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Analyses the Endowment Insurance System of Flexible Employment

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International English Education Research 2015年第6期 122-126页

作者： Rui Wang Jiayu Deng Yixuan Xie wenhui road no. 1000 songiiang district shanghai China

In modem society, flexible employment has become the important channel of improve employment. Workers who transfer into the flexible employment from regular employment easily lost the original endowment insurance rights and interests, which increase the cost of laborer to flexible employment and impede the development of flexible employment. The establishment of the endowment insurance system of flexible employment can eliminate the apprehension of supporting themselves and enjoy in old age well.

关键词： Endowment insurance Government support Flexible employment

Involvement of auxin in growth and stress response of cucumber

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Vegetable Research 2022年第1期2卷 115-123页

作者： Rahat Sharif Li Su Xuehao Chen Xiaohua Qi Department of Horticulture School of Horticulture and LandscapeYangzhou University48 Wenhui East RoadYangzhouJiangsu 225009P.R.China

Cucumber(Cucumis sativus L.)is an important vegetable,popular worldwide for its crispy texture and special *** hormones such as auxin stand out for its dominating function in morpho-and organo.enic processes,formation of organs as well as regulation of tropic *** developmental processes are entirely,or partially dependent on auxin biosynthesis,transport,and signal *** cucumber,auxin no. only fine-tunes its morphogenesis but also its response to environmental *** role of auxin in regulating different organs(root,hypocotyl,shoot,leaf,tendril,flower,and fruit)development in cucumber is reviewed in the present ***,the role of auxin in cucumber response to biotic stresses(powdery mildew,downy mildew,and nematode infections)and abiotic stresses(heat,iron,waterlogging,cold,salinity,drought,and heavy metal stresses)is ***,we point out the blind spots and future research thoughts to extend our understanding of this myriad molecule in cucumber growth and stress biology.

关键词： stress organs entirely

Relationship between gene expression and the accumulation of catechin during spring and autumn in tea plants (Camellia sinensis L.)

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Horticulture Research 2015年第1期2卷 264-271页

作者： Min Liu Heng-lu Tian Jian-Hua Wu Ren-Rong Cang Run-Xian Wang Xiao-Hua Qi Qiang Xu Xue-Hao Chen School of Horticulture and Plant Protection Yangzhou University48 Wenhui East RoadYangzhouJiangsu 225009P.R.China Vocational and Technical College of Agriculture and Forestry(School of Agriculture) 18 Wenchang East RoadJurongJiangsu 212400P.R.China Tea Research Institute JurongJiangsu 212400P.R.China

The tea plant(Camellia sinensis L.)is an important commercial crop with remarkably high catechin *** is popular worldwide given the plant's health *** are the main astringent substance in tea and are synthesized mainly via the phenylpropano.d *** this study,eight cultivars of tea plants harvested both in spring and autumn were used to investigate differences in catechin concentrations by using high-performance liquid *** expression levels of genes associated with catechin biosynthesis were investigated using reverse transcription-quantitative polymerase chain *** results indicated that the total catechin(TC)concentrations were significantly higher in tea plants harvested in autumn than in those harvested in spring,based on higher concentrations of epigallocatechin(EGC)in autumn tea(Pno.e 3-hydroxylase(F3H),flavono.d 3′,5′-hydroxylase(F3′5′H),dihydroflavono. 4-reductase(DFR),and anthocyanidin synthase(ANS)is closely related to the TC content of tea plants in both spring and *** correlations between PAL,cinnamate 4-hydroxylase(C4H),F3H,and DFR expression and EGC accumulation in autumn tea were identified,with correlation coefficients of 0.710,0.763,0.884,and 0.707,respectively.A negative correlation between ANS expression level and EGC concentrations in tea plants harvested in spring was no.ed(r=−0.732).Additionally,negative correlations between F3H and ANS expression levels and the catechin content were identified in spring tea,whereas the correlations were positive in autumn *** differences in the F3H and ANS expression levels between spring and autumn tea indicate that F3H and ANS are potentially key genes affecting catechin accumulation in tea plants.

关键词： reaction. spring autumn

Introgression of qPE9-1 allele,conferring the panicle erectness,leads to the decrease of grain yield per plant in japonica rice(Oryza sativa L.)

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Journal of Genetics and Geno.ics 2011年第5期38卷 217-223页

作者： Xiuhua Yi Zujian Zhang Shengyuan Zeng Chunyan Tian Juncheng Peng Min Li Yue Lu Qingcai Meng Minghong Gu Changjie Yan Jiangsu Key laboratory of Crop Genetics and Physiology Key Laboratory of Plant Functional Genomics Ministry of Education Agricultural College of Yangzhou University 12# East Wenhui Rd. Jiangsu 225009 China

Panicle architecture is closely related to yield formation. The qPE9-1 gene has been proved to be widely used in high-yield rice cultivar developments, conferring erect panicle character in japonica rice. Recently, qPE9-1 has been successfully cloned; however, the genetic effect on grain yield per plant of the erect panicle allele qPE9-1 is controversial yet. In the present study, a drooping panicle parent no.gken 57, carrying qpe9-1 allele, was used as recurrent parent to successively backcross to a typical erect panicle line from the double haploid （DH） population （Wuyunjing 8/no.gken 57）, which was previously shown to carry qPE9-1 allele. Thus a pair of near-isogenic lines （NILs） was developed. The comparison of agrono.ic traits between the NILs showed that, when qpe9-1 was replaced by qPE9-1, the panicle architecture was changed from drooping to erect; moreover, the panicle length, plant height, 1000-grain weight and the tillers were significantly decreased, consequently resulting in the dramatic decrease of grain yield per plant by 30%. Therefore, we concluded that the qPE9-1 was a major factor controlling panicle architecture, and qPE9-1 had pleiotropic nature, with negative effects on grain yield per plant. This result strongly suggests that the erect panicle allele qPEg-1 should be used together with other favorable genes in the high-yield breeding practice. In addition, the effect of qPE9-1 on eating and cooking quality was also discussed in the present study.

关键词： Rice Erect panicle Genetic analysis qPE9-1

SCR-22 of pollen-dominant S haplotype class is recessive to SCR-44 of pollenrecessive S haplotype class in Brassica rapa

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Horticulture Research 2019年第1期6卷 1596-1606页

作者： Chun-Lei Wang Zhi-Ping Zhang Eriko Oikawa Hiroyasu Kitashiba Takeshi Nishio School of Horticulture and Plant Protection Joint International Research Laboratory of Agriculture and Agri-Product SafetyKey Laboratory of Plant Functional Genomics of the Ministry of EducationYangzhou University48 Wenhui East RoadYangzhou 225009People’s Republic of China Graduate School of Agricultural Science Tohoku University468-1 Aza-AobaAramakiAoba-kuSendaiMiyagi 980-0845Japan

SCR/SP11 encodes the male determinant of recognition specificity of self-incompatibility(SI)in Brassica species and is sporophytically expressed in the anther *** on dominance relationships in pollen and nucleotide sequence similarity,the S haplotypes in Brassica have been classified as class I or class II,with class-I S haplotypes being dominant over class-II S ***,we revealed that S-22 in *** belonging to class I is recessive to class-II S-44 and class-I S-36 in pollen,whereas it is dominant over S-60,S-40,and S-29 based on pollination ***/SP11 of S-22(SCR-22)was sequenced,revealing that the deduced amino.acid sequence of SCR-22 has the longest C-terminal domain among the SCR/SP11 *** expression of SCR-22 was found to be suppressed in S-22/S-44 and S-22/S-36 *** transcription of SCR-44 was considered to be due to the transcription suppression of Smi sRNA of the S-22 haplotype and a very low methylation state of the SCR-44 promoter region in the tapetum of S-22/S-44 *** SCR-22,only the cytosine residue located at the–37 bp position of the promoter region was hypermethylated in the tapetum of S-22/S-44 heterozygotes,and few methylated cytosines were detected in the promoter and coding regions of SCR-22 in S-22/S-36 ***-22 was also expressed in microspores in S-22 homozygotes but no. in S-22/S-44 and S-22/S-36 *** results suggest that a mechanism different from class-II SCR/SP11 suppression may operate for the suppression of recessive class-I SCR-22 in S heterozygotes.

关键词： similarity residue dominance

A multidisciplinary,integrated approach for the elimination of schistosomiasis:a longitudinal study in a historically hyperendemic region in the lower reaches of the Yangtze River,China from 2005 to 2014

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Infectious Diseases of Poverty 2017年第1期6卷 484-494页

作者： Le-Ping Sun Wei Wang Yin-Ping Zuo Qing-Biao Hong Guang-Lin Du Yu-Cai Ma Jian Wang Guo-Jing Yang Dao-Jian Zhu You-Sheng Liang Key Laboratory of National Health and Family Planning Commission on Parasitic Disease Control and Prevention No.117 YangxiangMeiyuanWuxi CityJiangsu Province 214064China Jiangsu Provincial Key Laboratory on Parasites and Vector Control Techno.ogy No.117 YangxiangMeiyuanWuxi CityJiangsu Province 214064China Jiangsu Institute of Parasitic Diseases No.117 YangxiangMeiyuanWuxi CityJiangsu Province 214064China Yangzhou Municipal Center for Disease Control and Prevention No.36 Yanfu East RoadYangzhou CityJiangsu Province 225000China Hanjiang District Center for Disease Control and Prevention Wenhui West RoadYangzhou CityJiangsu Province 225000China

Background:Although great success has been achieved,schistosomiasis remains a major public health concern in China,and the remaining core endemic regions are concentrated along the middle and lower reaches of the Yangtze *** this longitudinal study,we evaluated the effectiveness of a multidisciplinary,integrated approach for schistosomiasis elimination in a historically hyper-endemic region in the lower reaches of the Yangtze River,China over the 10-year period from 2005 through ***:A three-step roadmap for schistosomiasis elimination was designed in the study site,and multidisciplinary,integrated interventions were implemented by the health,agriculture,water resources development,land and resources,and forestry sectors from 2005 to 2014,including chemotherapy for infected individuals,health education,management of the source of Schistosoma japonicum infection,and intermediate host snail *** annual number of schistosomiasis patients,*** infection in humans,bovines and Oncomelania hupensis snails,and water infectivity were observed to assess the effectiveness of the multidisciplinary,integrated approach for the elimination of ***:There was a tendency towards a gradual decline in both the number of schistosomiasis cases and the prevalence of *** human infection across the study period from 2005 through *** *** human infection was detected since 2012,and no.acute infection was seen since *** the study period,no.infection was found in bovines,and a 0.03%overall infection rate was observed in *** *** 2009,no.infected snails were identified,and the area of both snail habitats and infected snail habitats appeared a reduction over the study *** the 3-year multidisciplinary,integrated control,infection control was achieved,and transmission control was achieved after 6-year implementation,with all infected snails and water infectivity eliminated;in addition,the 10-year i

关键词： Schistosomiasis Elimination Multidisciplinary approach Integrated control Yangtze River Longitudinal study China

Host immune response to infection with porcine circoviruses

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Animal Diseases 2021年第3期1卷 140-149页

作者： Ruihan Shi Lei Hou Jue Liu Beijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry Institute of Animal Husbandry and Veterinary MedicineBeijing Academy of Agriculture and Forestry SciencesBeijing 100097China Department of Preventive Veterinary Medicine College of Veterinary MedicineYangzhou UniversityNo.48 Wenhui RoadHanjiang DistrictYangzhou 225009China Jiangsu Co-Inno.ation Center for Prevention and Control of Important Animal Infectious Diseases and Zoono.es Yangzhou UniversityYangzhou 225009China

Porcine circovirus type 2(PCV2),which serves as a major causative agent of PCV2-associated diseases and causes severe loss to the pig industry worldwide,can dysregulate the immune response and induce immuno.uppression in PCV2-infected *** to PCV2(porcine circovirus type 3(PCV3),a newly identified swine circovirus which might be closely associated with porcine dermatitis and nephropathy syndrome,reproductive disorder,and multisystemic inflammatoty responses,also interferes with host immune *** between host immune system and PCVs is considered to be a crucial determinant of pathogenicity in ***,we sought to briefly discuss the current kno.ledge regarding the interaction of porcine circovirus type 2 and/or 3 with host immune cells and immune responses to better depict the viral immuno.odulatory capacity,pathogenic mechanisms,and the future research direction in host immune responses to infection with PCV2 and PCV3.

关键词： Porcine circovirus(PCV) Porcine circovirus-associated disease Lymphoid depletion Immune responses Pathogenesis

A self-assembled affibody-PROTAC conjugate nano.edicine for targeted cancer therapy

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Nano.Research 2024年第11期17卷 9954-9964页

作者： Qingrong Li Xiaoyuan Yang Mengqiao Zhao Xuelin Xia wenhui Gao Wei Huang Xiaoxia Xia Deyue Yan School of Chemistry and Chemical Engineering Shanghai Jiao Tong University 800 Dongchuan Road Shanghai 200240 China State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology Shanghai Jiao Tong University 800 Dongchuan Road Shanghai 200240 China

Proteolysis targeting chimeras (PROTACs) have recently emerged as promising therapeutic agents for cancer therapy. However, their clinical application is considerably hindered by the poor membrane permeability and insufficient tumor distribution of PROTACs. Here we proposed a nano.ngineered targeting strategy to construct a self-assembled affibody-PROTAC conjugate nano.edicine (APCN) for tumor-specific delivery of PROTACs. As proof of concept, a hydrophobic PROTAC MZ1 (a bromodomain-containing protein 4 degrader) was selected to couple with a hydrophilic affibody ZHER2:342 (an affinity protein of human epidermal growth factor receptor 2, HER2) via a smart linker containing disulfide bond to form an amphiphilic ZHER2:342-MZ1 conjugate. It spontaneously self-assembled into nano.articles (ZHER2:342-MZ1 APCN) in water. Upon the excellent targeting property of ZHER2:342 and HER2 receptor-mediated endocytosis, ZHER2:342-MZ1 APCN was accumulated in tumor sites and internalized by cancer cells effectively in vitro. Under the intracellular high level of glutathione (GSH), ZHER2:342-MZ1 APCN released MZ1 to specifically degrade bromodomain-containing protein 4 (BRD4) and subsequently induced BRD4 deficiency-mediated apoptosis of cancer cells. By the tail-vein injection, ZHER2:342-MZ1 APCN showed the outstanding tumor-specific targeting ability, drug accumulation capacity, enhanced BRD4 degradation and antitumor efficacy in vivo for an HER2-positive SKOV-3 tumor model. Such an affibody mediated nano.ngineered strategy would facilitate the application of PROTACs for targeted cancer therapy.

关键词： amphiphilic affibody-PROTAC conjugate BRD4 degradation nano.edicine self-assembly targeted cancer therapy

Field measurement analysis of the influence of simultaneous construction of river channel and bridge on existing double shield tunnels

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Underground Space 2022年第5期7卷 812-832页

作者： wenhui Yang Dingwen Zhang Anhui Wang School of Transportation Southeast University2 Southeast University RoadNanjingJiangsu Province 210096PR China China Construction Industrial&Energy Engineering Group Co. Ltd.No.6 Wenlan RoadNanjingJiangsu Province 210046PR China

This study presents the construction of a river channel and a bridge adjacent to existing metro tunnels in *** influence of simultaneous construction on these existing tunnels was investigated via 3D numerical modelling to predict tunnel deformation before ***,a targeted protection scheme was developed according to the obtained numerical *** full construction period field monitoring scheme can monitor tunnel responses during ***,the safety of the tunnel structures was evaluated according to the monitoring results,and the evolution of tunnel deformations was *** analytical results can help to clarify the influence characteristics of different construction stages,verify the effect of the proposed protection scheme,and determine the disturbance mechanism of short-distance pile *** to the results,the tunnel deformation mainly occurred during pile construction and river channel excavation,and the tunnel vertical displacement and convergence were mainly affected by the *** anti-floating scheme of the partition excavation and casting effectively controlled the tunnel heave with an alarm value of approximately 6 *** penetration of the short-distance casing resulted in a tunnel *** main construction influence area of the casing pile was within 6D(D is the pile diameter).

关键词： Existing tunnel Field monitoring Casing pile Tunnel deformation Adjacent construction