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Double-layer probiotic encapsulation for enhanced bacteriotherapy against inflammatory bowel disease

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Nano Research 2024年第10期17卷 9103-9110页

作者： Yixin Wang Jun Liu Sichen Yuan Yawen You Quanyin Hu Pharmaceutical Sciences Division School of PharmacyUniversity of Wisconsin-MadisonMadisonWI 53705USA Carbone Cancer center School of Medicine and Public HealthUniversity of Wisconsin-MadisonMadisonWI 53705USA wisconsin center for nanobiosystems School of PharmacyUniversity of Wisconsin-MadisonMadisonWI 53705USA

Inflammatory bowel disease(IBD)is inflammatory intestinal disorders associated with dysregulated gut *** that leverages bacteria as therapeutics has shown tremendous promise in resolving gut dysbiosis and reducing inflammatory mediators to treat *** delivered probiotics,such as Escherichia coli Nissle 1917(EcN),can produce beneficial ingredients,competitively inhibit the proliferation of pathogens,and promote the restoration of gut microbiome ***,environmental stresses(such as gastric acids)in the gastrointestinal(GI)tract pose an enormous challenge to the probiotics following oral administration,leading to decreases in viability and activity of ***,the inferior mucoadhesive capability of probiotics results in low colonization efficacy,further compromising their therapeutic *** probiotics with functional biomaterials may protect them from elimination and prolong their retention in the GI ***,we developed a facile double-layer electrostatic assembly technique to encapsulate EcN bacteria in protective layers of mucoadhesive chitosan(CS)and immunomodulatory hyaluronic acid(HA)to generate *** biomaterials confer the coated EcN resistance to environmental assault and enhanced mucoadhesion in the GI *** probiotics equipped with the multifunctional shield can thus suppress inflammation and reshape the intestinal microenvironment to enhance therapeutic efficacy for the prevention and treatment of ***,this study presents a novel probiotic coating strategy to augment the outcome of bacteriotherapy to combat IBD.

关键词： probiotics biomaterial coating inflammatory bowel disease mucoadhesion oral administration

Convergence of nanomedicine and neutrophils for drug delivery

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Bioactive Materials 2024年第5期35卷 150-166页

作者： Sichen Yuan Quanyin Hu Pharmaceutical Sciences Division School of PharmacyUniversity of Wisconsin-MadisonMadisonWI53705United States Carbone Cancer center School of Medicine and Public HealthUniversity of Wisconsin-MadisonMadisonWI53705United States wisconsin center for nanobiosystems School of PharmacyUniversity of Wisconsin-MadisonMadisonWI53705United States

Neutrophils have recently emerged as promising carriers for drug delivery due to their unique properties including rapid response toward inflammation,chemotaxis,and *** integrated with nanotechnology that has enormous advantages in improving treatment efficacy and reducing side effects,neutrophil-based nano-drug delivery systems have expanded the repertoire of nanoparticles employed in precise therapeutic interventions by either coating nanoparticles with their membranes,loading nanoparticles inside living cells,or engineering chimeric antigen receptor(CAR)-*** neutrophil-inspired therapies have shown superior biocompatibility,targeting ability,and therapeutic *** this review,we summarized the benefits of combining neutrophils and nanotechnologies,the design principles and underlying mechanisms,and various applications in disease *** challenges and prospects for neutrophil-based drug delivery systems were also discussed.

关键词： Nanotechnology Neutrophil Drug delivery Cell therapy

Innovative hydrogel-based delivery systems for immunotherapy:A review of pre-clinical progress

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Nano Research 2024年第10期17卷 9031-9043页

作者： Narsimha Mamidi Michael Poellmann Kaila Javius-Jones KiChang Nam Seungpyo Hong wisconsin center for nanobiosystems University of Wisconsin-MadisonMadisonWI 53705USA Pharmaceutical Sciences Division School of PharmacyUniversity of Wisconsin-MadisonMadisonWI 53705USA Department of Medical Engineering College of MedicineDongguk UniversityGoyang 10326Republic of Korea Department of Pharmacy Yonsei UniversityIncheon 21983Republic of Korea Lachman Institute for Pharmaceutical Development University of Wisconsin-MadisonMadisonWI 53705USA

Immunotherapy has markedly reinvented how we treat cancer,as shown by numerous Food and Drug Administration(FDA)drug approvals that have made significant clinical impact and ongoing clinical ***,undesirable side effects,such as autoimmunity and inflammation,and inconsistent clinical outcomes remain a major *** response rates across various immunotherapeutic reagents is imperative to enhance overall effectiveness and reduce adverse side *** address this challenge,interdisciplinary approaches have been explored by incorporating immunotherapies into hydrogels,enabling finecontrolled delivery to target *** review focuses on recent progress in the utilization of hydrogel-based delivery systems for cancer immunotherapy and their potential to further enhance treatment response ***,recent preclinical advances in hydrogels implemented with immune checkpoint inhibitors,combination therapies,and vaccines,along with selfassembled peptide hydrogels,are *** also discuss technological advances and drawbacks in this area and provide insights to ultimately realize the clinical application of hydrogels in cancer immunotherapy.

关键词： cancer immunotherapy drug delivery hydrogels immunotherapeutic agents immune modulation clinical outcomes

In vitro study of enhanced photodynamic cancer cell killing effect by nanometer-thick gold nanosheets

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Nano Research 2020年第12期13卷 3217-3223页

作者： Ziyi Zhang Dalong Ni Fei Wang Xin Yin Shreya Goel Lazarus NGerman Yizhan Wang Jun Li Weibo Cai Xudong Wang Department of Materials Science and Engineering University of Wisconsin-MadisonMadisonWisconsin53706USA Department of Radiology University of Wisconsin-MadisonMadisonWisconsin53705USA University of wisconsin Carbone Cancer center MadisonWisconsin53705USA

Photodynamic therapy(PDT)by near-infrared(NIR)irradiation is a promising technique for treating various ***,we reported the development of free-standing wafer-scale Au nanosheets(NSs)that exhibited an impressive PDT *** Au NSs were synthesized by ionic layer epitaxy at the air-water interface with a uniform thickness in the range from 2 to 8.5 *** Au NSs were found very effective in generating singlet oxygen under NIR *** vitro cellular study showed that the Au NSs had very low cytotoxicity and high PDT efficiency due to their uniform 2D *** NSs could kill cancer cells after 5 min NIR irradiation with little heat *** performance is comparable to using 10 times mass loading of Au nanoparticles(NPs).This work suggests that two-dimensional(2D)Au NSs could be a new type of biocompatible nanomaterial for PDT of cancer with an extraordinary photon conversion and cancer cell killing efficiency.

关键词： gold nanosheet ionic layer epitaxy surface plasmon photodynamic effect cancer therapy

Carboxymethylation of the polysaccharide from the fermentation broth of Marasmius androsaceus and its antidepressant mechanisms

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Food Science and Human Wellness 2023年第6期12卷 2417-2427页

作者： Yu Qiu Yan Su Jia Song Fangming Mou Jia Gou Xiaoqi Geng Xinyue Li Zhiqiang Nie Jianxin Wang Yu Zheng Min Wang State Key Laboratory of Food Nutrition and Safety Tianjin Engineering Research Center of Microbial Metabolism and Fermentation Process ControlCollege of BiotechnologyTianjin University of Science&TechnologyTianjin 300457China Key Laboratory of Chemical Biology and Molecular Engineering Ministry of EducationInstitute of BiotechnologyShanxi UniversityTaiyuan 030006China wisconsin center for nanobiosystems School of PharmacyUniversity of Wisconsin-MadisonMadisonWI 53706USA Pharmaceutical Sciences Division School of PharmacyUniversity of Wisconsin-MadisonMadisonWI 53706USA

To investigate the structure-activity relationship of polysaccharide and obtain a better antidepressant polysaccharide,the antidepressant-like activity of a carboxymethyl polysaccharide(C-MEPS2)subjected to submerged fermentation was systematically ***12-H cell and Kunming mice were used to investigate the differences and their mechanism in the antidepressant effects of C-MEPS2 and *** experiments have showed that C-MEPS2 has a better antidepressant effect than MEPS2.C-MEPS2 could exert antidepressant effects related to catecholamine synthesis with specifi c sites of TH,D2DR,and *** addition,C-MEPS2 could repair the Res-induced damage in PC12-H cell,stabilize the mitochondrial membrane potential and regulate intracellular Ca^(2+) concentration,thus reducing cell apoptosis caused by *** common dosing experiments on animals further proved that CMEPS2 could signifi cantly improve the antidepressant effect of derivatives without affecting the antidepressant mechanism of *** is speculated that it may be related to carboxymethylated modifi cation.

关键词： Carboxymethyl polysaccharide Anti-depressant Catecholamine

Electrospun Aloe Vera Extract Loaded Polycaprolactone Scaffold for Biomedical Applications:A Promising Candidate for Corneal Stromal Regeneration

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Journal of Bionic Engineering 2024年第4期21卷 1949-1959页

作者： Amin Orash Mahmoud Salehi Mohammad Rafienia Narsimha Mamidi Saeed Heidari Keshel Alireza Baradaran-Rafii Department of Chemistry and Nanotechnology School of Engineering and ScienceTecnologico de MonterreyMonterreyNuevo Leon64849Mexico Biosensor Research center Isfahan University of Medical SciencesIsfahan81746-73461Iran wisconsin center for nanobiosystems School of PharmacyUniversity of Wisconsin-MadisonMadisonWisconsin53705USA Medical Nanotechnology Research center Shahid Beheshti University of Medical SciencesTehran19857-17443Iran Department of Ophthalmology Ophthalmic Research CenterLabbafinejad Medical CenterShahid Beheshti University of Medical SciencesTehran19395-4631Iran Department of Ophthalmology Morsani College of MedicineUniversity of South FloridaTampaFL33612USA Department of Tissue Engineering and Applied Cell Science School of Advanced Technologies in MedicineShahid Beheshti University of Medical SciencesTehran19857-17443Iran

Corneal diseases,the second leading cause of global vision loss affecting over 10.5 million people,underscores the unmet demand for corneal tissue *** the scarcity of fresh donor corneas and the associated risks of immune rejection,corneal tissue engineering becomes *** nanofibrous scaffolds that mimic the natural corneal structure is crucial for creating transparent and mechanically robust corneal equivalents in tissue ***,Aloe Vera Extract(AVE)/Polycaprolactone(PCL)nanofibrous scaffolds were primed using *** electrospun AVE/PCL fibers exhibit a smooth,bead-free morphology with a mean diameter of approximately 340±95 nm and appropriate light *** measurements reveal Young’s modulus and ultimate tensile strength values of around 3.34 MPa and 4.58 MPa,respectively,within the range of stromal *** addition,cell viability of AVE/PCL fibers was measured against Human Stromal Keratocyte Cells(HSKCs),and improved cell viability was *** cell-fiber interactions were investigated using scanning electron *** conclusion,the incorporation of Aloe Vera Extract enhances the mechanical,optical,hydrophilic,and biological properties of PCL fibers,positioning PCL/AVE fiber scaffolds as promising candidates for corneal stromal regeneration.

关键词： Corneal stromal regeneration Aloe vera extract Polycaprolactone Electrospinning

Targeting an oncogenic kinase/phosphatase signaling network for cancer therapy

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Acta Pharmaceutica Sinica B 2018年第4期8卷 511-517页

作者： Xiao-Mei Qi Fang Wang Matthew Mortensen Ryan Wertz Guan Chen Department of Pharmacology and Toxicology Medical College of Wisconsin Zablocki Veterans Affairs Medical center Medical College of Wisconsin

Protein kinases and phosphatases signal by phosphorylation and dephosphorylation to precisely control the activities of their individual and common substrates for a coordinated cellular outcome. In many situations, a kinase/phosphatase complex signals dynamically in time and space through their reciprocal regulations and their cooperative actions on a substrate. This complex may be essential for malignant transformation and progression and can therefore be considered as a target for therapeutic intervention. p38γ is a unique MAPK family member that contains a PDZ motif at its C-terminus and interacts with a PDZ domain-containing protein tyrosine phosphatase PTPH1. This PDZcoupled binding is required for both PTPH1 dephosphorylation and inactivation of p38γ and for p38γ phosphorylation and activation of PTPH1. Moreover, the p38γ/PTPH1 complex can further regulate their substrates phosphorylation and dephosphorylation, which impacts Ras transformation, malignant growth and progression, and therapeutic response. This review will use the p38γ/PTPH1 signaling network as an example to discuss the potential of targeting the kinase/phosphatase signaling complex for development of novel targeted cancer therapy.

关键词： Kinase/phosphatase signaling network PDZ-coupled protein-protein complex Phosphorylation and dephosphorylation Cancer development and progression Targeted cancer therapy

Neutrino astronomy： An update

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Frontiers of physics 2013年第6期8卷 759-770页

作者： Francis Halzen wisconsin IceCube Particle Astrophysics center (WIPAC) and Department of Physics University of Wisconsin Madison WI 53706 USA

Detecting neutrinos associated with the still enigmatic sources of cosmic rays has reached a new watershed with the completion of IceCube, the first detector with sensitivity to the anticipated fluxes. In this review, we will briefly revisit the rationale for constructing kilometer-scale neutrino detectors and summarize the status of the field.

关键词： neutrinos cosmic rays astrophysics

West Nile virus:North American experience

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Integrative Zoology 2011年第3期6卷 279-289页

作者： Erik K.HOFMEISTER USGS National Wildlife Health center MadisonWisconsinUSA

West Nile virus,a mosquito-vectored flavivirus of the Japanese encephalitis serogroup,was first detected in North America following an epizootic in the New York City area in *** the intervening 11 years since the arrival of the virus in North America,it has crossed the contiguous USA,entered the Canadian provinces bordering the USA,and has been reported in the Caribbean islands,Mexico,Central America and,more recently,South *** Nile virus has been reported in over 300 species of birds in the USA and has caused the deaths of thousands of birds,local population declines of some avian species,the clinical illness and deaths of thousands of domestic horses,and the clinical disease in over 30000 Americans and the deaths of over *** to the emergence of West Nile virus in North America,*** encephalitis virus and Dengue virus were the only other known mosquito-transmitted flaviviruses in North America capable of causing human *** review will discuss the North American experience with mosquito-borne flavivirus prior to the arrival of West Nile virus,the entry and spread of West Nile virus in North America,effects on wild bird populations,genetic changes in the virus,and the current state of West Nile virus transmission.

关键词： arbovirus emerging infectious disease North America West Nile virus zoonotic disease