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Advancements and Challenges in Biomarkers for Colorectal Cancer Detection:A Comprehensive Review

Proceedings of Anticancer Research 2024年第5期8卷 64-75页

作者： Yasir Hameed Department of Biotechnology Institute of BiochemistryBiotechnologyand BioinformaticsThe Islamia University of BahawalpurPakistan

This study provides an overview of the current landscape of biomarkers for colorectal cancer(CRC)detection,focusing on genetic,proteomic,circulating microRNA(miRNA),and metabolomic *** remains a significant global health challenge,ranking among the most prevalent cancers worldwide and being a leading cause of cancer-related *** advancements in screening methods such as colonoscopy,sigmoidoscopy,and fecal occult blood tests(FOBT),the asymptomatic nature of early-stage CRC often results in late diagnoses,negatively impacting patient *** biomarkers like APC,KRAS,TP53,and microsatellite instability(MSI)play critical roles in CRC pathogenesis and *** biomarkers,detectable through polymerase chain reaction,next-generation sequencing,and other advanced techniques,guide early detection and personalized treatment *** biomarkers such as CEA,CA 19-9,and novel signatures offer insights into CRC’s physiological changes and disease status,aiding prognosis and treatment response assessments through enzyme-linked immunosorbent assay and mass *** miRNAs,including miR-21 and miR-92a,present promising non-invasive biomarkers that can be detected in blood and stool samples,reflecting CRC presence,progression,and therapeutic *** biomarkers,encompassing amino acids,lipids,and TCA cycle intermediates,provide further insights into CRC-associated metabolic alterations,which are crucial for early detection and treatment monitoring using mass spectrometry and nuclear magnetic *** these advancements,challenges such as biomarker validation,standardization,and clinical utility *** research directions include integrating multi-omics approaches and leveraging technologies like liquid biopsies and AI for enhanced biomarker discovery and clinical *** addressing these challenges and advancing research in biomarker development,CRC screening and management could pote

关键词： Colorectal cancer Biomarker Diagnosis Detection

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Integrated application of synthetic community reduces consumption of herbicide in field Phalaris minor control

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Soil Ecology Letters 2024年第2期6卷 125-136页

作者： Amina Hadayat Zahir Ahmad Zahir Peng Cai Chun-Hui Gao National Key Laboratory of Agricultural Microbiology College of Resources and EnvironmentHuazhong Agricultural UniversityWuhan430070China Soil Microbiology and Biochemistry Laboratory Institute of Soil and Environmental SciencesUniversity of AgricultureFaisalabadPakistan

Herbicide-based weeds control impacts wheat crops as *** of Pseudomonas strains reduce the need for high-dose herbicides.100%Axial provides less weed control compared to 75%Axial with C4 *** 75%with C4 SynCom promotes... 详细信息

关键词： weed control synthetic microbial communities Phalaris minor wheat growth promotion synergistic effect

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Comparison of Adaptive Simulation Observation Experiments of the Heavy Rainfall in South China and Sichuan Basin

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Advances in Atmospheric Sciences 2024年第11期41卷 2173-2191页

作者： Linbin HE Weiyi PENG Yu ZHANG Shiguang MIAO Siqi CHEN Jiajing LI Duanzhou SHAO Xutao ZHANG College of Ocean and Meteorology Guangdong Ocean UniversityZhanjiang 524088China Chinese Academy of Meteorology Sciences Beijing 100081China Institute of Urban Meteorology China Meteorological AdministrationBeijing 100089China School of Marine Sciences Nanjing University of Information Science and TechnologyNanjing 210044China Dalian Marine Center Ministry of Nature Resources of the People's Republic of ChinaDalian 116001China

This study examines the effectiveness of adaptive observation experiments using the ensemble transformation sensitivity(ETS) method to improve precipitation forecasts during heavy rainfall events in South China and the Sichuan Basin. High-resolution numerical models are employed to simulate adaptive observations. By identifying the sensitive areas of key weather system positions 42 hours before heavy rainfall events, the adaptive observations improve the prediction of jet streams, strong winds, and shear lines, which are essential for accurate heavy rainfall forecasting. This improvement is reflected in both the precipitation structure and location accuracy within the verification region. In South China, targeted observations enhance rainfall predictions by improving water vapor transport. In the Sichuan Basin, adaptive observations refine water vapor transport and adjust vortex dynamics. This research highlights the importance of accurately predicting shear lines and jet streams for forecasting heavy rainfall in these areas. Overall, this study found that adaptive observation enhances the precipitation forecast skills of the structure and location for heavy rainfall in South China and the Sichuan Basin, emphasizing their potential utility in operational numerical weather prediction.

关键词： adaptive observation ensemble transform sensitivity data assimilation rainfall

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Electronic and thermoelectric properties of YbMg_(2)X_(2)(X=P,As,Sb,Bi)zintl compounds by first-principles method

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Journal of Rare Earths 2024年第1期42卷 147-154,I0006页

作者： Sajid Khan Dil Faraz Khan R.Neffati Tariq Usman Muhammad Waqar Ahsraf Shamim Khan Saeed Ullah Jan G.Murtaza Department of Physics University of Science&Technology BannuBannu28100Pakistan Department of Physics Faculty of ScienceKing Khalid UniversityP.O.Box 9004AbhaSaudi Arabia Laboratoire de Physique de La Matiere Condensee Departement de PhysiqueFaculte des Sciences de TunisUniversite Tunis El ManarCampus Universitaire1060TunisTunisia Department of Physics Shaoxing UniversityShaoxing312000China Department of Mathematics&Natural Sciences Prince Mohammad Bin Fahd UniversityAlkhobar31952Saudi Arabia Materials Modeling Lab Department of PhysicsIslamia College Peshawar25120KhyberPakhtunkhwaPakistan

In this work the structural,electronic and thermoelectric properties of YbMg_(2)X_(2)(X=P,As,Sb,Bi)zintl compounds were investigated comprehensively using first principles *** electronic properties were studied using PBE GGA,TB-mBJ and hybrid(YS-PBE0)*** the structural parameters of optimized structures are in harmonious agreement to the available *** band structure study illustrates that the titled materials manifest metallic and semi metallic nature using PBE and TB-mBJ potentials while they show wide band gap semiconducting behavior by following hybrid(YS-PBE0)*** density of states(TDOS)and partial density of states(PDOS)were also calculated to glimpse the contribution of orbitals of atoms in the formation of *** properties were studied by using BoltzTraP2 code employed to *** get enormous values of Seebeck coefficient(S),power factor(PF)and thermoelectric figure of merit(ZT)for all the samples YbMg_(2)X_(2)(X=P,As,Sb,Bi),Moreover,the overwhelming transport properties for the titled compounds indicate the optimum level of carriers’concentration which pinpoints these materials to be better thermoelectrics in the 1-2-2 zintl family.

关键词： Zintl compounds Hybrid functional Band structure Thermoelectrics Rare earths

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Metal Contamination in Nullah Dek Water and Accumulation in Rice

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Pedosphere 2007年第1期17卷 130-136页

作者： M.SARFRAZ S.M.MEHDI G.HASSAN S.T.ABBAS Plant Nutrition Division Soil Salinity Research InstitutePindi Bhattian(Pakistan) Crop Sciences Institute National Agricultural Research Centre(NARC)Islamabad (Pakistan)

A research study was carried out to determine the electrical conductivity （EC）, residual sodium carbonate （RSC）, sodium adsorption ratio （SAR）, pH and metals in metal-polluted irrigation water from a nullah and those in soils over a period of time, and the effect of metals on rice yield and metal concentrations in rice grain and straw. Two sites （I and If） were selected on the bank of Nullah Dek at Thatta Wasiran in Sheikhupura District （pakistan）, with two rice varieties, Super Basmati and Basmati 385, at both sites. Water samples were collected during rice crop growth at 15-day intervals from August 3 to November 1, 2002. The results showed that Nullah Dek water had an EC 〉1.0 dS m^-1 and RSC of 2.78-4.11 mmolc L^-1, which was hazardous for crops, but the SAR was within the safe limit. Cu, Mn Cd and Sr were also within safe limits. The soil analysis showed that Site Ⅱ was free from salinity/sodicity, whereas Site Ⅰ was saline sodic. Among metals, Zn was sometimes deficient, Cu, Mn and Fe were adequate, and St, Ni and Cd were within safe limits in the soil at both the sites. After the rice crop harvest, concentrations of all metals tested were usually slightly increased, being higher in the upper soil layer than the lower. In addition, Basmati 385 produced higher rice grain and straw yield than Super Basmati. Chemical analysis of rice grain indicated the presence of Zn, Cu, Fe, Mn, Pb and Sr, whereas rice straw contained Zn, Cu, Fe, Mn and Sr, with Cd and Ni both being found in minute quantities.

关键词： contaminated water metal accumulation rice salinity and sodicity

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Polypore funga and species diversity in tropical forest ecosystems of Africa,America and Asia,and a comparison with temperate and boreal regions of the Northern Hemisphere

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Forest Ecosystems 2024年第4期11卷 391-400页

作者： Heng Zhao Yingda Wu Zhirong Yang Honggao Liu Fang Wu Yucheng Dai Yuan Yuan State Key Laboratory of Efficient Production of Forest Resources School of Ecology and Nature ConservationBeijing Forestry UniversityBeijing 100083China Key Laboratory of Forest and Grassland Fire Risk Prevention Ministry of Emergency ManagementChina Fire and Rescue InstituteBeijing 102202China Yunnan Key Laboratory of Gastrodia and Fungi Symbiotic Biology Zhaotong UniversityZhaotong 657000China Yunnan Engineering Research Center of Green Planting and Processing of Gastrodia Zhaotong UniversityZhaotong 657000China

Polypores play a cru cial role in energy recycling and forest regeneration in forest *** majority of them are wood degraders;some are forest pathogens and others are ectomycorrhizal *** basidiocarps provide food and shelter for many organisms,mostly invertebrates,but also some vertebrates,as well as food and medicine for *** extensive research on the species diversity and phylogenetic relationships of polypores in recent years,there remains a lack of comprehensive understanding of their distribution patterns and species composition at the large *** of polypores from the tropical zone,including tropical Africa,tropical America,and tropical Asia,were analyzed for species diversity,distribution patterns,major taxa,and nutritional modes.A total of 1,902 polypore species was found in the three regions,representing 8 orders,46families,and 250 genera of *** orders Polyporales(especially the family Polyporaceae)and Hymenochaetales(especially the family Hymenochaetaceae)had the most prolific taxa,with their species accounting for 93.4%of the total polypores *** of 1,565(or 82.3%)of the total 1,902 species were found in only one of the three regions studied,and we treat them temporarily as"regional endemic species".Only 141species were shared among all three regions,accounting for a mere 7.4%.Tropical Africa and tropical America had the greatest number of shared species and the highest S?rensen similarity index(SC)*** forests had a higher species richness compared with temperate to boreal forests of the Northern Hemisphere,and in addition,also a higher proportion of white rot polypores compared to brown rot and ectomycorrhizal *** study outlines the distribution patterns and species diversity of polypores in the world,shedding light on their ecological significance in diverse ecosystems.

关键词： Agaricomycetes Macrofungi Species composition Wood-decay fungi

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Disaster effects of climate change in High Mountain Asia:State of art and scientific challenges Disaster effects of climate change in High Mountain Asia:State of art and scientific challenges

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Advances in Climate Change Research 2024年第3期15卷 367-389页

作者： Hao WANG Bin-Bin WANG Peng CUI Yao-Ming MA Yan WANG Jian-Sheng HAO Yu WANG Ya-Mei LI Li-Jun SUN Jiao WANG Guo-Tao ZHANG Wei-Mo LI Yu LEI Wen-Qing ZHAO Jin-Bo TANG Chao-Yue LI Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China China‒pakistan Joint Research Center on Earth Sciences Chinese Academy of SciencesIslamabad 45320Pakistan College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China College of Atmospheric Science Lanzhou UniversityLanzhou 730000China National Observation and Research Station for Qomolongma Special Atmospheric Processes and Environmental Changes Dingri 858200China

High Mountain Asia(HMA)shows a remarkable warming tendency and divergent trend of regional precipitation with enhanced meteorological *** rapid thawing of the HMA cryosphere may alter the magnitude and frequency of nature *** reviewed the influence of climate change on various types of nature hazards in HMA region,including their phenomena,mechanisms and *** reveals that:1)the occurrences of extreme rainfall,heavy snowfall,and drifting snow hazards are escalating;accelerated ice and snow melting have advanced the onset and increased the magnitude of snowmelt floods;2)due to elevating trigger factors,such as glacier debuttressing and the rapid shift of thermal and hydrological regime of bedrock/snow/ice interface or subsurface,the mass flow hazards including bedrock landslide,snow avalanche,ice-rock avalanches or glacier detachment,and debris flow will become more severe;3)increased active-layer detachment and retrogressive thaw slumps slope failures,thaw settlement and thermokarst lake will damage many important engineering structures and infrastructure in permafrost region;4)multi-hazards cascading hazard in HMA,such as the glacial lake outburst flood(GLOF)and avalanche-induced mass flow may greatly enlarge the destructive power of the primary hazard by amplifying its volume,mobility,and impact force;and 5)enhanced slope instability and sediment supply in the highland areas could impose remote catastrophic impacts upon lowland regions,and threat hydropower security and future water *** future,ongoing thawing of HMA will profoundly weaken the multiple-phase material of bedrock,ice,water,and soil,and enhance activities of nature *** and cascading hazards of high magnitude will prevail in *** the glacier runoff overpasses the peak water,low flow or droughts in lowland areas downstream of glacierized mountain regions will became more frequent and *** escalating hazards in the HMA region requires tackling s

关键词： High Mountain Asia Climate change Cryosphere degradation nature hazards Disaster risk

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Stock appraisal for Atlantic tripletail(Lobotes surinamensis;Bloch,1790)in the Bay of Bengal,Bangladesh

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Journal of Oceanology and Limnology 2024年第5期42卷 1683-1694页

作者： Suman BARUA Qun LIU Ahmed Fazley RABBY MdAbdullah AL-MAMUN Xu CHEN Rokeya SULTANA Aidah BALOCH College of Fisheries Ocean University of ChinaQingdao 266003China Department of Fisheries Ministry of Fisheries and LivestockDhaka 1215Bangladesh Bangladesh Fisheries Research Institute Cox’s Bazar 4700Bangladesh Directorate of Secondary and Higher Education Ministry of EducationDhaka 1000Bangladesh Gwadar Development Authority Gwadar 91200Pakistan

The Atlantic tripletail(Lobotes surinamensis)is a high revenue-generating fish species predominantly caught by mechanized artisanal fishers community and the most available member of its family in *** is a ground work of fish stock assessment study in the Bay of Bengal region to explore the life history parameters and associated biomass of this species,using three length-based approaches of TropFishR,the length-based Bayesian biomass estimation(LBB),and Froese’s length based indicators(LBIs).An almost homogenous body growth pattern(b=3.07;R^(2)=0.98)was observed in the length-weight relationship of *** life history parameters for tripletail,as determined by the von Bertalanffy Growth Function(VBGF)model,were L_(∞)=113.36 cm and k=0.51/*** length converted catch curve(LCCC)yielded an estimation of the total mortality(Z=1.77/a),with the natural mortality estimated at(M=0.53/a)and the fishing mortality estimated at(F=1.24/a).But,the ratio of mortality(F/M=0.15)by LBB captured the non-fully exploited status of biomass(B/B_(MSY)=2.1).LBI analysis indicated that the tripletail fishery’s spawning stock biomass is greater than the target and limit reference points,indicating a healthy state of biomass.

关键词： Bay of Bengal Lobotes surinamensis TropFishR length based indicator(LBI) length-based Bayesian biomass estimation(LBB) Bangladesh

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Integrating climate, biodiversity, and sustainable land-use strategies:innovations from China

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National Science Review 2021年第7期8卷 13-17页

作者： Guido Schmidt-Traub Harvey Locke Jixi Gao Zhiyun Ouyang Justin Adams Lin Li Enric Sala M.Rebecca Shaw Sebastian Troёng Jing Xu Chunquan Zhu Changxin Zou Tianxiao Ma Fuwen Wei Sustainable Development Solutions Network Beyond the Aichi Targets Task Force IUCN world Commission on Protected Areas Yellowstone to Yukon Conservation Initiative Center for Satellite Applications on Ecology and Environment Ministry of Ecology and Environment Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Tropical Forest Alliance World Economic Forum worldwide fund for nature National Geographic Society Conservation International Chinese Research Academy of Environmental Sciences nature Initiatives and Tropical Forest Alliance World Economic Forum Nanjing Institute of Environmental Sciences Ministry of Ecology and Environment Institute of Zoology Chinese Academy of Sciences

To reverse the accelerating degradation of biodiversity and ecosystem services(‘nature’) and climate [1,2], the Convention on Biological Diversity (CBD)and the UN Framework Convention on Climate Change (UNFCCC) will hold major meetings in 2021. We argue that, as a critical priority, countries need to design and implement integrated national strategies to achieve the goals of the three Rio Conventions (including the UN Convention to Combat Desertification—UNCCD) using spatially explicit analyses and policies. This integration can maximize co-benefits and help manage trade-offs to meet the Sustainable Development Goals(SDGs). nature-based solutions (NBS)provide an important framework for such integration.

关键词： ECOSYSTEM SERVICES

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Mode switching torque distribution strategy of timely four-wheel driven high-gap plant protection machine

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International Journal of Agricultural and Biological Engineering 2024年第4期17卷 176-184页

作者： Haijun Zhang Mingwei Guan Guojun Ji Ghulam Hussain Maohua Xiao Yejun Zhu College of Engineering Nanjing Agricultural UniversityNanjing 210031China Essen Agricultural Machinery Changzhou Co. Ltd.Changzhou 213000China Faculty of Mechanical Engineering Ghulam Ishaq Khan Institute of Engineering Sciences&TechnologyTopi 23460Pakistan

The high-gap plant protection machine is taken in this paper as the research object to ensure the good driving power and safety of the high-gap plant protection machine,and the control strategy of inter-shaft torque distribution is established under different working conditions to improve vehicle power and lateral *** anticipated demand torque is initially determined based on the structural characteristics and operational principles of the plant protection ***,a hierarchical control framework is devised by incorporating a formulated switching control ***,a simulation model for torque distribution control strategy between shafts is developed on the Matlab/Simulink platform,followed by simulation and experimental *** results are presented as follows:the inter-shaft torque distribution strategy established in this paper increases the average longitudinal acceleration by 0.13 m/s^(2) and 0.14 m/s^(2) under the control of low and high to low adhesion road surfaces,*** the control of the single-line shifting condition,the yaw velocity can successfully follow the expected value with a maximum value of 0.61 rad/*** side deflection angle of the center of mass does not exceed 2.8°,which can follow the ideal trajectory and improve power and safety.

关键词： plant protection robot torque distribution mode switching

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