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Journal of Clinical and Nursing Research 2024年第3期8卷 7-11页

作者： Jie Xu Linyan Li Ning Wang Affiliated Hospital of shandong Second Medical University Weifang 261031Shandong ProvinceChina

Objective:To observe the analgesic effect of combined spinal and epidural anesthesia on older patients undergoing hip fracture ***:One hundred and twenty elderly hip fracture surgery patients treated in our hospital from January 2021 to December 2022 were selected and randomly divided into two groups,with 60 cases in the experimental group and 60 in the control *** experimental group was given combined spinal-epidural anesthesia intervention measures,while the control group was given epidural anesthesia intervention *** analgesic effect,tumor necrosis factor-alpha(TNF-α),C-reactive protein(CRP)levels,and other observation indicators were analyzed after anesthesia ***:After the intervention,the analgesic effect and the evaluation results of the subjects in the experimental group were better than those in the control group(P<0.05);the obtained values of TNF-αand CRP levels in the experimental group were higher than those of the control group(P<0.05).Conclusion:The combined spinal-epidural anesthesia intervention demonstrated positive *** analgesic effect of patients during surgery and their inflammatory factor levels improved,which makes this intervention worthy of clinical application and promotion.

关键词： Hip fracture in the elderly Surgery Combined spinal and epidural anesthesia Analgesic effect TNF-α CRP level

Spatial Dynamics of Chickenpox Outbreaks in Rapidly Developing Regions:Implications for Global Public Health

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Biomedical and Environmental Sciences 2024年第7期37卷 687-697页

作者： Li Wang Miaomiao Wang Chengdong Xu Peihan Wang Meiying You Zihan Li Xinmei Chen Xinyu Liu Xudong Li Yuanyuan Wang Yuehua Hu Dapeng Yin College of Geography and Environmental Science Henan UniversityKaifeng 475001HenanChina State Key Laboratory of Resources and Environmental Information System Institute of Geographic Science and Natural Resource ResearchChinese Academy of SciencesBeijing 100101BeijingChina Key Laboratory of Geospatial Technology for the Middle and Lower Yellow River Regions(Henan University) Ministry of EducationKaifeng 475001HenanChina Office of Epidemiology Chinese Center for Disease Control and PreventionBeijing 102206BeijingChina University of Chinese Academy of Sciences(UCAS) Beijing 100101BeijingChina weifang Municipal Center for Disease Control and Prevention Weifang 261061ShandongChina Hainan Center for Disease Control and Prevention Haikou 570203HainanChina

Objective The occurrence of chickenpox in rapidly developing areas poses substantial seasonal risk to ***,certain factors influencing local chickenpox outbreaks have not been ***,we examined the relationship between spatial clustering,heterogeneity of chickenpox outbreaks,and socioeconomic factors in Southern *** We assessed chickenpox outbreak data from Southern China between 2006 and 2021,comprising both relatively fast-growing parts and slower sub-regions,and provides a representative sample of many developing *** analyzed the spatial clustering attributes associated with chickenpox outbreaks using Moran’s I and local indicators of spatial association and quantified their socioeconomic determinants using Geodetector q *** There were significant spatial heterogeneity in the risk of chickenpox outbreaks,with strong correlations between chickenpox risk and various factors,particularly demographics and living ***,interactive effects among specific are factors,such as population density and per capita residential building area,percentage of households with toilets,percentage of rental housing,exhibited q statistics of 0.28,0.25,and 0.24,*** This study provides valuable insights into the spatial dynamics of chickenpox outbreaks in rapidly developing regions,revealing the socioeconomic factors affecting disease *** implications extend the formulation of effective public health strategies and interventions to prevent and control chickenpox outbreaks in similar global contexts.

关键词： Chickenpox Spatial dynamics Socioeconomic factors

Exploration of the “Four-Three-Four” Internship and Training Mode in Higher Vocational Colleges Under the Modern Vocational Education System

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Journal of Contemporary Educational Research 2024年第3期8卷 111-117页

作者： Jifeng Liu Na Han Xiaojiao Li Jing Wang Xuezhen Feng shandong Maritime Vocational College Weifang 261108Shandong ProvinceChina College of Educational Sciences Xinjiang Normal UniversityUrumqi 830017Xinjiang Uygur Autonomous RegionChina weifang City Government Kindergarten Weifang 261041Shandong ProvinceChina

This article mainly introduces the innovative internship and training model of vocational colleges,including five aspects such as“four-party collaboration,three-stage progression,four-way integration,value-added evaluation,and double selection and promotion.”The model aims to improve students’practical skills and professional quality to better adapt to market demand and social *** article also presents the prospects of the future internship and training model,including strengthening cooperation and communication with industry enterprises,focusing on students’personalized development and practical skill cultivation,and establishing a scientific and objective evaluation and feedback mechanism.

关键词： Four-party collaboration Three-stage progression Four-way integration Value-added evaluation Double selection and promotion

Mesenchymal stem cells and mesenchymal stem cell-derived extracellular vesicles:Potential roles in rheumatic diseases

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World Journal of Stem Cells 2020年第7期12卷 688-705页

作者： Jing-Han Yang Feng-Xia Liu Jing-Hua Wang Min Cheng Shu-Feng Wang Dong-Hua Xu Central Laboratory of the First Affiliated Hospital Weifang Medical UniversityWeifang 261000Shandong ProvinceChina Department of Rheumatology of the First Affiliated Hospital Weifang Medical UniversityWeifang 261000Shandong ProvinceChina Department of Allergy Weifang People’s HospitalWeifang 261000Shandong ProvinceChina Department of Physiology Weifang Medical UniversityWeifang 261000Shandong ProvinceChina Medical Experimental Training Center Weifang Medical UniversityWeifang 261000Shandong ProvinceChina

BACKGROUND Mesenchymal stem cells(MSCs)have been widely investigated in rheumatic disease due to their immunomodulatory and regenerative ***,mounting studies have implicated the therapeutic potency of MSCs mostly due to the bioactive factors they *** vesicles(EVs)derived from MSCs have been identified as a promising cell-free therapy due to low *** disease,primarily including rheumatoid arthritis and osteoarthritis,is a group of diseases in which immune dysregulation and chronic progressive inflammation lead to irreversible joint *** MSCs and MSC-derived EVs may be a more effective and promising therapeutic strategy for rheumatic *** To evaluate the potential therapeutic effectiveness of MSCs and EVs generated from MSCs in rheumatic *** PubMed was searched for the relevant literature using corresponding search terms alone or in *** published in English language from January 1999 to February 2020 were *** screening of papers concerning analysis of"immunomodulatory function"or"regenerative function"by scrutinizing the titles and abstracts of the literature,excluded the papers not related to the subject of the *** other related studies were obtained by manually retrieving the reference lists of papers that comply with the selection criteria,and these studies were screened to meet the final selection and exclusion *** Eighty-six papers were ultimately selected for *** analysis of the literature,it was found that both MSCs and EVs generated from MSCs have great potential in multiple rheumatic diseases,such as rheumatoid arthritis and osteoarthritis,in repair and regeneration of tissues,inhibition of inflammatory response,and regulation of body immunity via promoting chondrogenesis,regulating innate and adaptive immune cells,and regulating the secretion of inflammatory *** EVs from MSCs exhibit much more advan

关键词： Mesenchymal stem cell Extracellular vesicle Autoimmunity Inflammation Rheumatoid arthritis Osteoarthritis

Giant struma ovarii with pseudo-Meigs’syndrome and raised cancer antigen-125 levels:A case report

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World Journal of Clinical Cases 2022年第30期10卷 11155-11161页

作者： Yan Liu Gao-Yan Tang Lu Liu Hui-Min Sun Hai-Yan Zhu Department of Gynecology Weifang People’s HospitalWeifang 261032Shandong ProvinceChina Department of Oncology Weifang People’s HospitalWeifang 261032Shandong ProvinceChina Department of Pathology Weifang People’s HospitalWeifang 261032Shandong ProvinceChina

BACKGROUND Struma ovarii is a type of monodermal mature teratoma composed entirely or mainly of thyroid tissue,accounting for 1%to 3%of all ovarian teratomas and 0.3%to 1.0%of all ovarian *** which,struma ovarii with ascites and pleural effusion,called pseudo-Meigs’syndrome and raised cancer antigen-125levels(CA 125)is even *** SUMMARY This paper reports the diagnosis and treatment of a patient of struma ovarii with pseudo-Meigs’syndrome,presenting with the clinical features of ovarian carcinoma:Complex pelvic mass,gross ascites,right pleural effusion and markedly elevated serum CA 125 *** the operation,a cystic-solid mass about 20cm×10 cm×5 cm in the right adnexa and a solid mass with the size of 3 cm×2cm×0.1 cm in the left ovary were *** underwent right adnexectomy and resection of the left ovarian mass and histopathology revealed a mature leftsided ovarian teratoma and struma ovarii of right adnexal *** 1-year follow-up,the patient recovered well,tumor markers and other indicators returned to *** The diagnosis and treatment process of this case suggests that the clinical symptoms of struma ovarii with pseudo-Meigs’syndrome are lack specificity,which is easily *** should improve the understanding of this disease,enhance the awareness of early screening,and improve the level of diagnosis and treatment.

关键词： Struma ovarii pseudo-Meigs’syndrome Ascites Pleural effusion Cancer antigen-125 Case report

Bone flare after initiation of novel hormonal therapy in patients with metastatic hormone-sensitive prostate cancer:A case report

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World Journal of Clinical Cases 2022年第15期10卷 4985-4990页

作者： Ke-Hao Li Yuan-Cheng Du Dong-Yu Yang Xin-Yuan Yu Xue-Ping Zhang Yong-Xiang Li Liang Qiao Department of Clinic Weifang Medical UniversityWeifang 261000Shandong ProvinceChina Department of Urology Weifang People's HospitalWeifang 261000Shandong ProvinceChina

BACKGROUND The 2020 European Association of Urology prostate cancer guidelines recommend androgen deprivation therapy(ADT)in combination with apalutamide and enzalutamide,a new generation of androgen receptor antagonists,as first-line therapy.A decrease in prostate-specific antigen(PSA)levels may occur in the early stages of novel hormonal therapy;however,radionuclide bone imaging may suggest disease *** follow-up,PSA,radionuclide bone imaging,and prostate-specific membrane antigen(PSMA)positron emission tomography–computed tomography(PET-CT)are needed for systematic *** SUMMARY We admitted a 56-year-old male patient with metastatic hormone-sensitive prostate *** radionuclide bone imaging,magnetic resonance imaging(MRI),and PSMA PET-CT showed prostate cancer with multiple bone ***-guided needle biopsy of the prostate revealed a poorly differentiated adenocarcinoma of the prostate with a Gleason score:5+4=*** final diagnosis was a prostate adenocarcinoma(T4N1M1).ADT with novel hormonal therapy(goseraline sustained-release implant 3.6 mg monthly and apalutamide 240 mg daily)was *** months later,radionuclide bone imaging and MRI revealed advanced bone ***,PSMA PET-CT examination showed a significant reduction in PSMA aggregation on the bone,indicating improved bone *** that progressive decrease in the presenting lumbar pain,treatment strategies were considered to be *** ADT using novel hormonal therapy is effective for treating patients with prostate *** evaluation must precede treatment plan changes.

关键词： Bone flare Novel hormonal therapy Metastatic hormone-sensitive prostate cancer Apalutamide Case report

Targeted screening of an anti-inflammatory polypeptide from Rhopilema esculentum Kishinouye cnidoblasts and elucidation of its mechanism in alleviating ulcerative colitis based on an analysis of the gut microbiota and metabolites

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Food Science and Human Wellness 2024年第3期13卷 1336-1347页

作者： Ziyan Wang Qiuyue Shi Ying Feng Jiaojiao Han Chenyang Lu Jun Zhou Zhonghua Wang Xiurong Su State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Ningbo UniversityNingbo 315000China School of Marine Science Ningbo UniversityNingbo 315000China Key Laboratory of Aquaculture Biotechnology(Ningbo University) Ministry of EducationNingbo UniversityNingbo 315000China College of Life Sciences Tonghua Normal UniversityTonghua 134000China shandong Beiyou Biotechnology Co. Ltd.Weifang 261000China

Ulcerative colitis(UC)is a recurrent inflammatory bowel disease that imposes a severe burden on families and *** recent years,exploiting the potential of marine bioactive peptides for the treatment of diseases has become a topic of intense research *** study revealed the mechanism underlying the protective effect of the dominant polypeptide PKKVV(Pro-Lys-Lys-Val-Val)of Rhopilema esculentum cnidoblasts against DSS-induced UC through a combined analysis of the metagenome and serum ***,the polypeptide composition of *** cnidoblasts was determined by matrix-assisted laser desorption ionization time-of-flight mass spectrometry(MALDI-TOF/TOF-MS).Molecular docking showed that the dominant peptide PKKVV could bind better with tumor necrosis factor-α(TNF-α)than the original *** animal experiments suggested that PKKVV could modulate disorganized gut microorganisms in mice with UC;affect serum metabolites through the arachidonic acid,glycerophospholipid and linoleic acid metabolism pathways;and further alleviate UC *** study provides a reference for the comprehensive development of marine bioactive substances and nonpharmaceutical treatments for UC.

关键词： Ulcerative colitis Rhopilema esculentum Kishinouye Cnidoblasts Marine bioactive polypeptides Metagenome Serum metabolome

Integrated multi-omics reveals the relationship between growth performance, rumen microbes and metabolic status of Hu sheep with different residual feed intakes

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ANIMAL NUTRITION 2024年第3期18卷 284-295页

作者： Zhang, Yanzhen Zhang, Xiaowei Cao, Dingren Yang, Jinyong Mao, Huiling Sun, Lingling Wang, Chong Zhejiang A&F Univ Coll Anim Sci & Technol Coll Vet Med Hangzhou 311300 Peoples R China Key Lab Appl Technol Green Ecohlth Anim Husb Zheji Hangzhou 311300 Peoples R China shandong Vocat Anim Sci & Vet Coll Dept Anim Sci Weifang 261061 Peoples R China Zhejiang Prov Anim Husb Technol Promot & Monitorin Hangzhou 310021 Peoples R China

Residual feed intake (RFI) is a metric that provides a more accurate measure of feed efficiency. The lower the RFI, the higher the feed efficiency. The changes in the host microbiome and metabolome contribute to the greater feed efficiency of low RFI (LRFI) animals. The aim of this study was to explore the differences in rumen microorganisms, rumen metabolites and plasma metabolites of Hu sheep with differing RFI through the microbiome and metabolome. A total of 80 Hu sheep were used. The experiment consisted of a 15-d pretrial period and a 128-d experimental period. The RFI in the experimental period was calculated for all sheep, and the sheep were screened into high RFI (HRFI, n = 8) and LRFI (n = 8) groups. The HRFI and LRFI sheep did not differ in their initial and final body weights, average daily gain and body measurements, but the dry matter intake of LRFI sheep was significantly decreased (28.4%, P < 0.001). The sheep with LRFI had higher digestibility of crude protein (P = 0.010) and ether extract (P = 0.010) compared to HRFI group. The concentrations of acetate (P = 0.036), propionate (P = 0.010), valerate (P = 0.027) and total volatile fatty acids (P = 0.048) in rumen of LRFI group were higher compared to HRFI group. The results of 16S rDNA sequencing indicated that the sheep with LRFI had higher proportions of Prevotella genus in rumen liquid (P = 0.031). The rumen metabolome and plasma metabolome results showed that the citrate cycle, pyruvate metabolism and alanine, aspartate and glutamate metabolism processes were more active for sheep in LRFI group, which provided more energy substrate such as malic acid, oxoglutaric acid and citric acid. In conclusion, sheep with LRFI can utilize feed more efficiently, and the more active energy metabolism pathway and the production of energy substances may account for the higher feed efficiency.

关键词： Feed efficiency Residual feed intake Rumen microbiome and metabolome Plasma metabolome CHAIN FATTY-ACIDS GENETIC-PARAMETERS MILK-PRODUCTION BEEF-CATTLE AMINO-ACID D-LACTATE EFFICIENCY SUPPLEMENTATION FERMENTATION DIVERGENCE

Combined laparoscopic-endoscopic approach for gastric glomus tumor:A case report

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World Journal of Clinical Cases 2021年第24期9卷 7181-7188页

作者： Wen-Hao Wang Ting-Ting Shen Zhi-Xing Gao Xin Zhang Zhao-Hui Zhai Yu-Li Li Clinical Medical College Weifang Medical UniversityWeifang 261042Shandong ProvinceChina Department of Gastroenterology Affiliated Hospital of Weifang Medical UniversityWeifang 261042Shandong ProvinceChina The Plastic Surgery Hospital of weifang University Weifang Medical UniversityWeifang 261042Shandong ProvinceChina Plastic Surgery Institute of weifang Medical University Yuhe Campus of Weifang Medical UniversityWeifang 261042Shandong ProvinceChina

BACKGROUND Gastric glomus tumor(GGT)is rare submucosal mesenchymal tumor that lacks specific clinical manifestations and is usually treated mainly by traditional surgical *** paper presents a case of a GGT,exhibited both intraluminally and extraluminally growth that was removed by laparoscopy-gastroscopy cooperative *** SUMMARY A 52-year-old male presented with epigastric discomfort accompanied by a sense of fullness for 3 *** gastrointestinal endoscopy identified a submucosal lump located in the gastric *** ultrasonography identified a 2.4 cm×1.8 cm lump located in the gastric *** originated from the muscularis propria and exhibited both intraluminally and extraluminally growth,with hypoechoicity on the periphery,hyperechoicity in the middle,and unclear *** tomography showed nodular thickening of 3.0 cm×2.2 cm in the gastric wall of the gastric antrum,and after enhancement,the lesion exhibited obvious enhancement We suspected that it was a gastrointestinal stromal tumor(glomus tumor and schwannoma were not excluded)and planned to perform laparoscopy-gastroscopy cooperative *** staining after the operation revealed that spinal muscular atrophy(+),hcaldesmon(+),cluster of differentiation 34(CD34)(+),2%Ki-67-positive rate,CD56,melanoma antigen,CD117,discovered on GIST-1,leukocyte common antigen,caudal type homeobox 2,cytokeratin,and S-100 were all *** tumor was finally diagnosed as a *** GGTs are rare submucosal tumors of the stomach and should be considered in the differential diagnosis of gastric submucosal ***-gastroscopy cooperative surgery is less invasive and more precise and could be an effective method for the treatment of GGTs.

关键词： Gastric glomus tumor Laparoscopy Gastroscopy Immunohistochemical staining Operation method Case report

Metachronous mixed cellularity classical Hodgkin’s lymphoma and T-cell leukemia/lymphoma: A case report

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World Journal of Clinical Cases 2021年第27期9卷 8177-8185页

作者： Yang Dong Lai-Jun Deng Mi-Mi Li Department of Clinical Pharmacy Weifang Hospital of Traditional Chinese MedicineWeifang 261000Shandong ProvinceChina Department of Hematology Weifang Hospital of Traditional Chinese MedicineWeifang 261000Shandong ProvinceChina Department of Pathology Weifang Hospital of Traditional Chinese MedicineWeifang 261000Shandong ProvinceChina

BACKGROUND The development of peripheral T-cell lymphoma(PTCL)after chemotherapy for Hodgkin’s lymphoma(HL)is rare,and highly aggressive TCL/leukemia has not been reported to *** relationship between HL and PTCL needs further exploration to understand the pathogenesis of metachronous lymphoma(ML)and find effective treatment *** report a patient with ML,whose biopsy of a right cervical lymph node initially confirmed classical HL(CHL).CASE SUMMARY We report a patient with ML,whose biopsy of a right cervical lymph node initially confirmed CHL,with typical reed–sternberg cells expressing CD30 and PAX-5.T-cell leukemia/lymphoma occurred 3 years after treatment,and a lymph node biopsy at the onset confirmed PTCL,nonspecific type,expressing CD3,CD4 and *** patient was treated with standard doses of chemotherapy,programmed cell death-ligand 1 monoclonal antibody,and chidamide,all of which failed to achieve complete *** patient was diagnosed with refractory state,and eventually died of leukocyte *** The accuracy of the diagnosis needs to be confirmed when chemotherapeutic drugs are not effective.

关键词： Classical Hodgkin’s lymphoma T-cell lymphoma/leukemia Bone marrow Chemotherapy Drug resistance Case report