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Measurement of very low-molecular weight metabolites by traveling wave ion mobility and its use in human urine samples

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Journal of Pharmaceutical Analysis 2024年第5期14卷 733-743页

作者： Alongkorn Kurilung Suphitcha Limjiasahapong Khwanta Kaewnarin Pattipong Wisanpitayakorn Narumol Jariyasopit Kwanjeera Wanichthanarak Sitanan Sartyoungkul Stephen Choong Chee Wong Nuankanya Sathirapongsasuti Chagriya Kitiyakara Yongyut Sirivatanauksorn Sakda Khoomrung Siriraj Center of Research Excellent in Metabolomics and Systems Biology(SiCORE-MSB) Faculty of Medicine Siriraj HospitalMahidol UniversityBangkok10700Thailand Siriraj Metabolomics and Phenomics Center Faculty of Medicine Siriraj HospitalMahidol UniversityBangkok10700Thailand Department of Biomedical Informatics University of Arkansas for Medical SciencesLittle RockAR72205USA SingHealth Duke-NUS Institute of Biodiversity Medicine National Cancer Centre Singapore168583Singapore waters pacific pte. Ltd.Singapore117528Singapore Program in Translational Medicine Faculty of Medicine Ramathibodi HospitalMahidol UniversityBangkok10400Thailand Chakri Naruebodindra Medical Institute Faculty of Medicine Ramathibodi HospitalMahidol UniversitySamut Prakan10540Thailand Department of Medicine Ramathibodi HospitalMahidol UniversityBangkok10400Thailand Department of Biochemistry Faculty of Medicine Siriraj HospitalMahidol UniversityBangkok10700Thailand Center of Excellence for Innovation in Chemistry(PERCH-CIC) Faculty of ScienceMahidol UniversityBangkok10400Thailand

The collision cross-sections(CCS)measurement using ion mobility spectrometry(IMS)in combination with mass spectrometry(MS)offers a great opportunity to increase confidence in metabolite ***,owing to the lack of sensitivity and resolution,IMS has an analytical challenge in studying the CCS values of very low-molecular-weight metabolites(VLMs250 Da).Here,we describe an analytical method using ultrahigh-performance liquid chromatography(UPLC)coupled to a traveling wave ion mobility-quadrupole-time-of-flight mass spectrometer optimized for the measurement of VLMs in human urine *** experimental CCS values,along with mass spectral properties,were reported for the 174 *** experimental data included the mass-to-charge ratio(m/z),retention time(RT),tandem MS(MS/MS)spectra,and CCS *** the studied metabolites,263 traveling wave ion mobility spectrometry(TWIMS)-derived CCS values(TWCCSN2)were reported for the first time,and more than 70%of these were CCS values of *** TWCCSN2 values were highly repeatable,with inter-day variations of<1%relative standard deviation(RSD).The developed method revealed excellent TWCCSN2 accuracy with a CCS difference(DCCS)within±2%of the reported drift tube IMS(DTIMS)and TWIMS CCS *** complexity of the urine matrix did not affect the precision of the method,as evidenced by DCCS within±1.92%.According to the Metabolomics Standards Initiative,55 urinary metabolites were identified with a confidence level of *** these 55 metabolites,53(96%)were *** larger number of confirmed compounds found in this study was a result of the addition of TWCCSN2 values,which clearly increased metabolite identification confidence.

关键词： Very low-molecular-weight metabolites Traveling wave ion mobility Collision cross-section Human urine

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Analysis of an Adulterated Herbal Medicinal Product Using Ultra-Performance Liquid Chromatography Coupled with QTOF Mass Spectrometry

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World Journal of Traditional Chinese Medicine 2016年第3期2卷 1-9页

作者： Kate Yu Mark Powell Margaret Maziarz Dhavalkumar Narendrabhai Patel waters Corporation Quay Pharmaceuticals Deeside Industrial Park Mark Powell Scientific waters pacific pte ltd The CapricornSingapore Science Park Ⅱ

The reports of severe adverse effects and fatalities associated with herbal medicinal products adulterated with synthetic compounds have raised global *** objective of this study is to analyze one commercial herbal medicinal product suspected to be adulterated with synthetic drugs in order to identify potential adulterants,to verify if the product contained the herbs listed as ingredients in label claim and to determine quality consistency among different batches of the *** of suspected product obtained from seven different batches were performed using ultra performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry(UPLC-Q-TOF-MS) with multiple data processing tools and multivariate *** addition,23 individual powdered herbs(12 as per label claim and 11 suspected herbs),11 marker compounds of the labeled herbs and five suspected synthetic drugs as adulterants were also concurrently analyzed to have clear understanding of product *** on our analysis,the major ingredients of studied product were found to be 5 synthetic compounds:caffeine,chlorphenamine,piroxicam,betamethasone and *** of them have been found to exceed their recommended *** the herbal composition analysis,Gan Cao(Glycyrrhizae radix et rhizoma) was found to be the main ingredient,which is not among the claimed 12 herbs that were supposed to be in the *** herbs detected as minor ingredients were Mu Gua(Chaenomelis fructus),Dang Gui(Angelicae sinensis radix),and Huang Qi(Astragali radix),which are among the 12 herbs that were supposed to be in the *** on our results we demonstrated that UPLC-QTOF MS is an effective and versatile tool for the analysis of herbal medicinal *** is highly desirable to have a streamlined process with automatic workflow and fit-forpurpose database to increase efficiency and productivity of sample *** of this work also highlight the need for the be

关键词： Synthetic adulterants Adulteration UPLC-QTOF-MS Herbal products Data independent acquisition Multi-Variate Statistical Analysis

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Effects of a multi-enzyme complex on growth performance,nutrient utilization and bone mineralization of meat duck

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Journal of Animal Science and Biotechnology 2015年第4期6卷 402-409页

作者： Qiufeng Zeng Xueqin Huang Yuheng Luo Xuemei Ding Shiping Bai Jianping Wang Yue Xuan Zhuowei Su Yonggang Liu Keying Zhang Institute of Animal Nutrition Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of EducationSichuan Agricultural University Adisseo Asia pacific pte ltd

Background： Previous studies with broiler have shown dietary supplementation with multi-enzyme complex containing non-starch polysaccharides （NSP） degrading enzymes and phytase is efficient in releasing phosphorus （P）, calcium （Ca）, energy and amino acids from corn-soybean meal diets or corn-sorghum diets, hence compensating considerable levels of nutrients in formulation. Notwithstanding, such potentials have not been well defined in duck nutrition. Giving China being the largest duck producing country, we conducted this study to establish adequate specifications of major nutrients along with multi-enzyme complex to meat duck from day-old to slaughter, focusing on performance, utilization of nutrients and bone mineralization. Five dietary treatments were： Positive control （PC,T1）： the nutrients concentration of diet for 1 to 14 d of age were apparent metabolizable energy（AME） 2,800 kcal/kg, crude protein （CP）1 9.39%, Ca 0.85%, available phosphorus （avP） 0.42%; for 15 to 35 d of age these parameters were AME 2,900 kcal/kg, CP 16.47%,Ca 0.76%,avP 0.38%; Negative control 1（NC1,7-2）, the AME and digestible amino acids （DAA） were reduced by 70 kcal/kg and 2.0%, avP and Ca by 1.0 g/kg from PC diet; Negative control 2（NC2,T4）, the down- spec from PC diet was AME 100 kcal/kg, DAA 2.5%, avP 1.5 g/kg and Ca 1.2 g/kg; The enzyme complex was added at the same dosage （200 mL/1,000 kg） on NC1 （T3） and NC2 （T5） diets. Results： Comparing with the ducks fed on T1, T3 and T5 diets, the birds fed on NC2 diet showed the lowest （P 〈 0.05） body weight （ d 14 and 35）, feed intake （d 35）, tibia ash, Ca and P contents （d 14 and 35）, and the utilization of nutrients （P 〈 0.05）. The supplementation with the enzyme complex to the NC diets restored growth rate, utilization of nutrients and bone mineralization to the level of the PC diet, and increased AME by 60 kcal/kg and 117 kcal/kg, respectively for the NC1 and NC2 diets. Conclusion： These results suggest that down-spec AME by 100 kcal/kg,

关键词： Formulation specification Growth Phytase Meat duck Non-starch polysaccharides enzyme

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New PAMA Technology Helps Tackle the New Challenges of China Automotive Sector

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润滑油 2010年第1期25卷 31-38页

作者： Alex Tsay Evonik RohMax Asia pacific pte.ltd

Polyalkylmethacrylate (PAMA) based viscosity index improver (VII) and pour point depressant (PPD), with the versatile chemistry and unique performance characteristics, are widely used in advanced formulations, enabling fluids to meet rheological requirement of modern specifications. This paper will be dedicated to the application of PAMA in helping China automotive lubricant formulators tackle the challenges of improving fuel economics from using lower viscosity fluids, of better protection strengthten in transmission performance and meeting new global specifications for low temperature performance.

关键词： polyalkylmethacrylate viscosity index improver pour point depressant automatic transmission fluid gear oil ROBO test

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Experimental Investigations of Various Methods of Sludge Measurements in Storage Oil Tanks

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Advances in Remote Sensing 2015年第2期4卷 119-137页

作者： Manuel Monteiro Victor Svet Donald Sandilands Sergey Tsysar International Tank Services (Asia pacific) pte ltd. Singapore Singapore

This article describes the results of experimental studies into various methods of measuring sludge volume and its 3D spatial distribution using a base of data received from the inspection of more than 30 storage tanks of different types: external floating roof, internal floating roof and fixed roof. The advantages and disadvantages of making measurements with existing methods are discussed, including the problem of accuracy. Numerous examples of tank survey results are presented.

关键词： Storage Tanks Sludge Volume of Sludge Acoustic Bathymetry Thermography

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Tailor-Made PAMA VII to Optimize Automatic Transmission Fluid Rheological Requirements

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润滑油 2008年第2期23卷 27-32页

作者： Alex Tsay Bernard Kinker Evonik RohMax Asia-pacific pte.ltd. Evonik RohMax USA

There are three predominant aspects of the rheological requirements: maximum possible high temperature thickening,minimum possible low-temperature thickening,and high shear stability for automatic transmission *** temperature thickening by VI improvers is largely a function of molecular size and high solubility to give extended polymer coil *** the other hand,the desirable characteristic of minimum low-temperature thickening is a function of somewhat the opposite characteristic;namely relatively poor solubility leading to minimal polymer coil size and thus low viscosity *** addition to not thickening fluids at cold temperatures VI improvers should also provide control of wax-gelation which,if unfettered,can lead to congealed *** the third property of high shear stability is in direct conflict with the desirable characteristic of large molecular size for effective high temperature *** this paper we shall attempt to sort out these conflicting properties and provide some insight into how we approach design of VI improvers for the highly demanding world of automatic transmission fluid rheology.

关键词：自动传动液润滑剂稳定性低温流最优化流变学特制

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The Peculiarities of Acoustical Monitoring of Moving Objects in Shallow Water Areas

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Open Journal of Acoustics 2014年第3期4卷 145-154页

作者： Manel Monteiro Victor Svet Donald Sandilands International Tank Services (Asia pacific) pte ltd. Singapore City Singapore

The article considers peculiarities of underwater monitoring of moving objects in the shallow water areas, particularly seaports. These areas are characterized by a multitude of factors influencing the efficiency of detection. Nonstationarity conditions of sound propagation and specific interference caused by shipping are the major factors. The various algorithms for the space-time signal processing have been tested and some experimental results are presented. It has been shown that the use of clipped mode in conjunction with the correlation processing of wideband signals and subsequent speckle tracking allow realizing high efficiency of monitoring.

关键词： Acoustical Underwater Monitoring Shallow Water Areas Multi-Ray Propagation Correlation Processing Speckle-Tracking

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升降机球铁件铸造工艺方案的模拟优化设计

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铸造技术 2010年第10期31卷 1383-1385页

作者： Richard hagaard Wi lfried Sch-fer Erik Hepp Christian Kleeberg Jan Franke MAGMA GieBereitechnologie GmbH MAGMA Engineering Asia-pacific pte ltd.

由于模拟的局限性常常在于缺乏正确全面的数据,因而人们怀疑能从整个铸造过程包括所有主要工艺参数的模拟中能得到什么;当把模拟结果应用到铸件上时,通过模拟方法增强铸造工程师解决复杂问题的能力,就会很清楚明白了.本文选择球墨铸铁... 详细信息

由于模拟的局限性常常在于缺乏正确全面的数据,因而人们怀疑能从整个铸造过程包括所有主要工艺参数的模拟中能得到什么;当把模拟结果应用到铸件上时,通过模拟方法增强铸造工程师解决复杂问题的能力,就会很清楚明白了.本文选择球墨铸铁升降机件生产的实例来说明模拟的应用潜力.

关键词：模拟方法铸造过程升降机优化设计工艺方案球铁件工艺参数球墨铸铁

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Ecological and Economic Benefits of Vegetation Management Measures in Citrus Orchards on Red Soils

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Pedosphere 2008年第2期18卷 214-221页

作者： SHUI Jian-Guo WANG Qiu-Zhen LIAO Gen-Qing J. AU J. L. ALLARD Institute of Environmental Resources and Soil Fertilizer Zhejiang Academy of Agricultural Sciences Hangzhou 310021 （China） College of Management Zhejiang University Hangzhou 310027 （China） Soil ＆ Fertilizer Station of Wucheng District Jinhua 321000 （China） Syngenta （China） Investment Co. ltd. Shanghai 200041 （China） Syngenta Asia pacific pte. ltd. 250 North Bridge Road Singapore 179101 （Singapore）

A three-year experiment was conducted to investigate and compare the economic and ecological benefits of six types of vegetation management measures in citrus orchards of the hilly red soil region of the eastern part of *** vegetation treatments,including tillage without herbicide(clean tillage)and no tillage without herbicide(sod culture) and with herbicide paraquat(paraquat),glyphosate(glyphosate),glyphosate-glyphosate-paraquat(G-G-P),and paraquat- paraquat-glyphosate(P-P-G),were applied in the citrus orchards on a clayey red soil with slopes of 8°and 13°and a sandy soil with slope of 25°.The results showed that the sod culture,paraquat,glyphosate,G-G-P,and P-P-G treatments reduced surface runoff by 38.8%,42.5%,18.7%,28.7%,and 37.5%,then the soil-water losses by 55.5%,51.7%,39.9%,46.8%, and 50.0%,and the N,P,and K nutrient losses by 60.3%,50.2%,37.0%,41.8%,and 45.4%,respectively,as compared with the clean tillage *** weed regeneration ratios with the treatments of clean tillage without herbicide,paraquat, glyphosate,G-G-P,and P-P-G were reduced by 55.1%,67.2%,30.3%,36.8%,and 51.2%,respectively,as compared with the sod *** sod culture,paraquat,glyphosate,G-G-P,and P-P-G treatments could increase the soil fertility (annual accumulation of N,P,K,and OM)by 7.1%,6.9%,5.3%,6.2%,and 6.6%,respectively,whereas the clean tillage treatment without herbicide reduced soil fertility by 4.4% after the three-year *** citrus fruit yields in the treatments of paraquat,glyphosate,G-G-P,and P-P-G increased by 7%-10%;the soluble solid,total sugar,total acidity,sugar-acid ratio,and single fruit weight of citrus fruits of all treatments except sod culture significantly(P>0.05) exceeded that of the clean tillage *** general,the paraquat treatment showed the best economic and ecological benefits among the six treatments;therefore,it could be regarded as the best available vegetation management measure in citrus orchards of hilly red soil region

关键词： benefits citrus herbicide red soil vegetation management

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学术出版的最佳实践:ISMTE首届亚洲会议综述(Ⅰ)

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编辑学报 2016年第6期28卷 612-616页

作者：付国乐汪旭婷张昕颜帅清华大学出版社期刊中心北京100084 SAGE Publications Asia-pacific pte ltd 新加坡049483

基于ISMTE首届亚洲会议的召开,对会议议题——出版伦理、出版数据监测与研究成果评价指标、开放获取、行业协会资源、出版技术和平台、出版实践新标准、投审稿系统、作者服务、编辑部运作等进行综述。综述分为《学术出版的最佳实践:ISMT... 详细信息

基于ISMTE首届亚洲会议的召开,对会议议题——出版伦理、出版数据监测与研究成果评价指标、开放获取、行业协会资源、出版技术和平台、出版实践新标准、投审稿系统、作者服务、编辑部运作等进行综述。综述分为《学术出版的最佳实践:ISMTE首届亚洲会议综述》(Ⅰ)(Ⅱ)2篇。本篇综述的内容对象为出版伦理、开放获取、出版数据监测和评价指标。通过此会议综述,期望对国内的学术出版会议的举办、议题的设置、编辑部的运作等提供参考和借鉴,从而使国内的学术期刊受益且更好地发展,为国家的创新建设提供专业服务。

关键词：学术出版出版伦理同行评议编辑部数据监测评价指标新兴指标开放获取

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