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Role of mucoadhesive polymers in enhancing delivery of nimodipine microemulsion to brain via intranasal route

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Acta Pharmaceutica Sinica b 2014年第2期4卷 151-160页

作者： Rudree Pathak Ranjeet Prasad Dash Manju Misr Manish Nivsarkar Department of Pharmaceutics National Institute of Pharmaceutical Education and Research-AhmedabadC/O–B.V.Patel Pharmaceutical Education and Research Development(PERD)CentreAhmedabad 380054GujaratIndia Department of Pharmacology and Toxicology B.V.Patel Pharmaceutical Education and Research Development(PERD)CentreAhmedabad 380054GujaratIndia

Intranasal drug administration is receiving increased attention as a delivery method for by-passing the blood–brain barrier and rapidly targeting therapeutics to the ***,rapid mucociliary clearance in the nasal cavity is a major *** purpose of this study was to evaluate the effect of mucoadhesive polymers in enhancing the delivery of nimodipine microemulsion to the brain via the intranasal *** optimized mucoadhesive microemulsion was characterized,and the in vitro drug release and in vivo nasal absorption of drug from the new formulation were evaluated in *** optimized formulation consisted of Capmul MCM as oil,Labrasol as surfactant,and Transcutol P as co-surfactant,with a particle size of 250 nm and zeta potential value of?15 *** vitro and ex vivo permeation studies showed an initial burst of drug release at 30 min and sustained release up to 6 h,attributable to the presence of free drug entrapped in the mucoadhesive *** vivo pharmacokinetic studies in rats showed that the use of the mucoadhesive microemulsion enhanced brain and plasma concentrations of *** results suggest that incorporation of a mucoadhesive agent in a microemulsion intranasal delivery system can increase the retention time of the formulation and enhance brain delivery of drugs.

关键词： blood–brain barrier Entrapment Permeation Pharmacokinetics Nasal mucosa

Enhancement of fruit byproducts through bioconversion by Hermetia llucens(Diptera:Stratiomyidae)

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Insect Science 2023年第4期30卷 991-1010页

作者： Carmen Scieuzo Antonio Franco Rosanna Salvia Micaela Triunfo Nicola Francesco Addeo Simone vozzo Giovanni Piccolo Fulvia b.v.ra Alberto Ritieni Antonio Di Francia Ambrogio Laginestra Eric Schmitt Patrizia Falabella Department of Sciences University of BasilicataPotenzaItaly Spinoff XFlies s.r.l University of BasilicataPotenzaItaly Department of veterinary Medicine and Animal Production University of Naples Federico IlNaplesItaly Department of Pharmacy University of Naples Federico llNaplesItaly Departmentof Agriculture University of Naples Federico llPorticiItaly Department of Relations with the Territory TotalEnergies EP Italia S.p.APotenzaItaly Protix b.v. DongenThe Netherlands

bioconversion is a biological process by which organic materials are converted into products with higher biological and commercial *** its larval stage the black soldier fly Hermetia illucens is extremely voracious and can feed on a wide vari-ety of organic *** study the impact of different fruit byproducts on the insect's growth,final larval biomass,substrate reduction,bioconversion parameters,and larval nu-tritional composition,10000 black soldier fly larvae(bSFL)were reared on 7.0 kg of one of three substrates(strawberry,tangerine,or orange)or on a standard diet as a *** results highlight that bSFL can successfully feed and grow on each of these diets,though their development time,growth rate,and final biomass were differently impacted by the substrates,with strawberry being the most *** lipid and protein contents of bSFL were similar among larvae fed on different substrates;however,major differences were detected in ash,micronutrient,fiber,fatty acid,and amino acid ***,the results indicate that fruit waste management through the bSFL bioconversion process rep-resents a commercially promising resource for regional and national agrifood *** study offers new perspectives for sustainable and environmentally friendly industrial development by which fruit byproducts or waste might be disposed of or unconventionally enhanced to create secondary products of high biological and economic value,including bSFL biomass as animal feed or,in perspective,as alternative protein source for human nutrition.

关键词： bioconversion black soldier fly byproducts circular economy feed

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采用双扫描平台技术的ArF浸液式光刻

电子工业专用设备 2005年第2期34卷 7-14页

作者： Jan Mulkens bob Streefkerk Martin Hoogendorp 童志义 ASML Netherlands B.V. De Run 6501 5504 DR Veldhoven

在193nm光刻中,已证明水是一种适于浸液式光刻的液体。浸液式光刻提出了一种可将传统的光学光刻拓展到45nm节点,甚至到32nm节点的潜能。另外,利用现有的透镜,浸液式光刻的选择提出了根据实际的数值孔径和特征图形可增大50%及更大的焦深... 详细信息

在193nm光刻中,已证明水是一种适于浸液式光刻的液体。浸液式光刻提出了一种可将传统的光学光刻拓展到45nm节点,甚至到32nm节点的潜能。另外,利用现有的透镜,浸液式光刻的选择提出了根据实际的数值孔径和特征图形可增大50%及更大的焦深范围。讨论了采用浸液式光刻获得的成像结果和套刻结果。采用一个0.75数值孔径的ArF透镜,我们用双扫描平台技术(TWINSCANTM)组装一台浸液式扫描光刻机的原理型样机。最初的浸液式曝光实验数据证明了焦深的增加较大,同时以高扫描速度保持了图像的对比度。在初期引入的生产型浸液式光刻中,将采用一个0.85数值孔径的ArF透镜。该系统的分辨率将以大于0.5μm的焦深有效地支持65nm节点半导体器件的加工。这种系统初始的成像技术数据证实有效的增大了其焦深范围。

关键词： 193nm 浸液式光刻大数值孔径双扫描平台

New Relationships between Steenrod Operations for Certain Spaces

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Acta Mathematica Sinica,English Series 1992年第1期8卷 99-111页

作者： John Klippenstein Department of Mathematics University of British Columbia VancouverB.C.Canada V6T 1Y4

In this paper,we show that under a certain technical condition,if a space has no2-torsion,then either Sq~2~nx≠0 or there exists some y with Sq~2~ny=Sq~(2)x,if for somen≥3 Sq~(2)x≠*** proof uses relations between St... 详细信息

关键词： Connective K-Theory torsion free spaces Adams operations Steenrod operations Adams spectral sequence

Quantum Steganography via Greenberger-Horne-Zeilinger GHZ_4 State

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Communications in Theoretical Physics 2012年第4期57卷 577-582页

作者： A.El Allati M.b.Ould Medeni Y.Hassouni Facultédes Sciences Département de PhysiqueLPT-URAC-13UniversitéMohammed V-Agdal.Av.Ibn BattoutaB.P.1014RabatMaroc The Abdus Salam International Centre for Theoretical Physics TriesteItaly Facultédes Sciences Laboratory of Mathematic Informatics and ApplicationsUniversitéMohammed V-Agdal.Av.Ibn BattoutaB.P.1014RabatMaroc

A quantum steganography communication scheme via Greenberger-Horne-Zeilinger GHZ 4 state is constructed to investigate the possibility of remotely transferred hidden ***,the multipartite entangled states are become a hectic topic due to its important applications and deep effects on aspects of quantum ***,the scheme consists of sharing the correlation of four particle GHZ4 states between the legitimate *** insuring the security of the quantum channel,they begin to hide the secret information in the cover of *** the scheme with the previous quantum steganographies,capacity and imperceptibility of hidden message are *** security of the present scheme against many attacks is also discussed.

关键词： quantum steganography GHZ4 entangled state quantum cryptography quantum communication

vR-based digital twin for remote monitoring of mining equipment:Architecture and a case study

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虚拟现实与智能硬件（中英文） 2024年第2期6卷 100-112页

作者： Jovana PLAvŠIĆ Ilija MIŠKOvIĆNorman bKeevil Norman b.Keevil Institute of Mining Engineering University of British ColumbiaVancouverBC V6T 1Z4Canada

background Traditional methods for monitoring mining equipment rely primarily on visual inspections,which are time-consuming,inefficient,and *** article introduces a novel approach to monitoring mission-critical systems and services in the mining industry by integrating virtual reality(vR)and digital twin(DT)***-based DTs enable remote equipment monitoring,advanced analysis of machine health,enhanced visualization,and improved decision *** This article presents an architecture for vR-based DT development,including the developmental stages,activities,and stakeholders involved.A case study on the condition monitoring of a conveyor belt using real-time synthetic vibration sensor data was conducted using the proposed *** study demonstrated the application of the methodology in remote monitoring and identified the need for further development for implementation in active mining *** article also discusses interdisciplinarity,choice of tools,computational resources,time and cost,human involvement,user acceptance,frequency of inspection,multiuser environment,potential risks,and applications beyond the mining *** The findings of this study provide a foundation for future research in the domain of vR-based DTs for remote equipment monitoring and a novel application area for vR in mining.

关键词： virtual reality Digital twin Condition monitoring Mining equipment

ACO-Inspired Load balancing Strategy for Cloud-based Data Centre with Predictive Machine Learning Approach

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Computers, Materials & Continua 2023年第4期75卷 513-529页

作者： Niladri Dey T.Gunasekhar K.Purnachand Department of CSE K.L.UniversityVaddeswaraam522302Andhra PradeshIndia Department of CSE(Data Science) B.V.Raju Institute of TechnologyTS502313India

virtual Machines are the core of cloud computing and are utilized toget the benefits of cloud computing. Other essential features include portability,recovery after failure, and, most importantly, creating the core mechanismfor load balancing. Several study results have been reported in enhancing loadbalancingsystems employing stochastic or biogenetic optimization *** examines the underlying issues with load balancing and the limitationsof present load balance genetic optimization approaches. They are criticizedfor using higher-order probability distributions, more complicated solutionsearch spaces, and adding factors to improve decision-making skills. Thus, thispaper explores the possibility of summarizing load characteristics. Second,this study offers an improved prediction technique for pheromone level predictionover other typical genetic optimization methods during load *** also uses web-based third-party cloud service providers to test and validatethe principles provided in this study. It also reduces vM migrations, timecomplexity, and service level agreements compared to other parallel standardapproaches.

关键词： Predictive load estimation load characteristics summarization correlation-based parametric reduction corrective coefficient-based

Modeling and simulation as a service architecture for deploying resources in the Cloud

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International Journal of Modeling, Simulation, and Scientific Computing 2016年第1期7卷 142-179页

作者： Sixuan Wang Gabriel Wainer Department of Systems and Computer Engineering Carleton University Centre for visualization and Simulation(v-Sim)Ottawa CanadaON K1S-5B6

In recent years,Cloud Computing has become popular to facilitate the use of Modeling and Simulation(M&S)***,there are still various issues to solve,including the structure constrain of chosen web service frameworks,the sharing of varied resources in the Cloud,and the difficulties in reproducing *** show a new architecture based on Cloud Computing and new modeling methods to deal with these *** layered architecture,called Cloud Architecture for Modeling and Simulation as a Service(CAMSaaS),simplifies the deployment of M&S resources as services in the *** supports hierarchical resource services,experimental frameworks,scalable infrastructure and makes everything as a *** deploy varied M&S resources as services in the Cloud,and build a Modeling and Simulation as a Service(MSaaS)middleware called CloudRISE to manage a variety of M&S *** also use the experimental framework concept to simplify the management of experiment *** present a case study for crowd evacuation application using the architecture.

关键词： Modeling and Simulation as a Service Cloud-based Simulation Simulation Middleware RESTful Web Services Cloud Services

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可可脂的结晶特性对巧克力质量的影响

中国食品工业 2001年第8期 26-27页

作者： Hans Kattenberg ADM Cocoa b.v.研究及发展部

巧克力的物理性质很大程度上取决于制造过程中所用的可可脂质量,特别是可可脂融化、结晶和固化的方法。以下将对可可脂在巧克力制造过程中的物理与化学特性,以及各种可可脂如何充分地改变巧克力的风味、易碎程度及口感进行讨论。可可... 详细信息

巧克力的物理性质很大程度上取决于制造过程中所用的可可脂质量,特别是可可脂融化、结晶和固化的方法。以下将对可可脂在巧克力制造过程中的物理与化学特性,以及各种可可脂如何充分地改变巧克力的风味、易碎程度及口感进行讨论。可可脂的结晶性晶形的形成由于可可脂具有复杂的结晶性,可通过多种不同的变性而结晶成多晶型脂肪。

关键词：可可脂结晶特性巧克力生产产品质量风味易碎程度口感