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Oxidative stress and stress signaling: menace of diabetic cardiomyopathy

Acta Pharmacologica Sinica 2005年第8期26卷 908-917页

作者： Loren E WOLD Asli F CEYLAN-ISIK Jun REN Department of Pharmacology Physiology and Therapeutics University of North Dakota Grand Forks ND 58203 USA Center for Cardiovascular Research and Alternative Medicine University of wyoming Laramie wy 82071 USA Department of Pharmacology Physiology and Therapeutics University of North Dakota Grand Forks ND 58203 USA Center for Cardiovascular Research and Alternative Medicine University of wyoming Laramie wy 82071 USA

Cardiovascular disease is the most common cause of death in the diabetic population and is currently one of the leading causes of death in the United States and other industrialized countries. The health care expenses associated with cardiovascular disease are staggering, reaching more than US$350 billion in 2003. The risk factors for cardiovascular disease include high fat/cholesterol levels, alcoholism, smoking, genetics, environmental factors and hypertension, which are commonly used to gauge an individual's risk of cardiovascular disease and to track their progress during therapy. Most recently, these factors have become important in the early prevention of cardiovascular diseases. Oxidative stress, the imbalance between reactive oxygen species production and breakdown by en- dogenous antioxidants, has been implicated in the onset and progression of car- diovascular diseases such as congestive heart failure and diabetes-associated heart dysfunction (diabetic cardiomyopathy). Antioxidant therapy has shown promise in preventing the development of diabetic heart complications. This review focuses on recent advances in oxidative stress theory and antioxidant therapy in diabetic cardiomyopathy, with an emphasis on the stress signaling pathways hypothesized to be involved. Many of these stress signaling pathways lead to activation of reactive oxygen species, major players in the development and progression of diabetic cardiomyopathy.

关键词： diabetes: heart cardiomyopathy oxidative stress: signal transduction

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RBM20 is an essential factor for thyroid hormone-regulated titin isoform transition

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Journal of Molecular Cell Biology 2015年第1期7卷 88-90页

作者： Chaoqun Zhu Zhiyong Yin Jun Ren Richard J.McCormick Stephen P.Ford Wei Guo Department of Animal Science College of Agriculture and Natural ResourcesUniversity of WyomingLaramieWY 82071USA Department of Cardiology XiJing HospitalFourth Military Medical UniversityXi’an 710032China Center for Cardiovascular Research and Alternative Medicine College of Health ScienceUniversityof WyomingLaramieWY 82071USA

Dear Editor,Diastolic heart failure(DHF)and systolic heart failure(SHF)are two main subsets of chronic heart failure that are commonly encountered in clinical practice(Chatterjee and Massie,2007).

关键词： clinical heart systolic

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Ethane dehydrogenation over the g-C_(3)N_(4)supported metal singleatom catalysts to enhance reactivity and coking-resistance ability

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Nano Research 2023年第5期16卷 6142-6152页

作者： Yuan Zhang Baojun Wang Maohong Fan Lixia Ling Riguang Zhang College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024China State Key Laboratory of Clean and Efficient Coal Utilization Taiyuan University of TechnologyTaiyuan 030024China Departments of Chemical and Petroleum Engineering University of WyomingLaramieWY 82071USA School of Civil and Environmental Engineering Georgia Institute of TechnologyAtlantaGA 30332USA School of Energy Resources University of WyomingLaramieWY 82071USA

Ethane dehydrogenation(EDH)to produce ethylene requires high operating temperature to achieve satisfactory ethylene yield,however,this process leads to coke formation and catalyst ***,an active site isolation strategy was employed to inhibit side reaction and coke formation over fifteen types of metal single-atom metal/graphitic carbon nitride(M/g-C_(3)N_(4))*** functional theory(DFT)calculations completely describe reaction network of ethane *** kinetic Monte Carlo simulations were carried out to evaluate catalytic performance under the realistic *** Co/g-C_(3)N_(4),Rh/g-C_(3)N_(4),Ni/g-C_(3)N_(4)catalysts were screened out to exhibit higher C_(2)H_(4)(g)formation activity and C_(2)H_(4)(g)selectivity close to or equal to 100%.The low reactant partial pressure 0%–5%at atmospheric pressure facilitates ethane dehydrogenation,and the appropriate temperatures over Co/g-C_(3)N_(4),Rh/g-C_(3)N_(4),Ni/g-C_(3)N_(4)catalysts are 673.15,723.15,723.15 K,***,Co/g-C_(3)N_(4)catalyst presents the highest C_(2)H_(4)(g)formation activity,attributing to the appropriate antibonding strength between C atom and metal ***,a simple descriptor,the reaction energy of C_(2)H_(5)*dehydrogenation to C_(2)H_(4)*,was proposed to quantitatively and quickly evaluate C_(2)H_(4)(g)formation *** present study laid a solid foundation for efficient design and development of single-atom catalysts with high-performance for selective dehydrogenation of alkanes.

关键词： ethane dehydrogenation single-atom catalyst graphitic carbon nitrides density functional theory(DFT)calculations kinetic Monte Carlo

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Enhanced near-zero-CO2-emission chemicals-oriented oil production from coal with inherent CO2 recycling: Part I—PRB coal fast pyrolysis coupled with CO2/CH4 reforming

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International Journal of Coal Science & Technology 2020年第3期7卷 433-443页

作者： Xingjun Wang Bin Wei Xin Huang Maohong Fan Yonggang Wang Xueli Chen School of Resources and Environment Engineering East China University of Science and TechnologyShanghai200237China School of Chemical and Environmental Engineering China University of Mining and TechnologyBeijing100080China Departments of Petroleum and Chemical Engineering University of WyomingLaramieWY82071USA School of Energy Resources University of WyomingLaramieWY82071USA

In this study,the Powder River Basin(PRB)coal fast pyrolysis was conducted at 700°C in the atmosphere of syngas produced by CH4-CO2 reforming in two different patterns,including the double reactors pattern(the first reactor is for syngas production and the second is for coal pyrolysis)and double layers pattern(catalyst was at upper layer and coal was at lower layer).Besides,pure gases atmosphere including N2,H2,CO,H2-CO were also tested to investigate the mechanism of the coal pyrolysis under different *** pyrolysis products including gas,liquid and char were characterized,the result showed that,compared with the inert atmosphere,the tar yield is improved with the reducing atmospheres,as well as the tar *** hydrogen partial pressure is the key point for that *** the atmosphere of H2,the tar yield was increased by 31.3%and the contained BTX(benzene,toluene and xylene)and naphthalene were increased by 27.1%and 133.4%.The double reactors pattern also performed outstandingly,with 25.4%increment of tar yield and 25.0%and 79.4%for the BTX and *** double layers pattern is not effective enough due to the low temperature(700°C)in which the Ni-based catalyst was not fully activated.

关键词： Coal pyrolysis Coal tar CO2/CH4 reforming BTX

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Application of multinomial and ordinal logistic regressionto model injury severity of truck crashes, using violationand crash data

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Journal of Modern Transportation 2018年第4期26卷 268-277页

作者： Mahdi Rezapour Khaled Ksaibati Department of Civil and Architectural Engineering University of Wyoming Office: EN 3084 E University AveDept. 3295 Laramie WY 82071 USA wyoming Technology Transfer Center 1000 E. UniversityAvenue Department 3295 Laramie WY 82071 USA

In 2016 alone, around 4000 people died in crashes involving trucks in the USA, with 21% of these fatalities involving only single-unit trucks. Much research has identified the underlying factors for truck ***, few studies detected the factors unique to single and multiple crashes, and none have examined these underlying factors to severe truck crashes in conjunction with violation data. The current research assessed all of these factors using two approaches to improve truck *** first approach used ordinal logistic regression to investigate the contributory factors that increased the odds of severe single-truck and multiple-vehicle crashes, with involvement of at least one truck. The literature has indicated that past violations can be used to predict future violations and crashes. Therefore, the second approach used risky violations, related to truck crashes, to identify the contributory factors to the risky violations and truck crashes. Driver actions of failure to keep proper lane following too close and driving too fast for conditions accounted for about 40% of all the truck crashes. Therefore, the same violations as the aforementioned driver actions were included in the analysis. Based on ordinal logistic regression, the analysis for the first approach indicated that being under non-normal conditions at the time of crash, driving on dry-road condition and having a distraction in the cabin are some of the factors that increase the odds of severe single-truck crashes. On the other hand,speed compliance, alcohol involvement, and posted speed limits are some of the variables that impacted the severity of multiple-vehicle, truck-involved crashes. With the second approach, the violations related to risky driver actions,which were underlying causes of severe truck crashes, were identified and analysis was run to identify the groups at increased risk of truck-involved crashes. The results of violations indicated that being nonresident, driving offpeak

关键词： Single-truck crash Multiple-truck crash Driving violation Traffic enforcement Logistic regression Injury truck crashes

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Mechanism and catalytic performance for direct dimethyl ether synthesis by CO2 hydrogenation over CuZnZr/ferrierite hybrid catalyst

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Journal of Environmental Sciences 2020年第6期32卷 106-117页

作者： Qingtao Sheng Run-Ping Ye Weibo Gong Xiufeng Shi Bang Xu Morris Argyle Hertanto Adidharma Maohong Fan College of Chemistry and Chemical Engineering Taiyuan University of TechnologyTaiyuan 030024China Department of Engineering and Applied Science University of WyomingLaramieWY 82071USA Key Laboratory of Coal to Ethylene Glycol and Its Related Technology Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFujian 350002China University of Chinese Academy of Sciences Beijing 100049China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190China Department of Chemical Engineering Brigham Young UniversityUT 84602USA Department of Petroleum Engineering University of WyomingLaramieWY 82071USA School of Energy Resources University of WyomingLaramieWY 82071USA School of Civil and Environmental Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

Direct synthesis of dimethyl ether(DME)by CO2 hydrogenation has been investigated over three hybrid catalysts prepared by different methods:co-precipitation,sol-gel,and solid grinding to produce mixed Cu,ZnO,ZrO2 catalysts that were physically mixed with a commercial ferrierite(FER)*** catalysts were characterized by N2 physisorption,X-ray diffraction(XRD),transmission electron microscopy(TEM),X-ray photoelectron spectroscopy(XPS),temperature programmed desorption of CO2(CO2-TPD),temperature programmed desorption of NH3(NH3-TPD),and temperature programmed H2 reduction(H2-TPR).The results demonstrate that smaller CuO and Cu crystallite sizes resulting in better dispersion of the active phases,higher surface area,and lower reduction temperature are all favorable for catalytic *** reaction mechanism has been studied using in situ diffuse reflectance infrared Fourier transform spectroscopy(DRIFTS).Methanol appears to be formed via the bidentate-formate(b-HCOO)species undergoing stepwise hydrogenation,while DME formation occurs from methanol dehydration and reaction of two surface methoxy groups.

关键词： CO2 hydrogenation Ether Dimethyl ether(DME)synthesis Mechanism

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Impact of surface roughness,surface charge,and temperature on sandstone wettability alteration by nanoparticles

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Petroleum Science 2023年第5期20卷 2852-2863页

作者： Bingjun Zhang Kaustubh Rane Mohammad Piri Lamia Goual Lam Research Corporation 11361 SW Leveton Dr.TualatinOR97062USA Champion X Chemical Technologies 11177 S.Stadium Dr.SugarlandTX77478USA Center of Innovation for Flow through Porous Media Dept.4311University of Wyoming1000 E.University AvenueLaramieWY82071USA Department of Energy and Petroleum Engineering Dept.3295University of Wyoming1000 E.University AvenueLaramieWY82071USA

The wettability of rocks affects the balance between capillary and viscous forces during multiphase flow through porous media,which in turn determines the fluid displacement process governing the recovery of oil from subsurface *** this work,the mechanism of wettability reversal of aged synthetic sandstones by metal oxide nanoparticles(SiO_(2) and Al_(2)O_(3))was investigated with particular focus on the impact of surface roughness,zeta potential,and *** synthetic surfaces were prepared from powders of Berea sandstone with known grain size ranges and their average roughness and roughness ratio were obtained from the 3D surface reconstruction of their microscope *** surface was subsequently aged in Permian crude oil to alter its *** surfaces with larger grain sizes and lower surface roughness ratios,the lower capillary pressure allowed stronger oil/surface interactions,leading to enhanced *** wettability alteration effects of nanoparticles were then examined through real-time top view imaging and dynamic front view contact angle *** negatively charged SiO_(2) nanoparticles rapidly reversed the sandstone wettability,indicating their potential applicability as wettability alteration *** contrast,the positively charged Al_(2)O_(3) counterpart caused no wettability *** mechanism of wettability alteration was further studied by microscale interaction analyses and nanoscale transmission electron *** nanoparticles were only a few nanometers large,the microscale roughness had a negligible effect on the wettability ***,the combined effect of van der Waals dispersion forces and surface-charge-induced electrostatic forces were recognized as the two key factors affecting the wettability of sandstone *** interactions may be curbed at elevated temperatures due to a decrease in the zeta potential and colloidal stability of the particles.

关键词： Wettability Sandstone Surface roughness Nanoparticle Microscope Enhanced oil recovery Contact angle Zeta potential

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Rare earth elements of fly ash from wyoming’s Powder River Basin coal

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Journal of Rare Earths 2020年第2期38卷 219-226页

作者： Zaixing Huang Maohong Fan Hanjing Tian Department of Chemical and Petroleum Engineering University of WyomingWY 82071USA School of Civil and Environmental Engineering Georgia Institute of TechnologyGA 30332USA Department of Chemical Engineering West Virginia UniversityWV 26506USA

The advancement and increasing interests in green energy production and environmental protection technologies have spurred the demand for rare earth *** the other hand,the *** to rely 100% on import of these materials as the industry was crashed because of the environmental issues associated with mining and processing,and more importantly lack *** rare earth elements have many applications in defense and national security sectors,some of the elements were listed as strategic materials or critical materials because of the uncertainties in supply and ***,it has become imperative in searching for alternative resources for supplying rare earth elements including unconventional *** the strong incentive,coal fly ash is identified as one of the candidates among *** this study,we present rare earth element data for the 42 ash samples(all derived from Powder River Basin coal) that we collected from seven states(UT,wy,10,WI,ND,CO,and MI) representing 158 million tons of fly *** results indicate scattered distributions of rare earth elements with concentration ranging from 156 to 590 ppm although all the ash samples originated from the same coal basin(Powder River Basin).The rare earth element resource in these ashes is estimated between 74000 and 106000 *** ash samples were also characterized by elemental analysis,XRD,SEM-EDS and BET surface *** characterizations of the ashes were discussed as they might have implications in the subsequent rare earth element extraction *** summary,fly ash may represent a potential resource for rare earth element production.

关键词： Rare earth elements Coal fly ash XRD SEM-EDS BET surface area Critical materials

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THE LIMITATIONS OF LEED: A CASE STUDY

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Journal of Green Building 2011年第1期6卷 25-33页

作者： Anthony S.Denzer Keith E.Hedges University of wyoming Dept.32951000 E.University AvenueLaramieWY 82071 Hammons School of Architecture Drury University.

The Xanterra houses are situated against the backdrop of one of America’s most spectacular natural landscapes,just a few hundred yards from the north entrance to Yellowstone National *** project consists of two single-family homes for seasonal workers,approximately 2000 square feet *** are mirrored east-to-west but otherwise identical(see Figure 1).The project was completed in 2003,and certified under LEED-NC v2.0,project#1353 on December 10,2004-the first building project in the National Park system to receive LEED(Leadership in Energy and Environmental Design)certification from the USGBC(United States Green Building Council).1 The houses were built with the explicit intent that they would become a model for future green building projects at Yellowstone and other national parks,2 and the project team felt it was fitting that these houses be situated in the nation’s first national ***,they were fundamentally well-designed and constructed,and they incorporated some of the latest technologies for saving energy and water,authentically earning the label“high-performance.”Yet the project only earned the lowest possible rating(“certified”)from LEED,meaning it is barely considered *** paper documents the green design strategies through the design and construction process,with special attention paid to the influence of the LEED scorecard on collaborative decision-making and to the difficulties this project encountered during the LEED assessment *** academic studies have examined the process of LEED self-reporting and scoring within a professional setting,3 even though contingencies such as common business practices and human limitations clearly affect a project’s LEED *** paper will show that the LEED scorecard turned out to be a poor assessment tool in this case study,because the reporting procedure inaccurately reflected the architectural design and ***,there have been a few important papers that conclude that

关键词： LEED energy modeling insulated concrete passive solar heating construction waste management

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Ultrasonographic measurement of median nerve cross-sectional area reference values in a healthy Han population from Guiyang,China

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Neural Regeneration Research 2011年第24期6卷 1883-1887页

作者： Jun Chen Shan Wu Jun Ren Department of Neurology Affiliated Hospital of Guiyang Medical College Guiyang 550004 Guizhou Province China University of wyoming College of Health Sciences Wyoming INBRE Program Laramie WY 82071 USA

High-resolution ultrasonography was used to analyze the nerve cross-sectional area （CSA） of the median nerve at 7 sites： the wrist crease, pisiform bone, hamate bone, 6 cm proximal to the tip of the wrist crease, proximal forearm （where the nerve enters the pronator teres muscle）, 4 cm proximal to the tip of the medial epicondyle, and mid-humerus （mid-point between elbow crease and axilla） in 200 healthy volunteers from Guiyang, China. Results showed similar CSA values between the left and right sides, but the CSA 6 cm proximal to the tip of the wrist crease, proximal forearm, 4 cm proximal to tip of the medial epicondyle, and mid-humerus in males was greater than that of females. Moreover, CSA values at the wrist crease, pisiform bone, and hamate bone were greater in the middle-aged and old groups when compared to the young group, and correlated with body mass and height. Thus, reference values of median nerve CSA of the upper limbs can facilitate the analysis of abnormal nerve conditions.

关键词： ultrasonography median nerve cross-sectional area Guiyang Han nationality

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