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Genomic and functional evaluation of TNFSF14 in multiple sclerosis susceptibility

Journal of Genetics and Genomics 2021年第6期48卷 497-507页

作者： Miriam Zuccala Nadia Barizzone Elena Boggio Luca Gigliotti Melissa Sorosina Chiara Basagni Roberta Bordoni Ferdinando Clarelli Santosh Anand Eleonora Mangano Domizia Vecchio Elena Corsetti Serena Martire Simona Perga Daniela Ferrante Alberto Gajofatto Andrei Ivashynka Claudio Solaro Roberto Cantello Vittorio Martinelli Giancarlo Comi Massimo Filippi Federica Esposito Maurizio Leone Gianluca De Beilis Umberto Dianzani Filippo Martinelli-Boneschi Sandra D’Alfonso Department of Health Sciences Center on Autoimmune and Allergic Diseases(CAAD)UPOUniversity of Eastern PiedmontA.AvogadroNovara 28100Italy Consorzio Interuniversitario di Biotecnologie(CIB) Trieste 34149Italy Laboratory of Human Genetics of Neurological Disorders Institute of Experimental NeurologyDivision of NeurosciencesIRCCS San Raffaele Scientific InstituteMilan 20132Italy National Research Council of Italy Institute for Biomedical TechnologiesSegrateMilan 20090Italy Department of Genetic Medicine and Development(GEDEV) Faculty of MedicineUniversity of Geneva Medical SchoolGeneva 1211Switzerland Department of Informatics Systems and Communications(DISCo)University of Milano-BicoccaMilan 20126Italy MS Centre SCDU NeurologyAOU Maggiore della CaritàNovara 28100Italy Department of Translational Medicine Interdisciplinary Research Center of Autoimmune Diseases(IRCAD)University of Eastern PiedmontNovaraAvogadro UniversityNovara 28100Italy Neuroscience Institute Cavalieri Ottolenghi OrbassanoTurin 10043Italy Neurobiology Unit Neurology-CReSM(Regional Referring Center of Multiple Sclerosis)AOU San Luigi GonzagaOrbassanoTurin 10043Italy Department of Neuroscience‘Rita Levi Montalcini’ University of TurinTurin 10126Italy Department of Neuroscience Biomedicine and Movement SciencesUniversity of VeronaVerona 37134Italy UO Neurologia Fondazione IRCCS Casa Sollievo della Sofferenza San Giovanni RotondoFoggia 71013Italy Centro Recupero e Rieducazione Funzionale“Mons L Novarese” Moncrivello(VC)13040Italy Department of Neurology IRCCS San Raffaele Scientific InstituteMilan 20132Italy Neuroimaging Research Unit Institute of Experimental NeurologyDivision of NeuroscienceIRCCS San Raffaele Scientific InstituteMilan 20132Italy Vita-Salute San Raffaele University Milan 20138Italy Neurophysiology Unit IRCCS San Raffaele Scientific InstituteMilan 20138Italy Dino Ferrari Centre Neuroscience SectionDepartment of Pathophysiology and Transplantation(DEPT)University of MilanMilan 20122

Among multiple sclerosis(MS)susceptibility genes,the strongest non-human leukocyte antigen(HLA)signal in the Italian population maps to the TNFSF14 gene encoding LIGHT,a glycoprotein involved in dendritic cell(DC)*** fine-mapping in a large Italian dataset(4,198 patients with MS and3,903 controls),we show that the TNFSF14 intronic SNP rs1077667 is the primarily MS-associated variant in the *** quantitative trait locus(e QTL)analysis indicates that the MS risk allele is significantly associated with reduced TNFSF14 messenger RNA levels in blood cells,which is consistent with the allelic imbalance in RNA-Seq reads(Pinc.eased percentage of LIGHT-positive peripheral blood myeloid DCs(CD11 c+,P=0.035)in 37 HCs,as well as in in vitro monocyte-derived DCs from 22 HCs(P=0.04).Our findings suggest that the intronic variant rs1077667 alters the expression of TNFSF14 in immune cells,which may play a role in MS pathogenesis.

关键词： Multiple sclerosis TNFSF14 LIGHT Fine-mapping analysis SNV

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Fluctuating temperature modifies heat-mortality association around the globe

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The Innovation 2022年第2期3卷 65-72页

作者： Yao Wu Bo Wen Shanshan Li Antonio Gasparrini Shilu Tong Ala Overcenco Ales Urban Alexandra Schneider Alireza Entezari Ana Maria Vicedo-Cabrera Antonella Zanobetti Antonis Analitis Ariana Zeka Aurelio Tobias Barrak Alahmad Ben Armstrong Bertil Forsberg CarmenÍñiguez Caroline Ameling César De la Cruz Valencia ChristoferÅström Danny Houthuijs Do Van Dung Dominic Royé Ene Indermitte Eric Lavigne Fatemeh Mayvaneh Fiorella Acquaotta Francesca de’Donato Francesco Sera Gabriel Carrasco-Escobar Haidong Kan Hans Orru Ho Kim Iulian-Horia Holobaca Jan Kyselý Joana Madureira Joel Schwartz Klea Katsouyanni Magali Hurtado-Diaz Martina SRagettli Masahiro Hashizume Mathilde Pascal Micheline de Sousa Zanotti Stagliorio Coélho Noah Scovronick Paola Michelozzi Patrick Goodman Paulo Hilario Nascimento Saldiva Rosana Abrutzky Samuel Osorio Tran Ngoc Dang Valentina Colistro Veronika Huber Whanhee Lee Xerxes Seposo Yasushi Honda Michelle L.Bell Yuming Guo Department of Epidemiology and Preventive Medicine School of Public Health and Preventive MedicineMonash UniversityMelbourne 3004Australia Climate Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourne 3004Australia Department of Public Health Environments and SocietyLondon School of Hygiene&Tropical MedicineLondon WC1E 7HTUK Centre for Statistical Methodology London School of Hygiene&Tropical MedicineLondon WC1E 7HTUK Centre on Climate Change&Planetary Health London School of Hygiene&Tropical MedicineLondon WC1E 7HTUK Shanghai Children’s Medical Centre Shanghai Jiao Tong UniversityShanghai 200025China School of Public Health Institute of Environment and Human HealthAnhui Medical UniversityHefei 230032China Center for Global Health Nanjing Medical UniversityNanjing 211166China School of Public Health and Social Work Queensland University of TechnologyBrisbane 4000Australia National Agency for Public Health of the Ministry of Health Labour and Social Protection of the Republic of MoldovaChisinau MD-2009Republic of Moldova Institute of Atmospheric Physics Czech Academy of SciencesPrague 14100Czech Republic Faculty of Environmental Sciences Czech University of Life SciencesPrague 16500Czech Republic Institute of Epidemiology Helmholtz Zentrum M€unchen-German Research Center for Environmental HealthNeuherberg 85747Germany Faculty of Geography and Environmental Sciences Hakim Sabzevari UniversitySabzevar ***Iran Institute of Social and Preventive Medicine University of BernBern 3012Switzerland Oeschger Center for Climate Change Research University of BernBern 3012Switzerland Department of Environmental Health Harvard T.H.Chan School of Public HealthHarvard UniversityBostonMA 02115USA Department of Hygiene Epidemiology and Medical StatisticsNational and Kapodistrian University of AthensAthens 11527Greece Institute for Environment Healthand SocietiesBrunel University LondonLondon UB83PNUK Institute of Environmental Assessment and

Studies have investigated the effects of heat and temperature variability(TV)on ***,few assessed whether TV modifies the heat-mortality *** on daily temperature and mortality in the warm season were collected from 717 locations across 36 *** was calculated as the standard deviation of the average of the same and previous days’minimum and maximum temperatures.

关键词： deviation modif heat

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汞污染渔业的恢复

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AMBIO－人类环境杂志 2007年第1期36卷 31-41页

作者： John Munthe R. A. （Drew） Bodaly Brian A. Branfireun Charles T. Driscoll Cynthia C. Gilmour Reed Harris Milena Horvat Marc Lucotte Olaf Malm 林宝法（译） IVL Swedish Environmental Research Institute PO BOX5302SE 400 14 GothenburgSweden Penobscot River Mercury Study（Maine） 115 Oystercatcher Place．Salt Spring IslandB．C．Canado V8K2W5 Department of Geography University of Torontoat Mississauga3359 Mississauga Road NorthMississaugaOntarioCanada L5L 1C6 Department of Civil and Environmental Engineering 151 Link HallSyracuse UniversitySyracuse．NY14244USA Smithsonian Environmental Research Centre．P．O．BOX28 647 Contees Wharf RoadEdgewater．Maryland21037 Tetra Tech inc. 180 Forestwood DriveOakvilleOntarioCanadaL6J4E6 Department of Environmental Sciences Jose Stefan Institute．Jamova 39．SI-1000 LjubljanaSlovenia Universite du Quebe ca Montreal．GEOTOP C．P．8888SUC．Centre-VilleMontrealQuebecH3C3P8Canada Lab．Radioisotopes EPF．Inst．Biofisica CCF．Universidade Federal do Rio de Janeiro 21941-900 Rio de JaneiroBrazil 不详

本文中,我们综合了有关生态系统无机汞(Hg)载荷变化与鱼体内甲基汞(MeHg)浓度之间联系的现有信息。尽管人们普遍假定水生生态系统汞载荷的增加导致鱼体内甲基汞浓度的增加,验证这一假定的定量数据尚很有限。这里,我们研究了源于一系列... 详细信息

本文中,我们综合了有关生态系统无机汞(Hg)载荷变化与鱼体内甲基汞(MeHg)浓度之间联系的现有信息。尽管人们普遍假定水生生态系统汞载荷的增加导致鱼体内甲基汞浓度的增加,验证这一假定的定量数据尚很有限。这里,我们研究了源于一系列出处的现有证据:关于被工业排放物污染的生态系统的研究;关于鱼类甲基汞对大气载荷的响应的观测资料;跨越空间和环境梯度的研究以及实验操作。本文概述了目前对从汞载荷到鱼体甲基汞的运输和转化所涉及的主要过程的了解情况。还结合影响与鱼体内甲基汞响应的时机和大小有关的汞循环和生物积累的其他因素探讨了汞载荷的作用。所得出的主要结论是,汞载荷的变化(增加或减少)将引起鱼体内甲基汞的反应,这种反应的时间和大小将根据生态系统特有的变量和所添加的汞的形态而变化。

关键词：汞污染水生生态系统载荷变化渔业甲基汞工业排放物观测资料实验操作

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quantitatively mapping local quality of super-resolution microscopy by rolling Fourier ring correlation

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Light(Science & Applications) 2023年第12期12卷 2826-2844页

作者： Weisong Zhao Xiaoshuai Huang Jianyu Yang Liying Qu Guohua Qiu Yue Zhao Xinwei Wang Deer Su Xumin Ding Heng Mao Yaming Jiu Ying Hu Jiubin Tan Shiqun Zhao Leiting Pan Liangyi Chen Haoyu Li Innovation Photonics and Imaging Center School of Instrumentation Science and EngineeringHarbin Institute of TechnologyHarbinChina Key Laboratory of Ultra-Precision Intelligent Instrumentation of Ministry of Industry and Information Technology Harbin Institute of TechnologyHarbinChina Biomedical Engineering Department International Cancer InstitutePeking University Cancer Hospital and InstituteHealth Science CenterPeking UniversityBeijingChina The Key Laboratory of Weak-Light Nonlinear Photonics of Education Ministry School of Physics and TEDA Institute of Applied PhysicsFrontiers Science Center for Cell ResponsesNankai UniversityTianjinChina State Key Laboratory of Membrane Biology Beijing Key Laboratory of Cardiometabolic Molecular MedicineInstitute of Molecular MedicineNational Biomedical Imaging CenterSchool of Future TechnologyPeking UniversityBeijingChina Department of Control Science and Engineering Harbin Institute of TechnologyHarbinChina School of Mathematical Sciences Peking UniversityBeijingChina Unit of Cell Biology and Imaging Study of Pathogen Host Interaction The Center for MicrobesDevelopment and HealthKey Laboratory of Molecular Virology and ImmunologyShanghai Institute of Immunity and InfectionChinese Academy of SciencesShanghaiChina School of Life Science and Technology Harbin Institute of TechnologyHarbinChina PKU-IDG/McGovern Institute for Brain Research BeijingChina Beijing Academy of Artificial Intelligence BeijingChina Frontiers Science Center for Matter Behave in Space Environment Harbin Institute of TechnologyHarbinChina Key Laboratory of Micro-systems and Micro-Structures Manufacturing of Ministry of Education Harbin Institute of TechnologyHarbinChina

In fluorescence microscopy,computational algorithms have been developed to suppress noise,enhance contrast,and even enable super-resolution(SR).However,the local quality of the images may vary on multiple scales,and these differences can lead to *** mapping methods fail to finely estimate the local quality,challenging to associate the SR scale ***,we develop a rolling Fourier ring correlation(rFRC)method to evaluate the reconstruction uncertainties down to SR *** visually pinpoint regions with low reliability,a filtered rFRC is combined with a modified resolution-scaled error map(RSM),offering a comprehensive and concise map for further *** demonstrate their performances on various SR imaging modalities,and the resulting quantitative maps enable better SR images integrated from different ***,we expect that our framework can become a routinely used tool for biologists in assessing their image datasets in general and inspire further advances in the rapidly developing field of computational imaging.

关键词： resolution local enable

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Impact of apolipoprotein A1 on tumor immune microenvironment, clinical prognosis and genomic landscape in hepatocellular carcinoma

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Precision Clinical Medicine 2023年第3期6卷 158-171页

作者： Ying Wang Shipeng Chen Xiao Xiao Fan Yang Jinhan Wange Hui Zong Yuzhen Gao Chenjun Huang Xuewen Xu Meng Fang Xiaoyan Zhang Chunfang Gao Clinical Laboratory Medicine Center Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai200437China Department of Laboratory Medicine Shanghai Eastern Hepatobiliary Surgery HospitalShanghai 200438China Research Center for Translational Medicine Shanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Department of Medical Microbiology and Infection Prevention Tumor Virology and Cancer ImmunotherapyUniversity Medical Center GroningenUniversity of GroningenGroningen 9712 CPThe Netherlands State Key Laboratory for Diagnosis and Treatment of Infectious Diseases The First Affliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310058China Department of Hepatobiliary and Pancreatic Surgery Shanghai East HospitalTongji University School of MedicineShanghai 200120China Institutes for systems Genetics Frontiers Science Center for Disease-Related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041China Department of Clinical Laboratory Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310058China

Background:Current knowledge on apolipoprotein A1(APOA1)in hepatocellular carcinoma(HCC)is fragmented and even ***-dimensional analyses are required to comprehensively elucidate its value and underlying ***:We collected 49 RNA-seq datasets,40 cell line types data and 70 scRNA pan-cancer datasets public available,inc.uding 17 HCC datasets(1754 tumor samples),and enrolled 73 pairs of HCC tissue and 516 blood samples independently from our ***1 impacting on the HCC tumor microenvironment(TME)was analyzed using intensive data *** sequencing,flow cy-tometry,quantitative PCR,western blot,immunohistochemistry and clinical chemistry assays were conducted for wet experimental ***:The APOA1 ontology fingerprint indicated that it played various crucial biological roles in HCC,primarily involved in choles-terol *** findings at histology,serology,and clinical follow-up revealed that high APOA1 was a good prognosis indicator of *** in the APOA1 promoter region was found in clinical samples which is in accordance with the reduction of APOA1 in *** cell cycle,DNA replication,mismatch repair pathways,and tumor cell proliferation were less observed in the HCC APOAihigh *** favorable immunoregulatory abilities of APOA1 showed interesting findings:a positive correlation between APOA1 and anti-tumor immune cells(NK,CD8+T cells)and a negative association with immune cells exerting immunosuppressive effects,inc.uding M2 ***:This is an integrative multidimensional exploration of APOA1 using bioinformatics and *** the prognostic value and anti-tumor effects based on APOA1 panoramic exploration in the HCC TME demonstrate a new potential clinicai target for HCC assessment and intervention in the future.

关键词： APOA1 HCC prognosis tumor microenvironment immune cells NK cell

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Biomarkers of aging

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Science China(Life Sciences) 2023年第5期66卷 893-1066页

作者： Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu Aging Biomarker Consortium(ABC) Beijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Aging Biology Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Clinic Center of Human Gene Research Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Clinical Research Center of Metabolic and Cardiovascular Disease Huazhong University of Science and TechnologyWuhan 430022China Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging Huazhong University of Science and TechnologyWuhan 430022China Stem Cell Translational Research Center Tongji HospitalTongji University School of MedicineShanghai 200065China Department of Nuclear Medicine Daping HospitalThird Military Medical UniversityChongqing 400042China CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Shanghai Key Laboratory of Maternal Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchShanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China The Department of Endovascular Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Ageing and Regenerative MedicineJ

Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological *** a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly *** immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this ***,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory *** fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant.

关键词： aging senescence biomarker clock

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