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Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions

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Neural Regeneration Research 2025年第7期20卷 2116-2128页

作者： Yuxue Mu Ning Zhang Dongyu Wei Guoqing Yang Lilingxuan Yao Xinyue Xu Yang Li Junhui Xue Zuoming Zhang Tao Chen Aerospace Clinical medical center School of Aerospace MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Aviation Medicine Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Emergency Medicine Wuhan No.1 HospitalWuhanHubei ProvinceChina Third Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Fourth Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina

A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain ***,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under *** 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic *** investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail *** results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to Müller cell activation,were significantly *** addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated *** findings indicate that Müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness.

关键词： glial fibrous acidic protein gliosis Müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear layer simulated weightlessness

Schistosomiasis and the Philippine campaign

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Asian Pacific Journal of Tropical Medicine 2008年第2期1卷 41-60页

作者： Cristóbal S.Berry-Cabá womack army medical center WAMC/IMD/Clinical Data Team Fort BraggNC 28310-5000

Schistosomiasis is an infection with one of a series of related trematode parasites that are endemic to at least 76 tropical and subtropical *** affects over 200 million people in tropical and subtropical regions of South America,Africa and *** paper reported more than 1500 soldiers of US troops and 560 men of Australian Air Force were affected schistosomiasis japonicum in the Leyte of the Philippines during the liberation of the Philippines from Octorber 1944 to the early months of *** troops there were affected by contaminated water with snail *** first,the medical corps knew little about the situations of the schistosomiasis japonica in the Leyte,no preventive measure was *** December 23,1944 CPT morris Goldberg discovered schistosomes first from the hospitalized soldiers while conducting a liver *** soldiers with markedly signs and symptoms were admitted to hospital for *** measure was taken *** US sent a lot of experts to Philippines for the research of schistosomiasis japonicum,including epidemiology, prevention,diagnosis,treatment and so *** chemicals were used to control snail hosts. In clinical,schistosomiasis has acute and chronic stages,the manifestations are plenty and various,the liver, intestine,veins,spleen and skin etc are common sites of *** extensive educational program was carried out in the troops through different means,which yielded remarkable effect,the new incidence of schistosomiasis *** hospitalized soldiers were a few,but there were scare and some morale and psychological problems among them and the other affected victims,they worried about their prognoses or being infected. Some patients were evacuated to United States for treatment after diagnosis,some patients were treated in *** World WarⅡ,schistosomiasis was treated generally with trivalent antimony compounds,Fuadin and tartar *** this event,no case died,relapses w

关键词： schistosomiasis epidemiology prevention treatment troop United States Leyte

Altered Energy Metabolism During Early Optic Nerve Crush Injury:Implications of Warburg-Like Aerobic Glycolysis in Facilitating Retinal Ganglion Cell Survival

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Neuroscience Bulletin 2020年第7期36卷 761-777页

作者： Jingyi Zhu Ping Li Yuan-Guo Zhou Jian Ye Department of Ophthalmology Army Medical Center of the People's Liberation Army(PLA)Army Medical UniversityChongqing 400042China Molecular Biology center State Key Laboratory of TraumaBumand Combined InjuryResearch Institute of SurgeryArmy Medical Center of the PLAArmy Medical UniversityChongqing 400042China

Neurons,especially axons,are metabolically demanding and energetically vulnerable during ***,the exact energy budget alterations that occur early after axon injury and the effects of these changes on neuronal survival remain *** a classic mouse model of optic nerve-crush injury,we found that traumatized optic nerves and retinas harbor the potential to mobilize two primary energetic machineries,glycolysis and oxidative phosphorylation,to satisfy the robustly increased adenosine triphosphate(ATP) *** exploration of metabolic activation showed that mitochondrial oxidative phosphorylation was amplified over other pathways,which may lead to decreased retinal ganglion cell(RGC) survival despite its supplement to ATP *** set enrichment analysis of a microarray(GSE32309) identified significant activation of oxidative phosphorylation in injured retinas from wild-type mice compared to those from mice with deletion of phosphatase and tensin homolog(PTEN),while PTEN-/-mice had more robust RGC ***,we speculated that the oxidation-favoring metabolic pattern after optic nervecrush injury could be adverse for RGC *** redirecting metabolic flux toward glycolysis(magnifying the Warburg effect) using the drug meclizine,we successfully increased RGC ***,we provide novel insights into a potential bioenergetics-based strategy for neuroprotection.

关键词： Optic nerve crush ATP Glycolysis Oxidative phosphorylation RGC survival

Dermatitis bullosa caused by the immune checkpoint inhibitor camrelizumab:A case report

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World Journal of Clinical Cases 2025年第8期13卷 15-21页

作者： Yuan-Jing Jiang Lu Wu Xiao Yang Yu Pu Bing-Jie Ning Na Peng Xiao-Ju Zhu Cancer center Daping HospitalArmy Medical UniversityChongqing 400042China

BACKGROUND Since the advent of the 20th century,alongside the progression of medical science and technological advancements,immunotherapy has emerged as a pivotal thera-peutic approach for tumor patients subsequent to undergoing radiotherapy and ***(camrelizumab),a flagship drug in the realm of immuno-therapy,functions as a monoclonal antibody specifically targeting the progra-mmed death protein 1(PD-1).This drug engages with the human PD-1 receptor,effectively inhibiting the PD-1/programmed death ligand 1 signaling *** inhibition results in the restoration of T cell activity and the induction of an anti-tumour ***,it is noteworthy that such interference could lead to immune-related adverse events resembling autoimmune *** grow-ing availability and clinical use of immune checkpoint inhibitors have raised sig-nificant clinical concerns regarding their *** instances of immune-related adverse reactions and the associated management strategies have been extensively *** identification and diagnosis,coupled with multidi-sciplinary consultation and the prompt administration of immunosuppressants,can effectively address severe immune-related adverse *** SUMMARY Arimab(camrelizumab),a monoclonal antibody targeting programmed death protein 1(PD-1),disrupts the PD-1/programmed death ligand 1(PD-L1)inter-action,reactivating T cell function and triggering anti-tumor ***,this disruption may trigger immune-mediated adverse events akin to autoim-mune *** 2.8%of such events manifest as immune-related dermatologic reactions,with 0.7%classified as grade 3,which are infrequently ***,this study describes a case of grade 3 bullous dermatitis occur-ring 15 days after initiating camrelizumab *** patient,a 67-year-old male with oesophageal squamous cell carcinoma,received camrelizumab plus paclitaxel alongside chemotherapy and radiotherapy in early ***

关键词： Camrelizumab Anti-programmed cell death protein-1 blockade Skin-related adverse events Immune-related dermatitis Case report

Prevention and management of post-instability glenohumeral arthropathy

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World Journal of Orthopedics 2017年第3期8卷 229-241页

作者： Brian R Waterman Kelly G Kilcoyne Stephen A Parada Josef K Eichinger Department of Orthopaedic Surgery and Rehabilitation William Beaumont Army Medical Center Eisenhower army medical center Madigan army medical center

Post-instability arthropathy may commonly develop in high-risk patients with a history of recurrent glenohumeral instability,both with and without surgical *** related to anterior shoulder instability,the incidence and rates of arthritic progression may vary *** arthritic changes may be present in up to two-thirds of patients after primary Bankart repair and 30%after Latarjet procedure,with increasing rates associated with recurrent dislocation history,prominent implant position,non-anatomic reconstruction,and/or lateralized bone graft ***,the presence radiographic arthrosis does not predict poor patient-reported *** exhausting conservative measures,both joint-preserving and arthroplasty surgical options may be considered depending on a combination of patient-specific and anatomic *** procedures are optimally indicated for individuals with focal disease and may yield superior symptomatic relief when combined with treatment of combined shoulder *** more advanced secondary arthropathy,total shoulder arthroplasty remains the most reliable option,although the clinical outcomes,wear characteristics,and implant survivorship remains a concern among active,young patients.

关键词： Arthropathy Glenohumeral Dislocation Latarjet Instability

Formation of granulation tissue on bilateral vocal cords after doublelumen endotracheal intubation:A case report

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World Journal of Clinical Cases 2022年第34期10卷 12690-12695页

作者： Xiao-Juan Xiong Li Wang Ting Li Department of Anesthesiology Army Medical Center of PLADaping HospitalArmy Medical UniversityChongqing 400042China

BACKGROUND Most case reports on laryngeal granuloma formation have described patients after tracheotomy and single-lumen endotracheal *** studies have investigated vocal cord granuloma formation after double-lumen endotracheal(DLT)*** SUMMARY We report granulation tissue formation on the bilateral vocal cords after DLT intubation in a 45-year-old,153-cm-tall female *** imaging reports showed no formation of vocal cord granuloma before DLT ***,we inferred that DLT intubation may have been the main reason for the postoperative granulation tissue formation on her bilateral vocal cords,based on the patient’s history of DLT intubation,persistent hoarseness after thoracic surgery,and fibrolaryngoscopic and pathological reports during 12 mo *** Thirty-two Fr DLT tubes should be utilized for thoracic surgery on female patients who are shorter than 153 cm in height.

关键词： DLT Double-lumen endotracheal Granulation Vocal cords Case report

Tuberculosis-associated hemophagocytic lymphohistiocytosis misdiagnosed as systemic lupus erythematosus:A case report

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World Journal of Clinical Cases 2022年第10期10卷 3178-3187页

作者： Wen-Ting Chen Zhi-Cheng Liu Meng-Shan Li Ying Zhou Shen-Ju Liang Yi Yang Department of Rheumatology and Clinical Immunology Army Medical CenterArmy Medical UniversityChongqing 400000China Southwest Hospital Army Medical UniversityChongqing 400000China

BACKGROUND Hemophagocytic lymphohistiocytosis(HLH)is a rare disorder with rapid progression and high *** occurs mostly due to infection,malignant tumors,and immune *** infections that cause HLH,viral infections,especially Epstein-Barr virus infections,are common,whereas tuberculosis is ***-associated HLH has a wide range of serological and clinical manifestations that are similar to those of systemic lupus erythematosus(SLE).CASE SUMMARY This study describes a case of tuberculosis-associated HLH misdiagnosed as SLE because of antinuclear antibody(ANA),Smith(Sm)antibody and lupus anticoagulant positivity;leukopenia;thrombocytopenia;pleural effusion;decreased C3,quantitatively increased 24 h urinary protein and *** patient was initially treated with glucocorticoids,which resulted in peripheral blood cytopenia and symptom ***,caseating granulomas and hemophagocytosis were observed in her bone *** was successfully treated with conventional category 1 antituberculous *** addition,we reviewed the literature on tuberculosis-associated HLH documented in Pub Med,including all full-text articles published in English from December 2009 to December 2019,and summarized the key points,including the epidemiology,clinical manifestations,diagnosis,and treatment of tuberculosis-associated HLH and the differences of the present case from previous *** Tuberculosis should be considered in patients with fever or respiratory *** drugs are important for treating tuberculosisassociated HLH.

关键词： Hemophagocytic lymphohistiocytosis Tuberculosis Systemic lupus erythematosus Misdiagnosis Case report

Description of United States Military Nurses Deployed to Afghanistan &Iraq, 2001-2015

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Open Journal of Nursing 2018年第1期8卷 93-101页

作者： Cristóbal Berry-Cabán Felecia Rivers Thomas A. Beltran Lawrence Anderson Department of Clinical Investigations Womack Army Medical Center Fort Bragg NC USA center for Nursing Science & Clinical Inquiry Womack Army Medical Center Fort Bragg NC USA

Since 2001, US military forces have been engaged in Afghanistan and in Iraq. During fifteen years of conflict in both operations US troops have incurred a total of 52,022 wounded and 6857 deaths. The aim of this analysis is to describe the characteristics of US military nurses that deployed to these combat theatres. Data for this retrospective analysis were provided by the US Department of Defense, Defense Manpower Data center and describes characteristics military nurses that deployed to Afghanistan, Iraq, or both between September 1, 2001 and July 31, 2015. A total of 6326 nurses deployed during this period;3296 nurses deployed to Afghanistan and 2683 nurses deployed to Iraq. Fifty-five percent of deployed nurses were male. The majority of deployed nurses were white (32.9%) followed by Hispanic (22.9%) and black nurses (14.5%). Most deployed nurses had a baccalaureate nursing degree (88.9%) and 9% deployed nurses had an advanced degree. Most deployed nurses were classified as general nurses (66.6%). Further research is needed to examine in detail the impacts of deployments upon nurses.

关键词： Military Nursing Afghanistan Iraq

Visuospatial Memory Alteration in Alzheimer’s Disease

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Neuroscience Bulletin 2020年第8期36卷 829-830页

作者： Sen Lin Department of Ophthalmology Daping HospitalArmy Medical Center of the People's Liberation ArmyArmy Medical UniversityChongqing 400042China

Although the treatment and drug discovery for Alzheimer’s disease (AD) are limited and some have failed recently,the search for potential biomarkers and early predictors *** is not only characterized by the decline o... 详细信息

关键词： Alzheimer impairment treatment