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Rationale and design of Tenecteplase Reperfusion Therapy in Acute Ischaemic Cerebrovascular Events III (TRACE III): a randomised, phase III, open- label, controlled trial

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Stroke & Vascular Neurology 2024年第1期9卷 82-89页

作者： Yunyun Xiong Bruce C V Campbell Marc Fisher Lee H Schwamm Mark Parsons Hao Li Yuesong Pan Xia Meng Xingquan Zhao Yongjun Wang Neurology Beijing Tiantan HospitalBeijingChina China National Clinical Research center for Neurological Diseases BeijingChina Department of Medicine and Neurology The University of MelbourneMelbourneVictoriaAustralia Neurology Beth Israel Deaconess Medical CenterBostonMassachusettsUSA Department of Neurology and Comprehensive Stroke center Massachusetts General HospitalBostonMassachusettsUSA Department of Neurology University of New South Wales South Western Sydney Clinical SchoolLiverpoolNew South WalesAustralia

Background and purpose Recombinant human TNK tissue-type plasminogen activator(rhTNK-tPA)was not inferior to alteplase for ischaemic stroke within *** study aimed to investigate the efficacy and safety of rhTNK-tPA in patients who had an ischaemic stroke due to large vessel occlusion(LVO)of anterior circulation beyond *** and design Tenecteplase Reperfusion Therapy in Acute Ischaemic Cerebrovascular Events-III(TRACE III)is a multicentre,prospective,randomised,open-label,blind endpoint,controlled clinical *** who had an ischaemic stroke due to anterior circulation LVO(internal carotid artery,middle cerebral artery M1 and M2 segments)within 4.5–24hours from last known well(including wake-up stroke and no witness stroke)and with salvageable tissue(ischaemic core volume6s at 24 hours and NIHSS score change from baseline at *** outcomes are symptomatic intracerebral haemorrhage within 36 hours and mortality at 90 *** TRACE III will provide evidence for the efficacy and safety of rhTNK-tPA in patients who had an ischaemic strokes due to anterior circulation LVO beyond *** registration number NCT05141305.

关键词： Therapy random Rational

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Strategies for translating proteomics discoveries into drug discovery for dementia

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Neural Regeneration Research 2024年第1期19卷 132-139页

作者： Aditi Halder Eleanor Drummond School of Medical Sciences and Brain&Mind center University of SydneyNSWSydneyAustralia Department of Aged Care Prince of Wales HospitalSydneyNSWAustralia

Tauopathies,diseases characterized by neuropathological aggregates of tau including Alzheimer's disease and subtypes of fro ntotemporal dementia,make up the vast majority of dementia *** there have been recent developments in tauopathy biomarkers and disease-modifying treatments,ongoing progress is required to ensure these are effective,economical,and accessible for the globally ageing *** such,continued identification of new potential drug targets and biomarkers is critical."Big data"studies,such as proteomics,can generate information on thousands of possible new targets for dementia diagnostics and therapeutics,but currently remain underutilized due to the lack of a clear process by which targets are selected for future drug *** this review,we discuss current tauopathy biomarkers and therapeutics,and highlight areas in need of improvement,particularly when addressing the needs of frail,comorbid and cognitively impaired *** highlight biomarkers which have been developed from proteomic data,and outline possible future directions in this *** propose new criteria by which potential targets in proteomics studies can be objectively ranked as favorable for drug development,and demonstrate its application to our group's recent tau interactome dataset as an example.

关键词： Alzheimer's disease biomarkers drug development drug discovery druggability frontotemporal dementia interactome proteomics tau tauopathies therapeutics

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The component-activity interrelationship of cobalt-based bifunctional electrocatalysts for overall water splitting:Strategies and performance

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Journal of Energy Chemistry 2024年第4期91卷 453-474页

作者： Mingjie Sun Riyue Ge Sean Li Liming Dai Yiran Li Bin Liu Wenxian Li School of Materials Science and Engineering Shanghai UniversityShanghai 200444China Institute of Textiles and Clothing The Hong Kong Polytechnic UniversityHong Kong SAR 999077China School of Materials Science and Engineering University of New South WalesSydneyNew South Wales 2052Australia UNSW Materials&Manufacturing Futures Institute UNSW SydneyNew South Wales 2052Australia School of Chemical Engineering University of New South WalesSydneyNew South Wales 2052Australia

Cobalt-based electrocatalysts take advantage of potentially harmonizable microstructure and flexible coupling effects compared to commercial noble metal-based catalytic ***,conventional water electrolysis systems based on cobalt-based monofunctional hydrogen evolution reaction(HER)or oxygen evolution reaction(OER)catalysts have certain shortcomings in terms of resource utilization and *** contrast,cobalt-based bifunctional catalysts(CBCs)have attracted much attention in recent years for overall water splitting systems because of their practicality and reduced preparation cost of *** review aims to address the latest development in CBCs for total *** main modification strategies of CBCs are systematically classified in water electrolysis to provide an overview of how to regulate their morphology and electronic ***,the catalytic performance of CBCs in total-hydrolysis is summarized according to the types of cobalt-based phosphides,sulfides and oxides,and the mechanism of strengthened electrocatalytic ability is emphasized through combining experiments and theoretical *** efforts are finally suggested to focus on exploring the dynamic conversion of reaction intermediates and building near-industrial CBCs,designing advanced CBC materials through micro-modulation,and addressing commercial applications.

关键词： Cobalt Bifunctional electrocatalysis Water splitting Modification strategies Electrocatalytic performances

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Molecular biomarkers for vascular cognitive impairment and dementia:the current status and directions for the future

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Neural Regeneration Research 2024年第12期19卷 2579-2580页

作者： Satoshi Hosoki Perminder SSachdev Centre for Healthy Brain Ageing Discipline of Psychiatry and Mental HealthSchool of Clinical MedicineFaculty of Medicine and HealthUniversity of New South WalesSydneyAustralia Department of Neurology National Cerebral and Cardiovascular CenterOsakaJapan

Dementia is a syndrome with various underlying pathologies acting independently or in concert to cause cognitive *** development of disease-specific treatments and targeted prevention strategies requires precise clinical sub-typing via etiology and pathophysiological ***,recent research advances in biomarkers,especially for Alzheimer's disease(AD)diagnosis,have improved diagnostic precision for dementia.

关键词： prevention diagnosis impairment

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Interface catalytic reduction of alumina by nickle for the aluminum nanowire growth: Dynamics observed by in situ TEM

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Nano Research 2024年第3期17卷 1225-1231页

作者： Zichun Wang Dan Wang Ang Li Lizhuo Wang Xiaodong Han Yijiao Jiang Jianfeng Chen Jun Huang Beijing Advanced Innovation center for Soft Matter Science and Engineering State Key Laboratory of Organic–Inorganic CompositesBeijing University of Chemical TechnologyBeijing 100029China Laboratory for Catalysis Engineering School of Chemical and Biomolecular EngineeringThe University of SydneyNew South Wales 2006Australia Beijing Key Laboratory of Microstructure and Property of Advanced Materials Beijing University of TechnologyBeijing 100024China Department of Engineering Macquarie UniversitySydneyNew South Wales 2109Australia

Metal nanowires show promise in a broad range of applications and can be fabricated via a number of methods,such as vapor–liquid–solid process and template-based ***,the synthesis of Al nanowires(NWs)is still challenging from the stable alumina *** this work,the Ni-catalyzed fabrication of Al NWs has been realized using various Al_(2)O_(3) *** growth dynamics of Al NWs on Ni/Al_(2)O_(3) was studied using in situ transmission electron microscopy(TEM).The effect of alumina structures,compositions,and growth temperature were *** growth of Al NWs correlates with the Na addition to the alumina *** no eutectic mixture of nickel aluminide was formed,a mechanism of Ni-catalyzed reduction of Al_(2)O_(3) for Al NWs growth has been proposed instead of the vapor–liquid–solid *** key insights reported here are not restricted to Ni-catalyzed Al NWs growth but can be extended to understanding the dynamic change and catalytic performance of Ni/Al_(2)O_(3) under working conditions.

关键词： in situ transmission electron microscopy(TEM) Al nanowires alumina reduction nanowire growth

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New perspectives in free nitrous acid (FNA) uses for sustainable wastewater management

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Frontiers of Environmental Science & Engineering 2024年第2期18卷 161-168页

作者： Zhiqiang Zuo Min Zheng Tao Liu Yongzhen Peng Zhiguo Yuan National Engineering Laboratory for Advanced Municipal Wastewater Treatment and Reuse Technology Engineering Research Center of BeijingBeijing University of TechnologyBeijing 100124China Australian Centre for Water and Environmental Biotechnology The University of QueenslandSt.LuciaQLD 4072Australia Water Research Centre School of Civil and Environmental EngineeringUniversity of New South WalesSydneyNew South Wales 2052Australia Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong 999077China School of Energy and Environment City University of Hong KongHong Kong 999077China

The biocidal effects of free nitrous acid (FNA) have found applications in multiple units in an urban wastewater system, including sewer networks, wastewater treatment processes, and sludge treatment processes. However, these applications are associated with chemical costs as both nitrite and acid are needed to produce FNA at the required levels. The recent discovery of novel acid-tolerant ammonia oxidizers offers the possibility to produce FNA from domestic wastewater, enabling the development of next-generation FNA-based technologies capable of achieving self-sustaining FNA production. In this study, we focus on the concept of in situ FNA generation facilitated by acid-tolerant ammonia oxidizers and highlight the multiple benefits it creates, after a brief review of the historical development of FNA-based technologies. We will discuss how wastewater systems can be made more energy-efficient and sustainable by leveraging the potential of acid-tolerant ammonia oxidizers.

关键词： Free nitrous acid Acid-toler antammonia oxidizer In situ generationl Wastewater management

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Climate change induced heat stress impact on workplace productivity in a net zero-carbon timber building towards the end of the century

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Building Simulation 2024年第6期17卷 893-906页

作者： Deepak Amaripadath Mattheos Santamouris Shady Attia School of Geographical Sciences and Urban Planning Arizona State UniversityTempeAZUSA Urban Climate Research center Arizona State UniversityTempeAZUSA School of Built Environment University of New South Wales2052SydneyAustralia Sustainable Building Design Lab Department of UEEFaculty of Applied SciencesUniversity of Liege4000LiegeBelgium

Changing climate intensifies heat stress,resulting in a greater risk of workplace productivity decline in timber office buildings with low internal thermal *** impact of climate change induced heat exposure on indoor workplace productivity in timber office buildings has not been extensively ***,further investigation to reduce the work capacity decline towards the end of the century is ***,heat exposure in a net zero-carbon timber building near Brussels,Belgium,was evaluated using a reproducible comparative approach with different internal thermal mass *** analysis indicated that strategies with increased thermal mass were more effective in limiting the effects of heat exposure on workplace *** medium and high thermal mass strategies reduced workplace productivity loss to 0.1%in the current,0.3%and 0.2%in the midfuture,and 4.9%and 3.9%for future *** comparison,baseline with low thermal mass yielded a decline of 2.3%,3.3%,and 8.2%.The variation in maximum and minimum wet-bulb globe temperatures were also lower for medium and high thermal mass strategies than for low thermal mass *** study findings lead to the formulation of design guidelines,identification of research gaps,and recommendations for future work.

关键词： heat exposure office buildings work capacity thermal mass climate change

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Advancing the National Immunization Program in an era of achieving universal vaccine coverage in China and beyond

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贫困所致传染病(英文) 2024年第2期13卷 1-5页

作者： Chen Shu Rodewald Lance E. Heng Du Anna Tang Shenglan ARC Centre of Excellence in Population Ageing Research (CEPAR) University of New South Wales Sydney Australia School of Risk and Actuarial Studies University of New South Wales Sydney Australia Department of the National Immunization Program Chinese Center for Disease Control and Prevention National Immunization Program China CDC Beijing China China Country Office Bill &amp Melinda Gates Foundation Beijing China Duke Global Health Institute Duke University Durham NC USA Global Health Research center Duke Kunshan University No. Duke Avenue Kunshan Jiangsu China SingHealth Duke-NUS Global Health Institute Duke-NUS Singapore Singapore

Background Immunization is a cornerstone of public health. Despite great success, China’s National Immunization Program (NIP) faces challenges, such as the integration of several World Health Organization-recommended vaccines and other systemic issues. The Innovation Laboratory for Vaccine Delivery Research (VaxLab), supported by the Bill & Melinda Gates Foundation and established in 2021 at Duke Kunshan University, focuses on enhancing China’s NIP through research and policy advocacy. This editorial aims to summarize the key findings of the manuscripts published in the collection contributed by VaxLab team and set the future research *** findings The collection contains eleven manuscripts discussing China’s immunization landscape and strategies to improve coverage, particularly for non-NIP vaccines like human papillomavirus vaccine (HPV), pneumococcal conjugate vaccine (PCV),Haemophilus influenzae type b vaccine (Hib), and rotavirus vaccines. Key findings include: (i) The COVID-19 vaccination campaign demonstrated China’s capacity for rapid, large-scale immunization efforts, suggesting potential for broader vaccine coverage improvements; (ii) Efforts in combating cervical cancer through the HPV vaccine indicate progress but also highlight challenges like vaccine supply and equitable access; (iii) The lag in adopting higher-valent paediatric combination vaccines in China needs attention to address regulatory and health system hurdles; (iv) Disparities in access to non-NIP vaccines underscore the need for government initiatives to improve vaccine coverage, especially for remote areas and marginalized populations; (v) Original studies emphasize the influence of caregivers’ knowledge, health workers’ financial incentives, and concerns about vaccine efficacy on immunization rates; (vi) Case studies from the Weifang City of China and Indonesia to introduce PCV offer insights on successful vaccine introduction strategies and the impact of innovative financing and g

关键词： National Immunization Program New vaccine introduction Universal vaccine coverage Health system strengthening

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Bacterial nanocellulose assembly into super-strong and humidity-responsive macrofibers

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Journal of Bioresources and Bioproducts 2024年第3期9卷 369-378页

作者： Yadong Zhao Zheng Yang Rusen Zhou Bin Zheng Meiling Chen Fei Liu Wenhua Miao Renwu Zhou Patrick Cullen Zhenhai Xia Liming Dai Kostya(Ken)Ostrikov School of Food and Pharmacy Zhejiang Ocean UniversityZhoushan 316022China State Key Laboratory of Electrical Insulation and Power Equipment Center for Plasma BiomedicineXi'an Jiaotong UniversityXi'an 710049China School of Chemical and Biomolecular Engineering University of SydneySydney 2006Australia School of Chemistry and Physics and Centre for Materials Science Queensland University of TechnologyBrisbane 4000Australia Key Laboratory of Bio-based Polymeric Materials Technology and Application of Zhejiang Province Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China Australian Carbon Materials Centre(A-CMC) School of Chemical EngineeringUniversity of New South WalesSydneyNew South Wales 2052Australia

Cellulose macrofibers (MFs) are gaining increasing interest as natural and biodegradable alternatives to fossil-derived polymers for both structural and functional applications. However, simultaneously achieving their exceptional mechanical performance and desired functionality is challenging and requires complex processing. Here, we reported a one-step approach using a tension-assisted twisting (TAT) technique for MF fabrication from bacterial cellulose (BC). The TAT stretches and aligns BC nanofibers pre-arranged in hydrogel tubes to form MFs with compactly assembled structures and enhanced hydrogen bonding among neighboring nanofibers. The as-prepared BC MFs exhibited a very high tensile strength of 1 057 MPa and exceptional lifting capacity (over 340 000 when normalized by their own weight). Moreover, due to the volume expansion of BC nanofibers upon water exposure, BC MFs quickly harvested energy from environmental moisture to untwist the bundled networks, thus generating a torsional spinning with a peak rotation speed of 884 r/(min·m). The demonstrated rapid and intense actuation response makes the MFs ideal candidates for diverse humidity-response-based applications beyond advanced actuators, remote rain indicators, intelligent switches, and smart curtains.

关键词： Nanocellulose assembly Cellulose macrofibers Super-strong Humidity-responsive actuation Moisture Fast actuation

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A refined deviatoric hardening plastic model for sand

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2813-2821页

作者： Min Wang Tongming Qu Yuntian Feng Teng Liang Liangtong Zhan MOE Key Laboratory of Soft Soils and Geoenvironmental Engineering Zhejiang UniversityHangzhou310058China Department of Civil and Environmental Engineering Hong Kong University of Science and TechnologyKowloon999077Hong KongChina Zienkiewicz Centre for Computational Engineering College of EngineeringSwansea UniversitySwanseaWalesSA18EPUK center for Hypergravity Experimental and Interdisciplinary Research Zhejiang UniversityHangzhou310058China

The classical deviatoric hardening models are capable of characterizing the mechanical response of granular materials for a broad range of degrees of *** work finds that it has limitations in accurately predicting the volumetric deformation characteristics under a wide range of confining/consolidation *** issue stems from the pressure independent hardening law in the classical deviatoric hardening *** overcome this problem,we propose a refined deviatoric hardening model in which a pressure-dependent hardening law is developed based on experimental *** between numerical results and laboratory triaxial tests indicate that the improved model succeeds in capturing the volumetric deformation behavior under various confining/consolidation pressure conditions for both dense and loose ***,to examine the importance of the improved deviatoric hardening model,it is combined with the bounding surface plasticity theory to investigate the mechanical response of loose sand under complex cyclic loadings and different initial consolidation *** is proved that the proposed pressure-dependent deviatoric hardening law is capable of predicting the volumetric deformation characteristics to a satisfactory degree and plays an important role in the simulation of complex deformations for granular geomaterials.

关键词： Elasto-plastic deformation Isotropic hardening Deviatoric plastic strain Granular material Kinematic hardening Bounding surface

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