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Effect of Body Mass Index on All-cause Mortality and Incidence of Cardiovascular Diseases─Report for Meta-Analysis of Prospective Studies on Optimal Cut-off Points of Body Mass Index in Chinese Adults

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Biomedical and Environmental Sciences 2002年第3期15卷 245-252页

作者： ZHOU BEI-FAN Cooperative Meta-Analysis group of the working group on Obesity in China

Objective To verify the optimal cut-off points for overweight and obesity in Chinese adults based on the relationship of baseline body mass index (BMI) to all-cause mortality, and incidence of cardiovascular diseases from pooled data of Chinese cohorts. Methods The prospective study data of existing cohort studies in China were collected, and the age-adjusted all-cause mortality stratified by BMI were estimated. The similar analysis was repeated after excluding deaths within the first three years of follow-up and after excluding smokers. The incidence of age-adjusted coronary heart disease (CHD) and stroke stratified by BMI were also analyzed. Multiple Cox regression coefficients of BMI for the incidence of CHD and stroke after controlling other risk factors were pooled utilizing the methods of weighting by inverse of variance to reveal whether BMI had independent effect and its strength on the incidence of CHD and stroke. Results The data of 4 cohorts including 76 227 persons, with 745 346 person-years of follow-up were collected and analyzed. The age-adjusted all-cause mortality stratified by BMI showed a U-shaped curve, even after excluding deaths within the first three years of follow-up and excluding smokers. Age-adjusted all-cause mortality increased when BMI was lower than 18.5 and higher than 28. The incidence of CHD and stroke, especially ishemic stroke increased with increasing BMI, this was consistent with parallel increasing of risk factors. Cox regression analysis showed that BMI was an independent risk factor for both CHD and stroke. Each amount of 2 kg/m2 increase in baseline BMI might cause 15.4%, 6.1% and 18.8 % increase in relative risk of CHD, total stroke and ischemic stroke. Reduction of BMI to under 24 might prevent the incidence of CHD by 11% and that of stroke by 15 % for men, and 22 % of both diseases for women. Conclusion BMI ≤18.5, 24-27.9 and ≥28 (kg/m2) is the appropriate cut-off points for underweight, overweight and obesity in C

关键词： Body mass index (BMI) All-cause mortality Coronary heart disease Stroke

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Predictive Values of Body Mass Index and Waist Circumference for Risk Factors of Certain Related Diseases in Chinese Adults - Study on Optimal Cut-off Points of Body Mass Index and Waist Circumference in Chinese Adults

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Biomedical and Environmental Sciences 2002年第1期15卷 83-96页

作者： ZHOU BEI-FAN2Cooperative Meta-Analysis group of the working group on Obesity in China Cooperative Meta-Analysis group of the working group on Obesity in China

Objective For prevention of obesity in Chinese population, it is necessary to definethe optimal range of healthy weight and the appropriate cut-off points of BMI and waistcircumference for Chinese adults. The working group on Obesity in China under the supportof International Life Sciences Institute Focal Point in China organized a meta-analysis on therelation between BMI, waist circumference and risk factors of related chronic diseases (e. g.,high diabetes, diabetes mellitus, and lipoprotein disorders). Methods 13 population studiesin all met the criteria for enrollment, with data of 239 972 adults (20-70 year) surveyed inthe 1990s. Data on waist circumference was available for 111411 persons and data on serumlipids and glucose were available for more than 80 000. The study populations located in21provinces, municipalities and autonomous regions in China's Mainland as well as inTaiwan. Each enrolled study provided data according to a common protocol and uniformformat. The Center for data management in Department of Epidemiology, Fu Wai Hospitalwas responsible for statistical analysis. Results and conclusion The prevalence ofhypertension, diabetes, dyslipidemia and clustering of risk factors all increased withincreasing levels of BMI or waist circumference. BMI at 24 with best sensitivity andspecificity for identification of the risk factors, was recommended as the cut-off point foroverweight, BMI at 28 which may identify the risk factors with specificity around 90 % wasrecommended as the cut-off point for obesity. Waist circumference beyond 85 cm for menand beyond 80 cm for women were recommended as the cut-off points for central *** of population attributable risk percent illustrated that reducing BMI to normalrange (<24) could prevent 45%-50% clustering of risk factors. Treatment of obese persons(BMI≥28)with drugs could prevent 15%-17% clustering of risk factors. The waistcircumference controlled under 85 cm for men and under 80 cm for women

关键词： Chinese adults Overweight Obesity BMI Waist circumference

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Technical Vaccination Recommendations for COVID-19 Vaccines in China(First Edition)

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China CDC weekly 2021年第21期3卷 459-461页

作者： COVID-19 Vaccine Technical working group COVID-19 Vaccine Technical working group

To date,five coronavirus disease 2019(COVID-19)vaccines have been conditionally approved for market authorization or granted emergency use authorization in China by the National Medical Products Administration(NMPA).Three inactivated COVID-19 vaccines and one adenovirus-vectored vaccine were granted conditional approval,as phaseⅢclinical trial data for these four conditionally-approved vaccines have demonstrated protective efficacy levels that meet requirements of NMPA’s Guidelines for Clinical Evaluation of COVID-19 vaccine(interim version)and also meet requirements recommended by the World Health Organization(WHO)in their COVID-19 Vaccines Target Product Profile.

关键词： approval Recommendations Edition

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Enhancing Public Health Competencies via Action on Salt China—China,2017–2022

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China CDC weekly 2023年第32期5卷 720-723页

作者： Puhong Zhang ASC working group The George Institute for Global HealthChinaBeijingChina.

The Action on Salt China(ASC)project is a noteworthy collaborative venture between China and UK,with the China CDC serving as a key *** objective of this report is to present a case study that demonstrates the significant role of ASC in bolstering the capacity of public health services in ***,this study aims to offer valuable references and provoke thoughtful insight for potential international collaborations in the future.

关键词： venture Action partner

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A dysregulated calcium homeostasis as the earliest pathological sign in stem cell-derived Parkinson's disease neurons?

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Neural Regeneration Research 2024年第7期19卷 1421-1422页

作者： Nilima Prakash working group Human Stem Cell Research Department Hamm 2Hamm-Lippstadt University of Applied SciencesHammGermany

Parkinson’s disease(PD) is characterized by the slow and progressive demise of dopamine(DA)-synthesizing neurons in the substantia nigra pars compacta(SNc),a nucleus located in the human ventral *** death also affects other regions in the brain at later stages of *** concomitant lack of DA in the human forebrain(striatum) leads to the typical motor symptoms of this still uncurable neurodegenerative disorder.

关键词： homeostasis dopamine death

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超声诊断在血吸虫病应用中的试行标准化方法

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国外医学（寄生虫病分册） 1993年第1期20卷 14-17页

作者：蔡卫民 The Cairo working group

本文概述1990年在开罗召开的专题会议上有关超声诊断用于血吸虫病的标准化方法的结论。为确保在不同地区和不同时期流行病学调查所获结果的可比性,超声检查应在同一标准化方法下进行操作与记录。该次会议讨论了这方面的问题,同时详细讨... 详细信息

本文概述1990年在开罗召开的专题会议上有关超声诊断用于血吸虫病的标准化方法的结论。为确保在不同地区和不同时期流行病学调查所获结果的可比性,超声检查应在同一标准化方法下进行操作与记录。该次会议讨论了这方面的问题,同时详细讨论3种主要类型血吸虫病所致损伤的特点,从而形成了一个适用于现场研究的试行标准化方法。

关键词：超声波诊断血吸虫病标准化

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Comparison of clinical course of patients with severe acute respiratory syndrome among the multiple generations of nosocomial transmission

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Chinese Medical Journal 2004年第1期117卷 14-18页

作者：伍卫王景峰刘品明江山平陈庆瑜陈为宪尹松梅严励詹俊陈锡龙李建国 The SARS working group Second Affiliated HospitalSun Yat-sen University

Background Severe acute respiratory syndrome (SARS) is characterized by both an atypical pneumonia and efficient nosocomial transmissin. However,it remains unknown whether the infectivity and the virulence of the pathogen will change throughout the successive transmission. This study was conducted to compare the clinical features and management regimens of patients with SARS among the multiple generations from nosocomial transmission initiated by a super-spreader. Methods The clinical data of 84 epidemiologically-linked SARS patients from a hospital outbreak were retrospectively studied. All patients,in whom a clear-cut transmission generation could be noted,had a direct or indirect exposure to the index patient and the epidemic successively propagated through the multiple generations of cases within a short period of time. Results There were 66 women and 18 men with mean age of (29.2 ± 10.3) years in this cluster;and 96.4% of whom were health care workers. Detailed contact tracing identified 35 (41.7%) first-generation cases,34 (40.5%) second-generation cases,and 15 (17.8%) third-generation cases. No statistical differences among the multiple generations of transmission were found in terms of age,gender,incubation period and length of hospital stay. With the advanced transmission generations,the initial temperature lowered,the number of cases with dry cough decreased. There were no statistical differences in the peak temperature and duration of fever,other accompanying symptoms,leucopenia;however,the time from initial pulmonary infiltrates to radiographic recovery shortened ( P 0.05). No statistical differences were found in modes of oxygen therapy and sorts of antibiotics prescribed among the various

关键词： severe acute respiratory syndrome·nosocomial infection·chain of transmission·clinical course

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China's Solution to Global Governance Crisis

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Contemporary World 2022年第3期 35-38页

作者： Néstor Restivo working group on China at Argentine Council for International Relations

In today’s highly globalized world, countries and regions are ever more closely intertwined with more complex relations. As COVID-19 pandemic changes international order in a profound way, the challenges facing global governance system have intensified. There is an urgent call for change. In this context, China offers a new solution to improving global governance by proposing the vision of building a community with a shared future for mankind.

关键词： intensified today profound

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Three-dimensional imaging reconstruction of the kidney’s anatomy for a tailored minimally invasive partial nephrectomy:A pilot study

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Asian Journal of Urology 2022年第3期9卷 263-271页

作者： Daniele Amparore Angela Pecoraro Federico Piramide Paolo Verri Enrico Checcucci Sabrina De Cillis Alberto Piana Mariano Burgio Michele Di Dio Matteo Manfredi Cristian Fiori Francesco Porpiglia Department of Urology San Luigi Gonzaga HospitalUniversity of TurinOrbassanoTurinItaly European Association of Urology(EAU)Young Academic Urologists(YAU)Renal Cancer working group ArnhemNetherlands European Association of Urology(EAU)Young Academic Urologists(YAU)Uro-technology and SoMe working group ArnhemNetherlands Division of Urology Department of SurgerySS Annunziata HospitalCosenzaItaly

Objective:The aim of the study was to evaluate three-dimensional virtual models(3DVMs)usefulness in the intraoperative assistance of minimally-invasive partial nephrectomy in highly complex renal ***:At our institution cT1-2N0M0 all renal masses with Preoperative Aspects and Dimensions Used for an Anatomical classification score≥10 treated with minimally-invasive partial nephrectomy were considered for the present *** inclusion a baseline contrast-enhanced computed tomography in order to obtain 3DVMs,the baseline and postoperative serum creatinine as well as estimated glomerular filtration rate values were *** patients,in which 3DVMs were used to assist the surgeon in the planning and intraoperative guidance,were then compared with a control group of patients who underwent minimally-invasive partial nephrectomy with the same renal function assessments,but without *** logistic regression models were used to predict the margin,ischemia,and complication score ***:Overall,79 patients met the inclusion criteria and were compared with 143 complex renal masses without 3DVM *** 3DVM group showed better postoperative outcomes in terms of baseline-weighted differential estimated glomerular filtration rate(-17.7%vs.-22.2%,p=0.03),postoperative complications(16.5%vs.23.1%,p=0.03),and major complications(Clavien Dindo>III,2.5%vs.5.6%,p=0.03).At multivariable logistic regression 3DVM assistance independently predicted higher rates of successful partial nephrectomy(odds ratio:1.42,p=0.03).Conclusion:3DVMs represent a useful tool to plan a tailored surgical approach in case of surgically complex *** can be used in different ways,matching the surgeon's needs from the planning phase to the demolitive and reconstructive phase,leading towards maximum safety and efficacy outcomes.

关键词： Three-dimensional Kidney cancer Renal cell carcinoma Robotic Laparoscopic Nephron-sparing surgery Complex renal mass

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A hospital outbreak of severe acute respiratory syndrome in Guangzhou,China

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Chinese Medical Journal 2003年第6期116卷 811-818页

作者：伍卫王景峰刘品明陈为宪尹松梅江山平严励詹俊陈锡龙李建国黄子通黄洪章 The SARS working group The Second Affiliated HospitalSun Yat-sen UniversityGuangzhou 510120China

Objective To describe a hospital outbreak of severe acute respiratory syndrome (SARS) and summarize its clinical features and therapeutic approaches.Methods The outbreak started with a SARS patient from the community, and a total of 96 people (76 women and 20 men, mean age (29. 5±10. 3) years, 93. 8% of whom were health care workers) who had exposure to this source patient became infected in a short time. Clinical data in this cohort were collected prospectively as they were identified.Results (1) The incubation period ranged from 1 to 20 (mean: 5. 9±3. 5) days. The duration of hospitalization was (17. 2±8. 0) days. (2) The initial temperature was (38. 3±0. 6)℃, while the highest was (39. 2 ±0. 6)℃( P<0. 001), with fever duration of (9. 0±4. 2) days. (3) Other most common symptoms included fatigue (93. 8%), cough (85. 4%), mild sputum production (66. 7%), chills (55.2%), headache (39.6%), general malaise (35.4%) and myalgia (21.9%). (4) The radiographic changes were predominantly bilateral in the middle or lower lung zones. The number of affected lung fields was 1. 2±0. 8 on presentation, which increased to 2. 9 ?1. 4 after admission (P<0. 001). The interval from the beginning of fever to the onset of abnormal chest radiographs was (3. 5±2. 3) days, which increased in size, extent, and severity to the maximum (6. 7±3. 5) days later. The time before the lung opacities were basically absorbed was (14.9±7.8) days. (5) Leukopenia was observed in 67. 7% of this cohort. The time between the onset of fever and leukopenia was (4. 4±2. 3) days, with the lowest white blood cell count of (2. 80±0. 72)×10~9/L (6) The lowest arterial oxygen saturation was (94.8±3.1 )% with supplementary oxygen. (7) Antibiotical therapies included tetracyclines ( 91. 0%), aminoglycosides ( 83. 3%), quinolones (79. 2%); 18. 8% of the patients received a combination of tetracyclines and aminoglycosides, while 11. 5% received a combination of tetracyclines and quinolones, and 6

关键词： severe acute respiratory syndrome·clinical features·treatment

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