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China CDC weekly 2021年第5期3卷 90-93,I0001,I0002页

作者： Yanfeng Gong Yinlong Li Lijuan Zhang Shan Lv Jing Xu Shizhu Li National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionChinese Center for Tropical Diseases ResearchWHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesMinistry of Science and TechnologyKey Laboratory of Parasite and Vector BiologyNational Health Commission of ChinaShanghaiChina

What is already known about this topic?Oncomelania hupensis(***)is the only intermediate host of Schistosoma *** distribution of *** is affected by a series of climate,geographical,sand ocioeconomic factors,which reflect the risk areas of *** is added by this report?There were certain geographical aggregations in the potential high distribution areas of ***,which were mainly distributed in Poyang Lake area,Dongting Lake area,and the middle and the lower reaches of the Yangtze *** are the implications for public health practice?Monitoring and forecasting the distribution of *** is conducive to improving the early warning capabilities of the potential risk of schistosomiasis transmission and progressively promoting the elimination of schistosomiasis nationwide.

关键词： Schistosoma schistosomiasis pens

Distribution Patterns of the Snail Intermediate Host of Schistosoma japonicum-China,2015−2019

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China CDC weekly 2021年第5期3卷 81-84页

作者： Lijuan Zhang Shan Lv Chunli Cao Jing Xu Shizhu Li National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionChinese Center for Tropical Diseases ResearchWHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesMinistry of Science and TechnologyKey Laboratory of Parasite and Vector BiologyMinistry of HealthShanghaiChina

What is already known about this topic?The endemic status of schistosomiasis appeared to continuously decrease in China from 2015 to *** snail species Oncomelania hupensis is the only intermediate host involved in the transmission of Schistosoma japonicum,and this snail’s geographic distribution is strictly consistent with that of *** is added by this report?The snail’s habitats did not decrease significantly in China from 2015 to 2019,and some habitats have been newly detected or recurrent in some *** habitats among nine counties in Hunan and Jiangxi covered nearly half of the areas with *** are the implications for public health practice?Considering the situation of snail distribution,strategies and measures on snail control should focus on key *** addition,study of the origin and causes of the newly-detected snail habitats and recurrent areas with snails needs to be strengthened,and comprehensive measures should be taken to prevent the spread of snails.

关键词： Schistosoma schistosomiasis continuously

Gamma oscillations and their role in orchestrating balance and communication following stroke

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Neural Regeneration Research 2025年第2期20卷 477-478页

作者： Montana Samantzis Cong Wang Matilde Balbi Queensland Brain Institute The University of QueenslandBrisbaneQLDAustralia Engineering Research centre of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina

Induced brain oscillations in the gamma range have recently garnered attention due to their reported neuroprotective effects in the treatment of Alzheimer’s *** method differs from pharmacological approaches by tapping into the neuronal population dynamics that underlie the homeostatic processes in the brain that are crucial for the recovery of ***,induced gamma-range oscillations have been used to improve cerebral blood flow,motor function,and synaptic plasticity in a mouse model of focal stroke,highlighting the broad potential of recruiting intrinsic recovery processes for the treatment of neurological *** open questions,such as the frequency specificity of the benefits,will shed light on the intrinsic processes involved and allow clinicians to optimize recovery after stroke.

关键词： protective specificity Alzheimer

Emerging potential of progranulin-dependent SorCS2 signaling in healthy and diseased nervous systems

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Neural Regeneration Research 2025年第9期20卷 2591-2593页

作者： Alena Salasova Anders Nykjær Danish Research Institute of Translational Neuroscience DANDRITE-Nordic EMBL Partnership for Molecular Medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The formation of the mammalian nervous system and its maturation into sensory,motor,cognitive,and behavioral circuits is a complex process that begins during early embryogenesis and lasts until young *** neurodevelopm... 详细信息

关键词： progr jointly CS2

Tuning beneficial calcineurin phosphatase activation to counterα-synuclein toxicity in a yeast model of Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 199-200页

作者： Srishti Chawla Mikael Molin Thomas Nystrom Institute for Biomedicine Sahlgrenska AcademyCentre for Ageing and Health-AgeCapUniversity of GothenburgGothenburgSweden Department of Life Sciences Chalmers University of TechnologyGothenburgSweden

Calcineurin(CN)is a calcium-and calmodulindependent serine/threonine that has been studied in many model organisms including yeast,filamentous fungi,plants,and *** biological functions range from ion homeostasis and virulence in lower eukaryotes to T-cell activation in humans by human nuclear factors of activated *** is a heterodimeric protein consisting of a catalytic subunit,calcineurin A(Cna1p),which contains an active site with a dinuclear metal center,and a regulatory Ca^(2+) binding subunit called calcineurin B(Cnb1p)required to activate *** calcineurin B subunit has been highly conserved through evolution:For example,the mammalian calcineurin B shows 54%identity with calcineurin B from Saccharomyces cerevisiae.

关键词： activation dinuclear conserved

Sustainable Pest Management for Health and Well-Being

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China CDC weekly 2020年第24期2卷 438-442页

作者： Qiyong Liu State Key Laboratory of Infectious Disease Prevention and Control Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesWHO Collaborating Centre for Vector Surveillance and ManagementNational Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina

Pests can not only cause nuisances and allergic reactions and transmit a range of diseases,but they can also pose serious threat to other aspects of life such as the environment,food,agriculture,crops,*** time,the pes... 详细信息

关键词： diseases allergic crops

A randomized, controlled, multicenter contraceptive efficacy clinical trial of the intravas device, a nonocclusive surgical male sterilization

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Asian Journal of Andrology 2014年第3期16卷 432-436页

作者： Wen-Hong Lu Xiao-Wei Liang Yi-Qun Gu Wei-Xiong Wu Li-Wei Bo Tian-Gui Zheng Zhen-Wen Chen Key Laboratory of Male Reproductive Health National Health and Family Planning Commission National Research Institute for Family Planning and WHO Collaborating Centre for Research in Human Reproduction Beijing Institute for Family Planning of Guangzhou city Guangzhou Institute for Family Planning of Henan Province Zhengzhou Institute for Family Planning of Putian City Putian China.

Because of unavoidable complications of vasectomy, this study was undertaken to assess the efficacy and safety of male sterilization with a nonobstructive intravas device （IVD） implanted into the vas lumen by a mini-surgical method compared with no-scalpel vasectomy （NSV）. IVDs were categorized into two types： IVD-B has a tail used for fixing to the vas deferens （fixed wing） whereas IVD-A does not. A multicenter prospective randomized controlled clinical trial was conducted in China. The study was comprised of 1459 male volunteers seeking vasectomy who were randomly assigned to the IVD-A （n = 487）, IVD-B （n = 485） or NSV （n = 487） groups and underwent operation. Follow-up included visits at the 3rd-6TM and 12~ postoperative months, The assessments of the subjects involved regular physical examinations （including general and andrological examinations） and semen analysis. The subjects＇ partners also underwent monitoring for pregnancy by monthly interviews regarding menstruation and if necessary, urine tests, There were no significant differences in pregnancy rates （0.65% for IVD-A, 0 for IVD-B and 0.21% for NSV） among the three groups （P 〉 0.05）. The cumulative rates of complications at the 12th postoperative month were zero, 0.9% and 1.7% in the three groups, respectively. In conclusion, IVD male sterilization exhibits a low risk of long-term adverse events and was found to be effective as a male sterilization method, similar to the NSV technique. IVD male sterilization is expected to be a novel contraceptive method.

关键词： complication male sterilization nonobstructive intravas device no-scalpel vasectomy

A rapid reporter assay for recombinant human brain natriuretic peptide(rhBNP)by GloSensor technology

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Journal of Pharmaceutical Analysis 2018年第5期8卷 297-301页

作者： Lei Yu Xinchang Shi Chunmei Han Chunming Rao Junzhi Wang National Institutes for Food and Drug Control Beijing 100050China who CoUahoration centre for Biologicals Standardization and Evaluation Beijing 100050China

Accurate determination of biological activity is essential in quality control of recombinant human brain natriuretic peptide （rhBNP）. In previous study, we successfully developed a genetically modified cell line 293GCAC3-based ELISA assay for rhBNP. But ELISA procedure is still tedious, so this study was aimed to develop a rapid and simple bioassay for rhBNP using GloSensor technology, which provides a platform of flexible luciferase-based biosensors for real-time detection of signaling events in live cells, including cGMP production. A reporter cell line 293GCAGIo-G1 was constructed by transfecting pGloSensorTM 40 F plasmid into 293GCAC3. The reporter assay based on 293GCAGIo-G1 showed high precision with intraassay CV being 8.3% and inter-assay CV being 14.1%; high accuracy with 80%, 100% and 120% recovery rate being 99.2%, 102.4% and 99.0% respectively; and great linearity with R^2 of linear fitting equation being 0.99. Besides, no significant difference was found in test results of reporter assay and 293GCAC3-based ELISA assay （paired t test,p = 0.630）. All these results suggested that the reporter assay was a viable assay for biological determination of rhBNP.

关键词： RhBNP cGMP GloSensor technology Reporter assay

China-UK-Tanzania Pilot Project on Malaria Control

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China CDC weekly 2020年第42期2卷 820-822页

作者： Xuejiao Ma Shenning Lu Duoquan Wang Zhengbin Zhou Jun Feng He Yan Shang Xia Wei Ding Ning Xiao Xiao-nong Zhou National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionChinese Center for Tropical Diseases ResearchWHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesMinistry of Science and TechnologyKey Laboratory of Parasite and Vector BiologyMinistry of HealthShanghaiChina

The China-UK-Tanzania Pilot Project on Malaria Control supported by the China-UK Global Health Support Programme and funded by the UK Department for International Development(DFID)is the first pilot project of its kind for the Chinese government in *** encouraging results of this pilot project demonstrated that the malaria burden could be reduced by 81%(1)when China’s experience with malaria control was shared in Tanzania through interactions between health officials from China and Tanzania.

关键词： Malaria malaria Pilot

Role of the Greenland Sea ice anomaly in the late-spring drought over Northwest China

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 1-5页

作者： Yang Liu Huopo Chen Nansen-Zhu International Research centre Institute of Atmospheric Physics Chinese Academy of SciencesBeijingChina Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University for Information Science and TechnologyNanjingChina

Drought across Northwest China in late spring has exerted a vital effect on the local climate and agricultural production,and has been alleviated during the past *** study explored the influence of the preceding Arctic sea ice on the May drought in Northwest China caused by the precipitation *** analysis indicated that when the Greenland Sea ice concentration is abnormally high during February to April,the dry conditions in Northwest China tend to be *** increase of sea ice in the Greenland Sea can excite a meridional circulation,which causes sea surface temperature(SST)anomalies in the North Atlantic via the sea-air interaction,manifested as significant warm SST anomalies over the south of Greenland and the subtropical North Atlantic,but negative SST anomalies over the west of the *** abnormal SST pattern maintains to May and triggers a zonal wave train from the North Atlantic through Scandinavia and Central Asia to Northwest China,leading to abnormal cyclones in Northwest ***,Northwest China experiences a more humid climate than usual.

关键词： Arctic sea ice Greenland Sea North Atlantic SST Drought Northwest China