), and unknown etiology (2, 0.2%). The lesions were most commonly located in the occipital lobes (45%) and the optic radiations (32.2%). Every type of HH, except for unilateral loss of temporal crescent and homonymous sectoranopia, was found in all lesion locations along the retrochiasmal visual pathways. Conclusion: Homonymous hemianopia is usually secondary to stroke, head trauma, and tumors. Although the characteristics of visual field defects can be helpful in lesion location, specific visual field defects do not always indicate specific brain locations.

关键词：临床特征解剖关系同侧偏盲神经功能缺陷视觉传导通路视野缺损人口统计学

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虐待性头部外伤硬脊膜下出血:回顾性研究

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国际医学放射学杂志 2012年第2期 171-171页

作者： A.K.Choudhary R.K.Bradford M.S.Dias G.J.Moore D.K.B.Boal 陈娟 Department of Radiology Penn State University College of MedicineMilton S.Hershey Medical Center500 University DrHershey PA 17033

目的比较虐待性头部外伤患儿与意外创伤患儿硬脊膜下出血的相对发病率、分布及影像学特征。方法本研究得到了人类受试者保护办公室的事先批准。免除了知情同意。符合HIPAA要求。通过病例回顾收集到1997年—2009年间在

关键词：头部外伤患儿病人硬脊膜意外创伤

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Pyogenic arthritis,pyoderma gangrenosum,and acne syndrome in a Chinese family:A case report and review of literature

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World Journal of Clinical Cases 2021年第22期9卷 6393-6402页

作者： Ling-Yun Lu Xue-Yang Tang Guo-Jing Luo Meng-Jia Tang Yi Liu Xi-Jie Yu Department of Endocrinology Laboratory of Endocrinology and MetabolismWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Integrated Traditional Chinese and Western Medicine West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Pediatric Surgery West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Endocrinology Zhuhai People's HospitalZhuhai Hospital Affiliated with Jinan UniversityZhuhai 519000Guangdong ProvinceChina Department of Rheumatology and Immunology Rare Disease CenterWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Pyogenic arthritis,pyoderma gangrenosum,and acne(PAPA)syndrome is a rare autosomal dominant genetic disease characterized by severe autoimmune inflammation,caused by mutations in the PSTPIP1 *** to PAPA heterogeneous clinical manifestation,misdiagnosis or delayed diagnoses are difficult to *** the use of whole-exome sequencing,we identified a missense mutation in the PSTPIP1 gene in a Chinese *** the best of our knowledge,this is the first case of PAPA reported in *** SUMMARY A 9-year-old boy suffered from recurrent aseptic pyogenic arthritis triggered by minor trauma or few obvious predisposing causes for more than 3 *** arthritis occurred every 3-5 mo,affecting his knees,elbows,and ankle ***,such as glucocorticoids,antibiotics,even surgeries could alleviate joints pain and swelling to some extent but could not inhibit the recurrence of *** symptoms were present in his younger brother but not in his *** to the whole-exome sequencing,a missense mutation in exon 11 of the PSTPIP1 gene(c.748G>C;p.E250Q)was detected in the boy,his young-er brother and his *** into account the similar phenotypic features with PAPA syndrome reported previously,we confirmed a diagnosis of PAPA syndrome for the *** In this case,a missense mutation(c.748G>C;p.E250Q)in PSTPIP1 gene was identified in a Chinese family with PAPA *** studies emphasize the fact that PAPA syndrome is hard to diagnose just through the clinical manifestations owing to its heterogeneous *** testing is an effectual auxiliary diagnostic method,especially in the early stages of pyogenic *** if we have a deep understanding and rich experience of this rare disease can we make a prompt diagnosis,develop the best clinical treatment plan,and give good fertility guidance.

关键词： Pyogenic arthritis,pyoderma gangrenosum,and acne syndrome PSTPIP1 Autoinflammatory disease Rare disease Case report

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A case of tiny foreign body hidden in the neck for 27 years

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Clinical Research Communications 2023年第3期6卷 7-9页

作者： Ming Huang Na Wang Zhi-Hua Hu Yu-Fei Zheng Shuang-Lin Qin Hubei Provincial Key Research Base for Humanities and Social Sciences Rural Education and Cultural Development center Hubei University of Science and TechnologyXianning 437100China Xianning medical College Hubei University of Science and TechnologyXianning 437100China Thyroid and Breast Surgery Xianning Central HospitalXianning 437100China

Neck trauma has the characteristics of diversity,complexity,and *** injuries generally require debridement and suturing or symptomatic *** severe cases,acute laryngeal obstruction,subcutaneous emphysema,severe deformation and collapse of laryngeal and tracheal cartilage,or damage to adjacent organs may *** not diagnosed in a timely manner or mishandled,it can endanger the patient’s life or leave *** foreign body residue is caused by head and neck trauma,a reasonable judgment should be made based on the patient’s condition and corresponding measures should be *** localization of foreign bodies before and during surgery,as well as appropriate surgical methods,are key to ensuring successful *** article reports a case of a small foreign body in the neck admitted to Xianning Central Hospital at the end of January 2023.

关键词： neck trauma foreign body metal nodule

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外伤性同侧偏盲

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世界核心医学期刊文摘（眼科学分册） 2006年第12期2卷 1-2页

作者： Bruce B.B. Kedar S. V. Biousse 张磊 Neuro-ophthalmology Unit Emory Eye Center 1365-B Clifton Road NE Atlanta GA 30322 United StatesDr.

Objective: To describe the characteristics of patients with homonymous hemianopia from traumatic brain injury (TBI) seen in our unit between 1989 and 2004. Methods: Only patients with a history of TBI, who had detailed clinical information and results of neuroimaging, were included in our study. Demographic characteristics, clinical features, types of visual field defects, location of lesion and evolution of visual field defects were recorded. Results: Of the 880 patients with homonymous hemianopia seen in our unit, 103 patients (112 with homonymous hemianopia) had TBI (74 men and 29 women, mean age 30.7 (SD 15.3) years). Median time from injury to initial visual field testing was 5 (range 0.5-360) months. In all, 64 (57.1%) patients sustained injuries that were motor vehicle-related; 19 (17%) violence-related; 17 (15.2%) due to falls; and 12 (10.7%) because of other blunt head trauma. Visual field defects included complete homonymous hemianopia in 44 (39.3%) patients and incomplete homonymous hemianopia in 68 (60.7%) patients. The lesion was occipital in 14 (12.5%) patients, associated with optic radiation in 26 (23.2%) and the optic tract in 12 (10.7%), and multiple in 60 (53.6%). Conclusion: Most cases of homonymous hemianopia from TBI were motor vehicle-related. Patients were younger, more often male, and had multiple brain lesions more often than patients with homonymous hemianopia from causes other than TBI. A median delay of 5 months was observed before the documentation of the homonymous hemianopia, which may have a major effect on the success of rehabilitation and driving training in these young patients.

关键词：外伤性同侧偏盲视野缺损颅脑外伤检查结果神经影像临床资料

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WNT5A drives interleukin-6-dependent epithelial-mesenchymal transition via the JAK/STAT pathway in keloid pathogenesis

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Burns & trauma 2022年第1期10卷 200-215页

作者： Young In Lee Jung Eun Shim Jihee Kim Won Jai Lee Jae Woo Kim Kee Hyun Nam Ju Hee Lee Department of Dermatology Severance HospitalCutaneous Biology Research InstituteYonsei University College of MedicineSeoul 03722Korea Bioinformatics Collaboration Unit Yonsei University College of MedicineSeoul 03722Korea Department of Plastic and Reconstructive Surgery Severance HospitalYonsei University College of MedicineSeoul 03722Korea Scar Laser and Plastic Surgery center Yonsei Cancer HospitalYonsei University College of MedicineSeoul 03722Korea Department of Biochemistry and Molecular Biology Chronic Intractable Disease for Systems Medicine Research CenterYonsei University College of MedicineSeoul 03722Korea Department of Surgery Severance HospitalYonsei University College of MedicineSeoulKorea

Background:Keloid scarring is a fibroproliferative disease caused by aberrant genetic activation with an unclear underlying *** predisposition,aberrant cellular responses to environmental factors,increased inflammatory cytokines and epithelial-mesenchymal transition(EMT)phenomena are known as major *** this study,we aimed to identify the molecular drivers that initiate keloid ***:Bulk tissue RNA sequencing analyses of keloid and normal tissues along with ex vivo and in vitro tests were performed to identify the contributing genes to keloid *** animal model of inflammatory keloid scarring was reproduced by replication of a skin fibrosis model with intradermal bleomycin injection in C57BL/6 ***:Gene set enrichment analysis revealed upregulation of Wnt family member 5A(WNT5A)expression and genes associated with EMT in keloid ***,human keloid tissues and the bleomycin-induced skin fibrosis animal model showed significantly increased expression ofWNT5A and EMT *** activation of the interleukin(IL)-6/Janus kinase(JAK)/signal transducer and activator of transcription(STAT)pathway and subsequent elevation of EMT markerswas also observed in keratinocytes co-cultured withWNT5A-activated fibroblasts or keloid ***,WNT5A silencing and the blockage of IL-6 secretion via neutralizing IL-6 antibody reversed hyperactivation of the STAT pathway and EMT markers in ***,STAT3 silencing significantly reduced the EMT-like phenotypes in both keratinocytes and IL-6-stimulated ***:Intercellular communication via the WNT5A and STAT pathways possibly underlies a partial mechanism of EMT-like phenomena in keloid ***-6 secreted from WNT5A-activated fibroblasts or keloid fibroblasts activates the JAK/STAT signaling pathway in adjacent keratinocytes which in turn express EMT markers.A better understanding of keloid development and the

关键词： Keloid Wnt family member 5A Interleukin-6 JAK/STAT pathway Epithelial-mesenchymal transition Scar Epithelial mesenchymal transition

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Enduring association between irritable bowel syndrome and war trauma during the Nicaragua civil war period:A population-based study

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World Journal of Gastroenterology 2023年第45期29卷 5953-5961页

作者： Edgar M Peña-Galo Daniel Wurzelmann Javier Alcedo Rodolfo Peña Loreto Cortes Douglas Morgan Department of Digestive Diseases Miguel Servet University HospitalZaragoza 50009AragonSpain Javier Alcedo Aragon Health Research InstituteIIS AragonZaragoza 50009AragonSpain Department of Mental Health Carolina PartnersDurhamNC 27707United States Department of Data Analysis CIDE(ResearchDevelopment and Epidemiology Center)Tegucigalpa 11101Francisco MorazánHonduras School of Medicine National Autonomous University of NicaraguaLeon 21000LeonNicaragua Department of Gastroenterology and Hepatology UAB University of Alabama BirminghamBirminghamAL 35233United States School of Medcine The University of North CarolinaChapel HillNC 9500United States

BACKGROUND Psychosocial and physical trauma are known risk factors for irritable bowel syndrome(IBS),including in war veterans,whereas war exposure in civilians is *** experienced two wars,1970-1990:The Sandinistas Revolution(1970s)and The Contra War(1980s).Our aim was to investigate the role of exposure to war trauma in the subsequent development of IBS in the context of an established health surveillance system(11000 households).AIM To investigate in a civilian population the relationship between exposure to war trauma and events and the subsequent development of IBS in the context of an established public health and demographic surveillance system in western *** We conducted a nested population-based,cross-sectional study focused on functional gastrointestinal disorders based on Rome II criteria.1617 adults were randomly *** Spanish Rome II Modular Questionnaire and Harvard trauma Questionnaire were validated in *** exposure was assessed with 10 measures of direct and indirect war trauma and post-war *** exposures were defined by≥3 *** The prevalence of IBS was 15.2%[Female(F)17.1%,Male(M)12.0%],war exposure 19.3%(F 9.3%,M 36.7%),and post-traumatic stress disorder(PTSD)5.6%(F 6.4%,M 4.3%).Significant associations with IBS in the civilian population were observed(adjusted by gender,age,socioeconomic status,education):physical and psychological abuse[adjusted odds ratio(aOR):2.25;95%confidence interval:1.1-4.5],witnessed execution(aOR:2.4;1.1-5.2),family member death(aOR:2.2;1.2-4.2),and multiple exposures(aOR:2.7;1.4-5.1).PTSD was independently associated with IBS(aOR:2.6;1.2-5.7).CONCLUSION An enduring association was observed in the Nicaragua civilian population between specific civil war-related events and subsequent *** populations in regions with extended armed conflict may warrant provider education and targeted interventions for patients.

关键词： Irritable bowel syndrome Functional gastrointestinal disorders War trauma Civil war Post-traumatic stress disorder Central America

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