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International Journal of Ophthalmology(English edition) 2017年第2期10卷 254-261页

作者： Michael Waisbourd Rebekah H.Gensure Ardalan Aminlari Sonya B.Shah Nitasha Khanna Neil Sood Jeanne Molineaux Alberto Gonzalez Jonathan S.Myers L.Jay Katz wills eyehospital glaucoma research center PhiladelphiaPA 19107USA Diopsys Inc. Pine BrookNJ 07058USA

AIM： To evaluate the use of short-duration transient visual evoked potentials（VEP） and color reflectivity discretization analysis（CORDA） in glaucomatous eyes,eyes suspected of having glaucoma,and healthy ***： The study included 136 eyes from 136 subjects： 49 eyes with glaucoma,45 glaucoma suspect eyes,and 42 healthy *** underwent Humphrey visual field（VF） testing,VEP testing,as well as peripapillary retinal nerve fiber layer optical coherence tomography imaging studies with post-acquisition CORDA *** analysis was performed using means and ranges,ANOVA,post-hoc comparisons using Turkey＇s adjustment,Fisher＇s Exact test,area under the curve,and Spearman correlation ***： Parameters from VEP and CORDA correlated significantly with VF mean deviation（MD）（P〈0.05）.In distinguishing glaucomatous eyes from controls,VEP demonstrated area under the curve（AUC） values of 0.64-0.75 for amplitude and 0.67-0.81 for *** CORDA HR1 parameter was highly discriminative for glaucomatous eyes vs controls（AUC=0.94）.CONCLUSION： Significant correlations are found between MD and parameters of short-duration transient VEP and CORDA,diagnostic modalities which warrant further consideration in identifying glaucoma characteristics.

关键词： short-duration transient visual evoked potentials optical coherence tomography color reflectivity discretization analysis glaucoma

Long-term outcomes in patients initially responsive to selective laser trabeculoplasty

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International Journal of Ophthalmology(English edition) 2015年第5期8卷 960-964页

作者： Varun Patel Eman El Hawy Michael Waisbourd Camila Zangalli Daniel M.Shapiro Lalita Gupta Michael Hsieh Abigail Kasprenski L.Jay Katz George L.Spaeth glaucoma research center Wills Eye Hospital

AIMTo determine the long-term effects of selective laser trabeculoplasty (SLT) on intraocular pressure (IOP) and the number of medications used up to 5y following treatment in glaucoma patients receiving maximally tolerated medical therapy (MTMT).METHODSThe wills Eye Hospital glaucoma research center retrospectively reviewed the charts of glaucoma patients who underwent SLT after receiving MTMT. Eyes that did not achieve their target pressure within 3mo following SLT were excluded from the study. Changes in mean IOP and number of glaucoma medications used were analyzed at 1, 3, and 5y following ***-five eyes of 67 patients were included in the study. Fifteen eyes that received SLT failed to achieve their target pressure within 3mo and were excluded from the study. The average follow-up time was 37.4mo (±14.4). Mean IOP was significantly reduced 1y after treatment (P=0.005). It was also reduced 3, 5y after treatment without reaching statistical significance (P=0.20 and P=0.072, respectively). There was a significant decrease in mean number of medications used 1, 3, 5y after treatment (Pglaucoma surgery and an additional 3 eyes (4.0%) underwent *** significantly reduced the number of glaucoma medications used 5y following treatment in glaucoma patients receiving MTMT. SLT may delay operating-room surgery.

关键词： selective laser trabeculoplasty long-term intraocular pressure number of medications used maximally tolerated medical therapy glaucoma

Changes in macular thickness following glaucoma surgery

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International Journal of Ophthalmology(English edition) 2016年第8期9卷 1236-1237页

作者： Priyamvada M. Pitale Usma Chatha Varun Patel Lalita Gupta Michael Waisbourd Michael J Pro glaucoma research center Wills Eye Hospital

Dear Sir,Previous reports have illustrated reversible structural changes in optic disc cupping,the lamina cribrosa,and the retinal nerve fiber layer(RNFL)following glaucoma surgery[1-3].However,few studies have assessed changes in macular thickness following such *** aim was to investigate the impact of intraocular pressure(IOP)reduction after glaucoma surgery on total macular thickness

关键词： IOP RNFL Changes in macular thickness following glaucoma surgery

Head trauma can cause transient elevation of intraocular pressure in patients with open angle glaucoma

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International Journal of Ophthalmology(English edition) 2011年第3期4卷 298-302页

作者： George L.Spaeth glaucoma research center Wills Eye InstituteJefferson Medical College

AIM: To describe a newly-recognized entity, illustrated by five cases of glaucoma in whom trauma to the head, but not the eye, resulted in marked, transient elevation of intraocular pressure (IOP). METHODS: Retrospective case series. Chart review. RESULTS: All five cases had a diagnosis of primary open-angle glaucoma prior to the experience of trauma to the head. All cases had an unusual elevation of IOP (around 70 percent) for days to weeks following the trauma, after which the IOP fell to pre-accident levels. No cause other than the trauma could be determined. CONCLUSION: The relationship between head trauma and elevation of IOP appears real.

关键词： head trauma open angle glaucoma intraocular pressure

Implantation of trabecular micro-bypass stent using a novel “landing strip” technique

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International Journal of Ophthalmology(English edition) 2017年第5期10卷 738-741页

作者： Cindy X.Zheng Marlene R.Moster Priyanka Gogte Yang Dai Remy S.Manzi Michael Waisbourd glaucoma research center Wills Eye Hospital PhiladelphiaPA 19107 USA

AIM：To describe a novel technique of creating a landing strip within the trabecular meshwork to guide trabecular micro-bypass stent（iStent） implantation in patients who underwent ***：Thirty-four eyes from 30 patients who underwent i Stent implantation after phacoemulsification from May 2014 to February 2015 were included in our retrospective study. All iStents were implanted via the ＂landing strip＂ technique. A 25-gauge microvitreoretinal blade was used to bisect the trabecular meshwork to less than 1 clock-hour, effectively creating a landing strip. The iStent applicator was pressed along the landing strip and then the stent was released into the trabecular meshwork. RESULTS：Of the 34 eyes with iStent implantation, 27（79.4%） eyes had primary open-angle glaucoma, 6（17.6%） eyes had pseudoexfoliation glaucoma, and 1（2.9%） eye had ocular hypertension. At 6-month follow-up（n=17）, the mean number of hypotensive medications decreased from 2.2±1.2 at baseline to 0.8±1.3（P=0.05） and mean intraocular pressure decreased from 19.7±4.1 mm Hg at baseline to 16.7±2.1 mm Hg（P=0.58）. Two eyes（5.9%） required subsequent trabeculectomy. CONCLUSION：The ＂landing strip＂ technique appears to be an effective way to assist with iS tent implantation.

关键词： iStent trabecular micro-bypass stent microinvasive glaucoma surgery glaucoma trabecular meshwork

Discriminating performance of macular ganglion cellinner plexiform layer thicknesses at different stages of glaucoma

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International Journal of Ophthalmology(English edition) 2019年第3期12卷 464-471页

作者： Melih Ustaoglu Nilgun Solmaz Feyza Onder glaucoma research center Wills Eye Hospital Ophthalmology Clinic Sisli Hamidiye Etfal Training and Research Hospital Ophthalmology Clinic Haseki Training and Research Hospital

AIM: To determine the discriminating performance of the macular ganglion cell-inner plexiform layer(GCIPL) parameters between all the consecutive stages of glaucoma(from healthy to moderate-to-severe glaucoma), and to compare it with the discriminating performances of the peripapillary retinal nerve fiber layer(RNFL) parameters and optic nerve head(ONH) ***: Totally 147 eyes(40 healthy, 40 glaucoma suspects, 40 early glaucoma, and 27 moderate-to-severe glaucoma) of 133 subjects were included. Optical coherence tomography(OCT) was obtained using Cirrus HD-OCT 5000. The diagnostic performances of GC-IPL, RNFL, and ONH parameters were evaluated by determining the area under the curve(AUC) of the receiver operating characteristics. RESULTS: All GC-IPL parameters discriminated glaucoma suspect patients from subjects with healthy eyes and moderate-to-severe glaucoma from early glaucoma patients(Pglaucoma patients from glaucoma suspects, whereas no RNFL or ONH parameter could discriminate between the two. The best parameters to discriminate glaucoma suspects from subjects with healthy eyes were superonasal GC-IPL, superior RNFL and average c/d ratio(AUC=0.746, 0.810 and 0.746, respectively). Discriminating performances of all the parameters for early glaucoma vs glaucoma suspect comparison were lower than that of the other consecutive group comparisons, with the bestGC-IPL parameters being minimum and inferotemporal(AUC=0.669 and 0.662, respectively). Moreover, minimum GC-IPL, average RNFL, and rim area(AUC=0.900, 0.858, 0.768, respectively) were the best parameters for discriminating moderate-to-severe glaucoma patients from early glaucoma ***: GC-IPL parameters can discriminate glaucoma suspect patients from subjects with healthy eyes, and also all the consecutive stages of glaucoma from each other(from glaucoma suspect to moderate-tosevere

关键词： retinal nerve fiber layer optic nerve head cirrus HD-OCT ganglion cell-inner plexiform layer glaucoma suspect

Validation and reproducibility of the Heidelberg Edge Perimeter in the detection of glaucomatous visual field defects

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International Journal of Ophthalmology(English edition) 2019年第4期12卷 577-581页

作者： Qi N.Cui Priyanka Gogt Jonathan M.Lam Safa Siraj Lisa A.Hark Jonathan S.Myers L.Jay Katz Michael Waisbourd glaucoma research center Wills Eye Hospital Scheie Eye center University of Pennsylvania Department of Ophthalmology Tel Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine Tel Aviv University

AIM: To validate the ability of the Heidelberg Edge Perimeter(HEP) in detecting glaucomatous visual field(VF) defects compared to the Octopus Visual Field(OVF) Analyzer and to determine the test-retest repeatability of both ***: This prospective, cross-sectional study was conducted at wills Eye Hospital, Philadelphia, PA. glaucoma subjects and unaffected controls underwent VF testing using HEP standard automated perimetry(SAP) Ⅲ 30-2 Adaptive Staircase Thresholding Algorithm(ASTA) FAST protocol and OVF G-TOP white-on-white strategy. Testing order was randomized. Pearson's correlation coefficient was calculated for both mean deviation(MD) and pattern standard deviation/square root of loss of variance(PSD/s LV). Receiver operating characteristic(ROC) curves were used to determine the diagnostic abilities of both modalities. glaucoma subjects returned for repeat testing and intraclass correlation coefficients(ICCs) were calculated to assess test-retest repeatability. RESULTS: Seventy-nine subjects with glaucoma and 36 unaffected controls were enrolled. HEP and OVF were significantly correlated for both MD(r=-0.84; Pglaucoma. The test-retest repeatability is high for both HEP and OVF, however the average testing duration of HEP is significantly longer than that of OVF.

关键词： glaucoma Heidelberg Edge Perimeter standard automated perimetry Octopus Visual Field Analyzer visual field

Trabeculectomy with Ex-PRESS implant versus Ahmed glaucoma valve implantation-a comparative study

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International Journal of Ophthalmology(English edition) 2016年第10期9卷 1415-1420页

作者： Michael Waisbourd Naomi Fischer Hadas Shalev Oriel Spierer Elad Ben Artsi Rony Rachmiel Gabi Shemesh Shimon Kurtz Department of Ophthalmology Tel-Aviv Medical CenterAffiliated to the Sackler Faculty of Medicine Tel-Aviv University Tel-Aviv 64239 Israel wills Eye glaucoma research center Philadelphia PA19107 USA

AIM：To compare the surgical outcomes of trabeculectomy with Ex-PRESS implant and Ahmed glaucoma valve（AGV） implantation. METHODS： Patients who underwent trabeculectomy with Ex-PRESS implants or AGV implantation separately were included in this retrospective chart *** outcome measures were surgical failure and *** was defined as intraocular pressure（IOP）〉21 mm Hg or 〈5 mm Hg on two consecutive visits after 3mo,reoperation for glaucoma,or loss of light *** that had not failed were considered as complete success if they did not required supplemental medical ***： A total of 64 eyes from 57 patients were included： 31 eyes in the Ex-PRESS group and 33 eyes in the AGV *** mean follow-up time was 2.6 ±1.1y and 3.3±1.6y,*** in the AGV group had significantly higher baseline mean IOP（P =0.005）,lower baseline mean visual acuity（VA）（P =0.02）,and higher proportion of patients with history of previous trabeculectomy（P 〈0.0001）.Crude failure rates were 16.1%,n =5/31 in the Ex-PRESS group and 24.2%,n =8/33 in the AGV *** cumulative proportion of failure was similar between the groups,P =*** proportion of eyes that experienced postoperative complications was32.3% in the Ex-PRESS group and 60.1% in the AGV group（P =0.0229）.CONCLUSION： Trabeculectomy with Ex-PRESS implant and AGV implantation had comparable failure *** AGV group had more post-operative complications,but also included more complex cases with higher baselinemean IOP,worse baseline mean VA,and more previous glaucoma ***,the results are limited to the cohort included in this study.

关键词： Ex-PRESS glaucoma implant trabeculectomy Ahmed glaucoma valve implantation

Perspective on early lens extraction for primary angle-closure glaucoma

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Eye Science 2017年第1期32卷 9-11页

作者： Osama M.Ahmed Lisa A.Hark Michael Waisbourd glaucoma research center Wills Eye HospitalPhiladelphiaPAUSA Department of Ophthalmology Tel-Aviv Medical CenterAffiliated to the Sackler Faculty of MedicineTel-Aviv UniversityTel-AvivIsrael

Primary angle-closure glaucoma(PACG)is a subtype of glaucoma that affects 16 million people worldwide,of whom4 million are bilaterally *** prevalence of PACG is expected to increase to 21 million cases by 2020,and it ... 详细信息

关键词： PACG IOP Perspective on early lens extraction for primary angle-closure glaucoma LPI