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Polystyrene nanoplastics induce glycolipid metabolism disorder via NF-κB and MAPK signaling pathway in mice

Journal of Environmental Sciences 2024年第3期137卷 553-566页

作者： Xingpei Fan Xiaoyan Li Jiaxin Li Yuxia Zhang Xiangjuan Wei Hailong Hu Boya Zhang Haining Du Meimei Zhao Ruijiao Zhu Daqian Yang Yuri Oh Ning Gu School of Life Science and Technology Harbin Institute of TechnologyHarbin 150001China State Key Laboratory of Urban Water Resource and Environment Harbin Institute of TechnologyHarbin 150006China Department of Medicine Renal Electrolyte and Hypertension DivisionDepartment of GeneticsPerelman School of MedicineUniversity of PennsylvaniaPhiladelphia 19104USA Faculty of Education Wakayama UniversityWakayama 640-8441Japan

Nanoplastics-induced developmental and reproductive toxicity,neurotoxicity and immunotoxicity are a focus of widespread ***,the effects of nanoplastics(NPs)on glycolipid metabolism and the precise underlying mechanisms are unclear at ***,we showed that oral administration of polystyrene nanoparticles(PS-NPs)disrupts glycolipid metabolism,with reactive oxygen species(ROS)identified as a potential key signaling *** PS-NPs treatment,excessive production of ROS induced the infammatory response and activated the antioxidant pathway through nuclear factor-erythroid factor 2-related factor *** activation of nuclear factor-κB(NFκB)signaling pathway induced the phosphorylation of the mitogen-activated protein kinases(MAPK)signaling pathway,which induced the activation of extracellular regulated kinases(ERK)and *** activation of the MAPK signaling proteins induced high continued phosphorylation of insulin receptor substrate-1,in turn,leading to decreased protein kinase B(Akt)activity,which weakened the sensitivity of liver cells to insulin signals and induced insulin *** parallel,phosphorylation of Akt led to loss of control of Fo XO1,a key gene of gluconeogenesis,activating transcription of glucose-6-phosphatase(G6PC)and phosphoenolpyruvate carboxykinase(PEPCK)in a manner dependent on PGC1α.Moreover,the activated ERK promoted lipid accumulation through ERK-PPARγ***,sterol regulatory element-binding protein-1 and levels of its downstream lipogenic enzymes,ACC-1,were *** treatment with the antioxidant resveratrol,PS-NPs-induced glucose and lipid metabolic disorders were improved by inhibiting ROS-induced activation of NFκB and MAPK signaling pathway in *** on above,PS-NPs exposure disrupts glycolipid metabolism in mice,with ROS identified as a potential key signaling molecule.

关键词： Nanoplastics Resveratrol Hyperglycemia Lipid metabolism Infammatory response Reactive oxygen species(ROS)

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Stage at diagnosis of colorectal cancer through diagnostic route:Who should be screened?

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World Journal of Gastroenterology 2024年第10期30卷 1368-1376页

作者： Nobukazu Agatsuma Takahiro Utsumi Yoshitaka Nishikawa Takahiro Horimatsu Takeshi Seta Yukitaka Yamashita Yukari Tanaka Takahiro Inoue Yuki Nakanishi Takahiro Shimizu Mikako Ohno Akane Fukushima Takeo Nakayama Hiroshi Seno Department of Gastroenterology and Hepatology Kyoto University Graduate School of MedicineKyoto 606-8507Japan Department of Gastroenterology and Hepatology Japanese Red Cross Wakayama Medical CenterWakayama 640-8558Japan Department of Health Informatics Kyoto University School of Public HealthKyoto 606-8501Japan Institute for Advancement of Clinical and Translational Science(iACT) Kyoto University HospitalKyoto 606-8507Japan Medical Support Section Medical Affairs DivisionKyoto University HospitalKyoto 606-8507Japan

BACKGROUND Colorectal cancer(CRC)is a global health concern,with advanced-stage diagnoses contributing to poor *** efficacy of CRC screening has been well-established;nevertheless,a significant proportion of patients remain unscreened,with>70%of cases diagnosed outside *** identifying specific subgroups for whom CRC screening should be particularly recommended is crucial owing to limited resources,the association between the diagnostic routes and identification of these subgroups has been less *** the Japanese cancer registry,the diagnostic routes for groups discovered outside of screening are primarily categorized into those with comorbidities found during hospital visits and those with CRC-related *** To clarify the stage at CRC diagnosis based on diagnostic *** We conducted a retrospective observational study using a cancer registry of patients with CRC between January 2016 and December 2019 at two *** diagnostic routes were primarily classified into three groups:Cancer screening,follow-up,and *** early-stage was defined as Stages 0 or *** and univariate logistic regressions were exploited to determine the odds of early-stage diagnosis in the symptomatic and cancer screening groups,referencing the follow-up *** adjusted covariates were age,sex,and tumor *** Of the 2083 patients,715(34.4%),1064(51.1%),and 304(14.6%)belonged to the follow-up,symptomatic,and cancer screening groups,*** the 2083 patients,CRCs diagnosed at an early stage were 57.3%(410 of 715),23.9%(254 of 1064),and 59.5%(181 of 304)in the follow-up,symptomatic,and cancer screening groups,*** symptomatic group exhibited a lower likelihood of early-stage diagnosis than the follow-up group[P<0.001,adjusted odds ratio(aOR),0.23;95%confidence interval(95%CI):0.19-0.29].The likelihood of diagnosis at an early stage was similar between the follow-up and cancer screening gro

关键词： Colorectal neoplasms Cancer registry Diagnostic route Cancer screening Stage at diagnosis

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Visual simulation of clouds

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Visual Informatics 2017年第1期1卷 1-8页

作者： Yoshinori Dobashi Kei Iwasaki Yonghao Yue Tomoyuki Nishita Hokkaido university/uei research Japan wakayama university/uei research Japan The university of Tokyo Japan uei research/Hiroshima Shudo university Japan

Clouds play an important role when synthesizing realistic images of outdoor *** realistic display of clouds is therefore one of the important research topics in computer *** order to display realistic clouds,we need methods for modeling,rendering,and animating clouds *** is also important to control the shapes and appearances of clouds to create certain visual *** this paper,we explain our efforts and research results to meet such requirements,together with related researches on the visual simulation of clouds.

关键词： Clouds Procedural modeling Image-based modeling Fluid simulation Feedback control Genetic algorithms

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A method for estimating the errors in many-light rendering with supersampling

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Computational Visual Media 2019年第2期5卷 151-160页

作者： Hirokazu Sakai Kosuke Nabata Shinya Yasuaki Kei Iwasaki wakayama university WakayamaWakayama640-8510Japan Dwango CG research KADOKAWA Hongo Bldg.5245 HongoBunkyo-kuTokyo1130033Japan

In many-light rendering, a variety of visual and illumination effects, including anti-aliasing,depth of field, volumetric scattering, and subsurface scattering, are combined to create a number of virtual point lights(VPLs). This is done in order to simplify computation of the resulting illumination. Naive approaches that sum the direct illumination from many VPLs are computationally expensive;scalable methods can be computed more efficiently by clustering VPLs, and then estimating their sum by sampling a small number of VPLs. Although significant speed-up has been achieved using scalable methods, clustering leads to uncontrollable errors, resulting in noise in the rendered images. In this paper, we propose a method to improve the estimation accuracy of manylight rendering involving such visual and illumination effects. We demonstrate that our method can improve the estimation accuracy by a factor of 2.3 over the previous method.

关键词： anti-aliasing depth of field many-light rendering participating media

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Helicobacter pylori-related chronic gastritis as a risk factor for colonic neoplasms

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World Journal of Gastroenterology 2014年第6期20卷 1485-1492页

作者： Izumi Inoue Jun Kato Hideyuki Tamai Mikitaka Iguchi Takao Maekita Noriko Yoshimura Masao Ichinose the Second Department of Internal Medicine Wakayama Medical University Department of Joint Disease research Graduate School of Medicine The University of Tokyo Bunkyoku

To summarize the current views and insights on associations between Helicobacter pylori(H. pylori)-related chronic gastritis and colorectal neoplasm, we reviewed recent studies to clarify whether H. pylori infection/H. pylori-related chronic gastritis is associated with an elevated risk of colorectal neoplasm. Recent studies based on large databases with careful control for confounding variables have clearly demonstrated an increased risk of colorectal neoplasm associated with H. pylori infection. The correlation between H. pylori-related chronic atrophic gastritis(CAG) and colorectal neoplasm has only been examined in a limited number of studies. A recent large study using a national histopathological database, and our study based on the stage of H. pylori-related chronic gastritis as determined by serum levels of H. pylori antibody titer and pepsinogen, indicatedthat H. pylori-related CAG confers an increased risk of colorectal neoplasm, and more extensive atrophic gastritis will probably be associated with even higher risk of neoplasm. In addition, our study suggested that the activity of H. pylori-related chronic gastritis is correlated with colorectal neoplasm risk. H. pylori-related chronic gastritis could be involved in an increased risk of colorectal neoplasm that appears to be enhanced by the progression of gastric atrophy and the presence of active inflammation.

关键词： Colorectal neoplasm Cancer risk Pepsinogen Helicobacter pylori antibody Atrophic gastritis

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Analysis of shopping behavior characteristics in the Keihanshin metropolitan area in Japan based on a person trip survey

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Geo-Spatial Information Science 2020年第4期23卷 305-315页

作者： Takashi Yamada Takumi Hayashida Department of Human Factors Engineering and Environmental Design Faculty of Biology-Oriented Science and TechnologyKindai UniversityKinokawaWakayamaJapan

This study analyzed weekday shopping behavior from a home base to a destination using data from the 4th Keihanshin metropolitan area person trip *** first analyzed the relationships between occupation and transportation means,transportation means and travel time,and transportation means and duration of time at the *** of a chi-square test,residual analysis,and correspondence analysis confirmed that employed persons tend to travel by cars while unemployed persons tend to travel by bus or *** relationship between travel time and duration of time at the destination was also revealed according to transportation *** of a cluster analysis then classified shopping behaviors to expose four ***,multiple regression analyzed the degree to which certain variables were related to duration of time at the *** confirmed a strong relationship between duration of time at the destination and travel *** degree of this factor’s influence on other variables was also *** value of these findings is that the relationship between travel time by means of transportation and the duration of time at the destination was clarified using statistical *** then found a highly accurate equation that estimates the duration of time at a destination from the travel *** the duration of time at a destination can be estimated,it may be possible to more accurately develop the structure of rest facilities,the number of parking lots,the degree of congestion,and so on,which can be associated with the customer’s usage behavior in a shopping *** research in this paper contributes to the field of urban analysis and marketing by presenting a new effective method for person trip survey and analysis.

关键词： Person trip survey shopping behavior transportation means travel time duration of time at a destination

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An event mixing technique for Bose-Einstein correlations of two pions in photoproduction around 1 GeV

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Chinese Physics C 2016年第11期40卷 67-74页

作者：何庆华 H.Fujimura H.Fukasawa R.Hashimoto Y.Honda T.Ishikawa T.Iwata S.Kaida J.Kasagi A.Kawano S.Kuwasaki K.Maeda S.Masumoto M.Miyabe F.Miyahara K.Mochizuki N.Muramatsu A.Nakamura K.Nawa S.Ogushi Y.Okada Y.Onodera K.Ozawa Y.Sakamoto M.Sato H.Shimizu H.Sugai K.Suzuki Y.Tajima S.Takahashi Y.Taniguchi Y.Tsuchikawa H.Yamazaki R.Yamazaki H.Y.Yoshida research Center for Electron Photon Science Tohoku University Institute of Fluid Physics China Academy of Engineering Physics Department of Physics Wakayama Medical University Department of Physics Yamagata University Department of Information Science Tohoku Gakuin University Department of Physics Tohoku University Department of Physics University of Tokyo Accelerator Laboratory KEK Institute of Particle and Nuclear Studies KEK Wakasa-wan Energy research Center

We have developed an event mixing technique to observe Bose-Einstein correlations （BEC） between two identical neutral pions produced in photo-induced reactions in the non-perturbative QCD energy region. It is found that the missing-mass consistency cut and the pion-energy cut are essential for the event mixing method to effectively extract BEC observables. A Monte Carlo （MC） simulation is used to validate these constraints and confirms the efficiency of this method. Our work paves the way for similar BEC studies at lower energies where the multiplicity of emitted bosons is limited.

关键词： Bose-Einstein correlations photoproduction event mixing

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Extraction of yarn positional information from three-dimensional CT image of textile fabric using a yarn model for its structure analysis

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仪器仪表学报 2008年第8期29卷 1569-1576页

作者： Toshihiro Shinohara Jun-ya Takayama Shinji Ohyama Akira Kobayashi School of Biology-Oriented Science and Technology Kinki university Kinokawa-shi Wakayama-kenJapan Graduate School of Science and Engineering Tokyo Institute of Technology1-12-1 Meguro-kuTokyoJapan Faculty of university Evaluation and research National Institution for Academic Degrees and universityEvaluation Kodaira-shi TokyoJapan

This paper proposes a novel method for analyzing a textile fabric structure to extract positional information regarding each yarn using three-dimensional X-ray computed tomography(3D CT) *** relationship among the yarns can be reconstructed using the extracted yarn positional *** this paper,a sequence of points on the center line of each yarn of the sample is defined as the yarn positional information,since the sequence can be regarded as the representative position of the *** sequence is extracted by tracing the *** yarn is traced by estimating the yarn center and direction and correlating the yarn part of the 3D CT image with a 3D yarn model,which is moved along the estimated yarn *** trajectory of the center of the yarn model corresponds to the positional information of the *** application of the proposed method is shown by experimentally applying the proposed method to a 3D CT image of a double-layered woven ***,the experimental results for a plain knitted fabric show that this method can be applied to even knitted fabrics.

关键词：纺织品 CT影像分析方法物理结构

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Hyperhomocysteinemia and Increased Oxidative Stress Levels Are Associated with Impaired Membrane Fluidity of Red Blood Cells in Hypertensive and Normotensive Men: An Electron Spin Resonance Investigation

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International Journal of Clinical Medicine 2013年第1期4卷 58-65页

作者： Kazushi Tsuda Cardiovascular and Metabolic research Center Kansai University of Health Sciences Osaka Japan 2Division of Cardiology School of Medicine Wakayama Medical University Wakayama Japan

Hyperhomocysteinemia and oxidative stress may be strongly linked to hypertension, atherosclerosis and other cardiovascular diseases. The present study was performed to investigate possible relationships among plasma total homocysteine, plasma 8-iso-prostaglandin F2α (8-isoPG F2α: an index of oxidative stress), and membrane fluidity (a reciprocal value of membrane microviscosity) in hypertension. We measured the membrane fluidity of red blood cells (RBCs) in hypertensive and normotensive men using an electron spin resonance (ESR) and spin-labeling method. Membrane fluidity of RBCs was significantly decreased in hypertensive men compared with normotensive men. Plasma total homocysteine levels were significantly higher in hypertensive men than in normotensive men, and correlated with plasma 8-isoPG F2α. In contrast, plasma nitric oxide (NO)-metabolites (an index of endothelial function) were lower in hypertensive men than in normotensive men. The reduced membrane fluidity of RBCs was associated with increased total homocysteine and plasma 8-isoPG F2α levels and decreased plasma NO-metabolite levels. Multivariate regression analysis showed that, after adjusting for general risk factors, plasma total homocysteine and 8-isoPG F2α were significant determinants of membrane fluidity of RBCs, respectively. These results suggest that hyperhomocysteinemia and oxidative stress with endothelial dysfunction might have a close correlation with impaired rheologic behavior of RBCs and circulatory disorders in hypertensive men.

关键词： Homocysteine Oxidative Stress 8-Iso-Prostaglandin F2α Nitric Oxide Membrane Fluidity Red Blood Cell Electron Spin Resonance Hypertension

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Novel eradicative high-dose rate brachytherapy for internal mammary lymph node metastasis from breast cancer

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World Journal of Radiology 2012年第11期4卷 443-449页

作者： Kazushi Kishi Hirokazu Tanino Tetsuo Sonomura Shintaro Shirai Yasutaka Noda Morio Sato Yoshitaka Okamura Department of Radiation Oncology Wakayama Medical UniversityWakayama 641-8510Japan Department of Surgery Naga HospitalUchi-da 1282Kinokawa CityWakayama Prefecture 649-6414Japan Department of Radiology Wakayama Medical UniversityWakayama 641-8510Japan 1st Department of Surgery Wakayama Medical University Wakayama 641-8510 Japan

AIM: To develop a method of delivering an eradicative high radiotherapeutic dose safely preserving the surrounding skin in the treatment of internal mammary lymph node metastasis (IMLNM) of breast cancer. METHODS: We report a 38-year-old female patient with a solo IMLNM showing no response to 60 Gy in 2.5 Gy fractions of external beam radiotherapy. To eradicate this tumor, a boost brachytherapy plan was created after percutaneous insertion of an applicator needle into the IMLNM lesion avoiding the pleura and vessels under ultrasound monitoring. According to the dose distribution, the required thickness of a spacer between the skin and the tumor was determined, and hyaluronic gel was injected up to this thickness under ultrasound monitoring. We evaluated skin doses, target doses and clinical outcome. RESULTS: All procedures were performed easily. Sixteen Gy (34.7 Gy equivalent in 2 Gy fractions calculated by the linear quadratic model at α/β = 10: EQD2, α/β = 10, cumulative total was 101.9 Gy EQD10) to 100% of the target volume was irradiated with cumulative maximum skin dose of 70 Gy EQD2, α/β = 3 which was 98.7 Gy EQD2, α/β = 3 without spacer. No procedure related- or late complications and no local recurrence at the treated site were observed for three years until expiration. CONCLUSION: We consider that this procedure will provide an eradicative high-dose irradiation to IMLNM of breast cancer, preserving skin from overdose complications.

关键词： Brachytherapy Hyaluronate Internal mammary lymph node Metastasis Skin preservation Breast cancer Organ at risk

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